Accommodating intraocular lens device

Abstract
An accommodating intraocular lens device is provided. The accommodating intraocular lens device comprises a base assembly and a power lens. The base assembly comprises a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens is configured to fit within the central cavity. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.
Description
FIELD OF THE INVENTION

The invention relates generally to an accommodating intraocular lens device and, more particularly, to an accommodating intraocular lens device configured for implantation in a lens capsule or sulcus of a subject's eye.


BACKGROUND

Surgical procedures on the eye have been on the rise as technological advances permit for sophisticated interventions to address a wide variety of ophthalmic conditions. Patient acceptance has increased over the last twenty years as such procedures have proven to be generally safe and to produce results that significantly improve patient quality of life.


Cataract surgery remains one of the most common surgical procedures, with over 16 million cataract procedures being performed worldwide. It is expected that this number will continue to increase as average life expectancies continue to rise. Cataracts are typically treated by removing the crystalline lens from the eye and implanting an intraocular lens (“IOL”) in its place. As conventional IOL devices are primarily focused for distance visions, they fail to correct for presbyopia and reading glasses are still required. Thus, while patients who undergo a standard IOL implantation no longer experience clouding from cataracts, they are unable to accommodate, or change focus from near to far, from far to near, and to distances in between.


Surgeries to correct refractive errors of the eye have also become extremely common, of which LASIK enjoys substantial popularity with over 700,000 procedures being performed per year. Given the high prevalence of refractive errors and the relative safety and effectiveness of this procedure, more and more people are expected to turn to LASIK or other surgical procedures over conventional eyeglasses or contact lens. Despite the success of LASIK in treating myopia, there remains an unmet need for an effective surgical intervention to correct for presbyopia, which cannot be treated by conventional LASIK procedures.


As nearly every cataract patient also suffers from presbyopia, there is convergence of market demands for the treatment of both these conditions. While there is a general acceptance among physicians and patients of having implantable intraocular lens in the treatment of cataracts, similar procedures to correct for presbyopia represent only 5% of the U.S. cataract market. There is therefore a need to address both ophthalmic cataracts and/or presbyopia in the growing aging population.


BRIEF SUMMARY

In one embodiment, an accommodating intraocular lens device having one of a high profile or a low profile. The accommodating intraocular lens device may comprise a base assembly and a power lens. The base assembly may comprise a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The power lens may be configured to fit within the central cavity. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.


In one optional aspect, the accommodating intraocular lens may have a high profile, with the predetermined distance being in the range of about 0 mm to about 0.75 mm. In another optional aspect, the predetermined distance may be about 0.01% to about 37% of the height of the outer periphery.


In another optional aspect, the accommodating intraocular lens may have a low profile, with the predetermined distance being in the range of about 0.75 mm to about 1.5 mm. In a further optional aspect, the predetermined distance may be about 38% to about 75% of the height of the outer periphery.


In another optional aspect, the inner surface of the haptic may face the central cavity and the inner surface may comprise a plurality of spaced apart contact points configured to engage a portion of the peripheral edge of the power lens.


In another optional aspect, outer grooves may be provided to extend along at least a portion of the height of the haptic. The outer grooves may be configured to permit the haptic to be radially compressed, radially expanded, or both. The outer grooves may be disposed in the outer periphery opposite the inner surface contact points.


In another optional aspect, the haptic may further comprise a plurality of tabs extending radially inwardly into the cavity. The power lens may be secured to the base assembly by the plurality of tabs. In one aspect, the plurality of tabs comprise a bottom surface that is configured to contact the first side of the power lens. The bottom surface of the plurality of tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of the haptic. The bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 0.01% to about 37% of the height of the haptic. In another aspect, the bottom surface of the plurality of tabs may be positioned at a distance of about 0.75 mm to about 1 mm from the first edge of the haptic. The bottom surface of the tabs may also be provided at a distance, from the first edge of the haptic, of about 38% to about 75% of the height of the haptic.


In another optional aspect, the haptic may further comprise a plurality of tables extending radially inwardly into the cavity. A channel may be formed between the plurality of tabs and the plurality of tables to secure the power lens to the base assembly.


In another optional aspect, the accommodating intraocular lens device may further comprise a plurality of arms coupling the base lens to the haptic. The plurality of arms may vault the base lens away from the central cavity.


In another optional aspect, the first side of the power lens may comprise one of a flexible membrane and an optic and the second side of the power lens may comprise the other of the flexible membrane and the optic. The power lens may further comprise an optic coupler disposed from the peripheral edge to couple the optic to the peripheral edge. The optic coupler may be angled to vault the optic toward the flexible membrane.


In another optional aspect, the fluid contained in the closed cavity of the power lens may be one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.


In another embodiment, an accommodating intraocular lens device is provided. The accommodating intraocular lens device may comprise a base and a power lens. The base may comprise an outer portion, an inner portion and a closed space defined between the outer and inner portions. The closed space may comprise a reservoir configured to contain a fluid. The inner portion may circumscribe a substantially circular space. The power lens may comprise a flexible membrane on one side, an optic on the opposing side and a circumferential peripheral edge coupling the flexible membrane and the optic. A portion of the circumferential peripheral edge may be configured to be in facing relation to at least a portion of the inner portion of the base.


In one optional aspect, the base may be shaped as a ring.


In another optional aspect, the base may comprise a base lens.


In another optional aspect, the base may be shaped as an incomplete ring having two closed ends. The reservoir may extend around a portion of the circumference of the base at an arc degree of about 90 to about 350.


In another optional aspect, a thickness of the inner portion is less than a thickness of the outer portion.


In another optional aspect, the reservoir contains a fluid. The fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.


In another optional aspect, the power lens may further comprise a membrane coupler extending radially inwardly from the circumferential edge to couple the membrane with the peripheral edge.


In another optional aspect, the power lens may further comprise an optic coupler disposed from the circumferential peripheral edge to couple the optic to the peripheral edge. The optic coupler is angled to vault the optic toward the flexible membrane.


In another optional aspect, the base may further comprise upper and lower flanges extending radially inwardly and forming a channel adapted to accommodate the peripheral edge of the power lens.


In another optional aspect, the reservoir may comprise an outer reservoir, an inner reservoir and a narrowed channel between the outer and the inner reservoir. The inner reservoir may comprise a support structure or a braided structure.


In another optional aspect, the circumferential peripheral edge facing the inner portion of the base may be in direct physical contact with the inner portion.


In another optional aspect, the flexible membrane, the optic and the circumferential peripheral edge define a closed cavity within the power lens. The closed cavity may be configured to contain a fluid. The fluid may be any one or a combination selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether.


In another embodiment, a toric base assembly for an accommodating intraocular lens device is provided. The toric base assembly can be used as a part of a two-part accommodating intraocular lens device that further includes a power lens that can be provided in connection with the toric base assembly. The toric base assembly provides for an asymmetric translation of a radially compressive force onto a power lens that is provided centrally within the toric base assembly. The toric base assembly may thus comprise a base assembly comprising a base lens and a substantially circular haptic surrounding the base lens. The substantially circular haptic may have an outer periphery and at least one region in which the flexibility of the haptic is greater than the flexibility in remaining regions of the haptic. Application of a radially compressive force may result in an asymmetric deformation of the substantially circular haptic and the asymmetric deformation of the substantially circular haptic may provide a toric power change in one or both of the base lens and the power lens.


In one optional aspect, the at least one region may comprise two regions on opposing sides of the substantially circular haptic.


In another optional aspect, the greater structural flexibility may be provided by reducing a thickness of the at least one region.


In another optional aspect, the greater structural flexibility may be provided by forming one or more shaped cut-outs in the circular haptic in the at least one region.


In another optional aspect, the circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.


In another optional aspect, the circular haptic may comprise two portions that extend radially outwardly of the outer periphery. The two regions may be on opposing sides of the circular haptic.


In another optional aspect, in the at least one region, the substantially circular haptic may comprise at least one portion that extends radially outwardly of the outer periphery.


In another optional aspect, the accommodating intraocular lens device may further comprise one or more tabs extending radially inwardly from the outer periphery.


In another optional aspect, the accommodating intraocular lens device may further comprise a power lens configured to engage the circular haptic.


In another optional aspect, the asymmetric deformation of the substantially circular haptic provides a toric power change in both of the base lens and the power lens.


In another embodiment, an accommodating intraocular lens device may be provided with a retaining system that permits the power lens and the base assembly to couple or interlock. The accommodating intraocular lens device may comprise a base assembly comprising a first open end, a second end comprising a base lens, and a haptic surrounding the base lens. The haptic may comprise an outer periphery surrounding a cavity. A power lens may be sized to fit within the cavity and a retaining system may be provided to secure the power lens within the cavity.


In one optional aspect, the retaining system may comprise a plurality of tabs extending radially inwardly from the haptic and into the cavity.


In another optional aspect, the retaining system may comprise a plurality of fins extending from a peripheral edge of the power lens and a plurality of corresponding recesses defined within an inner periphery of the haptic. The plurality of recesses may each be defined by a raised portion and an entry passage on at least one side of the raised portion.


In another optional aspect, the retaining system may comprise a pair of flanges extending outwardly from a peripheral edge of the power lens and a channel. The channel may be formed in the inner periphery of the haptic. The channel may also be formed between a pair of opposing tabs extending from the inner periphery of the haptic.


In another optional aspect, the retaining system may comprise a plurality of tabs that extend radially inwardly from the first open end of the base assembly.


In another optional aspect, the haptic is substantially circular.


In another embodiment, an accommodating intraocular lens device is provided in which the power lens is attachable or attached to a base assembly. The accommodating intraocular lens device may comprise a base assembly and a power lens. The base assembly may comprise a first open end, an open second end, and a substantially circular haptic surrounding the base lens. The substantially circular haptic may comprise an outer periphery and an inner periphery facing a cavity. The power lens may be sized to fit within the cavity. The power lens may comprise a circumferential peripheral edge, wherein at least a portion of the circumferential peripheral edge may be engaged with the inner periphery of the substantially circular haptic.


In one optional aspect, the base assembly does not comprise an optic or lens in addition to the power lens.


In another optional aspect, a portion of the power lens may be attached to the substantially circular haptic. The portion of the power lens that is attached to the substantially circular haptic may be one or both of the circumferential peripheral edge or the posterior edge of the power lens.


In another optional aspect, the power lens may be attached to the substantially circular haptic by one or a combination selected from the group consisting of: bonding and insert-molding.


Other objects, features and advantages of the described preferred embodiments will become apparent to those skilled in the art from the following detailed description. It is to be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the present invention, are given by way of illustration and not limitation. Many changes and modifications within the scope of the present invention may be made without departing from the spirit thereof, and the invention includes all such modifications.





BRIEF DESCRIPTION OF THE DRAWINGS

Illustrative embodiments of the present disclosure are described herein with reference to the accompanying drawings, in which:



FIG. 1A depicts a perspective view of a fluid-filled base assembly, in accordance with an embodiment of the present disclosure.



FIG. 1B depicts a cross-sectional view of the fluid-filled base assembly of FIG. 1A.



FIG. 1C depicts an exploded perspective view of a power lens being inserted into the fluid-filled base assembly of FIG. 1A.



FIG. 2A depicts a perspective view of a fluid-filled open base ring, in accordance with an embodiment of the present disclosure.



FIG. 2B depicts a top plan view of the fluid-filled open base ring of FIG. 2A.



FIG. 2C depicts a cross-sectional view of the fluid-filled open base ring of FIG. 2A.



FIG. 3A depicts a perspective view of a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure.



FIG. 3B depicts a top plan view of the fluid-filled closed base ring of FIG. 3A.



FIG. 3C depicts an exploded perspective view of a power lens coupled to the fluid-filled closed base ring of FIG. 3A.



FIG. 4A depicts a perspective view of a power lens coupled to a fluid-filled closed base ring, in accordance with an embodiment of the present disclosure.



FIG. 4B depicts a perspective view of a power lens coupled to a fluid-filled open base ring, in accordance with an embodiment of the present disclosure.



FIG. 5A depicts a perspective view of a power lens having a fluid transfer system, in accordance with an embodiment of the present disclosure.



FIG. 5B is a close up view of a fluid transfer system, in accordance with an embodiment of the present disclosure.



FIG. 6A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure.



FIG. 6B depicts a top plan view of the toric base assembly of FIG. 6A.



FIG. 7A depicts a perspective view of a toric base assembly, in accordance with an embodiment of the present disclosure.



FIG. 7B depicts a top plan view of the toric base assembly of FIG. 7A.



FIG. 8A depicts a perspective view of a base assembly, in accordance with an embodiment of the present disclosure.



FIG. 8B depicts a top plan view of the base assembly of FIG. 8A.



FIG. 8C depicts a cross-sectional view of the base assembly of FIG. 8A.



FIG. 9A depicts a perspective view of an accommodating IOL configured to position a power lens closer to a base lens of the base assembly, in accordance with an embodiment of the present disclosure.



FIG. 9B depicts a top plan view of the accommodating IOL of FIG. 9A.



FIG. 9C depicts a cross-sectional view of the accommodating IOL of FIG. 9A.



FIG. 10A depicts an exploded perspective view of a low profile accommodating IOL, in accordance with an embodiment of the present disclosure.



FIG. 10B depicts a perspective view of the low profile accommodating IOL of FIG. 10A.



FIG. 10C depicts a top plan view of the low profile accommodating IOL of FIG. 10A.



