ACTIVE INGREDIENT COMBINATIONS COMPRISING PYRIDYLETHYLBENZAMIDES AND OTHER ACTIVE INGREDIENTS

The present invention relates to new active ingredient combinations which consist of fluopyram and other known active ingredients and which are very well suited to the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in seed treatment, and also to the boosting of yields.

It is already known that certain pyridylethylbenzamides possess fungicidal, insecticidal, and acaricidal and nematicidal properties.

WO 2004/016088 describes pyridylethylbenzamides and their use as fungacides. The possibility of combining one or more of the disclosed pyridylethylbenzamide derivatives with other known fungicides, insecticides, nematicides or acaricides for the purpose of broadening the spectrum of activity is likewise described. The application, however, teaches neither which insecticidal mixing partners are suitable, nor the mixing ratio in which insecticides and pyridylethylbenzamide derivatives are combined with one another. WO 2005/077901 teaches fungicidal compositions comprising at least one pyridylethylbenzamide, a fungicide and an inhibitor of electron transport in the respiratory chain of fungi. The patent application, however, does not mention any mixtures of pyridylethylbenzamides with insecticides. WO 2008/003738 teaches fungicidal compositions comprising at least one pyridylethylbenzamide and an insecticide. A possible nematicidal action of the compositions is described in the application, but not explicitly for mixtures comprising N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide.

The activity of the active ingredients and active ingredient compositions described in the prior art is good, but is capable of improvement at low application rates in certain cases, especially in the context of nematode control.

The object on which the present invention is based, therefore, is that of providing nematicidal, insecticidal and acaricidal active ingredient combinations having improved activity, especially with regard to nematodes.

It has now been found that active ingredient combinations comprising

(I-1) N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}-2-trifluoromethylbenzamide of formula (I) (fluopyram)

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and also its N-oxides;

and

(II) at least one further active ingredient selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade™) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact™) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II-9), Rhizobium spp. (II-10), Beauverin spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752, (II-14), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus amyloliquefaciens strain FZB 42 (II-19), Myrothecium verrucaria strain AARC-0255 (II-20), pyrethrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana strain ATCC 74040 (II-25), Beauveria brongniartii (II-26), Lecanicillium lecanii (also known as Verticillium lecanii) (II-27), Bacillus thuringiensis subsp. tenebrionis (11-28)

are very well suited to the control of phytopathogenic fungi and animal pests, more particularly nematodes, in foliar and soil application, particularly in the context of seed treatment, and also to the boosting of yields.

The insecticides or active nematicidal ingredients of group (II) are selected from the group consisting of the following:

fluensulfone (II-1) known from WO-A 2001/002378

and/or

imicyafos (II-2) known from EP-A 0464830

and/or

Bacillus subtilis (II-3)

and/or

Bacillus subtilis strain QST 713 (II-4)

and/or

Paecilomyces lilacinus (II-5)

and/or

Paecilomyces lilacinus strain 251 (II-6)

and/or

azadirachtin (Cas-No 11141-17-6) (II-7)

and/or

Thymol (II-8)

and/or

Metarhizium anisopliae (II-9),

and/or

Rhizobium spp. (II-10),

and/or

Beauveria spp. (II-11),

and/or

Verticillium spp (II-12)

and/or

Metschnikowia fructicola (II-13) known from Kurztman and Droby, System. Application Microbiol. (2001), 24, pp 395-399

and/or

Metschnikowia fructicola strain NRRL Y-30752, (II-14) known from U.S. Pat. No. 6,994,849 B2

and/or

Bacillus subtilis strain GB03 (II-15) known under the name Kodiak™ marketed by Gustafson LLC

and/or

Bacillus pumilus strain GB34 known under the name YieldShield™ marketed by Gustafson LLC

and/or

Bacillus pumilus strain QST2808 known under the name Sonata™ marketed by Agraquest

and/or

Bacillus amyloliquefaciens strain IN937a

and/or

Myrothecium verrucaria strain AARC-0255 known under the name DiTera™ marketed by Valent Biosciences

and/or

pyrethrum (II-21)

and/or

Cydia pomonella granulosis virus (CpGV) (II-22)

and/or

Metarhizium anisopliae strain F52 (II-23)

and/or

arbuscular mycorrhiza fungus (II-24)

and/or

Beauveria bassiana strain ATCC 74040 (known under the name Naturalis®) (II-25)

and/or

Beauveria brongniartii (II-26)

and/or

Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27)

and/or

Bacillus thuringiensis subsp. tenebrionis (II-28).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade™) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact™) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II-9), Rhizobium spp. (II-10), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752, (II-14).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of bacteria consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade™) (II-4), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Rhizobium spp. (II-10), Bacillus thuringiensis subsp. tenebrionis (II-28).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of Bacillus species consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade™) (II-4), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus thuringiensis subsp. tenebrionis (II-28).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of fungal species consisting of Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact™) (II-6), Metarhizium anisopliae (II-9), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752, (II-14), Myrothecium verrucaria strain AARC-0255 (II-19), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana, in particular strain ATCC 74040 (II-25), Beauveria brongniartii (II-26), Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact™) (II-6), Metarhizium anisopliae (II-9), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752, (II-14), Bacillus subtilis strain GB03 (II-15), Bacillus amyloliquefaciens strain FZB 42 (II-19), Bacillus thuringiensis subsp. tenebrionis (II-28), pyrethrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24).

In one particularly preferred embodiment of the invention the active ingredients of group (II) are selected from the group consisting of fluensulfone (II-1), imicyafos (II-2), Bacillus subtilis strain QST 713 (Serenade™) (II-4), Paecilomyces lilacinus strain 251 (Bioact™) (II-6).

In one preferred embodiment of the invention the active ingredients of group (II) are selected from the group of the low molecular mass active ingredients fluensulfone (II-1), imicyafos (II-2), azadirachtin (II-7), thymol (II-8).

Surprisingly, the fungicidal, insecticidal and/or acaricidal and/or nematicidal action, more particularly the nematicidal action, of the active ingredient combinations of the invention, particularly after sod application, is substantially higher than the sum of the actions of the individual active ingredients. The effect is an unpredictable true synergistic effect, and not merely a supplementation of action. Moreover, the active ingredient combinations of the invention are suitable for effecting a boost to yield.

Preferred active ingredient combinations are those comprising the compounds of the formula (I-1) and at least one active ingredient of the formula (II).

Of particular interest are the following combinations:

(I-1)+(II-1), (I-1)+(II-2), (I-1)+(II-3), (I-1)+(II-4), (I-1)+(II-5), (I-1)+(II-6), (I-1)+(II-7), (I-1)+(II-8), (I-1)+(II-9), (I-1)+(II-10), (I-1)+(II-11), (I-1)+(II-12), (I-1)+(II-13), (I-1)+(II-14), (I-1)+(II-15), (I-1)+(II-16), (I-1)+(II-17), (I-1)+(II-18), (I-1)+(II-19), (I-1)+(II-20), (I-1)+(II-21), (I-1)+(II-22), (I-1)+(II-23), (1-1)+(II-24), (I-1)+(II-25), (I-1)+(II-26), (I-1)+(II-27), (I-1)+(II-28).

The active ingredient combinations may also, furthermore, comprise other, admix components with fungicidal, acaricidal, nematicidal or insecticidal activity.

If the active ingredients are present in particular weight ratios in the active ingredient combinations of the invention, the improved action is apparent with particular clarity. However, within the active ingredient combinations, the weight ratios of the active ingredients can be varied within a relatively wide range. In general the combinations of the invention comprise active ingredients of the formula (I-1) and the mixing partner in the preferred and particularly preferred mixing ratios indicated in the table below:

Very particularly

Mixing
Preferred mixing ratio
Particularly preferred mixing
preferred mixing ratio

partner
(I-1):Mixing partner
ratio (I-1):Mixing partner
(I-1):Mixing partner

II-1
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-2
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-3
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-4
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-5
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-6
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-7
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-8
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-9
500:1 to 1:50000
125:1 to 1:12500
25:1 to 1:2500

II-10
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-11
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-12
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-13
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-14
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-15
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-16
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-17
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-18
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-19
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-20
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-21
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-22
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-23
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-24
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-25
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-26
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-27
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

II-28
500:1 to 1:500
125:1 to 1:125
25:1 to 1:25

Animal Pests

The active ingredient combinations combine good tolerance by plants with suitability for controlling animal pests, such as insects and/or arachnids, and more particularly nematodes, which are prevalent in viticulture, fruit growing, agriculture, horticulture, and forestry. They can be used with preference as crop protection compositions. They are active against normally sensitive species and resistant species, and also against all or individual development stages. The aforementioned pests include the following:

Insects

Examples from the order of the Anoplura (Phthiraptera): Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.

