Claims
- 1. A compound of the formula ##STR3## wherein: X is methyl or --R--(CO).sub.m
- Y is --R.sup.1 --CO--NH--R.sup.2 (CO).sub.m when X is methyl, and hydrogen when X is --R--(CO).sub.m
- R, R.sup.1, and R.sup.2 are independently aliphatic linking groups of from 1 to 12 carbon atoms each;
- Z is a poly(amino acid) residue which is an enzyme;
- m is zero or one; and
- n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
- 2. A compound of the formula: ##STR4## wherein: R is a aliphatic linking froup of from 1 to 12 carbon atoms;
- Z is a poly(amino acid) residue which is an enzyme;
- m is zero or one; and
- n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
- 3. A compound according to claim 2 in which R is fully separated and has a straight-chain configuration.
- 4. A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 2 to 8 carbon atoms.
- 5. A compound according to claim 2 in which R is fully saturated, has a straight-chain configuration, and contains from 3 to 6 carbon atoms.
- 6. A compound of the formula: ##STR5## wherein: R.sup.1 is an aliphatic linking group of from 1 to 12 carbon atoms;
- R.sup.2 is an aliphatic linking group of from 1 to 12 carbon atoms;
- Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, or a group capable of forming an activated ester capable of amide formation with an amino acid in an aqueous medium, or a poly(amino acid) residue which is antigenic or an enzyme;
- m is zero or one when Z is a poly(amino acid) residue, and is otherwise one; and
- n is an integer ranging from one to a value approximately equal to the molecular weight of Z divided by 500 when Z is a poly(amino acid), and is otherwise one.
- 7. A compound according to claim 6 in which R.sup.1 and R.sup.2 are each fully saturated each has a straight-chain configuration.
- 8. A compound according to claim 6 in which R.sup.1 and R.sup.2 are each fully saturated, each has a straight-chain configuration, and each contains from 1 to 6 carbon atoms.
- 9. A compound according to claim 6 in which R.sup.1 and R.sup.2 are each fully saturated and each has a straight-chain configuration, and R.sup.1 contains from 1 to 4 carbon atoms, and R.sup.2 contains from 1 to 3 carbon atoms.
- 10. A compound according to claims 1, 2, or 6 in which Z in an enzyme having a molecular weight of from about 10,000 to about 1,000,000 daltons, and n ranges from about 2 to about 20.
- 11. A compound according to claims 1, 2, or 6 in which Z is glucose-6-phosphate dehydrogenase.
Parent Case Info
This is a division of application Ser. No. 364,836 filed Apr. 2, 1982, now U.S. Pat No. 4,424,150.
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Number |
Name |
Date |
Kind |
3975342 |
Gross |
Aug 1976 |
|
3981863 |
Niswender et al. |
Sep 1976 |
|
4181719 |
Margetts et al. |
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Divisions (1)
|
Number |
Date |
Country |
Parent |
364836 |
Apr 1982 |
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