FIG. 10D depicts a perspective cross-sectional view of the low profile accommodating IOL of FIG. 10A.



FIG. 11A depicts a perspective view of an accommodating IOL comprising a base assembly and a power lens having a fin-lock, in accordance with an embodiment of the present disclosure.



FIG. 11B depicts an exploded perspective view of the accommodating IOL of FIG. 11A.



FIG. 11C depicts a top plan view of the accommodating IOL of FIG. 11A.



FIG. 11D depicts a cross-sectional view of the accommodating IOL of FIG. 11A.



FIG. 12A depicts an exploded perspective view of an accommodating IOL having a base assembly and a power lens with a plate haptic, in accordance with an embodiment of the present disclosure.



FIG. 12B depicts an exploded plan view of the accommodating IOL of FIG. 12A.



FIG. 12C depicts a top plan view of the power lens of the accommodating IOL of FIG. 12A.



FIG. 12D depicts a top plan view of the accommodating IOL of FIG. 12A.



FIG. 12E depicts a cross-section view of the accommodating IOL of FIG. 12A.



FIG. 12F depicts a bottom perspective view of the accommodating IOL of FIG. 12A.



FIG. 13A depicts a perspective view of a base assembly having extended tabs, in accordance with an embodiment of the present disclosure.



FIG. 13B depicts a top plan view of the base assembly of FIG. 13A.



FIG. 13C depicts a cross-sectional view of the base assembly of FIG. 13A.



FIG. 14A depicts a perspective view of a base ring, in accordance with an embodiment of the present disclosure.



FIG. 14B depicts a top plan view of the base ring of FIG. 14A.



FIG. 14C depicts a cross-sectional view of the base ring of FIG. 14A.



FIG. 14D depicts an alternative cross-sectional view of the base ring of FIG. 14A.



FIG. 14E depicts a perspective view of a mesh braid that may be incorporated into the base ring of FIG. 14D.



FIG. 15A depicts a perspective view of an accommodating IOL having a one-piece base assembly and a power lens, in accordance with an embodiment of the present disclosure.



FIG. 15B depicts a top plan view of the accommodating IOL of FIG. 15A.



FIG. 15C depicts a cross-sectional view of the accommodating IOL of FIG. 15A.



FIG. 15D depicts a bottom perspective view of the accommodating IOL of FIG. 15A.



FIG. 16A depicts a perspective view of an accommodating IOL having a no gap base assembly, in accordance with an embodiment of the present disclosure.



FIG. 16B depicts a side plan view of the accommodating IOL of FIG. 16A.



FIG. 16C depicts a perspective view of a no gap base assembly that may be utilized in the accommodating IOL of FIG. 16A.



FIG. 16D depicts a perspective view of a power lens that may be utilized in the accommodating IOL of FIG. 16A.



FIG. 16E depicts a top plan view of the accommodating IOL of FIG. 16A.



FIG. 16F depicts a cross-sectional view of the accommodating IOL of FIG. 16A.





Like numerals refer to like parts throughout the several views of the drawings.


DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Specific, non-limiting embodiments of the present invention will now be described with reference to the drawings. It should be understood that such embodiments are by way of example and are merely illustrative of but a small number of embodiments within the scope of the present invention. Various changes and modifications obvious to one skilled in the art to which the present invention pertains are deemed to be within the spirit, scope and contemplation of the present invention.


Various embodiments of accommodating intraocular lenses (IOL) described herein and may comprise the power changing feature of a power lens in connection with a base lens. In one optional embodiment, the power changing feature of the IOL is driven by fluid optics within a closed volume of a power lens that comprises a flexible membrane and a lens or optic. One significant advantage of this embodiment is that the closed volume of the power lens that spaces apart the flexible membrane and the lens maintains a substantially constant volume and therefore avoids many of the problems associated with fluid optic IOLs that require substantial changes in volume, i.e., fluid being fed into the chamber from reservoirs. The many disadvantages exhibited by fluid optics having changing volumes include non-uniform power change and buckling. Certain embodiments of the IOLs and the power lens disclosed herein may avoid or mitigate such problems by maintaining a substantially constant volume, while at the same time maintaining good optical quality throughout the range of power change. Additionally, various embodiments of the IOLs that comprise a two-part assembly of the power lens and the base assembly as described herein provide a smaller delivery profile, a smaller implant profile or both, so as to require a substantially smaller incision size for implantation. This, in turn, may have the concomitant advantage of reducing biocompatibility issues associated with the delivery and implantation of larger IOLs and may result in faster healing and a more stable refraction.


The IOLs disclosed herein may be configured in any number of ways. Generally, the IOLs may comprise a base assembly and a power lens that can be coupled within the base assembly. In one embodiment, the radially compressive forces exerted on an implanted IOL may be concentrated onto a flexible membrane of the power lens to cause the flexible membrane to change in curvature. The lens or optic of the power lens may be configured to axially displace toward the flexible membrane in response to its change in curvature. This axial displacement may be facilitated by coupling the optic to the peripheral edge of the IOL in a manner that permits the optic to float. As the flexible membrane of the power lens changes in curvature, fluid adhesion or surface tension may pull the optic or lens of the power lens toward the flexible membrane. In another embodiment, the radially compressive forces exerted on the power lens may be concentrated onto the optic to cause the optic to axially displace and to push the flexible membrane in the same direction as the axial displacement of the optic to effectuate the change in curvature of the flexible membrane. In yet a further embodiment, the radially compressive forces on the power lens may be exerted on both the optic and the flexible membrane to cause the axial displacement and change in curvature, respectively.


In a further embodiment, the radially compressive forces exerted on the power lens may be applied to one or both of the flexible membrane and the optic to cause the change in curvature of the flexible membrane and to cause axial displacement of the optic toward the flexible membrane, while maintaining a constant volume during radial compression.


In one embodiment, the term “constant volume” includes a volume which changes no more than about 1% from its resting state, no more than about 2% from its resting state, no more than about 3% from its resting state, no more than about 4% from its resting state, no more than about 5% from its resting state, no more than about 10% from its resting state, no more than about 15% from its resting state, no more than about 20% from its resting state, no more than about 25% from its resting state, no more than about 30% from its resting state, no more than about 35% from its resting state, no more than about 40% from its resting state, no more than about 45% from its resting state, no more than about 50% from its resting state, no more than about 55% from its resting state, no more than about 60% from its resting state, no more than about 65% from its resting state, no more than about 70% from its resting state, and no more than about 75% from its resting state. In another embodiment, the term “constant volume” refers to a volume that changes in a range that includes and is between any two of the foregoing values. The term “resting state” describes the configuration of the IOL or power lens when no radially compressive forces are exerted on the IOL or the power lens.


As used herein, the term “power lens” may refer to an assembly that provides a range of accommodation or refractive correction in response to the application of radially compressive or expansive forces. In one embodiment, the power lens may provide a range of accommodation of about 1 diopter, about 2 diopters, about 3 diopters, about 4 diopters, about 5 diopters, about 6 diopters, about 7 diopters, about 8 diopters, about 9 diopters, about 10 diopters, about 11 diopters, about 12 diopters, about 13 diopters, about 14 diopters, about 15 diopters, about 16 diopters, about 17 diopters, about 18 diopters, about 19 diopters, or about 20 diopters. In another embodiment, the power lens may provide a range of accommodation between and including any two of the foregoing values. The term “power lens” may also include an assembly which comprises a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. In one aspect, the first and second sides may be a flexible membrane or an optic. In another aspect, the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic. In a further aspect, the power lens may further be characterized as having a closed fluid-filled cavity having a constant volume throughout the range of accommodation.


Certain embodiments of the two-part accommodating IOL devices disclosed herein may provide a number of advantages owing to their separate two-part construction. Implantation of the two-part IOL device may require a significantly reduced incision size, as the two parts of the IOL device (e.g., the base assembly and the power lens) are implanted separately and thus significantly reducing the delivery profile for implantation. The reduced incision size may provide a number of advantages, including obviating the need for anesthesia and sutures to close the incision site and improved surgical outcomes. In one embodiment, the incision size required to implant the two-part accommodating IOL devices is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm. Stated a different way, each part of the two-part accommodating IOL device may be provided in a delivery state having a delivery profile that is less than about 5 mm, less than about 4 mm, less than about 3 mm, or less than about 2 mm. The delivery state of each part of the two-part accommodating IOL device may be provided when each part is rolled, folded or otherwise compressed to reduce its size for delivery. A hinge or a predetermined crease may be provided on one or both of the base assembly and the power lens to facilitate folding or rolling into the delivery state.


Additionally, greater control is afforded with respect to adjusting the sizing and the power of the IOL during surgery. Implanting the base assembly into the lens capsule will provide the physician an impression as to the size of the patient's lens capsule and will thus help select the correct size of the power changing lens that will subsequently be implanted into the base assembly.



FIG. 1A depicts a perspective of an embodiment of a fluid-filled base assembly 100 of an accommodating IOL. FIG. 1B provides a cross-sectional view of the fluid-filled base assembly 100. The base assembly 100 shown in FIGS. 1A-1B may include a base lens 110 and a haptic system 120 disposed substantially circumferentially around the base lens 110. The haptic system 120 may be sized and configured to receive a separate power lens, such as the power lens 195, 350 depicted in FIGS. 1C and 3C respectively. The power lens 195, 350 can be inserted within the base assembly 100 to form a two-part accommodating IOL device.


In one embodiment, the haptic system 120 may include a reservoir 130 that extends through at least a portion of the haptic system 120. In accordance with one aspect, the reservoir 130 can extend around a portion of the circumference of the haptic system 120, as depicted in FIGS. 2A-2C and 4B, such that the reservoir 130 has an arc degree of at least 90, at least 100, at least 110, at least 120, at least 130, at least 140, at least 150, at least 160, at least 170, at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300, at least 310, at least 320, at least 330, at least 340, at least 350, or about 360. In accordance with another aspect, the reservoir 130 can extend around a portion of the circumference of the haptic system 120 within a range that includes and is between any two of the foregoing values, e.g. 180 arc degrees to 270 arc degrees. In accordance with another aspect, the reservoir 130 can extend around an entire circumference of the haptic system 120, e.g., 360 arc degrees, as provided in the embodiment depicted in FIGS. 1A-1C.


The reservoir 130 can be defined or bounded by an inner region 180 and outer region 150. The reservoir 130 is configured to contain a fluid (e.g., a liquid or a gas). In certain embodiments, the fluid can be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether. The fluid contained within the reservoir 130 can function to distribute forces applied to the outer region 150 of the haptic system 120 to the inner region 180. For example, fluid contained within the reservoir 130 can be used to substantially evenly transmit compressive forces applied to the outer region 150 of the haptic system 120, e.g. forces caused from the relaxation of the ciliary muscles, to the inner region 180. Forces transmitted to the inner region 180 can subsequently be transmitted to a power lens (195, 350 as depicted in FIGS. 1C and 3C respectively) that is coupled centrally within the base assembly 100. Alternatively or in addition, forces transmitted to the inner region 180 can be transmitted to the base lens 110.


The fluid-filled base assembly 100 can include an upper flange 160 and a lower flange 170 extending inwardly from the haptic system 120 along at least a portion of the circumference of the haptic system 120. The upper flange 160 and the lower flange 170 define a channel that is configured to secure a power lens 195 to the fluid-filled base assembly 100. FIG. 1C depicts an exploded perspective view of a power lens 195 being inserted into the base assembly 100, with the peripheral edge 197 of the power lens 195 being adapted to fit within the channel defined by the upper and lower flanges 160, 170. Additionally, at least a portion of the peripheral edge 197, if not the entirety of the peripheral edge 197 is configured to engage or directly contact the inner region 180 so as to effectively transmit the forces transmitted to the inner region 180 onto one or both of the first and second sides 196, 199 of the power lens 195 to provide accommodation. As explained above, the first and second sides may be a flexible membrane or an optic or, alternatively, the first side may be one of a flexible membrane or an optic and the second side may be the other of a flexible membrane or an optic.



FIG. 2A depicts a perspective view of an open fluid-filled base ring 200 of an accommodating IOL. FIGS. 2B and 2C depict top plan and cross-sectional views of the open fluid-filled base ring 200, respectively. The open fluid-filled base ring 200 represents an alternative embodiment of the fluid-filled base assembly 100 discussed above with reference to FIGS. 1A-1C and can be used in connection with the power lens 195 depicted in relation to FIG. 1C. The open fluid-filled base ring 200 includes a haptic system 210. The open fluid-filled base ring 200 differs from the base assembly 100 of FIG. 1 in that the open fluid-filled base ring 200 does not include a base lens. As such, any visual correction must be provided by a power lens 195 that may be inserted into the open fluid-filled base ring 200 in a manner depicted in relation to FIG. 1C.