Examples from the class of the Arachnida: Acarus spp., Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphitetranychus viennensis, Aigas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Halotydeus destructor, Hermitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Nuphersa spp., Oligonychus spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsoneinus talus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici.

Examples from the class of the Bivalva: Dreissena spp.

Examples from the order of the Chilopoda: Geophilus spp., Scutigera spp.

Examples from the order of the Coleoptera: Acalymma vittatum, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apion spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Cassida spp., Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnema spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Ctenicera spp. Curculio spp., Cryptorhynchus lapathi, Cylindnocopturus spp., Dermestes spp., Diabrotica spp., Dichocrocis spp., Diloboderus spp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides, Hellula undalis, Heteronychus arator, Heteronyx spp., Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Lema spp., Leptinotarsa decernlineata, Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp., Luperodes spp., Lyctus spp., Megascelis spp., Melanotus spp., Meligethes aeneus, Melolontha spp., Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otyzaphagus oryzae, Otiorrhynchus spp., Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Phyllotreta spp., Popilha japonica, Premnotrypes spp., Psylliodes spp., Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tanymecus spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.

Example from the order of the Collernbola: Onychiurus armatus.

Example from the order of the Diplopoda: Blaniulus guttulatus.

Examples from the order of the Diptera: Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chironomus spp., Chrysomyia spp., Cochliomyia spp., Contarinia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dasyneura spp., Delia spp., Dermatobia horninis, Drosophila spp., Echinocnemus spp., Fannia spp., Gastrophilus spp., Hydrellia spp., Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia spp., Phorbia spp., Prodiplosis spp., Psila rosae, Rhagoletis spp., Stornoxys spp., Tabanus spp., Tannia spp., Tetanops spp., Tipula spp.

Examples from the class of the Gastropoda: Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Pomaeea spp., Succinea spp.

Examples from the class of the helminths: Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lumbricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp, Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vernicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp, Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichiura, Wuchercria bancrofti.

It is also possible for protozoa, such as Eimeria, to be controlled.

Examples from the order of the Heteroptera: Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus spp., Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.

Examples from the order of the Homoptera: Acyrthosipon spp., Acrogonia spp., Aeneolamia spp., Agonoseena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui. Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Gilligypona marginata, Cameocephala fulgida, Ceratovaeuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola. Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Daibulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Hieroglyphus spp., Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoceus spp., Phloeomyzus passerinii, Phorodon huinuli, Phylloxera spp., Pinnaspis aspidisirae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis earyaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes spp., Trioza spp., Typhkxyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.

Examples from the order of the Hymenoptera: Athalia spp., Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.

Examples from the order of the Isopoda: Annadillidium vulgare, Oniscus asellus, Porcellio scaber.

Examples from the order of the Isoptera: Acromyrmex spp., Atta spp., Cornitermes cumulans, Micmtennes obesi, Odontotermes spp., Reticulitermes spp.

Examples from the order of the Lepidoptera: Acronicta major, Adoxophyes spp., Aedia leucomelas, Agmtis spp., Alabama spp., Amyelois transitella, Anarsm spp., Anticarsia spp., Argyroploce spp., Barathra brassieae, Borbo cinnara, Bucculatrix thurbericlla, Bupalus piniarius, Busseola spp., Cacoecia spp., Caloptilia theivora, Capua reticulana, Carpocapsa pomonella, Caiposina niponensis, Cheimatobia brumata, Chiki spp., Choristoneura spp., Clysia arnbiguella, Cnaphalocerus spp., Cnephasia spp., Conopomorpha spp., Conotrachelus spp., Copitarsia spp., Cydia spp., Dalaca noctuides, Diaphania spp., Diatraea saceharalis, Earias spp., Eedytolopha aurantium, Elasmopalpus lignosellus, Eldana saceharina, Ephestia kuehniella, Epinotia spp., Epiphyas postxdttana, Etiella spp., Eulia spp., Eupoetilia ambiguella, Euproctis spp., Euxoa spp., Feltia spp., Galleria mellonella, Graeillaria spp., Grapholitha spp., Hedylepta spp., Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homoeosoma spp., Homona spp., Hyponomeuta padella, Kakivoria flavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodes orbonalis, Leueoptera spp., Lithicolletis spp., Lithophane antennata, Lobesia spp., Loxagrotis albicosta, Lymantria spp., Lyonetia spp., Malaeosoma neustria, Maruca testulalis, Klamestra brassieae, Mocis spp., Myihimna separata, Nymphula spp., Oikelicus spp., Oria spp., Orthaga spp., Ostrinia spp., Oulema oryzae, Panolis flammca, Pamara spp., Pectinophora spp., Peri leueoptera spp., Phthorimaea spp., Phyllocnistis citrella, Phyllonorycter spp., Pieris spp., Platynota slultana, Plusia spp., Plutella xylostella, Prays spp., Prodenia spp., Pratoparce spp., Pscudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Rachiplusia nu, Schoenobius spp., Seirpophaga spp., Scotia segetum, Sesamia spp., Sparganothis spp., Spodoptera spp., Stathmopoda spp., Stomopteryx subsecivella, Synanthedon spp., Tecia solanivora, Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix spp., Trichoplusia spp., Tula absoluta, Virachola spp.

Examples from the order of the Orthoptera: Achela domeslicus, Blatta orientalis, Blaltella germanica, Dichroplus spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerea gregaria.

Examples from the order of Siphonaptera: Ceratophyllus spp., Xenopsylla cheopis.

Example from the order of the Symphyla: Scutigerella spp.

Examples from the order of the Thysanoptera: Anaphothrips obscurus, Baliothrips biformis, Drepanothris reuteri, Enneothrips flavens, Frankliniella spp., Heliolhrips spp., Hercinothrips femoralis, Rhipiphomthrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.

Example from the order of the Thysanura: Lepisma saccharina.

Nematodes

All species of plant-parasitic nematodes may in principle be controlled using the active ingredient combinations of the invention. The active ingredient combinations of the invention prove particularly advantageous in the control of nematodes selected from the group consisting of the following: Aglenchus agricola, Anguina tritici, Aphelenchoides arachidis, Aphelencboides fragariae, Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni, Cacopaurus pestis, Criconemella curvata, Criconemella onoensis, Criconemella ornata, Criconemella rusiuin, Criconemella xenoplax (=Mesocriconerna xenoplax) and Criconemella spp. in general, Crieonemoides ferniae, Criconemoides onoense, Criconemoides omatum and Criconemoides spp. in general, Ditylenchus destructor, Dilylenchus dipsaci, Ditylenchus myceliophagus and Ditylenchus spp. in general, Dolichodorus heteroeephalus, Globodera pallida (=Heterodera pallida), Globodera rostochiensis, Globodera solanacearum, Globodera tabacum, Globodera virginiae, Helicotylenchus digonicus, Helicolylenchus dihyslera, Helicotylenchus eiythrine, Helicotylenchus multicinctus, Helicotylenchus nannus, Helicotylenchus pseudorobustus and Helicotylenchus spp. in general, Hemicriconemoides, Hemicycliophora arenaria, Hemicycliophora nudata, Heimcycliophora parvana, Heterodera avenae, Heterodera cruciferae, Heterodera glycines, Heterodera oryzae, Heterodera schachtii, Heterodera zeae and Heteixxlera spp. in general, Hoplolaimus aegyptii, Hoplolaimus califomicus, Hoplolaimus columbus, Hoplolaimus galeiitus, Hoplolaimus indicus, Hoplolaimus inagnistylus, Hoplolannus pararobustus, Longidorus africanus, Longidorus breviannulalus, Longidorus elongatus, Longidorus laevicapitatus, Longidorus vineacola and Longidorus spp. in general, Meloidogyne acronea, Meloidogyne africana, Meloidogyne arenaria, Meloidogyne arenaria tharnesi, Meloidogyne artiella, Meloidogyne chitwoodi, Meloidogyne coffeicola, Meloidogyne ethiopica, Meloidogyne exigua, Meloidogyne graminicola, Meloidogyne graminis, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogyne javanica, Meloidogyne kikuyensis, Meloidogyne naasi, Meloidogyne paranaensis, Meloidogyne thamesi and Meloidogyne spp. in general, Meloinema spp., Nacobbus aberrans, Neotylencbus vigissi, Paraphelenchus pseudopanetinus, Paratrichodorus allius, Paratrichodorus lobatus, Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus pomsus, Paratrichodorus teres and Paratrichodorus spp. in general, Paratylenchus hamalus, Paratylenebus minutus, Paratylenchus projectus and Paratylenchus spp. in general, Pratylenchus agilis, Pratylenchus alleni, Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis, Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei, Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus, Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus pralensis, Pratylenchus scribneri, Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae and Pratylenchus spp. in general, Pseudobalenebus minutus, Psilenchus magmdens, Psilenchus tumidus, Punctodera chalaxnsis, Quinisulcius acutus, Radopholus citrophilus, Radopholus similis, Rolylenchulus borealis, Rotylenchulus parvus, Rotylenchulus renifonnis and Rotylenchulus spp. in general, Rotylenchus laurentinus, Rotylenchus maemdoratus, Rotylenchus mbustus, Rotylenchus uniformis and Rotylenchus spp. in general, Scutellonema brachyurum, Scutellonema bradys, Scutellonema clathricaudatum and Scutellonema spp. in general, Subanguina radiciola, Tetylenchus nicotianae, Trichodorus eylindncus, Trichodorus minor, Trichodorus primitivus, Trichodorus proximus, Trichodorus similis, Trichodorus sparsus and Trichodorus spp. in general, Tylenchorhynchus agri, Tylenchorhynchus brassicae, Tylenchorhynchus clarus, Tylenchorhynchus claytoni, Tylenchorhynchus digitatus, Tylenchorhynchus ebriensis, Tylenchorhynchus maximus, Tylenchorhynchus nudus, Tylenchorhynchus vulgaris and Tylenchorhynchus spp. in general, Tylenchulus semipenetrans, Xiphinema americanum, Xiphinema brevicolle, Xiphinema dimorphiamdiitum, Xiphinema index and Xiphinema spp. in general.

