Claims
- 1. A compound of the general formula III ##STR8## wherein MATRIX is a water and organic insoluble radical selected from the group consisting of:
- cross-linked polysaccharides, subsituted by C.sub.2 -C.sub.8 alkyl or alkenyl groups, macroporous synthetic polymers, co-polymers of cross-linked substituted polysaccharides with macroporous synthetic polymers, cross-linked co-polymers of unsubstituted polysaccharides with macroporous synthetic polymers, and rigid supports with pendant hydroxyalkyl groups, and Y is a member selected from the group consisting of:
- imidazolyl; 1,2,4-triazolyl; and 1,2,3-benzotriazolyl.
- 2. A compound as claimed in claim 1 wherein said MATRIX is a polysaccharide selected from the group consisting of agarose, starch, dextran, cellulose, regenerated cellulose, hydroxy C.sub.2 -C.sub.4 alkylated cellulose and hydroxy C.sub.2 -C.sub.4 alkylated regenerated cellulose.
- 3. A compound as claimed in claim 2 wherein said MATRIX is cross-linked allyl dextran and Y is imidazolyl.
- 4. The compound as claimed in claim 1 wherein said MATRIX is a copolymer of polyacrylamide with a cross-linked substituted or unsubstituted polysaccharide selected from the group consisting of: agarose, starch, dextran, cellulose, regenerated cellulose, hydroxy C.sub.2 -C.sub.4 alkylated cellulose and hydroxy C.sub.2 -C.sub.4 alkylated regenerated cellulose.
- 5. The compound of claim 4 wherein said MATRIX is an agarose/polyacrylamide copolymer and Y is imidazolyl.
- 6. The compound of claim 1 wherein said MATRIX is a said rigid support comprising silica beads having pendant ##STR9## radicals and Y is imidazolyl.
- 7. The compound of claim 1 wherein said MATRIX is hydroxyethyl methacrylate and Y is imidazolyl.
- 8. A process for the preparation of a compound of the general formula III as claimed in claim 1 which process comprises carbonylating a said MATRIX having reactive hydroxyl groups in an organic solvent at a temperature of 0.degree. C. to 80.degree. C., the upper temperature limit being the degradation temperature of said MATRIX, with a carbonylating agent of the general formula IV: ##STR10## wherein Y is selected from the group consisting of an imidazolyl, 1,2,3-triazolyl, and 1,2,3-benzotriazolyl.
- 9. The process of claim 8 wherein said organic solvent is a member selected from the group consisting of dioxan, dimethyl formamide and acetone.
- 10. The process as claimed in claim 9 wherein said MATRIX is selected from the group consisting of agarose, starch, dextran, cellulose, regenerated cellulose, hydroxy C.sub.2 -C.sub.4 alkylated cellulose and hydroxy C.sub.2 -C.sub.4 alkylated regenerated cellulose substituted by C.sub.2 -C.sub.8 alkyl or alkenyl groups.
- 11. A process as claimed in claim 10 wherein said MATRIX is cross-linked allyl dextran and Y is imidazolyl.
- 12. The process as claimed in claim 9 wherein said MATRIX is a copolymer of polyacrylamide with a cross-linked substituted or unsubstituted polysaccharide selected from the group consisting of: agarose, starch, dextran, cellulose, regenerated cellulose, hydroxy C.sub.2 -C.sub.4 alkylated cellulose and hydroxy C.sub.2 -C.sub.4 alkylated regenerated cellulose.
- 13. The process as claimed in claim 12 where said MATRIX is an agarose/polyacrylamide copolymer and Y is imidazolyl.
- 14. The process as claimed in claim 9 wherein said MATRIX is a said rigid support comprising silica beads with pendant ##STR11## radicals and Y is imidazolyl.
- 15. The process as claimed in claim 9 wherein said MATRIX is hydroxyethyl methacrylate and Y is imidazolyl.
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part of our application Ser. No. 874,628 filed Feb. 2, 1978, entitled "Activated Matrix and Method of Activation" now U.S. Pat. No. 4,224,439.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4211865 |
Ferruti et al. |
Jul 1980 |
|
4224439 |
Ayers et al. |
Sep 1980 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
874628 |
Feb 1978 |
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