In one embodiment, the open fluid-filled base ring 200 is an open ring, i.e., it is not a complete ring. In one embodiment, the open fluid-filled base ring 200 is provided as a C-shape having two closed ends, 210A, 210B, in which its outer periphery is less than 360 arc degrees. In another embodiment, the open fluid filled base ring 200 is provided as a circular shape of substantially about 360 arc degrees but comprises a pair of closed ends such that the inner cavity 250 is not a continuous circumferential volume but comprises a circumferential volume having a pair of closed ends. Both embodiments permit for the open fluid-filled base ring 200 to increase the diameter defined within the central area of the haptic 210 and accommodate power lenses of varying diameters. The C-shaped or incomplete ring configuration can also allow for toric or non-uniform deformation of a power lens, as a portion of the periphery of the power lens will not be contacted by the open fluid-filled base ring 200 and, therefore, the uncontacted portion of the periphery of the power lens will not experience radially-inward forces applied by the open fluid-filled base ring 200. Thus in one embodiment, the open fluid-filled base ring 200 can transmit a radially-compressive forces around only a pre-determined portion of the circumference of a power lens 195 peripheral edge 197 that is provided or coupled within the open fluid-filled base ring 200 so as to provide an asymmetric radial compression of the power lens 195 implanted within the open fluid-filled base ring 200.


In one embodiment, the open fluid-filled base ring 200 has an arc degree of at least 180, at least 190, at least 200, at least 210, at least 220, at least 230, at least 240, at least 250, at least 260, at least 270, at least 280, at least 290, at least 300 at least 310, at least 320, at least 330, at least 340, at least 350, or 360. In each of the foregoing embodiments, the open-fluid filled base ring has a circumference that defines an angle that is provided within a range between any two of the foregoing values.


The open fluid-filled base ring 200 includes upper and lower flanges 220 and 230, forming a channel 240 therebetween. The channel 240 may be configured to receive and secure the power lens. The haptic system 210 includes a reservoir 250 (see FIG. 2C) that extends through at least a portion of the haptic system 210, e.g. around substantially the entire haptic system 210. The haptic system 210 may include an inner wall 260 and an outer wall 270 that define the reservoir 250. In one embodiment, the inner wall 260 may have a thickness that is less than a thickness of the outer wall 270. The thickness of the inner wall 260 may be about 90%, about 80%, about 70%, about 60%, about 50%, about 40%, about 30%, about 20%, about 10% and about 5% of the thickness of the outer wall 270. The thickness of the inner wall 260 may also be within a range that is between and includes any two of the foregoing values.


The reservoir 250 may be configured to contain a fluid. In certain embodiments, the fluid may be selected from the group consisting of: a silicone oil, a fluorinated silicone oil, a polyphenyl ether, and a fluorinated polyphenyl ether. The fluorinated polyphenyl ether may be one or a combination of a pentafluoro m-phenoxyphenyl ether and an m(pentafluorophenoxy)phenyl m-phenoxyphenyl ether. The fluid contained within the reservoir 250 may function to distribute forces applied to the outer wall 270 of the haptic system 210 to the inner wall 240. For example, the fluid contained within the reservoir 250 may be used to substantially evenly transmit compressive forces applied to a periphery of the haptic system 210, e.g. forces caused from the contraction and/or relaxation of the ciliary muscles. Forces transmitted to the inner wall 260 may subsequently be transmitted to a power lens contained within the channel 240.



FIG. 3A depicts a perspective view of a fluid-filled base ring 300, in accordance with another embodiment of the present disclosure. FIG. 3B is a top plan view of the fluid-filled base ring 300. The fluid-filled base ring 300 is substantially similar to the open fluid-filled base ring 200 of FIGS. 2A-C, with the primary difference being that the fluid-filled base ring 300 is a closed ring, rather than an open ring. The fluid-filled base ring 300 may also include a haptic system 310 that is ring shaped. The fluid-filled base ring 300 may also include an upper flange 320 and a lower flange 330 extending radially inwardly from the haptic system 310. The upper flange 320 and the lower flange 330 together define a channel that is configured to secure a power lens within a central portion of the fluid-filled base ring 300. An inner wall 340 is defined between the upper flange 320 and the lower flange 330. As described above with the embodiments of FIGS. 1 and 2, external forces applied to the outer wall of the haptic system 310 (e.g., by the ciliary muscles of an eye) can be translated through the fluid-filled base ring 300 to the inner wall 340 of the haptic system 310 (the channel) to apply forces to a power lens inserted into the channel.



FIG. 3C depicts an exploded perspective view of a power lens 350 that is configured to be coupled to the fluid-filled base ring 300. The fluid-filled base ring 300 is configured to secure the power lens 350 to form an accommodating IOL.


In various embodiments, the power lens 350 includes a flexible membrane 352 on one side, an optic 354 on the opposing side, and a circumferential peripheral edge 358 coupling the flexible membrane and the optic 354. A membrane coupler 356 can extend radially inwardly from the internal side of the circumferential peripheral edge 358 to couple the membrane 352 to the peripheral edge 358. In accordance with one optional aspect, at least a portion of the peripheral edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300. In accordance with another optional aspect, the entirety of the peripheral edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300. The power lens 350 can comprise an optic coupler 360 extending radially inwardly from the internal side of the circumferential peripheral edge 358 to couple the optic 354 to the peripheral edge 358. Preferably, the optic coupler 360 is angled toward the flexible membrane 352 such that it vaults the optic 354 toward the flexible membrane 352. See, e.g., power lens 920 of FIG. 9C and power lens 1020 of FIG. 10D for exemplary cross-sectional views. Thus, in one embodiment, the power lens 350 can be identical to the power lens 920 of FIG. 9C or the power lens 1020 of FIG. 10D.


Other examples of accommodating IOLs are disclosed in U.S. Patent Application Publication No. 2013/0053954, entitled Accommodating Intraocular Lens; U.S. Patent Application Publication No. 2014/0180403, entitled Accommodating Intraocular Lens; U.S. Patent Application Publication No. 2015/0105760, entitled Method and System for Adjusting the Refractive Power of an Implanted Intraocular Lens; and U.S. patent application Ser. No. 14/447,621, entitled Accommodating Intraocular Lens, the entire contents of which are incorporated by reference in their entirety as if fully set forth herein. Any of the features disclosed with respect to the accommodating intraocular lenses in the above-cited references may be applied to any of the base assemblies, the power lenses, or the accommodating IOLs disclosed herein. For example, the various one-piece accommodating IOL embodiments disclosed in U.S. Patent application Publication Nos. 2013/0053954, 2014/0180403, and 2015/0105760 can be utilized as the power lens 350. U.S. patent application Ser. No. 14/447,621 discloses a two-piece accommodating IOL that utilizes a base assembly and a power lens inserted into the base assembly (sometimes referred to as an accommodating IOL or IOL). It should be understood that various embodiments are possible.



FIG. 4A depicts a perspective view of a power lens 350 coupled to a fluid-filled base ring 300. FIG. 4B depicts a perspective view of a power lens 350 coupled to an open fluid-filled base ring 200. In accordance with one aspect, only at least a portion of the circumferential peripheral edge 358 is in direct physical contact with the inner wall 240, 340 of the fluid-filled base ring 200, 300 (e.g. FIG. 4B). In accordance with another aspect, the entire circumferential edge 358 is in direct contact with the inner wall 340 of the fluid-filled base ring 300 (e.g., FIG. 4A).



FIG. 5A provides a perspective view of a fluid-exchange power lens 500 in accordance with an embodiment of the present disclosure. The power lens 500 shown in FIG. 5A can include the components as described with respect to the power lens 350 shown in, for example, FIG. 3C. In various embodiments, the power lens 500 includes a reservoir for storing a fluid that can be transferred to a fluid-filled base assembly that forms part of an accommodating IOL. The power lens 500 includes a fluid transfer valve 510 that is configured to be removably coupled to the fluid-filled base assembly (see FIG. 5B). The fluid transfer valve 510 functions to provide a fluid communication between the power lens 500 and a base assembly shown in FIGS. 1-4.



FIG. 5B depicts an embodiment of a fluid transfer system for transferring fluid between a power lens and a fluid-filled base assembly of an accommodating IOL. The fluid transfer valve 510 is configured to interact with a receiving valve 520 that is disposed on an inner wall of the fluid-filled base assembly (e.g., 180, 240, 340 of FIGS. 1B, 2A, 3A, respectively. In various embodiments, the fluid transfer valve 510 can be implemented as part of a power lens 500 and the receiving valve 520 can be implemented as part of a fluid-filled base assembly 590 or vice versa. The fluid transfer valve 510 includes a canal 530 leading to a one-way valve 540. The receiving valve 520 includes valve release canal 550. The receiving valve 520 includes its own one-way valve 560. When the fluid transfer valve 510 and the receiving valve 520 stand alone, both one-way valves 530, 560 are closed, and no fluid escapes either the power lens 500 or the fluid-filled base assembly 590. When the canal 530 of the fluid transfer valve 510 is inserted into the one-way valve 560 of the fluid-filled base assembly 590, the canal 530 forces open the one-way valve 560. Similarly, the valve release canal 550 forces open the one-way valve 540. As a result, both one-way valves 540, 560 are pushed open, and fluid can freely flow between the power lens 500 and the fluid-filled base assembly 590.



FIGS. 6 and 7 depict embodiments of a toric base assembly 600, 700. The base assembly 600, 700 comprises a base lens 610, 710 and a substantially circular haptic system 620, 720 having an outer periphery and at least two regions having different flexibility. Because at least two regions have greater flexibility 640, 730 than in the remaining regions of the haptic system 620, 720, the application of a radially-compressive force onto the outer periphery of the haptic system 620, 720 results in an asymmetric deformation of the haptic system 620, 720 in the regions of greater flexibility 640, 730. In other words, the regions of greater flexibility 640, 730 are radially compressed or compressible to a greater extent than the remaining regions of the haptic system 620, 720. This asymmetric deformation, in turn, may provide a toric power change in one or both of a base lens 610, 710 and a power lens that is provided within the haptic system 620, 720.



FIGS. 6A-6B depicts one embodiment of the toric base assembly 600. FIG. 6A depicts a perspective view of a toric base assembly 600 of an accommodating toric IOL, in accordance with an embodiment of the present disclosure. FIG. 6B provides a top plan view of the toric base assembly 600. The toric base assembly 600 includes a base lens 610 and substantially circular haptic system 620. The toric base assembly 600 includes a plurality of tabs 630 to engage an inserted power lens (not depicted). The outer periphery of the haptic system 620 is configured to receive deforming forces caused by the ciliary muscles of the eye to cause radially-inward compression of the haptic system 620. These forces are then translated to either one or both of the base lens 610 and/or a power lens that can be inserted into the base assembly 600. In the embodiment shown in FIGS. 6A and 6B, portions of the haptic system 620 have greater structural flexibility, leading to uneven translation of a radially-inwardly applied force by various portions of the haptic system 620. In the embodiment shown, cutouts 640 are formed in the haptic system 620 to create greater flexibility proximate the cutouts 640. The cutouts 640 can be formed to provide an area of the haptic 620 that is thinner than the remaining areas of the haptic 620. As a result, greater compressive forces are applied by the haptic system 620 proximate the cutouts 640, which in turn results in toric deformation of either or both the base lens 610 and an inserted power lens.



FIGS. 7A and 7B provide perspective and top plan views, respectively, of an alternative toric base assembly 700, in accordance with an embodiment of the present disclosure. The toric base assembly 700 includes a base lens 710 and a haptic system 720. In the toric base assembly 700 shown in FIGS. 7A and 7B, in addition to having cutouts 740 to create greater flexibility in certain regions of the haptic system 720, the haptic system 720 includes two extended regions 730 that extend beyond the circumference defined by the haptic system 720. The extended regions 730 and the cutouts 740 cause an unequal distribution of compressive forces, resulting in toric deformation of either or both the base lens 710 and an inserted power lens.


The accommodating IOL may be provided with a base assembly that permits for varying profiles. The varying profiles may be provided by configuring the base assembly such that the power lens is placed farther away from the base lens (i.e., high profile) or closer to the base lens (i.e., low profile).



FIGS. 8A-8C depict an embodiment of a high profile IOL base assembly 800. FIG. 8A depicts a perspective view of the base assembly 800 and FIGS. 8B and 8C depict top plan and cross-sectional views, respectively, of the base assembly 800.


The base assembly 800 includes a first open end 800A and a second end 800B that may optionally include a base lens 830. The haptic system 810 includes an outer periphery and an inner surface facing a central cavity. The inner surface may comprise a plurality of spaced-apart contact points 862 configured to engage a portion of a peripheral edge of an implanted power lens (not depicted) that may be provided to fit within a central cavity of the base assembly 800. A plurality of tabs 840 may be provided to extend into a cavity 850 and to create a plurality of recesses 860 within the cavity 850 to retain a portion of a peripheral edge of a power lens. A plurality of tables 870 extend from a bottom of the base assembly 800 into the cavity 850 along portions of a periphery of the cavity 850. The tables 870 rise to a level such that a top surface of the tables 870 is in substantially the same plane formed by the bottom surfaces of the recesses 860. The tables 870 in combination with the recesses 860 ensure that an inserted power lens is secured at a desired position within the cavity 850 with respect to the base lens 830.


The haptic system 810 has a height h2 between a first edge and a second edge of its outer periphery. The power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides. The power lens may further comprise a closed cavity configured to house a fluid The first side of the power lens is positioned at a predetermined distance h1 from the first edge of the haptic system 810. This predetermined distance h1 determines the profile of the base assembly 800. In one exemplary embodiment, the predetermined distance h1 may be in the range of about 0 mm to about 0.75 mm. In accordance with another embodiment, the predetermined distance h1 may be in the range of about 0.01% to about 37% of the height of the haptic h2. As shown in FIG. 8C, the predetermined distance can be measured by reference to a bottom surface of a plurality of tabs 840 that is used to secure a first side of the power lens. Thus, in accordance with this embodiment, the bottom surface of the tabs may be positioned at a distance of about 0 mm to about 0.75 mm from the first edge of the haptic system 810 or at a distance, from the first edge of the haptic system 810, of about 0.01% to about 37% of the height h2 of the haptic system 810.