The active ingredient combinations of the invention prove especially advantageous in the control of nematodes selected from the group consisting of the following: Meloidogyne spp., such as Meloidogyne incognita, Meloidogyne javanica, Meloidogyne hapla, Meloidogyne arenaria; Ditylenchus ssp., such as Ditylenchus dipsaei, Ditylelenchus destructor, Pratylenchus ssp., such as Pratylenchus penetrans, Pratylenchus fallax, Pratylenchus coffeae, Pratylenchus loosi, Pratylenchus vulnus; Globodera spp., such as Globodera rostochiensis, Globodera pallida etc.; Heterodera spp., such as Heterodera glycines Heterodera shachtoii etc.; Aphelenchoides spp., such as Aphelenchoides besseyi, Aphelenchoides ritzemabosi, Aphelenchoides fragarieae; Aphelenchus ssp., such as Apbelenchus avenae; Raiktpholus ssp, such as Radopholus similis; Tylenchulus ssp., such as Tylenchulus semipenetrans; Rotylenchulus ssp., such as Rotylenchulus reniformis;

Bursapbelencbus spp., such as Hursaphelencbus xylophilus, Aphelenchoides spp., Longidorus spp., Xiphinema spp., Trichodorus spp.

Furthermore, the active ingredient combinations of the invention prove active in the control of nematodes which infect humans or animals, such as round worm, pin worm, filaria, Wuchereri bancrofti, thread worms (convoluted filaria), Gnathostorna etc.

Animal Health

The active ingredient combinations of the invention do not act only against plant, hygiene and stored-product pests but also in the veterinary sector, against animal parasites (ecto- and endoparasites) such as hard ticks, soft ticks, mange mites, leaf mites, flies (biting and licking), parasitic fly larvae, lice, hair lice, feather lice, and fleas. These parasites including the following:

Examples from the order of the Anoplurida: Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp.

Examples from the order of the Mallophagida and the suborders Amblycerina and Ischnocerina: Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.

Examples from the order Diptera and the suborders Nematocerina and Brachycerina: Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stoinoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lueilia spp., Cluysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypodenna spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp.

Examples from the order of the Siphonapterida: Pulex spp., Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp.

Examples from the order of the Heteropterida: Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.

Examples from the order of the Blattarida: Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp.

Examples from the subclass of the Acari (Acarina) and from the orders of the Meta- and Mesostigmata: Argas spp., Omithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermaeentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp.

Examples from the order of the Aetinedida (Prostigmata) and Acaridida (Astigmata): Acarapis spp., Cheyletiella spp., Ormtlioeheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombieula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidoeoptes spp., Cytodites spp., Laminosioptes spp.

The active ingredient combinations of the invention are also suitable in the control of arthropods which infest agricultural livestock, such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffalos, rabbits, chickens, turkeys, ducks, geese and bees, for example, other domesticated animals such as dogs, cats, caged birds and aquarium fish, for example, and also so-called experimentation animals, such as hamsters, guinea pigs, rats and mice, for example. The aim of controlling these arthropods is to reduce fatalities and yield reductions (of meat, milk, wool, hides, eggs, honey, etc.), so that more economic and easier animal husbandry is possible through the use of the active ingredient combinations of the invention.

Application of the active ingredient combinations of the invention in the veterinary sector and in animal husbandry is, in a conventional way, through enteral administration in the form of, for example, tablets, capsules, potions, drenches, granules, pastes, boluses, the feed-through method, and suppositories, and by parenteral administration, as for example through injections (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.), implants, by nasal administration, by dermal application in the form, for example, of bathing or dipping, spraying, pour-on and spot-on, washing, and powdering, and also with the aid of molded articles containing active ingredient, such as collars, ear marks, tail marks, limb bands, halters, marking devices, etc.

In the context of application for livestock, poultry, domestic animals, etc., the active ingredient combinations may be applied as formulations (for example, powders, emulsions, flowable compositions) which comprise the active ingredients in an amount from 1 to 80 wt. %, directly or after 100- to 10 000-fold dilution, or may be used in the form of a chemical bath.

Crops

The crops to be protected, which have only been described in a general manner, are differentiated and specified below. Thus, with regard to use, vegetables are understood to mean, for example, fruit vegetables and flower-heads as vegetables, for example carrots, bell peppers, chilli peppers, tomatoes, aubergines, cucumbers, cucurbits, courgettes, broad beans, runner beans, bush beans, peas, artichokes, maize;

but also leafy vegetables, for example lettuce, chicory, endives, cress, rocket salad field salad, iceberg lettuce, leek, spinach, swiss chard;

additionally tuber vegetables, root vegetables and stem vegetables, for example celeriac, beetroot, carrots, garden radish, horseradish, salsify, asparagus, table beet, palm shoots, bamboo shoots, and also bulb vegetables, for example onions, leek, fennel, garlic;

additionally brassica vegetables, such as cauliflower, broccoli, kohlrabi, red cabbage, white cabbage, green cabbage, savoy cabbage, brussels sprouts, Chinese cabbage.

With regard to use, perennial crops are understood to mean citrus fruit, for example oranges, grapefruit, mandarins, lemons, limes, bitter oranges, kumquats, satsumas;

but also pome fruit, for example apples, pears and quince, and stone fruit, for example peaches, nectarines, cherries, plums, common plums, apricots;

additionally grapevine, hops, olives, tea, soya, oilseed rape, cotton, sugar cane, beet, potatoes, tobacco and tropical crops, for example mangoes, papayas, figs, pineapples, dates, bananas, durians, kakis, coconuts, cacao, coffee, avocados, lychees, maracujas, guavas,

and also almonds and nuts, for example hazelnuts, walnuts, pistachios, cashew nuts, brazil nuts, pecan nuts, butter nuts, chestnuts, hickory nuts, macadamia nuts, peanuts,

and additionally also soft fruit, for example blackcurrants, gooseberries, raspberries, blackberries, blueberries, strawberries, red bilberries, kiwis, cranberries.

With regard to use, ornamental plants are understood to mean annual and perennial plants, for example cut flowers, for example roses, carnations, gerbera, lilies, marguerites, chrysanthemums, tulips, daffodils, anemones, poppies, amaryllis, dahlias, azaleas, malves, but also, for example, bedding plants, potted plants and shrubs, for example roses, tagetes, pansies, geraniums, fuchsias, hibiscus, chrysanthemums, busy lizzies, cyclamen, african violets, sunflowers, begonias, in ornamental lawns, in golf lawns, but also in cereals such as barley, wheat, rye, triticale, oats, in rice, in millet, in maize, additionally, for example, bushes and conifers, for example fig trees, rhododendron, spruce trees, fir trees, pine trees, yew trees, juniper trees, stone pines, rose bays.

With regard to use, spices are understood to mean annual and perennial plants, for example aniseed, chilli pepper, bell pepper, pepper, vanilla, majoram, thyme, cloves, juniper berries, cinnamon, tarragon, coriander, saffron, ginger.

The crops to be protected are highlighted in particular as follows: bell peppers, chilli peppers, tomatoes, aubergines, cucumbers, cucurbits, courgettes, artichokes, maize, celeriac, beetroot, carrots, garden radish, horseradish, salsifies, asparagus, table beet, palm shoots, bamboo shoots, onions, leek, oranges, grapefruit, mandarins, lemons, limes, bitter oranges, kumquats, satsuinas, apples, pears, and quince, and stone fruit, such as, for example, peaches, nectarines, cherries, plums, common plums, apricots, grapevine, hops, soya, oilseed rape, cotton, sugar cane, beet, potatoes, tobacco, hazelnuts, walnuts, pistachios, cashew nuts, brazil nuts, pecan nuts, butter nuts, chestnuts, hickory nuts, macadamia nuts, peanuts, roses, carnations, gerbera, lilies, marguerites, chrysanthemums, tulips, daffodils, anemones, poppies, amaryllis, dahlias, azaleas, malves, barley, wheat, rye, triticale, oats, nee, millet, maize.

