Accuracy of Examining Cough Function and its Relationship to Airway Protection

Information

  • Research Project
  • 8719355
  • ApplicationId
    8719355
  • Core Project Number
    R33DC011131
  • Full Project Number
    7R33DC011131-04
  • Serial Number
    011131
  • FOA Number
    PAR-09-057
  • Sub Project Id
  • Project Start Date
    8/1/2010 - 14 years ago
  • Project End Date
    11/30/2014 - 10 years ago
  • Program Officer Name
    SHEKIM, LANA O
  • Budget Start Date
    7/1/2013 - 11 years ago
  • Budget End Date
    11/30/2014 - 10 years ago
  • Fiscal Year
    2013
  • Support Year
    04
  • Suffix
  • Award Notice Date
    8/12/2013 - 11 years ago
Organizations

Accuracy of Examining Cough Function and its Relationship to Airway Protection

DESCRIPTION (provided by applicant): Dysphagia and aspiration pneumonia are the main cause of life-threatening morbidity in Parkinson's disease (PD). Impaired airway clearance leads to penetration of foreign material which seeds the subglottic airways resulting in a high prevalence of aspiration pneumonia. Mortality rates of aspiration pneumonia can approach 40%. There is a compelling need for strategies to enhance the screening of airway protective behaviors in patients with neurodegenerative disease. While screening tools currently exist to assess aspiration risk in clinical settings they primarily assess swallow function. Importantly, swallow screening measures are unable to assess corrective airway protection modalities and therefore give limited information as to an individual's ability to defend his or her airway, should aspiration occur. The R21 will comprise a comparison of two different devices for capturing peak cough airflow data to the more costly and technically demanding gold standard pneumotachograph protocol in the assessment of cough airflow measures in healthy participants and individuals with PD. First, cough peak flow data will be collected from each of the three devices produced by healthy controls and individuals with PD. Next, we will define the cough ranges produced within the healthy control and PD groups across elicited weak, moderate and strong coughs to determine the devices' ability to measure airflow change. Intra and inter - reliability of the devices for the measurement of cough will be completed. Participants with PD will be recruited from the University of Florida Movement Disorders Center. The acceptability of each device will be measured by a calculated total score based on visual analogue scales of perception of task difficulty, discomfort, pain, and ease of use. Separate scales will be administered to participants and clinicians. Comparison of meter acceptability will be conducted using ANOVA. The comparability of the devices for expressing expiratory peak airflow in healthy control vs. PD sample will be reviewed using receiver operator curves (ROC). Area under the curve will be calculated (AUROC) and compared for the different devices using hypothesis testing. The R33 aims follow the R21 phase to determine if cough peak airflow can predict the presence and severity of airway penetration as defined by PA scores made from videofluoroscopic assessment of sequential swallows completed by a cohort of participants with PD. Participants will undergo measurement of peak cough airflows using the device selected during the R21 portion and receive an assessment of swallowing function under videofluoroscopy. Subsequent statistical analyses will determine the relationship, if any, between measures of peak cough airflow and P-A scores for participants with PD. Statistical modeling procedures will provide a preliminary predictive equation of risk for airway compromise.

IC Name
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
  • Activity
    R33
  • Administering IC
    DC
  • Application Type
    7
  • Direct Cost Amount
    133225
  • Indirect Cost Amount
    56114
  • Total Cost
    189339
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    173
  • Ed Inst. Type
  • Funding ICs
    NIDCD:189339\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    JACKSONVILLE UNIVERSITY
  • Organization Department
  • Organization DUNS
    078314903
  • Organization City
    JACKSONVILLE
  • Organization State
    FL
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    322113321
  • Organization District
    UNITED STATES