The haptic system 810 may be is substantially circular with a plurality of outer grooves 820. The outer grooves 820 may extend along at least a portion of the height of the haptic system 810. The outer grooves 820 may be configured to permit the haptic to be radially compressed, radially expanded, or both. In one embodiment, the outer grooves 820 may be disposed in the outer periphery of the haptic system 810 opposite the inner surface contact points 862.



FIGS. 9 and 10 depict embodiments of a low profile base assembly.



FIG. 9A depicts a perspective view of an accommodating intraocular lens 900 including a base assembly 900 and a power lens 920 coupled to the base assembly 910. Compared to the base assembly 800 of FIG. 8A, the base assembly 900 of the accommodating IOL 900 is configured to position the power lens 920 deeper within the base assembly 910, and closer to a base lens of the base assembly 910. FIG. 9B provides a top plan view of the accommodating IOL and FIG. 9C provides a cross-sectional view of the accommodating IOL including the base assembly 900 and the power lens 920. The accommodating IOL includes a power lens 920 that is secured in the base assembly 900, and held in place, in part, by a plurality of tabs 930 that extend radially inwardly from the base assembly 900 into a central cavity within the base assembly 900. The bottom surface of the tabs 930 contact a first side of the power lens 920, similarly as with FIG. 8C. As can be seen most clearly in FIG. 9C, the power lens 920 is positioned proximate a base lens 940. In the embodiment shown, the power lens 920 comprises a flexible membrane 950, and a power lens optic 960. The flexible membrane 950 and the power lens optic are spaced apart, and a fluid fills the space between the two. The power lens optic 960 and the base lens 940 are proximate one another.


A haptic system 910 has a height h2 between a first edge and a second edge of its outer periphery. The power lens comprises a first side, a second side and a peripheral edge coupling the first and second sides. The power lens may further comprise a closed cavity configured to house a fluid The first side of the power lens is positioned at a predetermined distance h1 from the first edge of the haptic system 910. This predetermined distance h1 determines the profile of the base assembly 900. In one exemplary embodiment, the predetermined distance h1 may be in the range of about 0 mm to about 0.75 mm. In accordance with another embodiment, the predetermined distance h1 may be in the range of about 0.01% to about 37% of the height of the haptic h2. As shown in FIG. 9C, the predetermined distance can be measured by reference to a bottom surface of a plurality of tabs 930 that is used to secure a first side of the power lens. Thus, in accordance with this embodiment, the bottom surface of the tabs may be positioned at a distance of about 0.75 mm to about 1.5 mm from the first edge of the haptic system 810 or at a distance, from the first edge of the haptic system 910, of about 38% to about 75% of the height h2 of the haptic system 910.


The haptic system 910 may be substantially circular with a plurality of outer grooves 920. The outer grooves 920 may extend along at least a portion of the height of the haptic system 910. The outer grooves 920 may be configured to permit the haptic to be radially compressed, radially expanded, or both. In one embodiment, the outer grooves 920 may be disposed in the outer periphery of the haptic system 910 opposite the inner surface contact points 962.


The lower profile of the accommodating IOL amplifies power change by the accommodating IOL 900, as will be described in greater detail below with respect to FIG. 10.



FIGS. 10A-10D depict another embodiment of a low profile accommodating IOL 1000, in which a low profile base assembly 1010 is configured to place a power lens 1020 deeper within the base assembly 1010, in close proximity with a base lens 1030, to create a greater range of optical power possible with a particular IOL configuration. The low profile accommodating IOL 1000 includes a base assembly 1010, and a power lens 1020 configured to be secured within the base assembly 1010. The base assembly 1010 comprises a haptic portion 1015 for translating forces applied to the periphery of the haptic portion 1015 to the power lens 1020.


As can be seen in cross sectional view of FIG. 10D, the power lens 1020 includes a flexible membrane 1050 and a power lens optic 1040, while the base assembly 1010 includes a haptic portion 1015 for translating forces applied to the periphery of the haptic portion 1015 to the power lens 1020 and a base lens 1030. The base lens 1030 and the power lens optic 1040 are proximate one another, and the lower profile of the accommodating IOL amplifies power change by the power lens 1020. Change in power by the accommodating IOL 1000 is largely produced by accommodation of the power lens 1020. Furthermore, accommodation of the power lens 1020 is most effectively produced by applying forces to the membrane 1050, rather than to the power lens optic 1040. As such, power change of the accommodating IOL 1000 is most efficient when forces applied to the periphery of the haptic 1015 are translated efficiently to the membrane 1050.


The low profile accommodating IOL 1000 efficiently translates forces from the haptic 1015 to the membrane 1050 in several ways. First, placement of the power lens 1020 deeper within the haptic 1015 leads to more efficient translation of forces from the haptic 1015 to the power lens 1020 (which comprises the membrane 1050). This is due, at least in part, to the fact that when the power lens 1020 is positioned higher up within the haptic 1015, a greater proportion of the forces exerted on the periphery of the haptic 1015 are distributed to the base lens 1030, rather than the power lens 1020. The portion of the force that is distributed to the base lens 1030 does not significantly affect accommodation and/or power change, and therefore, is not utilized efficiently to effect power change by the accommodating IOL 1000. By moving the power lens 1020 lower within the haptic 1015, a greater proportion of forces are distributed to the power lens 1020 rather than being lost to the base lens 1030. Furthermore, placement of the power lens 1020 proximate the base lens 1030 allows for the power lens 1020 to be in closer proximity with a hinge portion 1090, which translates at least a portion of the forces being distributed to the base lens 1030 to the power lens 1020.


As discussed above, even if forces are applied to the power lens 1020, accommodation is maximized when forces are applied to the membrane 1050 rather than the power lens optic 1040. A cutout 1080 on a lower portion of a periphery of the power lens 1020 results in forces being translated to the membrane 1050 rather than the power lens optic 1040. By removing a lower portion of the periphery of the power lens 1020 (cutout 1080), the haptic 1015 engages primarily with an upper portion 1070 of the periphery of the power lens 1020 and forces are exerted primarily on the membrane 1050 (which is on the upper portion of the power lens 1020) rather than the power lens optic 1040 (which is on the lower portion of the power lens 1020), thereby affecting greater power change in the power lens 1020.


In the embodiment depicted in FIGS. 8A-8C, the accommodating intraocular lens may have a higher profile as compared to the embodiments depicted in FIGS. 9 and 10. In other words, in the high profile embodiments, the power lens is positioned closer to the open end of the haptic system 810 and farther away from the base lens 830 (FIGS. 8A-8C) and in the low profile embodiments, the power lens 920, 1020 is placed farther away from the open end and closer to the base lens 940, 1030 (FIGS. 9A-9C and FIGS. 10A-10D). The position of the power lens is represented in FIGS. 8C and 10D with reference to the distance h1 of the peripheral edge of the power lens from the first edge of the outer periphery of the haptic.


Thus, in accordance with one aspect, the power lens is positioned at a predetermined distance from the first edge of the outer periphery of the haptic, as represented by h1 in FIGS. 8C and 10D. In one aspect, the predetermined distance h1 may be about 0 mm, about 0.1 mm, about 0.15 mm, about 0.2 mm, about 0.25 mm, about 0.30 mm, about 0.35 mm, about 0.40 mm, about 0.45 mm, about 0.50 mm, about 0.55 mm, about 0.60 mm, about 0.65 mm, about 0.70 mm, about 0.75 mm, about 0.80 mm, about 0.85 mm, about 0.90 mm, about 0.95 mm, about 1 mm, about 1.1 mm, about 1.15 mm, about 1.2 mm, about 1.25 mm, about 1.3 mm, about 1.35 mm, about 1.4 mm, about 1.45 mm, about 1.5 mm, about 1.55 mm, about 1.6 mm, about 1.65 mm, about 1.7 mm, about 1.75 mm, about 1.8 mm, about 1.85 mm, about 1.9 mm, about 1.95 mm, and about 2 mm. In another aspect, the predetermined distance h1 is may be provided within a range that is between and includes any two of the foregoing values. In a further aspect, the predetermined distance h1 for a high profile accommodating IOL may be in the range of about 0 mm to about 0.75 mm. In yet a further aspect, the predetermined distance h1 for a low profile accommodating IOL may be in the range of greater than 0.75 mm to about 1 mm.


The predetermined distance h1 may also be provided as a percentage of the total height h2 of the outer periphery of the haptic system 810, 1015. In one aspect, the predetermined distance h1 may be about 0.01%, about 1%, about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, and about 90% of the total height h2 of the outer periphery of the haptic system 810, 1015. In another aspect, the predetermined distance h1 may be provided within a range that is between and includes any two of the foregoing values. In a further aspect, the predetermined distance h1 for a high profile accommodating IOL may be about 0.01% to about 37% of the total height h2 of the outer periphery of the haptic system 810, 1015. In yet a further aspect, the predetermined distance h1 for a high profile accommodating IOL may be about 38% to about 75% of the total height h2 of the outer periphery of the haptic system 810, 1015.



FIG. 11A depicts a perspective view of an accommodating IOL 1100 including a base assembly 1110 and a power lens 1120, in accordance with an embodiment of the present disclosure. FIG. 11B provides an exploded view of the accommodating IOL 1100, FIG. 11C provides a top plan view of the accommodating IOL 1100, and FIG. 11D provides a cross-sectional view of the accommodating IOL 1100. The base assembly 1110 includes a haptic system 1130. As most clearly seen in FIG. 11C, the haptic system 1130 includes a plurality of recesses or cutouts 1140 defined within an inner periphery of the haptic system 1130 for receiving one or more fins 1150 extending from a peripheral edge of the power lens 1120. The plurality of recesses or cutouts 1140 may be defined by a raised portion or tab 1160 and an entry passage on at least one side of the raised portion. The power lens 1120 is lowered into the base assembly 1110 such that each of the fins 1150 enter in through one of the plurality of cutouts 1140. The power lens 1120 is then rotated, such that each fin 1150 is no longer positioned within one of the cutouts 1140, but rather, is positioned below one of a plurality of tabs 1160. Once each fin 1150 (or at least one of the fins 1150) is positioned below a tab 1160, the power lens 1120 becomes secured to the base assembly 1110. In certain embodiments, manipulation holes may be created on the power lens 1120 to allow a user to insert a tool into the one or more manipulation holes to assist in rotating the power lens 1120.



FIGS. 12A-12F provide various views of an accommodating IOL 1200, according to an embodiment of the present disclosure. In this embodiment, the accommodating IOL 1200 comprises a base assembly 1210 and a power lens 1220. The base assembly 1210 includes a base lens 1290. The power lens 1220 includes a flexible membrane 1230 and an optic 1235 and flanges 1240 that extend outwardly from a peripheral edge of the power lens 1220. The flanges 1240 can be inserted into a channel 1250 that is formed in the inner periphery of the base assembly 1240 or haptic by a plurality of upper tabs 1260 and lower tabs 1270. The positioning of the flanges 1240 towards the anterior portion of the power lens 1220 may be advantageous in that the flanges 1240 and the tabs 1260 securing the flanges 1240 are positioned such that they do not interfere with the visual elements of the accommodating IOL, i.e., the flexible membrane 1230, the optic 1235, and the base lens 1290. As such, visual artifacts or light distortions caused by the flanges and the tabs 1260, 1270 are minimized or eliminated altogether. The flanges 1240 do not extend out of the power lens 1220 at regions 1280 to allow for easier insertion of the power lens 1220 into the base assembly 1210.



FIGS. 13A-13C depict an embodiment a base assembly 1300 with extended tabs for an accommodating IOL. The base assembly 1300 includes a haptic system 1310 and a cavity 1320 for receiving a power lens. Extended tabs 1330 extend over a portion of the circumference of the haptic system 1310 and into the cavity. The extended tabs 1330 are used to secure a power lens within the base assembly 1310. In certain embodiments, each tab 1330 may be measured by an angular coverage, indicative of the portion of the circumference encompassed by each tab 1330. In certain embodiments, each tab 1330 may encompass between 30 degrees and 180 degrees. Each tab 1330 may also include a width measurement, indicative of how far in towards the center of the base assembly the tab 1330 extends. An outer edge of the haptic system 1310 and applicable haptic systems described in this disclosure can be approximately 1 mm thick.



FIGS. 14A-D depict various views of an astigmatism-free base ring 1400, in accordance with an embodiment of the present disclosure. The astigmatism-free base ring 1400 is a fluid-filled base ring configured to receive a power lens in a manner as depicted with reference to FIGS. 1C and 3C. The astigmatism-free base ring 1400 includes a haptic system 1410 and may be provided as a ring shaped to enclose a region 1420. A power lens may be inserted into the region 1420 to form an accommodating IOL. The astigmatism-free base ring 1400 includes upper flanges 1430 and a lower surface 1435 to secure the power lens between the upper flanges 1430 and the lower surface 1435.