According to the invention, it is possible to treat all plants and plant parts. Plants are understood here to mean all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which can or cannot be protected by plant breeders' certificates.

GMOs

In a further preferred embodiment, transgenic plants and plant cultivars which have been obtained by genetic engineering methods, if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated. The terms “parts” and “plant parts” have been explained above.

More preferably, plants of the plant cultivars which are in each case commercially available or in use are treated in accordance with the invention.

Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, nutrition), the treatment in accordance with the invention may also result in superadditive (“synergistic”) effects. For example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions which can be used in accordance with the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, better quality and/or higher nutritional value of the harvested products, better storage qualities and/or processability of the harvested products are possible which exceed the effects which were actually to be expected.

According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant varietal property or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering anil genetic engineering methods. By plant parts are meant all above-ground and below-ground parts and organs of plants such as shoot, leaf, blossom and root, where for example leaves, needles, stems, branches, flowers, fruiting bodies, fruits anil seed anil also roots, corms and rhizomes are listed. Crops anil vegetative anil generative propagating material, for example cuttings, corns, rhizones, runners anil seals, also belong to plant parts.

Among the plants that can be protected by the method according to the invention, mention may be made of major field crops such as maize, soya bean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet, triticale, flax, vine and various fruits anil vegetables of various botanical taxa such as Rosaceae sp. (for instance pome fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, soft fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaeeae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant). Liliaceae sp., Composiliae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans—such as climbing beans and broad beans). Chenopodiaceae sp. (for instance Swiss chard, while cabbage spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; and also genetically modified homologs of these crops.

The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seals. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into the genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using, for example, antisense technology, cosuppression technology or RNA interference—RNAi—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation event or transgenic event.

Depending on the plant species or plant cultivars, their location and growth conditions (sods, climate, vegetation period, nutrition), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage qualities and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.

At certain application rates, the active ingredient combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, also those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active ingredients.

Plants and plant cultivars which are preferably treated according to the invention include all plants which have genetic material which imparts particularly advantageous, useful trails to these plants (whether obtained by breeding and/or biotechnological means).

Plants and plant cultivars winch are also preferably treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.

For example, examples of nematode-resistant plants are described in U.S. patent application Ser. Nos. 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396 or 12/497,221.

Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, or shade avoidance.

Plants and plant cultivars which may also be treated according to the invention are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage qualities.

Examples of plants with the above-mentioned traits are non-exhaustively listed in table A.

Plants that may be treated according to the invention are hybrid plants that already express the characteristics of heterosis or hybrid vigor which results in generally higher yield and vigor, and improved health and resistance toward biotic and abiotic stresses. Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male-sterile plants and sold to growers. Male-sterile plants can sometimes (e.g. in maize) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or male flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome, in that case, and especially when seeds are the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) have for example been described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male-sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as a barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation or by selection of plants containing a mutation imparting such herbicide tolerance.

Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants am be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), the genes encoding a petunia EPSPS (Shah et al., Science (1986), 233, 478-481), a tomato EPSPS (Gasser et al., J. Biol. Chem. (1988), 263, 4280-4289), or an eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described for example in EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants am also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent application Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.

Other herbicide-resistant plants are for example plants that have been made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is for example an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

Further herbicide-tolerant plants are also plants that have been made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). HPPD is an enzyme that catalyses the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585 and WO 99/24586. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate dehydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.

Still further herbicide-resistant plants are plants that have been made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidine, pyrimidinyloxy(thio)benzoate and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxy acid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright, Weed Science (2002), 50, 700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870 and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373. WO 2006/015376, WO 2006/024351 and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024782 and U.S. patent application No. 61/288,958.

Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soya beans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599 or for sunflower in WO 01/065922.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005) in the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ae.uk/Home/Neil_Criekmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa or Ciy3Bb or insecticidal portions thereof (e.g. EP-A 1999141 and WO 2007/107302), or such proteins encoded by synthetic genes as for example described in U.S. patent application Ser. No. 12/249,016; or
2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al., Nat. Biotechnol. (2001), 19, 668-72; Schnepf et al., Applied Environm. Microbiol. (2006), 71, 1765-1774) or the binary toxin made up of the Cry1A or Cry 1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
3) a hybrid insecticidal protein comprising parts of two different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g. the Cry1A.105 protein produced by arm event MON89034 (WO 2007/027777); or
4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes induced in the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in arm events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
5) an insecticidal secreted protein Bacillus thuringiensis or from Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or
6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795) or
7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT 102; or
9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and Cry1A or Cry1F (U.S. patent application Nos. 61/126,083 and 61/195,019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein).

Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described for example in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

1) plants which contain a transgene capable of reducing the expression and/or the activity of the poly(ADP-ribose)polymerase (PARP) gene in the plant cells or plants as described in WO 00/04173, WO/2006/045633, EP 04077984.5 or EP 06009836.5;
2) plants which contain a stress tolerance-enhancing transgene capable of reducing the expression and/or the activity of the PARG-encoding genes of the plants or plants cells, as described in e.g. WO 2004/090140;
3) plants which contain a stress tolerance-enhancing transgene encoding a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage biosynthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphoribosyltransferase as described e.g. in EP 04077624.7, WO 2006/133827, PCT/EP07/002433, EP 1999263 or WO 2007/107326.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according (o the invention show altered quantity, quality and/or storage qualities of the harvested product and/or altered properties of specific constituents of the harvested product, such as:

1) transgene plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behavior, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesized starch in wild type plant cells or plants, so that this modified starch is better suited for special applications. Such transgenic plants synthesizing a modified starch are disclosed, for example in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 0709007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66150, WO 99/53072, U.S. Pat. No. 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, U.S. Pat. Nos. 5,824,790, 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026 and WO 97/20936.
2) Transgenic plants which synthesize non-starch carbohydrate polymers or which synthesize non-starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Example are plants producing polyfructose, especially of the inulin and levan type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460 and WO 99/24593, plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, U.S. Pat. Nos. 6,284,479, 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, and plants producing alternan, as disclosed in WO 00/47727, WO 00/73422, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213.
3) Transgenic plants which produce hyaluronan, as for example disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779 and WO 2005/012529.
4) Transgenic plants or hybrid plants, such as onions with characteristics such as ‘high soluble solids content’, ‘low pungency’ (LP) and/or ‘long storage’ (LS), as described in U.S. patent application Ser. Nos. 12/020,360 and 61/054,026.

a) plants, such as cotton plants, containing an altered form of cellulose synthase genes as described in WO 98/00549,
b) plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO 2004/053219;
c) plants, such as cotton plants, with increased expression of sucrose phosphate synthase as described in WO 01/17333;
d) plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 02/45485;
e) plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as described in WO 2005/017157, or as described in EP 08075514.3 or in U.S. patent application No. 61/128,938;
f) plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of N-acetylglucosamintransferase gene including nodC and chitin synthase genes as described in WO 2006/136351.

Plants or plant cultivars (that have been obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered oil characteristics and include:

a) plants, such as oilseed rape plants, producing oil having a high oleic acid content as described e.g. in U.S. Pat. Nos. 5,969,169, 5,840,946 or 6,323,392 or 6,063,947;
b) plants such as oilseed rape plants, producing oil having a low linolenic acid content as described in U.S. Pat. Nos. 6,270,828, 6,169,190 or 5,965,755.
c) Plants such as oilseed rape plants, producing oil having a low level of saturated fatty acids as described e.g. in U.S. Pat. No. 5,434,283 or U.S. patent application Ser. No. 12/668,303.

Plants or plant cultivars (that have been obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in U.S. patent application No. 61/135,230, WO09/068313 and WO10/006732.

Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combinations of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA), whether such petitions are granted or are still pending. At any lime this information is readily available from APHIS (4700 River Road, Riverdale, Md. 20737, USA), for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for non-regulated status that were pending with APHIS or granted by APHIS were those listed in table B which contains the following information:

- Petition: the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
- Extension of a petition: reference to a previous petition for which an extension is requested.
- Institution: the name of the entity submitting the petition.
- Regulated article: the plant species concerned.
- Transgenic phenotype: the trait conferred to the plants by the transformation event.
- Transformation event or line: the name of the event or events (sometimes also designated as line or lines) for which non-regulated status is requested.
- APHIS documents: various documents published by APHIS in relation to the petition and which can be requested from APHIS.