FIG. 14C provides a cross-sectional view of the astigmatic free base ring 1400. The astigmatism-free base ring 1400 may include an outer reservoir 1440 and an inner reservoir 1450. The outer reservoir 1440 and the inner reservoir 1450 may contain a fluid, and may be in fluid communication with one another. In one embodiment, the outer reservoir 1440 and the inner reservoir 1450 may be provided in fluid communication with one another through a channel 1460 that is narrower than at least one of the outer reservoir 1440 and the inner reservoir 1450. The use of the two reservoirs 1440, 1450 in fluid communication with one other through a narrowed channel 1460 more evenly distributes a radially-compressive force onto the inner surface of the base ring 1400 that is located between the upper flange 1420 and the lower surface 1435 when a radially compressive force applied to the periphery of the haptic system 1410. As such, a more even, non-toric deformation is created in the accommodating IOL.



FIG. 14D provides a cross-sectional view of an alternative embodiment of the astigmatism-free base ring 1400. In certain embodiments, a mesh braid, such as that shown in FIG. 14E, may be incorporated into the inner reservoir 1450. In certain embodiments, the mesh braid may comprise a Nitinol braid. The mesh braid (FIG. 14E) may allow for fluid to flow between the inner and outer reservoirs 1450, 1440, while providing additional structure support for the inner reservoir, thereby facilitating even disbursement of forces applied to the astigmatism-free base ring 1400. Thus, in one embodiment, the base ring 1400 described above may further comprise a porous support structure or a mesh braid, such as the one depicted in FIG. 14E, which may be disposed along a portion of or along an entirety of the inner reservoir 1450.



FIG. 15A depicts a perspective view of an accommodating IOL 1500 having a base assembly and power lens that is attached or attachable to one another by bonding or insert molding. FIG. 15B provides a top plan view of the accommodating IOL 1500. FIG. 15C depicts a cross-sectional view of the accommodating IOL 1500. FIG. 15D depicts a bottom perspective view of the accommodating IOL 1500. The accommodating IOL 1500 includes a haptic base assembly 1510 attached to a power lens 1520 during manufacture. The attachment may be effectuated by one or both of bonding or insert molding, in which one of the base assembly 1510 and the power lens 1520 is molded and then the other of the base assembly 1510 and the power lens 1520 is molded directly onto the first molded part (i.e., the base assembly 1510 or the power lens 1520). The portion of the power lens 1520 that is attached to the base assembly 1510 may be one or both of a portion of the circumferential peripheral edge 1522 or a posterior edge 1524 of the power lens 1520. The entire accommodating IOL 1500 can then be inserted into a patient. In order to reduce the bulk of the bonded base and power lens, the accommodating IOL 1500 can include just a single optic, such that power correction comes only from the power lens 1520. Thus, in one embodiment, the base assembly 1510 itself does not comprise an optic that provides refractive correction and the IOL 1500 only comprises the power lens 1520 to provide refractive correction.



FIGS. 16A-F depict various views a no gap accommodating IOL 1600 including a gapless base assembly 1610 and a power lens 1620. The gapless base assembly 1610 includes a base lens 1630 and a haptic system 1640. The base lens 1630 and the haptic system 1104 are secured together so no gaps are formed leading into the power lens 1620. This limits the ability of cells to flow into a cavity 1670 between the base lens 1630 and the power lens 1620 when a power lens 1620 is inserted into the gapless base assembly 1610. In various embodiments, a similar effect may be had by applying a Parylene coating a base assembly having gaps to prevent cell migration into and out of the cavity between the power lens and the base lens.


In various embodiments, the base assemblies described in this paper can provide a portion of power correction. As a result, a base assembly can be installed and an appropriate power lens to install can be selected to allow for correction within ¼ of a diopter. Further, in various embodiments, an optic of the base assemblies can include a UV absorber or UV absorbent coating to absorb UV entering the eye of the patient. In various embodiments Purkinje images can be used to adjust a power lens or a base assembly to ensure that they are properly installed during the installation of the accommodating IOL.


In various embodiments, through the use of a power lens and a base assembly, such as the base assemblies described in this disclosure, the two-part accommodating IOLs disclosed herein allow for greater efficiency in cataloguing products. For example, 4 base assemblies and 9 power lenses are needed to cover a range of 12 to 27.5 diopters at half diopter steps. Using single lenses requires 32 different lenses. As only 4 base assemblies and 9 power lenses are needed, only 13 stock keeping units (hereinafter referred to as “SKUs”) are needed to store and organize the power lenses and base assemblies as opposed to 32 different SKUs. This reduces chances of misplacement and leads to easier organization. This increase in efficiency is even greater with respect to toric lenses. For example, assuming 4 different toric powers, for 32 single lens types, 128 SKUs are need to organize the lenses. However, with a two-part accommodating IOL, assuming 4 different toric powers of the base assemblies, only 16 base assemblies and 9 power lenses are needed, for a total of 25 SKUs, which is dramatically less than the 128 SKUs needed for single toric lenses.


In various embodiments, the tabs and the flanges of the base assemblies discussed in this paper can be colored differently than a power lens to allow a surgeon to see when a power lens has been correctly inserted into a base assembly. In various embodiments, a power lens or an edge of a power lens can be colored to further aid in insertion of the power lens into a base assembly. In various embodiments a base lens or a haptic system of a base assembly can be colored. Coloration can be achieved by adding roughness or a coating to outer surfaces of any of the previously described components.


In various embodiments, Purkinje images may be utilized to assist in adjustment and placement of a power lens into a base assembly. Images can be used to adjust the power lens and base lens after implantation to assure the best fit. This approach gives immediate and simple feedback for the surgeon through the eye piece of a scope. For example, a surgeon can receive an indication that a power lens is correctly placed into a base lens if the surgeon can see a perfect circle when looking through the scope. If the circle is deformed or misshaped at all, the surgeon will know that they have to continue adjusting the power lens.

Claims
  • 1. An accommodating intraocular lens device comprising: a haptic component comprising an outer portion and an inner portion spaced inward relative to the outer portion, the outer portion configured to engage a capsular bag, and the inner portion extending radially inward, the haptic component having an asymmetric profile in cross-section about an anterior-posterior axis disposed through an anterior-most portion of the haptic component, wherein the asymmetric profile comprises a radially inward protrusion of the inner portion; anda power lens comprising a flexible membrane on one side, an optic on an opposing side, a circumferential peripheral edge coupling the flexible membrane and the optic, and an inner reservoir disposed between the flexible membrane, the optic, and the circumferential peripheral edge, wherein the circumferential peripheral edge comprises a radially outwardly facing depression, the depression configured to receive the radially inward protrusion of the inner portion of the haptic component to restrict anterior-posterior relative movement of one of the power lens and the haptic component relative to the other of the power lens and the haptic component.
  • 2. The accommodating intraocular lens device of claim 1, wherein the depression extends about at least a portion of an optical axis of the accommodating intraocular lens device.
  • 3. The accommodating intraocular lens device of claim 1, wherein the radially inward protrusion of the inner portion of the haptic component extends radially inward relative to a first outer surface of the circumferential peripheral edge of the power lens.
  • 4. The accommodating intraocular lens device of claim 1, wherein a thickness of the inner portion as defined in an anterior-posterior direction is less than a thickness of the outer portion as defined in the anterior-posterior direction.
  • 5. The accommodating intraocular lens device of claim 1, wherein the haptic component comprises an incomplete ring.
  • 6. The accommodating intraocular lens device of claim 5, wherein the power lens of the accommodating intraocular lens device is completely supported by a single incomplete ring.
  • 7. The accommodating intraocular lens device of claim 1, wherein the haptic component is tapered from a first anterior-posterior thickness disposed radially outward of the inner portion to a second lesser anterior-posterior thickness at the inner portion.
  • 8. The accommodating intraocular lens device of claim 1, wherein the haptic component comprises an outer reservoir disposed between the outer portion and the inner portion, the outer reservoir in fluid communication with the inner reservoir.
  • 9. The accommodating intraocular lens device of claim 1, wherein the flexible membrane is disposed on an anterior side of the accommodating intraocular lens device and the optic is disposed on a posterior side of the accommodating intraocular lens device.
  • 10. The accommodating intraocular lens device of claim 9, wherein a posterior side of the optic faces an interior surface of the capsular bag when the accommodating intraocular lens device is implanted in an eye such that light passing through the posterior side of the optic does not pass through another component of the accommodating intraocular lens device in traversing the eye to a retina thereof.
  • 11. An accommodating intraocular lens device comprising: a haptic system comprising an outer portion, an inner portion, and a closed space defined between the outer and the inner portions, wherein the closed space comprises an outer reservoir configured to contain a fluid and wherein the inner portion circumscribes at least a portion of a central space; anda power lens comprising a flexible membrane having a first side disposed on one outer side of the accommodating intraocular lens device, an optic having a first side disposed on an opposing outer side of the accommodating intraocular lens device, an uninterrupted fluid reservoir extending from a second side of the flexible membrane to a second side of the optic, and a circumferential peripheral edge coupling the flexible membrane and the optic;wherein the power lens is configured to be disposed within the central space such that at least a portion of the circumferential peripheral edge is in facing relation to the inner portion of the haptic system.
  • 12. The accommodating intraocular lens device of claim 11, wherein the haptic system is shaped as an incomplete ring having at least one closed end.
  • 13. The accommodating intraocular lens device of claim 12, wherein the outer reservoir extends around a portion of a circumference of the haptic system at an arc degree of 90 to 350 degrees.
  • 14. The accommodating intraocular lens device of claim 11, wherein a thickness of the inner portion as defined in an anterior-posterior direction is less than a thickness of the outer portion as defined in the anterior-posterior direction.
  • 15. The accommodating intraocular lens device of claim 11, wherein the haptic system comprises a portion of a base that is shaped as a ring, the base comprising a base lens.
  • 16. The accommodating intraocular lens device of claim 11, wherein the circumferential peripheral edge facing the inner portion of the haptic system is in direct physical contact with the inner portion.
  • 17. The accommodating intraocular lens device of claim 11, wherein one of the haptic system and an outer circumference of the power lens comprises a circumferential channel and the other of the haptic system and the outer circumference of the power lens comprises a projection configured to rest in the circumferential channel to restrain anterior-posterior relative motion of the haptic system and the outer circumference of the power lens.
  • 18. The accommodating intraocular lens device of claim 17, wherein the circumferential channel is formed on the inner portion of the haptic system.
  • 19. The accommodating intraocular lens device of claim 17, wherein the circumferential channel comprises at least one flat surface.
  • 20. The accommodating intraocular lens device of claim 17, wherein the circumferential channel comprises at least one curved surface.
  • 21. The accommodating intraocular lens device of claim 20, wherein the at least one curved surface follows a radius oriented in a direction transverse to an optical axis of the accommodating intraocular lens device.
  • 22. The accommodating intraocular lens device of claim 21, wherein the power lens comprises the uninterrupted reservoir in fluid communication with the outer reservoir of the haptic system.
  • 23. The accommodating intraocular lens device of claim 22, wherein the accommodating intraocular lens device further comprises a fluid canal providing fluid communication between the outer reservoir and the uninterrupted reservoir, the fluid canal being disposed radially between the outer reservoir and the uninterrupted reservoir.
  • 24. The accommodating intraocular lens device of claim 17, wherein the haptic system has a first dimension in an anterior-posterior direction at a first location and the circumferential channel has a second dimension in the anterior-posterior direction at a second location disposed radially inwardly of the first location, the second dimension being less than the first dimension.
  • 25. The accommodating intraocular lens device of claim 24, wherein the first location is within the outer reservoir of the haptic system and the second location is at an opening into the circumferential channel.
  • 26. The accommodating intraocular lens device of claim 17, wherein the haptic system is tapered from a first anterior-posterior height disposed radially outward of a location of the circumferential channel and the projection to a second lesser anterior-posterior height disposed at or adjacent to the location of the circumferential channel and the projection.
  • 27. The accommodating intraocular lens device of claim 11, wherein a first outer surface of the haptic system comprises a convex surface configured to engage an equator of a capsular bag and a second outer surface of the haptic system comprises a concave surface facing at least one of anteriorly and posteriorly.
  • 28. The accommodating intraocular lens device of claim 11, wherein a posterior side of the optic faces an interior surface of a capsular bag when the accommodating intraocular lens device is implanted in an eye such that light passing through the posterior side does not pass through another component of the accommodating intraocular lens device in traversing the eye to a retina thereof.
  • 29. An accommodating intraocular lens device comprising: a base comprising an outer portion, an inner portion, and a closed space defined between the outer and the inner portions, wherein the closed space comprises a first reservoir configured to contain a fluid; anda power lens comprising a flexible membrane on one side, an optic on an opposing side, a circumferential peripheral edge coupling the flexible membrane and the optic, and a second reservoir disposed between the flexible membrane, the optic, and the circumferential peripheral edge, wherein the circumferential peripheral edge comprises an outer surface and an inner surface disposed radially inward relative to the outer surface, the outer surface and the inner surface cooperating to receive the inner portion of the base against the inner surface of the power lens after insertion of the power lens into an eye to restrict anterior-posterior relative movement of at least one of the power lens and the base relative to the other of the power lens and the base;wherein a posterior side of the optic faces an interior surface of a capsular bag when the accommodating intraocular lens device is implanted in the eye such that light passing through the posterior side does not pass through another component of the accommodating intraocular lens device in traversing the eye to a retina thereof; andwherein the second reservoir is in fluid communication with the first reservoir of the base to cause the fluid in the first reservoir to flow into the second reservoir to apply or to enhance application of fluid pressure directly to a surface of the flexible membrane.
  • 30. The accommodating intraocular lens device of claim 29, wherein the base comprises an anterior-most portion and a posterior-most portion, and wherein the power lens is disposed entirely between the anterior-most portion and the posterior-most portion.
  • 31. The accommodating intraocular lens device of claim 29, wherein a first canal is disposed at least partially through the circumferential peripheral edge of the power lens to provide for flow of the fluid between the first reservoir and the second reservoir.
  • 32. The accommodating intraocular lens device of claim 31, wherein a second canal is disposed at least partially through the inner portion of the base to provide for the flow of fluid between the first reservoir and the second reservoir.
  • 33. The accommodating intraocular lens device of claim 32, wherein the first canal is configured to be placed in fluid communication with the second canal to provide for the flow of fluid between the first reservoir and the second reservoir.
  • 34. The accommodating intraocular lens device of claim 31, wherein the first canal is disposed through a projection of the circumferential peripheral edge.
  • 35. The accommodating intraocular lens device of claim 34, wherein the projection extends radially outward from the outer surface of the circumferential peripheral edge of the power lens.
  • 36. The accommodating intraocular lens device of claim 35, wherein a radially outwardly extending opening in the inner portion of the base is configured to receive the projection of the circumferential peripheral edge such that fluid communication can be provided between the first reservoir and the second reservoir.
  • 37. The accommodating intraocular lens device of claim 34, wherein a second canal is at least partially disposed within the projection of the power lens when fluid communication between the first reservoir and the second reservoir is provided through the first canal and the second canal.
  • 38. The accommodating intraocular lens device of claim 37, wherein at least one of the first canal and the second canal comprises a valve to restrict flow.
  • 39. The accommodating intraocular lens device of claim 31, wherein a second canal is disposed at least partially through the inner portion of the base, the second canal at least partially disposed within the circumferential peripheral edge of the power lens when the first canal is in fluid communication with the second canal.
  • 40. The accommodating intraocular lens device of claim 29, wherein the base is configured to be separate from the power lens prior to insertion into the capsular bag of the eye and to be coupled to each other within the eye.
  • 41. The accommodating intraocular lens device of claim 29, wherein the base comprises an arcuate structure partially surrounding the power lens when the base and the power lens are coupled.
  • 42. The accommodating intraocular lens device of claim 41, wherein the base comprises a C-shaped ring.
  • 43. The accommodating intraocular lens device of claim 29, wherein the circumferential peripheral edge comprises an optic coupler coupled to the optic of the power lens and a membrane coupler coupled to the flexible membrane of the power lens, the membrane coupler comprising the inner surface and being disposed anteriorly of the optic coupler.
  • 44. The accommodating intraocular lens device of claim 43, wherein an outer periphery of the flexible membrane is coupled with an inner periphery of the membrane coupler, the inner surface disposed radially outward of the outer periphery of the flexible membrane.
  • 45. The accommodating intraocular lens device of claim 29, wherein the inner surface against which the inner portion of the base is received is disposed anteriorly of a posterior portion of the circumferential peripheral edge.
  • 46. The accommodating intraocular lens device of claim 29, wherein the inner surface against which the inner portion of the base is received to restrict anterior-posterior relative movement is disposed anteriorly of a posterior portion of the circumferential peripheral edge.
  • 47. The accommodating intraocular lens device of claim 46, wherein the inner surface against which the inner portion of the base is received to restrict anterior-posterior relative movement is disposed on an anterior portion of the circumferential peripheral edge.
  • 48. The accommodating intraocular lens device of claim 46, wherein the inner surface against which the inner portion of the base lens is received to restrict anterior-posterior relative movement is disposed on an anterior facing surface of the circumferential peripheral edge.
  • 49. The accommodating intraocular lens device of claim 48, wherein the anterior facing surface extends from the outer surface to a peripheral edge of the flexible membrane.
CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a continuation of U.S. application Ser. No. 15/996,188, filed on Jun. 1, 2018, which is a continuation of International Patent Application No. PCT/US2016/064491, filed on Dec. 1, 2016, which in turn claims the benefit of U.S. Provisional Application No. 62/261,790, filed Dec. 1, 2015, the contents of which are incorporated herein by reference in their entireties into the present disclosure.

US Referenced Citations (578)
Number Name Date Kind
4032502 Lee et al. Jun 1977 A
4073014 Poler Feb 1978 A
4118808 Poler Oct 1978 A
4373218 Schachar Feb 1983 A
4512040 McClure Apr 1985 A
4585457 Kalb Apr 1986 A
4676791 LeMaster et al. Jun 1987 A
4720286 Bailey et al. Jan 1988 A
4731078 Stoy et al. Mar 1988 A
4822360 Deacon Apr 1989 A
4842601 Smith Jun 1989 A
4882368 Elias et al. Nov 1989 A
4888012 Horn et al. Dec 1989 A
4892543 Turley Jan 1990 A
4932966 Christie et al. Jul 1990 A
5035710 Nakada et al. Jul 1991 A
5059668 Fukuda et al. Oct 1991 A
5074876 Kelman Dec 1991 A
5091121 Nakada et al. Feb 1992 A
5152788 Isaacson et al. Oct 1992 A
5167883 Takemasa et al. Dec 1992 A
5171773 Chaffe et al. Dec 1992 A
5227447 Sato et al. Jul 1993 A
5236970 Christ et al. Aug 1993 A
5264522 Mize et al. Nov 1993 A
5275623 Sarfarazi Jan 1994 A
5278258 Gerace et al. Jan 1994 A
5312860 Mize et al. May 1994 A
5326506 Vanderbilt Jul 1994 A
5336487 Refojo et al. Aug 1994 A
5443506 Garabet Aug 1995 A
5447987 Sato et al. Sep 1995 A
5489302 Skottun Feb 1996 A
5583178 Oxman et al. Dec 1996 A
5607472 Thompson Mar 1997 A
5665794 Maxson et al. Sep 1997 A
5854310 Maxson Dec 1998 A
6071439 Bawa et al. Jun 2000 A
6117171 Skottun Sep 2000 A
6197057 Peyman et al. Mar 2001 B1
6200342 Tassignon Mar 2001 B1
6200581 Lin et al. Mar 2001 B1
6201091 Halloran et al. Mar 2001 B1
6361561 Huo et al. Mar 2002 B1
6551354 Ghazizadeh et al. Apr 2003 B1
6616691 Tran Sep 2003 B1
6695881 Peng et al. Feb 2004 B2
6730123 Klopotek May 2004 B1
6797004 Brady et al. Sep 2004 B1
6836374 Esch et al. Dec 2004 B2
6855164 Glazier Feb 2005 B2
6858040 Nguyen et al. Feb 2005 B2
6860601 Shadduck Mar 2005 B2
6881225 Okada Apr 2005 B2
6926736 Peng et al. Aug 2005 B2
6930838 Schachar Aug 2005 B2
6935743 Shadduck Aug 2005 B2
6966649 Shadduck Nov 2005 B2
6969403 Peng et al. Nov 2005 B2
6991651 Portney Jan 2006 B2
7041134 Nguyen et al. May 2006 B2
7063723 Ran Jun 2006 B2
7068439 Esch et al. Jun 2006 B2
7122053 Esch Oct 2006 B2
7150760 Zhang Dec 2006 B2
7217288 Esch et al. May 2007 B2
7220279 Nun May 2007 B2
7223288 Zhang et al. May 2007 B2
7226478 Ting et al. Jun 2007 B2
7229475 Glazier Jun 2007 B2
7238201 Portney et al. Jul 2007 B2
7247168 Esch et al. Jul 2007 B2
7261737 Esch et al. Aug 2007 B2
7264351 Shadduck Sep 2007 B2
7276619 Kunzler et al. Oct 2007 B2
7278739 Shadduck Oct 2007 B2
7316713 Zhang Jan 2008 B2
7416562 Gross Aug 2008 B2
7438723 Esch Oct 2008 B2
7452377 Watling et al. Nov 2008 B2
7453646 Lo Nov 2008 B2
7455691 Feingold et al. Nov 2008 B2
7485144 Esch Feb 2009 B2
7591849 Richardson Sep 2009 B2
7637947 Smith et al. Dec 2009 B2
7662179 Sarfarazi Feb 2010 B2
7675686 Lo et al. Mar 2010 B2
7753953 Yee Jul 2010 B1
7776088 Shadduck Aug 2010 B2
7780729 Nguyen et al. Aug 2010 B2
7815678 Nun Oct 2010 B2
7842087 Nun Nov 2010 B2
7854764 Nun Dec 2010 B2
7857850 Mentak et al. Dec 2010 B2
7918886 Aharoni et al. Apr 2011 B2
7981155 Cumming Jul 2011 B2
7985253 Cumming Jul 2011 B2
7986465 Lo et al. Jul 2011 B1
7998198 Angelopoulos et al. Aug 2011 B2
7998199 Nun Aug 2011 B2
8012204 Weinschenk, III et al. Sep 2011 B2
8018658 Lo Sep 2011 B2
8034106 Mentak et al. Oct 2011 B2
8034107 Stenger Oct 2011 B2
8038711 Clarke Oct 2011 B2
8048155 Shadduck Nov 2011 B2
8052752 Woods et al. Nov 2011 B2
8062361 Nguyen et al. Nov 2011 B2
8066768 Werblin Nov 2011 B2
8066769 Werblin Nov 2011 B2
8070806 Khoury Dec 2011 B2
8158712 Your Apr 2012 B2
8182531 Hermans et al. May 2012 B2
8187325 Zadno-Azizi et al. May 2012 B2
8197541 Schedler Jun 2012 B2
8216306 Coroneo Jul 2012 B2
8246679 Nguyen et al. Aug 2012 B2
8254034 Shields et al. Aug 2012 B1
8257827 Shi et al. Sep 2012 B1
8273123 Nun Sep 2012 B2
8303656 Shadduck Nov 2012 B2
8308800 Chu Nov 2012 B2
8314927 Choi et al. Nov 2012 B2
8320049 Huang et al. Nov 2012 B2
8328869 Smiley et al. Dec 2012 B2
8361145 Scholl et al. Jan 2013 B2
8377124 Hong et al. Feb 2013 B2
8377125 Kellan Feb 2013 B2
8398709 Nun Mar 2013 B2
8414646 De Juan, Jr. et al. Apr 2013 B2
8425597 Glick et al. Apr 2013 B2
8425599 Shadduck Apr 2013 B2
8430928 Liao Apr 2013 B2
8447086 Hildebrand et al. May 2013 B2
8454688 Esch et al. Jun 2013 B2
8475529 Clarke Jul 2013 B2
8491651 Tsai et al. Jul 2013 B2
8496701 Hermans et al. Jul 2013 B2
8500806 Phillips Aug 2013 B1
8518026 Culbertson et al. Aug 2013 B2
8545556 Woods et al. Oct 2013 B2
8579972 Rombach Nov 2013 B2
8585758 Woods Nov 2013 B2
8603167 Rombach Dec 2013 B2
8608799 Blake Dec 2013 B2
8608800 Portney Dec 2013 B2
8613766 Richardson et al. Dec 2013 B2
8647384 Lu Feb 2014 B2
8657810 Culbertson et al. Feb 2014 B2
8657878 Mentak et al. Feb 2014 B2
8668734 Hildebrand et al. Mar 2014 B2
8690942 Hildebrand et al. Mar 2014 B2
8715345 DeBoer et al. May 2014 B2
8715346 De Juan, Jr. et al. May 2014 B2
8734509 Mentak et al. May 2014 B2
8771347 DeBoer et al. Jul 2014 B2
8814934 Geraghty et al. Aug 2014 B2
8834565 Nun Sep 2014 B2
8834566 Jones Sep 2014 B1
8858626 Noy Oct 2014 B2
8867141 Pugh et al. Oct 2014 B2
8900298 Anvar et al. Dec 2014 B2
8900300 Wortz Dec 2014 B1
8920495 Mirlay Dec 2014 B2
8956408 Smiley et al. Feb 2015 B2
8968396 Matthews et al. Mar 2015 B2
8968399 Ghabra Mar 2015 B2
8992609 Shadduck Mar 2015 B2
9005282 Chang et al. Apr 2015 B2
9005283 Nguyen et al. Apr 2015 B2
9034035 Betser et al. May 2015 B2
9044317 Hildebrand et al. Jun 2015 B2
9072600 Tran Jul 2015 B2
9090033 Carson et al. Jul 2015 B2
9095424 Kahook et al. Aug 2015 B2
9125736 Kahook et al. Sep 2015 B2
9149356 Sarfarazi Oct 2015 B2
9186244 Silvestrini et al. Nov 2015 B2
9198752 Woods Dec 2015 B2
9277987 Smiley et al. Mar 2016 B2
9277988 Chu Mar 2016 B1
9289287 Kahook et al. Mar 2016 B2
9326846 Devita Gerardi et al. May 2016 B2
9333072 Ichikawa May 2016 B2
9358103 Wortz et al. Jun 2016 B1
9364316 Kahook et al. Jun 2016 B1
9387069 Kahook et al. Jul 2016 B2
9398949 Werblin Jul 2016 B2
9421088 Kahook et al. Aug 2016 B1
9427312 DeBoer et al. Aug 2016 B2
9433497 DeBoer et al. Sep 2016 B2
9456895 Shadduck Oct 2016 B2
9486311 Argento et al. Nov 2016 B2
9610155 Matthews Apr 2017 B2
9622852 Simonov et al. Apr 2017 B2
9629712 Stenger Apr 2017 B2
9636213 Brady May 2017 B2
9655716 Cumming May 2017 B2
9681946 Kahook et al. Jun 2017 B2
9693858 Hildebrand et al. Jul 2017 B2
9713526 Rombach Jul 2017 B2
9713527 Nishi et al. Jul 2017 B2
9717589 Simonov et al. Aug 2017 B2
9744027 Jansen Aug 2017 B2
9744028 Simonov et al. Aug 2017 B2
9795472 Culbertson et al. Oct 2017 B2
9795473 Smiley et al. Oct 2017 B2
9808339 Dorronsoro Diaz et al. Nov 2017 B2
9814568 Ben Nun Nov 2017 B2
9814570 Robert et al. Nov 2017 B2
9820849 Jansen Nov 2017 B2
9848980 McCafferty Dec 2017 B2
9855137 Smiley et al. Jan 2018 B2
9855139 Matthews et al. Jan 2018 B2
9861469 Simonov et al. Jan 2018 B2
9872762 Scholl et al. Jan 2018 B2
9872763 Smiley et al. Jan 2018 B2
9877825 Kahook et al. Jan 2018 B2
9883940 Nishi et al. Feb 2018 B2
9925039 Sohn et al. Mar 2018 B2
9925040 Kahook et al. Mar 2018 B2
9931202 Borja et al. Apr 2018 B2
9987126 Borja et al. Jun 2018 B2
10004596 Brady et al. Jun 2018 B2
10010405 Hayes Jul 2018 B2
10028824 Kahook et al. Jul 2018 B2
10039635 Wanders Aug 2018 B2
10045844 Smiley et al. Aug 2018 B2
10080648 Kahook et al. Sep 2018 B2
10080649 Zhang et al. Sep 2018 B2
10111745 Silvestrini et al. Oct 2018 B2
10159562 Cady Dec 2018 B2
10159564 Brady et al. Dec 2018 B2
10195017 Culbertson et al. Feb 2019 B2
10195018 Salahieh et al. Feb 2019 B2
10195020 Matthews Feb 2019 B2
10285805 De Juan, Jr. et al. May 2019 B2
10299910 Cady May 2019 B2
10299913 Smiley et al. May 2019 B2
10327886 Sohn et al. Jun 2019 B2
10350056 Argento et al. Jul 2019 B2
10363129 Ghabra et al. Jul 2019 B2
10368979 Scholl et al. Aug 2019 B2
10390937 Smiley et al. Aug 2019 B2
10433949 Smiley et al. Oct 2019 B2
10463473 Rombach et al. Nov 2019 B2
10485654 Brady et al. Nov 2019 B2
10526353 Silvestrini Jan 2020 B2
10548719 Pallikaris et al. Feb 2020 B2
10647831 Silvestrini et al. May 2020 B2
10772721 Rao et al. Sep 2020 B2
10842614 Cady Nov 2020 B2
10842616 Silvestrini et al. Nov 2020 B2
10888219 Smith et al. Jan 2021 B2
10905547 Auld et al. Feb 2021 B2
10912676 Schaller et al. Feb 2021 B2
10917543 Luna et al. Feb 2021 B2
10945832 Cady Mar 2021 B2
10959836 Qureshi et al. Mar 2021 B2
10980629 Anvar et al. Apr 2021 B2