Additionally particularly useful plants containing single transformation events or a combination of transformation events are listed for example in the database from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://cera-gmc.org/index.php?evidcode=&hstIDXCode=&gType=&AbbrCode=&atCode-&stCode=&coIDCode=&action=gm_crop_database&mode=Submit).

Further particular transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in table C.

In one embodiment of the invention the plants A-1 to A-183 of table A, in total or in part, or propagation material of said plants, is treated or contacted with the active ingredient combinations of the invention, alone or in the form of compositions comprising an active ingredient combination.

Transgenic

No.
event
Company
Description
Crop

A-1
ASR368
Scotts Seeds
Glyphosate tolerance derived by inserting a modified 5-

Agrostis

enolpyruvylshikimate-3-phosphate synthase (EPSPS)

stolonifera

encoding gene from Agrobacterium tumefaciens, parent
Creeping

line B99061.
bentgrass

A-2
Asr-368

Glyphosate tolerance; US 2006-162007
bentgrass

A-3
H7-1
Monsanto
Glyphosate herbicide tolerant sugar beet produced by

Beta vulgaris

Company
inserting a gene encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase (EPSPS)

from the CP4 strain of Agrobacterium tumefaciens;

WO 2004-074492

A-4
T120-7
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)

Beta vulgaris

Science
encoding gene from Streptomyces viridochromogenes,

(Aventis Crop-
an aerobic soil bacterium. PPT normally acts to inhibit

Science
glutamine synthetase, causing a fatal accumulation of

(AgrEvo))
ammonia. Acetylated PPT is inactive.

A-5
GTSB77
Novartis Seeds;
Glyphosate herbicide tolerant sugar beet produced by

Beta vulgaris

Monsanto
inserting a gene encoding the enzyme 5-
(sugar beet)

Company
enolypyruvylshikimate-3-phosphate synthase (EPSPS)

from the CP4 strain of Agrobacterium tumefaciens.

A-6
T227-1

Glyphosate tolerance; US 2004-117870

Beta vulgaris

sugar beet

A-7
23-18-17, 23-
Monsanto
High laurate acid (12:0) and myristate acid (14:0) canola

Brassica

198
Company
produced by inserting a thioesterase encoding gene from

napus

(formerly
the California bay laurel (Umbellularia californica).
(Argentine

Calgene)

Canola)

A-8
45A37, 46A40
Pioneer Hi-Bred
High oleic acid and low linolenic acid canola produced

Brassica

International
through a combination of chemical mutagenesis to select

napus

Inc.
for a fatty acid desaturase mutant with elevated oleic
(Argentine

acid content, and traditional back-crossing to introduce
Canola)

the low linolenic acid trait.

A-9
46A12, 46A16
Pioneer Hi-Bred
Combination of chemical mutagenesis, to achieve the

Brassica

International
high oleic acid trait, and traditional breeding with

napus

Inc.
registered canola varieties.
(Argentine

Canola)

A-10
GT200
Monsanto
Glyphosate herbicide tolerant canola produced by

Brassica

Company
inserting genes encoding the enzymes 5-

napus

enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(Argentine

from the CP4 strain of Agrobacterium tumefaciens and
Canola)

glyphosate oxidase from Ochrobactrum anthropi.

A-11
GT73, RT73
Monsanto
Glyphosate herbicide tolerant canola produced by

Brassica

Company
inserting genes encoding the enzymes 5-

napus

enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(Argentine

from the CP4 strain of Agrobacterium tumefaciens and
Canola)

glyphosate oxidase from Ochrobactrum anthropi.

A-12
HCN10
Aventis
Introduction of the PPT-acetyltransferase (PAT)

Brassica

CropScience
encoding gene from Streptomyces viridochromogenes,

napus

an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine

glutamine synthetase, causing a fatal accumulation of
Canola)

ammonia. Acetylated PPT is inactive.

A-13
HCN92
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)

Brassica

Science
encoding gene from Streptomyces viridochromogenes,

napus

(Aventis Crop-
an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine

Science
glutamine synthetase, causing a fatal accumulation of
Canola)

(AgrEvo))
ammonia. Acetylated PPT is inactive.

A-14
MS1, RF1 =>
Aventis
Male sterility, fertility restoration, pollination control

Brassica

PGS1
CropScience
system displaying glufosinate herbicide tolerance. MS

napus

(formerly Plant
lines contained the barnase gene from Bacillus
(Argentine

Genetic

amyloliquefaciens, RF lines contained the barstar gene
Canola)

Systems)
from the same bacterium, and both lines contained the

phosphinothricin N-acetyltransferase (PAT) encoding

gene from Streptomyces hygroscopicus.

A-15
MS1, RF2 =>
Aventis
Male sterility, fertility restoration, pollination control

Brassica

PGS2
CropScience
system displaying glufosinate herbicide tolerance. MS

napus

(formerly Plant
lines contained the barnase gene from Bacillus
(Argentine

Genetic

amyloliquefaciens, RF lines contained the barstar gene
Canola)

Systems)
from the same bacterium, and both lines contained the

phosphinothricin N-acetyltransferase (PAT) encoding

gene from Streptomyces hygroscopicus.

A-16
MS8 × RF3
Bayer
Male sterility, fertility restoration, pollination control

Brassica

CropScience
system displaying glufosinate herbicide tolerance. MS

napus

(Aventis
lines contained the barnase gene from Bacillus
(Argentine

CropScience

amyloliquefaciens, RF lines contained the barstar gene
Canola)

(AgrEvo))
from the same bacterium, and both lines contained the

phosphinothricin N-acetyltransferase (PAT) encoding

gene from Streptomyces hygroscopicus.

A-17
MS-B2

Male sterility, WO 01/31042

Brassica

napus

(Argentine

Canola)

A-18
MS-BN1/RF-

Male sterility/restoration; WO 01/41558

Brassica

BN1

napus

(Argentine

Canola)

A-19
NS738,
Pioneer Hi-Bred
Selection of somaclonal variants with altered

Brassica

NS1471,
International
acetolactate synthase (ALS) enzymes, following

napus

NS1473
Inc.
chemical mutagenesis. Two lines (P1, P2) were initially
(Argentine

selected with modifications at different unlinked loci.
Canola)

NS738 contains the P2 mutation only.

A-20
OXY-235
Aventis
Tolerance to the herbicides bromoxynil and ioxynil by

Brassica

CropScience
incorporation of the nitrilase gene from Klebsiella

napus

(formerly Rhône

pneumoniae.
(Argentine

Poulenc Inc.)

Canola)

A-21
PHY14,
Aventis
Male sterility was obtained via insertion of the barnase

Brassica

PHY35
CropScience
ribonuclease gene from Bacillus amyloliquefaciens;

napus

(formerly Plant
fertility restoration by insertion of the barstar RNase
(Argentine

Genetic
inhibitor; PPT resistance via PPT-acetyltransferase
Canola)

Systems)
(PAT) from Streptomyces hygroscopicus.

A-22
PHY36
Aventis
Male sterility was obtained via insertion of the barnase

Brassica

CropScience
ribonuclease gene from Bacillus amyloliquefaciens;

napus

(formerly Plant
fertility restoration by insertion of the barstar RNase
(Argentine

Genetic
inhibitor; PPT-acetyltransferase (PAT) from
Canola)

Systems)

Streptomyces hygroscopicus.

A-23
RT73

Glyphosate resistance; WO 02/36831

Brassica

napus

(Argentine

Canola)

A-24
T45 (HCN28)
Bayer Crop-
Introduction of the PPT-acetyltransferase (PAT)

Brassica

Science
encoding gene from Streptomyces viridochromogenes,

napus

(Aventis
an aerobic soil bacterium. PPT normally acts to inhibit
(Argentine

CropScience
glutamine synthetase, causing a fatal accumulation of
Canola)

(AgrEvo))
ammonia. Acetylated PPT is inactive.

A-25
HCR-1
Bayer Crop
Introduction of the glufosinate ammonium herbicide

Brassica

Science
tolerance trait from transgenic B. napus line T45. This

rapa

(Aventis
trait is imparted by the gene for phosphinothricin
(Polish

CropScience
acetyltransferase (PAT) from S. viridochromogenes.
Canola)

(AgrEvo))

A-26
ZSR500/502
Monsanto
Introduction of a modified 5-enol-pyruvylshikimate-3-

Brassica

Company
phosphate synthase (EPSPS) and a gene from

rapa

Achromobacter sp., that degrades glyphosate by
(Polish

conversion to aminomethylphosphonic acid (AMPA)
Canola)

and glyoxylate by interspecific crossing with GT73.