10987183 Brennan et al. Apr 2021 B2
11000363 Campin et al. May 2021 B2
11000364 Brady et al. May 2021 B2
11000367 Wu et al. May 2021 B2
11026838 Raksi Jun 2021 B2
11039901 Tripathi Jun 2021 B2
11040477 Chauvin et al. Jun 2021 B2
11045309 Kahook et al. Jun 2021 B2
11046490 Cerveny Jun 2021 B2
11051884 Tripathi et al. Jul 2021 B2
11065107 Brady et al. Jul 2021 B2
11065109 Argento et al. Jul 2021 B2
11065152 Kelleher et al. Jul 2021 B2
11071449 Heeren Jul 2021 B2
11071622 Matthews Jul 2021 B2
11076948 Kahook et al. Aug 2021 B2
11083567 Honigsbaum Aug 2021 B2
11109957 Cady Sep 2021 B2
11109960 Borja et al. Sep 2021 B2
11110005 Diao et al. Sep 2021 B2
11111055 Reece et al. Sep 2021 B2
11141263 Argento et al. Oct 2021 B2
11162065 Fachin et al. Nov 2021 B2
11166808 Smiley et al. Nov 2021 B2
11166844 Charles Nov 2021 B2
11173008 Mirsepassi et al. Nov 2021 B2
11213606 Jiang et al. Jan 2022 B2
11224540 Sivadas Jan 2022 B2
11298221 McCulloch Apr 2022 B2
20020005344 Heidlas et al. Jan 2002 A1
20020055776 Juan, Jr. et al. May 2002 A1
20020071856 Dillingham et al. Jun 2002 A1
20020120329 Lang et al. Aug 2002 A1
20020138140 Hanna Sep 2002 A1
20030060881 Glick et al. Mar 2003 A1
20030093149 Glazier May 2003 A1
20030105522 Glazier Jun 2003 A1
20030109926 Portney Jun 2003 A1
20030158295 Fukuda et al. Aug 2003 A1
20030204254 Peng et al. Oct 2003 A1
20030204256 Peng et al. Oct 2003 A1
20040015236 Sarfarazi Jan 2004 A1
20040082993 Woods Apr 2004 A1
20040082994 Woods et al. Apr 2004 A1
20040111152 Kelman Jun 2004 A1
20040148023 Shu Jul 2004 A1
20040162612 Portney et al. Aug 2004 A1
20040169816 Esch Sep 2004 A1
20040249455 Tran Dec 2004 A1
20050021139 Shadduck Jan 2005 A1
20050071002 Glazier Mar 2005 A1
20050107873 Zhou May 2005 A1
20050137703 Chen Jun 2005 A1
20050251253 Gross Nov 2005 A1
20050251254 Brady et al. Nov 2005 A1
20050267575 Nguyen et al. Dec 2005 A1
20060041307 Esch et al. Feb 2006 A1
20060047339 Brown Mar 2006 A1
20060069178 Rastogi et al. Mar 2006 A1
20060074487 Gilg Apr 2006 A1
20060111776 Glick et al. May 2006 A1
20060134173 Liu et al. Jun 2006 A1
20060135477 Haitjema et al. Jun 2006 A1
20060212116 Woods Sep 2006 A1
20060238702 Glick et al. Oct 2006 A1
20060241752 Israel Oct 2006 A1
20060271186 Nishi et al. Nov 2006 A1
20070016293 Tran Jan 2007 A1
20070032868 Woods Feb 2007 A1
20070050024 Zhang Mar 2007 A1
20070050025 Nguyen et al. Mar 2007 A1
20070078515 Brady et al. Apr 2007 A1
20070088433 Esch et al. Apr 2007 A1
20070100445 Shadduck May 2007 A1
20070106377 Smith et al. May 2007 A1
20070118216 Pynson May 2007 A1
20070129798 Chawdhary Jun 2007 A1
20070129799 Schedler Jun 2007 A1
20070129800 Cumming Jun 2007 A1
20070129801 Cumming Jun 2007 A1
20070132949 Phelan Jun 2007 A1
20070213817 Esch et al. Sep 2007 A1
20070260308 Tran Nov 2007 A1
20070260310 Richardson Nov 2007 A1
20080015689 Esch et al. Jan 2008 A1
20080033547 Chang et al. Feb 2008 A1
20080046074 Smith et al. Feb 2008 A1
20080046075 Esch et al. Feb 2008 A1
20080046077 Cumming Feb 2008 A1
20080051886 Lin Feb 2008 A1
20080154364 Richardson et al. Jun 2008 A1
20080200982 Your Aug 2008 A1
20080269887 Cumming Oct 2008 A1
20080300680 Nun Dec 2008 A1
20080306587 Your Dec 2008 A1
20080306588 Smiley et al. Dec 2008 A1
20080306589 Donitzky et al. Dec 2008 A1
20090005865 Smiley et al. Jan 2009 A1
20090027661 Choi et al. Jan 2009 A1
20090043384 Niwa et al. Feb 2009 A1
20090116118 Frazier et al. May 2009 A1
20090125106 Weinschenk, III et al. May 2009 A1
20090149952 Shadduck Jun 2009 A1
20090198326 Zhou et al. Aug 2009 A1
20090204209 Tran Aug 2009 A1
20090204210 Pynson Aug 2009 A1
20090264998 Mentak et al. Oct 2009 A1
20090292355 Boyd et al. Nov 2009 A1
20090319040 Khoury Dec 2009 A1
20100004742 Cumming Jan 2010 A1
20100055449 Ota Mar 2010 A1
20100057095 Khuray et al. Mar 2010 A1
20100094412 Wensrich Apr 2010 A1
20100094413 Rombach et al. Apr 2010 A1
20100131058 Shadduck May 2010 A1
20100131059 Callahan et al. May 2010 A1
20100179653 Argento Jul 2010 A1
20100204787 Noy Aug 2010 A1
20100211169 Stanley et al. Aug 2010 A1
20100228344 Shadduck Sep 2010 A1
20100288346 Esch Sep 2010 A1
20100324672 Esch et al. Dec 2010 A1
20100324674 Brown Dec 2010 A1
20110029074 Reisin et al. Feb 2011 A1
20110071628 Gross et al. Mar 2011 A1
20110118834 Lo et al. May 2011 A1
20110118836 Jain May 2011 A1
20110208301 Anvar et al. Aug 2011 A1
20110224788 Webb Sep 2011 A1
20110264209 Wiechmann et al. Oct 2011 A1
20110282442 Scholl et al. Nov 2011 A1
20110288638 Smiley et al. Nov 2011 A1
20120016473 Brady et al. Jan 2012 A1
20120035724 Clarke Feb 2012 A1
20120071972 Zhao Mar 2012 A1
20120078364 Stenger Mar 2012 A1
20120095125 Hu et al. Apr 2012 A1
20120232649 Cuevas Sep 2012 A1
20120245683 Christie et al. Sep 2012 A1
20120253458 Geraghty et al. Oct 2012 A1
20120253459 Reich et al. Oct 2012 A1
20120290084 Coroneo Nov 2012 A1
20120296423 Caffey Nov 2012 A1
20120296424 Betser Nov 2012 A1
20120310341 Simonov et al. Dec 2012 A1
20120310343 Van Noy Dec 2012 A1
20130006353 Betser et al. Jan 2013 A1
20130035760 Portney Feb 2013 A1
20130038944 Chang et al. Feb 2013 A1
20130040073 Pett et al. Feb 2013 A1
20130060331 Shadduck Mar 2013 A1
20130110234 DeVita et al. May 2013 A1
20130110235 Shweigerling May 2013 A1
20130116781 Nun May 2013 A1
20130131794 Smiley et al. May 2013 A1
20130190867 Peyman Jul 2013 A1
20130231741 Clarke Sep 2013 A1
20130250239 Hildebrand et al. Sep 2013 A1
20130268070 Esch et al. Oct 2013 A1
20130297018 Brady et al. Nov 2013 A1
20130317607 DeBoer et al. Nov 2013 A1
20130317608 Hermans et al. Nov 2013 A1
20140012277 Matthews et al. Jan 2014 A1
20140058507 Reich et al. Feb 2014 A1
20140085726 Portney Mar 2014 A1
20140100654 Portney et al. Apr 2014 A1
20140107459 Lind et al. Apr 2014 A1
20140111765 DeBoer et al. Apr 2014 A1
20140121768 Simpson May 2014 A1
20140135917 Glazier May 2014 A1
20140135918 De Juan, Jr. et al. May 2014 A1
20140142558 Culbertson et al. May 2014 A1
20140172089 Lee et al. Jun 2014 A1
20140172092 Carson et al. Jun 2014 A1
20140180404 Tram Jun 2014 A1
20140180405 Weinschenk, III et al. Jun 2014 A1
20140180406 Simpson Jun 2014 A1
20140180407 Sohn et al. Jun 2014 A1
20140180410 Gerardi Jun 2014 A1
20140227437 DeBoer et al. Aug 2014 A1
20140228949 Argento et al. Aug 2014 A1
20140249625 Shadduck Sep 2014 A1
20140257478 McCafferty Sep 2014 A1
20140257479 McCafferty Sep 2014 A1
20140296977 Culbertson et al. Oct 2014 A1
20140309734 Sohn et al. Oct 2014 A1
20150087743 Anvar et al. Mar 2015 A1
20150105760 Rao et al. Apr 2015 A1
20150127102 Wortz May 2015 A1
20150173892 Borja et al. Jun 2015 A1
20150202041 Shadduck Jul 2015 A1
20150216652 Jansen Aug 2015 A1
20150230980 Culbertson et al. Aug 2015 A1
20150238310 Matthews et al. Aug 2015 A1
20150327991 Hayes Nov 2015 A1
20150342728 Simonov et al. Dec 2015 A1
20150359625 Argal et al. Dec 2015 A1
20150366656 Wortz et al. Dec 2015 A1
20160000558 Honigsbaum Jan 2016 A1
20160008126 Salahieh et al. Jan 2016 A1
20160051361 Phillips Feb 2016 A1
20160058553 Salahieh et al. Mar 2016 A1
20160074154 Woods Mar 2016 A1
20160106534 Deboer et al. Apr 2016 A1
20160113761 Nishi et al. Apr 2016 A1
20160184089 Dudee et al. Jun 2016 A1
20160184092 Smiley et al. Jun 2016 A1
20160208138 Nishijima et al. Jul 2016 A1
20160256265 Borja et al. Sep 2016 A1
20160262875 Smith et al. Sep 2016 A1
20160281019 Deklippel et al. Sep 2016 A1
20160287380 Shi et al. Oct 2016 A1
20160361157 Honigsbaum Dec 2016 A1
20170020662 Shadduck Jan 2017 A1
20170049561 Smiley et al. Feb 2017 A1
20170049562 Argento et al. Feb 2017 A1
20170100234 Culbertson et al. Apr 2017 A1
20170216021 Brady Aug 2017 A1
20170290658 Hildebrand et al. Oct 2017 A1
20170319332 Kahook et al. Nov 2017 A1
20170348095 Wortz et al. Dec 2017 A1
20180014928 Kahook et al. Jan 2018 A1
20180028308 Smiley et al. Feb 2018 A1
20180085211 Culbertson et al. Mar 2018 A1
20180110613 Wortz et al. Apr 2018 A1
20180125640 Smiley et al. May 2018 A1
20180132997 Smiley et al. May 2018 A1
20180147051 Scholl et al. May 2018 A1
20180153682 Hajela et al. Jun 2018 A1
20180161152 Argento et al. Jun 2018 A1
20180161153 Kahook et al. Jun 2018 A1
20180177589 Argento et al. Jun 2018 A1
20180177639 Rao et al. Jun 2018 A1
20180185139 Sohn et al. Jul 2018 A1
20180256315 Hildebrand et al. Sep 2018 A1