A-27
EE-1

Insect resistance (Cry1Ac); WO 2007/091277
aubergine

A-28
55-1/63-1
Cornell
Papaya ringspot virus (PRSV)-resistant papaya produced

Carica

University
by inserting the coat protein (CP)-encoding sequences

papaya

from this plant potyvirus.
(papaya)

A-29
RM3-3, RM3-
Bejo Zaden BV
Male sterility was obtained via insertion of the barnase

Cichorium

4, RMS-6

ribonuclease gene from Bacillus amyloliquefaciens; PPT

intybus

resistance was obtained via the bar gene from
(chicory)

S. hygroscopicus, which encodes the PAT enzyme.

A-30
A, B
Agritope Inc.
Reduced accumulation of S-adenosylmethionine (SAM),

Cucumis

and consequently reduced ethylene synthesis, by

melo

introduction of the gene encoding S-adenosylmethionine
(melon)

hydrolase.

A-31
CZW-3
Asgrow (USA);
Cucumber mosaic virus (CMV)-, zucchini yellows

Cucurbita

Seminis
mosaic virus (ZYMV)- and watermelon mosaic virus

pepo

Vegetable Inc.
(WMV) 2-resistant squash (Curcurbita pepo) produced
(squash)

(Canada)
by inserting the coat protein (CP)-encoding sequences

from each of these plant viruses into the host genome.

A-32
ZW20
Upjohn (USA);
Zucchini yellows mosaic (ZYMV)- and watermelon

Cucurbita

Seminis
mosaic virus (WMV) 2-resistant squash (Curcurbita

pepo

Vegetable Inc.

pepo) produced by inserting the coat protein
(squash)

(Canada)
(CP)-encoding sequences from each of these plant

potyviruses into the host genome.

A-33
66
Florigene Pty
Delayed senescence and sulfonylurea herbicide-tolerant

Dianthus

Ltd.
carnations produced by inserting a truncated copy of the

caryophyllus

carnation aminocyclopropane cyclase (ACC) synthase
(carnation)

encoding gene in order to suppress expression of the

endogenous unmodified gene, which is required for

normal ethylene biosynthesis. Tolerance to sulfonylurea

herbicides was obtained via the introduction of a

chlorosulfuron-tolerant version of the acetolactate

synthase (ALS)-encoding gene from tobacco.

A-34
4, 11, 15, 16
Florigene Pty
Modified color and sulfonylurea herbicide-tolerant

Dianthus

Ltd.
carnations produced by inserting two anthocyanin

caryophyllus

biosynthetic genes whose expression results in a
(carnation)

violet/mauve coloration. Tolerance to sulfonylurea

herbicides was obtained via the introduction of a

chlorosulfuron-tolerant version of the acetolactate

synthase (ALS)-encoding gene from tobacco.

A-35
959A, 988A,
Florigene Pty
Introduction of two anthocyanin biosynthetic genes

Dianthus

1226A, 1351A,
Ltd.
which results in a violet/mauve coloration; introduction

caryophyllus

1363A, 1400A

of a variant form of acetolactate synthase (ALS).
(carnation)

A-36
3560.4.3.5

Glyphosate/ALS inhibitor-tolerance; WO 2008002872

Glycine max

L. (soya

bean)

A-37
A2704-12

Glufosinate tolerance; WO 2006/108674

Glycine max

L. (soya

bean)

A-38
A2704-12,
Aventis
Glufosinate ammonium herbicide-tolerant soya bean

Glycine max

A2704-21,
CropScience
produced by inserting a modified phosphinothricin
L. (soya

A5547-35

acetyltransferase (PAT)-encoding gene from the soil
bean)

bacterium Streptomyces viridochromogenes.

A-39
A5547-127
Bayer
Glufosinate ammonium herbicide-tolerant soya bean

Glycine max

CropScience
produced by inserting a modified phosphinothricin
L. (soya

(Aventis
acetyltransferase (PAT)-encoding gene from the soil
bean)

CropScience
bacterium Streptomyces viridochromogenes.

(AgrEvo))

A-40
A5547-35

Glufosinate tolerance; WO 2006/108675

Glycine max

L. (soya

bean)

A-41
DP-305423-1

High oleic acid content/ALS inhibitor tolerance;

Glycine max

WO 2008/054747
L. (soya

bean)

A-42
DP356043
Pioneer Hi-Bred
Soya bean event with two herbicide tolerance genes:

Glycine max

International
glyphosate N-acetyltransferase, which detoxifies
L. (soya

Inc.
glyphosate, and a modified acetolactate synthase (A
bean)

A-43
G94-1, G94-
DuPont Canada
High oleic acid soya bean produced by inserting a

Glycine max

19, G168
Agricultural
second copy of the fatty acid desaturase (GmFad2-1)
L. (soya

Products
encoding gene from soya bean, which resulted in
bean)

“silencing” of the endogenous host gene.

A-44
GTS 40-3-2
Monsanto
Glyphosate-tolerant soya bean variety produced by

Glycine max

Company
inserting a modified 5-enolpyruvylshikimate-3-
L. (soya

phosphate synthase (EPSPS)-encoding gene from the
bean)

soil bacterium Agrobacterium tumefaciens.

A-45
GU262
Bayer
Glufosinate ammonium herbicide-tolerant soya bean

Glycine max

CropScience
produced by inserting a modified phosphinothricin
L. (soya

(Aventis
acetyltransferase (PAT)-encoding gene from the soil
bean)

CropScience
bacterium Streptomyces viridochromogenes.

(AgrEvo))

A-46
MON87701

Insect resistance (Cry1Ac); WO 2009064652

Glycine max

L. (soya

bean)

A-47
MON87705

altered fatty acid levels (mid-oleic acid and low

Glycine max

saturated); WO 2010037016
L. (soya

bean)

A-48
MON87754

Increased oil content; WO 2010024976

Glycine max

L. (soya

bean)

A-49
MON87769

Stearidonic acid (SDA)-comprising oil;

Glycine max

WO 2009102873
L. (soya

bean)

A-50
MON89788
Monsanto
Glyphosate-tolerant soya bean variety produced by

Glycine max

Company
inserting a modified 5-enolpyruvylshikimate-3-
L. (soya

phosphate synthase (EPSPS)-encoding aroA (epsps)
bean)

gene from Agrobacterium tumefaciens CP4;

WO 2006130436

A-51
OT96-15
Agriculture &
Low linolenic acid soya bean produced through

Glycine max

Agri-Food
traditional cross-breeding to incorporate the novel trait
L. (soya

Canada
from a naturally occurring fan1 gene mutant that was
bean)

selected for low linolenic acid content.

A-52
W62, W98
Bayer
Glufosinate ammonium herbicide-tolerant soya bean

Glycine max

CropScience
produced by inserting a modified phosphinothricin
L. (soya

(Aventis
acetyltransferase (PAT)-encoding gene from the soil
bean)

CropScience
bacterium Streptomyces hygroscopicus.

(AgrEvo))

A-53
15985
Monsanto
Insect-resistant cotton derived by transformation of the

Gossypium

Company
DP50B parent variety, which contained event 531

hirsutum L.

(expressing Cry1Ac protein), with purified plasmid
(cotton)

DNA containing the cry2Ab- gene from B. thuringiensis

subsp. kurstaki.

A-54
1143-14A

Insect resistance (Cry1Ab); WO 2006/128569

Gossypium

hirsutum L.

(cotton)

A-55
1143-51B

Insect resistance (Cry1Ab); WO 2006/128570

Gossypium

hirsutum L.

(cotton)

A-56
19-51A
DuPont Canada
Introduction of a variant form of acetolactate synthase

Gossypium

Agricultural
(ALS).

hirsutum L.

Products

(cotton)

A-57
281-24-236
DOW
Insect-resistant cotton produced by inserting the cry1F

Gossypium

AgroSciences
gene from Bacillus thuringiensisvar. aizawai. The

hirsutum L.

LLC
PAT-encoding gene from Streptomyces
(cotton)

viridochromogenes was introduced as a selectable

marker.

A-58
3006-210-23
DOW
Insect-resistant cotton produced by inserting the cry1Ac

Gossypium

AgroSciences
gene from Bacillus thuringiensissubsp. kurstaki. The

hirsutum L.

LLC
PAT-encoding gene from Streptomyces
(cotton)

viridochromogenes was introduced as a selectable

marker.

A-59
31807/31808
Calgene Inc.
Insect-resistant bromoxynil herbicide-tolerant cotton

Gossypium

produced by inserting the cry1Ac gene from Bacillus

hirsutum L.

thuringiensis and a nitrilase-encoding gene from
(cotton)

Klebsiella pneumoniae.

A-60
BXN
Calgene Inc.
Bromoxynil herbicide-tolerant cotton produced by

Gossypium

inserting a nitrilase-encoding gene from Klebsiella

hirsutum L.

pneumoniae.
(cotton)

A-61
CE43-67B

Insect resistance (Cry1Ab); WO 2006/128573

Gossypium

hirsutum L.

(cotton)

A-62
CE44-69D

Insect resistance (Cry1Ab); WO 2006/128571

Gossypium

hirsutum L.

(cotton)

A-63
CE46-02A

Insect resistance (Cry1Ab); WO 2006/128572

Gossypium

hirsutum L.

(cotton)

A-64
Cot102

Insect resistance (Vip3A); US 2006-130175

Gossypium

hirsutum L.

(cotton)

A-65
COT102
Syngenta Seeds,
Insect-resistant cotton produced by inserting the

Gossypium

Inc.
vip3A(a) gene from Bacillus thuringiensis AB88. The

hirsutum L.

APH4-encoding gene from E. coli was introduced as a
(cotton)

selectable marker.

A-66
COT202

Insect resistance (VIP3A); US2009181399

Gossypium

hirsutum L.

(cotton)

A-67
Cot202

Insect resistance (VIP3); US 2007-067868

Gossypium

hirsutum L.

(cotton)

A-68
DAS-21Ø23-5 ×
DOW
WideStrike ™, a stacked insect-resistant cotton derived

Gossypium

DAS-24236-5
AgroSciences
from conventional cross-breeding of parental lines 3006-

hirsutum L.

LLC
210-23 (OECD identifier: DAS-21Ø23-5) and 281-24-
(cotton)

236 (OECD identifier: DAS-24236-5).

A-69
DAS-21Ø23-5 ×
DOW
Stacked insect-resistant and glyphosate-tolerant cotton

Gossypium

DAS-24236-5 ×
AgroSciences
derived from conventional cross-breeding of WideStrike

hirsutum L.

MON88913
LLC und
cotton (OECD identifier: DAS-21Ø23-5 × DAS-24236-
(cotton)

Pioneer Hi-Bred
5) with MON88913, known as RoundupReady Flex

International
(OECD identifier: MON-88913-8).

Inc.

A-70
DAS-21Ø23-5 ×
DOW
WideStrike ™/Roundup Ready ® cotton, a stacked

Gossypium

DAS-24236-5 ×
AgroSciences
insect-resistant and glyphosate-tolerant cotton derived

hirsutum L.

MON-Ø1445-2
LLC
from conventional cross-breeding of WideStrike cotton
(cotton)

(OECD identifier: DAS-21Ø23-5 × DAS-24236-5) with

MON1445 (OECD identifier: MON-Ø1445-2).

A-71
EE-GH3

Glyphosate tolerance; WO 2007/017186

Gossypium

hirsutum L.

(cotton)

A-72
EE-GH5

Insect resistance (Cry1Ab); WO 2008/122406

Gossypium

hirsutum L.

(cotton)

A-73
EE-GH6

Insect resistance (cry2Ae); WO2008151780

Gossypium

hirsutum L.

(cotton)

A-74
event 281-24-

Insect resistance (Cry1F); WO 2005/103266

Gossypium

236

hirsutum L.

(cotton)

A-75
event3006-

Insect resistance (Cry1Ac); WO 2005/103266

Gossypium

210-23

hirsutum L.

(cotton)

A-76
GBH614
Bayer
Glyphosate herbicide-tolerant cotton produced by

Gossypium

CropScience
inserting the 2MEPSPS gene into variety Coker312 by

hirsutum L.

(Aventis

Agrobacterium under the control of Ph4a748At and
(cotton)

CropScience
TpotpC.

(AgrEvo))

A-77
LLCotton25
Bayer
Glufosinate ammonium herbicide-tolerant cotton

Gossypium

CropScience
produced by inserting a modified phosphinothricin

hirsutum L.

(Aventis
acetyltransferase (PAT)-encoding gene from the soil
(cotton)

CropScience
bacterium Streptomyces hygroscopicus;

(AgrEvo))
WO 2003013224

A-78
LLCotton25 ×
Bayer
Stacked herbicide-tolerant and insect-resistant cotton

Gossypium

MON15985
CropScience
combining tolerance to glufosinate ammonium herbicide

hirsutum L.

(Aventis
from LLCotton25 (OECD identifier: ACS-GHØØ1-3)
(cotton)

CropScience
with resistance to insects from MON15985 (OECD

(AgrEvo))
identifier: MON-15985-7).

A-79
MON 15985

Insect resistance (Cry1A/Cry2Ab); US 2004-250317

Gossypium

hirsutum L.

(cotton)

A-80
MON1445/1698
Monsanto
Glyphosate herbicide-tolerant cotton produced by

Gossypium

Company
inserting a naturally glyphosate-tolerant form of the

hirsutum L.

enzyme 5-enolpyruvylshikimate-3-phosphate synthase
(cotton)

(EPSPS) from the CP4 strain of A. tumefaciens.

A-81
MON15985 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant cotton

Gossypium

MON88913
Company
produced by conventional cross-breeding of the parental

hirsutum L.

lines MON88913 (OECD identifier: MON-88913-8) and
(cotton)

15985 (OECD identifier: MON-15985-7). Glyphosate

tolerance is derived from line MON88913 which

contains two genes encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase (EPSPS)

from the CP4 strain of Agrobacterium tumefaciens.

Insect resistance is derived from the line MON15985

which was produced by transformation of the DP50B

parent variety, which contained event 531 (expressing

the Cry1Ac protein), with purified plasmid DNA

containing the cry2Ab gene from B. thuringiensis subsp.

kurstaki.

A-82
MON-15985-7 ×
Monsanto
Stacked insect-resistant and herbicide-tolerant cotton

Gossypium

MON-Ø1445-2
Company
derived from conventional cross-breeding of the parental

hirsutum L.

lines 15985 (OECD identifier: MON-15985-7) and
(cotton)

MON-1445 (OECD identifier: MON-Ø1445-2).

A-83
MON531/757/
Monsanto
Insect-resistant cotton produced by inserting the cry1Ac

Gossypium

1076
Company
gene from Bacillus thuringiensis subsp. kurstaki HD-73

hirsutum L.

(B.t.k.).
(cotton)

A-84
MON88913
Monsanto
Glyphosate herbicide-tolerant cotton produced by

Gossypium

Company
inserting two genes encoding the enzyme 5-

hirsutum L.

enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(cotton)

from the CP4 strain of Agrobacterium tumefaciens; WO

2004/072235

A-85
MON-ØØ531-
Monsanto
Stacked insect-resistant and herbicide-tolerant cotton

Gossypium

6 × MON-
Company
derived from conventional cross-breeding of the parental

hirsutum L.

Ø1445-2

lines MON531 (OECD identifier: MON-ØØ531-6) and
(cotton)

MON-1445 (OECD identifier: MON-Ø1445-2).

A-86
PV-GHGT07

Glyphosate tolerance; US 2004-148666

Gossypium

(1445)

hirsutum L.

(cotton)

A-87
T304-40

Insect resistance (Cry1Ab); WO2008/122406

Gossypium

hirsutum L.

(cotton)

A-88
T342-142

Insect resistance (Cry1Ab); WO 2006/128568

Gossypium

hirsutum L.

(cotton)

A-89
X81359
BASF Inc.
Tolerance to imidazolinone herbicides by selection of a

Helianthus

naturally occurring mutant.

annuus

(sunflower)

A-90
RH44
BASF Inc.
Selection for a mutagenized version of the enzyme

Lens

acetohydroxy acid synthase (AHAS), also known as

culinaris

acetolactate synthase (ALS) or acetolactate pyruvate
(lentil)

lyase.

A-91
FP967
University of
A variant form of acetolactate synthase (ALS) was

Linum

Saskatchewan,
obtained from a chlorosulfuron-tolerant line of

usitatissimum

Crop Dev.

A. thaliana and used to transform flax.
L. (flax,

Centre

linseed)

A-92
5345
Monsanto
Resistance to lepidopteran pests through the introduction

Lycopersicon

Company
of the cry1Ac gene from Bacillus thuringiensis subsp.

esculentum

kurstaki.
(tomato)

A-93
8338
Monsanto
Introduction of a gene sequence encoding the enzyme 1-

Lycopersicon

Company
aminocyclopropane-1-carboxylic acid deaminase

esculentum

(ACCd) that metabolizes the precursor of the fruit
(tomato)

ripening hormone ethylene.

A-94
1345-4
DNA Plant
Delayed ripening tomatoes produced by inserting an

Lycopersicon

Technology
additional copy of a truncated, gene encoding 1-

esculentum

Corporation
aminocyclopropane-1-carboxylic acid (ACC) synthase,
(tomato)

which resulted in downregulation of the endogenous

ACC synthase and reduced ethylene accumulation.