20180271642 Wortz et al. Sep 2018 A1
20180280135 Otts Oct 2018 A1
20180296323 Olcina Portilla Oct 2018 A1
20180307061 State et al. Oct 2018 A1
20180318068 Otts et al. Nov 2018 A1
20180344453 Brady Dec 2018 A1
20180360659 Culbertson et al. Dec 2018 A1
20180368971 Zacher et al. Dec 2018 A1
20180368973 Wortz et al. Dec 2018 A1
20180368974 Kahook et al. Dec 2018 A1
20190015198 Kuiper Jan 2019 A1
20190021848 Kahook et al. Jan 2019 A1
20190069989 Otts et al. Mar 2019 A1
20190076239 Wortz et al. Mar 2019 A1
20190076241 Alarcon Heredia et al. Mar 2019 A1
20190076243 Hadba et al. Mar 2019 A1
20190083235 Wortz Mar 2019 A1
20190269499 Ellis Sep 2019 A1
20190269500 De Juan, Jr. et al. Sep 2019 A1
20190274823 Argento et al. Sep 2019 A1
20190358025 Smiley et al. Nov 2019 A1
20190374333 Shadduck Dec 2019 A1
20190374334 Brady et al. Dec 2019 A1
20200000577 Smiley et al. Jan 2020 A1
20200054445 Rosen et al. Feb 2020 A1
20200085568 Brady et al. Mar 2020 A1
20200129287 Culbertson et al. Apr 2020 A1
20200138564 Culbertson et al. May 2020 A1
20200157124 Silvestrini May 2020 A1
20200179104 Brady et al. Jun 2020 A1
20200261217 Dudee Aug 2020 A1
20200337833 Green Oct 2020 A1
20200345481 Ellis Nov 2020 A1
20200369853 Silvestrini et al. Nov 2020 A1
20200397562 Cady Dec 2020 A1
20210007554 Byun et al. Jan 2021 A1
20210015303 Byun et al. Jan 2021 A1
20210015359 Goldshleger et al. Jan 2021 A1
20210030530 Smiley et al. Feb 2021 A1
20210038373 Collins et al. Feb 2021 A1
20210063767 Hong et al. Mar 2021 A1
20210093447 Heckler et al. Apr 2021 A1
20210100649 Smiley Apr 2021 A1
20210100650 Smiley et al. Apr 2021 A1
20210100652 Walz et al. Apr 2021 A1
20210113327 Auld et al. Apr 2021 A1
20210128195 Abt May 2021 A1
20210128516 Cheng et al. May 2021 A1
20210128800 Chon et al. May 2021 A1
20210154957 Olson et al. May 2021 A1
20210191153 Borja et al. Jun 2021 A1
20210191154 Borja et al. Jun 2021 A1
20210196890 Appy et al. Jul 2021 A1
20210196893 Appy et al. Jul 2021 A1
20210196894 Appy et al. Jul 2021 A1
20210196900 Appy et al. Jul 2021 A1
20210205134 Rao et al. Jul 2021 A1
20210220067 Charles Jul 2021 A1
20210228333 Hubschman et al. Jul 2021 A1
20210244488 Carbone et al. Aug 2021 A1
20210251718 Tripathi Aug 2021 A1
20210259827 Brady et al. Aug 2021 A1
20210282920 Cady Sep 2021 A1
20210284944 Grandhi et al. Sep 2021 A1
20210290369 Cady Sep 2021 A1
20210290370 Cady Sep 2021 A1
20210290371 Anvar et al. Sep 2021 A1
20210290374 Kahook et al. Sep 2021 A1
20210291469 Zheng et al. Sep 2021 A1
20210292557 Cheng et al. Sep 2021 A1
20210292558 Bassampour et al. Sep 2021 A1
20210297560 Luna et al. Sep 2021 A1
20210302625 Cheng et al. Sep 2021 A1
20210315688 Matthews Oct 2021 A1
20210322151 Kahook et al. Oct 2021 A1
20210322219 Raksi Oct 2021 A1
20210361415 Borja et al. Nov 2021 A1
20210369106 Campin et al. Dec 2021 A1
20210369446 Taber et al. Dec 2021 A1
20210371150 Leibold et al. Dec 2021 A1
20220000606 Cady Jan 2022 A1
20220015946 Hallen et al. Jan 2022 A1
20220047383 Brady et al. Feb 2022 A1
Foreign Referenced Citations (102)
Number Date Country
1064611 Sep 1992 CN
20 2010 003217 Aug 2011 DE
0 356 050 Feb 1990 EP
0 766 540 Aug 1999 EP
1 852 090 Jan 2009 EP
1 859 760 Apr 2010 EP
2 451 380 Mar 2014 EP
2 473 137 Mar 2014 EP
2 111 822 Aug 2014 EP
1 881 818 Jul 2015 EP
2 512 374 Nov 2015 EP
2 501 336 Sep 2016 EP
3 049 023 Jun 2017 EP
3 035 889 Feb 2019 EP
3 171 821 Mar 2020 EP
3 463 186 Aug 2020 EP
3 003 217 Oct 2020 EP
3 782 584 Feb 2021 EP
3 651 693 May 2021 EP
3 370 647 Jun 2021 EP
3 197 396 Sep 2021 EP
3 888 595 Oct 2021 EP
3 932 367 Jan 2022 EP
3 946 155 Feb 2022 EP
H09-150002 Jun 1997 JP
2005-511201 Apr 2005 JP
2006-511245 Apr 2006 JP
2006-516002 Jun 2006 JP
2007-313326 Dec 2007 JP
2009-516570 Apr 2009 JP
2009-518146 May 2009 JP
2010-514507 May 2010 JP
2013-047290 Mar 2013 JP
WO 199217132 Oct 1992 WO
WO 199929266 Jun 1999 WO
WO 1999056670 Nov 1999 WO
WO 2000021467 Apr 2000 WO
WO 2001034067 May 2001 WO
WO 2001060286 Aug 2001 WO
WO 2002009619 Feb 2002 WO
WO 2004037127 May 2004 WO
WO 2004052242 Jun 2004 WO
WO 2004054471 Jul 2004 WO
WO 2004072689 Aug 2004 WO
WO 2006047383 May 2006 WO
WO 2007005778 Jan 2007 WO
WO 2007047529 Apr 2007 WO
WO 2007047530 Apr 2007 WO
WO 2008024766 Feb 2008 WO
WO 2008031231 Mar 2008 WO
WO 2008077040 Jun 2008 WO
WO 2008082957 Jul 2008 WO
WO 2008103798 Aug 2008 WO
WO 2009015161 Jan 2009 WO
WO 2009015226 Jan 2009 WO
WO 2009015234 Jan 2009 WO
WO 2009015240 Jan 2009 WO
WO 2009064876 May 2009 WO
WO 2010010565 Jan 2010 WO
WO 2010081093 Jul 2010 WO
WO 2011026068 Mar 2011 WO
WO 2011106435 Sep 2011 WO
WO 2011137191 Nov 2011 WO
WO 2012006616 Jan 2012 WO
WO 2012129407 Sep 2012 WO
WO 2013016804 Feb 2013 WO
WO 2013070924 May 2013 WO
WO 2013142323 Sep 2013 WO
WO 2013166068 Nov 2013 WO
WO 2013180254 Dec 2013 WO
WO 2013190130 Dec 2013 WO
WO 2014099630 Jun 2014 WO
WO 2014145562 Sep 2014 WO
WO 2014152017 Sep 2014 WO
WO 2014197170 Dec 2014 WO
WO 2015066502 May 2015 WO
WO 2015066532 May 2015 WO
WO 2015126604 Aug 2015 WO
WO 2015148673 Oct 2015 WO
WO 2016018932 Feb 2016 WO
WO 2016033217 Mar 2016 WO
WO 2016049059 Mar 2016 WO
WO 2016122805 Aug 2016 WO
WO 2016201351 Dec 2016 WO
WO 2017079449 May 2017 WO
WO 2017079733 May 2017 WO
WO 2017087358 May 2017 WO
WO 2017096087 Jun 2017 WO
WO 2017192855 Nov 2017 WO
WO 2017205811 Nov 2017 WO
WO 2018081595 May 2018 WO
WO 2018119408 Jun 2018 WO
WO 2018167099 Sep 2018 WO
WO 2018222579 Dec 2018 WO
WO 2018227014 Dec 2018 WO
WO 2019005859 Jan 2019 WO
WO 2019027845 Feb 2019 WO
WO 2019089515 May 2019 WO
WO 2019236908 Dec 2019 WO
WO 2021092222 May 2021 WO
WO 2021119174 Jun 2021 WO
WO 2021126451 Jun 2021 WO
Non-Patent Literature Citations (14)
Entry
International Search Report and Written Opinion dated Apr. 20, 2017 for PCT/US2016/064491. (14 pages).
Aliancy, et al., “Long-term capsule clarity with a disk-shaped intraocular lens”, Journal of Cataract & Refractive Surgery, Apr. 2018, vol. 44, Issue 4, pp. 504-509.
Ehrmann, et al., “Biomechanical analysis of the accommodative apparatus in primates”, Clinical and Experimental Optometry, May 2008, vol. 91, Issue 3, pp. 302-312.
Ehrmann, et al., “Ex Vivo Accommodation Simulator II—Concept and Preliminary Results”, Proceedings of SPIE vol. 5314, Ophthalmic Technologies XIV, Jul. 2004, pp. 48-58.
Gabel, et al., “Silicone oil with high specific gravity for intraocular use”, British Journal of Ophthalmology, Apr. 1987, vol. 71, 262-267.
Ghallagher-Wetmore, et al., “Supercritical fluid processing: a new dry technique for photoresist developing”, SPIE's 1995 Symposium on Microlithography, 1995, vol. 2438, 16 pages.
Kramer, et al., “Prevention of postoperative capsular bag opacification using intraocular lenses and endocapsular devices maintaining an open or expanded capsular bag”, Journal of Cataract & Refractive Surgery, Mar. 2016, vol. 42, Issue 3, pp. 469-484.
Lane, et al., “Comparison of the biomechanical behavior of foldable intraocular lenses”, Journal of Cataract Refract Surg, Nov. 2004, vol. 30, pp. 2397-2402.
Leishman, et al., “Prevention of capsular bag opacification with a modified hydrophilic acrylic disk-shaped intraocular lens”, Journal of Cataract & Refractive Surgery, Sep. 2012, vol. 38, Issue 9, pp. 1664-1670.
Nakamura, et al., “Analysis and Fractionation of Silicone and Fluorosilicone Oils for Intraocular Use”, Investigative Ophthalmology & Visual Science, vol. 31, No. 10, Oct. 1990, 2059-2069.
National Center for Biotechnology Information. PubChem Substance Database; SID=184590955, https://pubchem.ncbi.nlm.nih.gov/substance/184590955 (accessed Sep. 20, 2017).
Zhang, et al., “Fluidic adaptive lens with high focal length tunability”, Applied Physics Letters, May 2003, vol. 82, No. 19, pp. 3171-3172.
Zhang, et al., “Integrated fluidic adaptive zoom lens”, Optics Letters, Dec. 2004, vol. 29, No. 24, pp. 2855-2857.
Zhao, et al., “Strategies for Supercritical CO2 Fractionation of Polydimethylsiloxane,” Journal of Applied Polymer Science, 1995, vol. 55, 773-778.
Related Publications (1)
Number Date Country
20210401570 A1 Dec 2021 US
Provisional Applications (1)
Number Date Country
62261790 Dec 2015 US
Continuations (2)
Number Date Country
Parent 15996188 Jun 2018 US
Child 17305200 US
Parent PCT/US2016/064491 Dec 2016 US
Child 15996188 US