A-95
35 1 N
Agritope Inc.
Introduction of a gene sequence encoding the enzyme S-

Lycopersicon

adenosylmethionine hydrolase that metabolizes the

esculentum

precursor of the fruit ripening hormone ethylene.
(tomato)

A-96
B, Da, F
Zeneca Seeds
Delayed softening tomatoes produced by inserting a

Lycopersicon

truncated version of the polygalacturonase

esculentum

(PG)-encoding gene in the sense or anti-sense
(tomato)

orientation in order to reduce expression of the

endogenous PG gene, and thus reduce pectin

degradation.

A-97
FLAVR SAVR
Calgene Inc.
Delayed softening tomatoes produced by inserting an

Lycopersicon

additional copy of the polygalacturonase (PG)-encoding

esculentum

gene in the anti-sense orientation in order to reduce
(tomato)

expression of the endogenous PG gene and thus reduce

pectin degradation.

A-98
J101, J163
Monsanto
Glyphosate herbicide-tolerant alfalfa (Lucerne) produced

Medicago

Company und
by inserting a gene encoding the enzyme 5-

sativa

Forage Genetics
enolypyruvylshikimate-3-phosphate synthase (EPSPS)
(alfalfa)

International
from the CP4 strain of Agrobacterium tumefaciens.

A-99
C/F/93/08-02
Societe National
Tolerance to the herbicides bromoxynil and ioxynil by

Nicotiana

d'Exploitation
incorporation of the nitrilase gene from Klebsiella

tabacum L.

des Tabacs et

pneumoniae.
(tobacco)

Allumettes

A-100
Vector 21-41
Vector Tobacco
Reduced nicotine content through introduction of a

Nicotiana

Inc.
second copy of the tobacco quinolinic acid

tabacum L.

phosphoribosyltransferase (QTPase) in the antisense
(tobacco)

orientation. The NPTII-encoding gene from E. coli was

introduced as a selectable marker to identify

transformants.

A-101
CL121,
BASF Inc.
Tolerance to the imidazolinone herbicide imazethapyr,

Oryza sativa

CL141,

induced by chemical mutagenesis of the acetolactate
(rice)

CFX51

synthase (ALS) enzyme using ethyl methanesulfonate (EMS).

A-102
GAT-OS2

Glufosinate tolerance; WO 01/83818

Oryza sativa

(rice)

A-103
GAT-OS3

Glufosinate tolerance; US 2008-289060

Oryza sativa

(rice)

A-104
IMINTA-1,
BASF Inc.
Tolerance to imidazolinone herbicides induced by

Oryza sativa

IMINTA-4

chemical mutagenesis of the acetolactate synthase (ALS)
(rice)

enzyme using sodium azide.

A-105
LLRICE06,
Aventis
Glufosinate ammonium herbicide-tolerant rice produced

Oryza sativa

LLRICE62
CropScience
by inserting a modified phosphinothricin
(rice)

acetyltransferase (PAT)-encoding gene from the soil

bacterium Streptomyces hygroscopicus.

A-106
LLRICE601
Bayer Crop-
Glufosinate ammonium herbicide-tolerant rice produced

Oryza sativa

Science
by inserting a modified phosphinothricin
(rice)

(Aventis
acetyltransferase (PAT)-encoding gene from the soil

CropScience
bacterium Streptomyces hygroscopicus.

(AgrEvo))

A-107
PE-7

Insect resistance (Cry1Ac); WO 2008/114282

Oryza sativa

(rice)

A-108
PWC16
BASF Inc.
Tolerance to the imidazolinon herbicide imazethapyr,

Oryza sativa

induced by chemical mutagenesis of the acetolactate
(rice)

synthase (ALS) enzyme using ethyl methanesulfonate

(EMS).

A-109
TT51

Insect resistance (Cry1Ab/Cry1Ac); CN1840655

Oryza sativa

(rice)

A-110
C5
United States
Plum pox virus (PPV)-resistant plum tree produced

Prunus

Department of
through Agrobacterium-mediated transformation with a

domestica

Agriculture -
coat protein (CP) gene from the virus.
(plum)

Agricultural

Research

Service

EH92-527
BASF Plant
Crop composition; Amflora; Unique EU identifier: BPS-25271-9

Science

A-111
ATBT04-6,
Monsanto
Colorado potato beetle-resistant potatoes produced by

Solanum

ATBT04-27,
Company
inserting the cry3A gene from Bacillus thuringiensis

tuberosum

ATBT04-30,

(subsp. tenebrionis).
L. (potato)

ATBT04-31,

ATBT04-36,

SPBT02-5,

SPBT02-7

A-112
BT6, BT10,
Monsanto
Colorado potato beetle-resistant potatoes produced by

Solanum

BT12, BT16,
Company
inserting the cry3A gene from Bacillus thuringiensis

tuberosum

BT17, BT18,

(subsp. tenebrionis).
L. (potato)

BT23

A-113
RBMT15-101,
Monsanto
Colorado potato beetle- and potato Y-virus (PVY)-

Solanum

SEMT15-02,
Company
resistant potatoes produced by inserting the cry3A gene

tuberosum

SEMT15-15

from Bacillus thuringiensis (subsp. tenebrionis) and the
L. (potato)

coat protein-encoding gene from PVY.

A-114
RBMT21-129,
Monsanto
Colorado potato beetle- and potato leaf roll virus

Solanum

RBMT21-350,
Company
(PLRV)-resistant potatoes produced by inserting the

tuberosum

RBMT22-082

cry3A gene from Bacillus thuringiensis (subsp.
L. (potato)

tenebrionis) and the replicase-encoding gene from

PLRV.

A-115
AP205CL
BASF Inc.
Selection for a mutagenized version of the enzyme

Triticum

acetohydroxy acid synthase (AHAS), also known as

aestivum

acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)

lyase.

A-116
AP602CL
BASF Inc.
Selection for a mutagenized version of the enzyme

Triticum

acetohydroxy acid synthase (AHAS), also known as

aestivum

acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)

lyase.

A-117
BW255-2,
BASF Inc.
Selection for a mutagenized version of the enzyme

Triticum

BW238-3

acetohydroxy acid synthase (AHAS), also known as

aestivum

acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)

lyase.

A-118
BW7
BASF Inc.
Tolerance to imidazolinone herbicides induced by

Triticum

chemical mutagenesis of the acetohydroxy acid synthase

aestivum

(AHAS) gene using sodium azide.
(wheat)

A-119
Event 1

Fusarium resistance (trichothecene 3-O-

Triticum

cetyltransferase); CA 2561992

aestivum

(wheat)

A-120
JOPLIN1

Disease (fungal) resistance (trichothecene 3-O-

Triticum

acetyltransferase); US 2008064032

aestivum

(wheat)

A-121
MON71800
Monsanto
Glyphosate-tolerant wheat variety produced by inserting

Triticum

Company
a modified 5-enolpyruvylshikimate-3-phosphate

aestivum

synthase (EPSPS)-encoding gene from the CP4 strain of
(wheat)

the soil bacterium Agrobacterium tumefaciens.

A-122
SWP965001
Cyanamid Crop
Selection for a mutagenized version of the enzyme

Triticum

Protection
acetohydroxy acid synthase (AHAS), also known as

aestivum

acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)

lyase.

A-123
Teal 11A
BASF Inc.
Selection for a mutagenized version of the enzyme

Triticum

acetohydroxy acid synthase (AHAS), also known as

aestivum

acetolactate synthase (ALS) or acetolactate pyruvate
(wheat)

lyase.

A-124
176
Syngenta Seeds,
Insect-resistant maize produced by inserting the cry1Ab

Zea mays

Inc.
gene from Bacillus thuringiensis subsp. kurstaki. The
L. (maize)

genetic modification affords resistance to attack by the

European Corn Borer (ECB).

A-125
3272

Self-processing corn (alpha-amylase); US 2006-230473

Zea mays

L. (maize)

A-126
3751IR
Pioneer Hi-Bred
Selection of somaclonal variants by culture of embryos

Zea mays

International
on imidazolinone-containing media.
L. (maize)

Inc.

A-127
676, 678, 680
Pioneer Hi-Bred
Male-sterile and glufosinate ammonium herbicide-

Zea mays

International
tolerant maize produced by inserting genes encoding
L. (maize)

Inc.
DNA adenine methylase and phosphinothricin

acetyltransferase (PAT) from Escherichia coli and

Streptomyces viridochromogenes.

A-128
ACS-ZMØØ3-
Bayer Crop-
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

2 × MON-
Science
hybrid derived from conventional cross-breeding of the
L. (maize)

ØØ81Ø-6
(Aventis
parental lines T25 (OECD identifier: ACS-ZMØØ3-2)

CropScience
and MON810 (OECD identifier: MON-ØØ81Ø-6).

(AgrEvo))

A-129
B16

Glufosinate resistance; US 2003-126634

Zea mays

L. (maize)

A-130
B16 (DLL25)
Dekalb Genetics
Glufosinate ammonium herbicide-tolerant maize

Zea mays

Corporation
produced by inserting the gene encoding
L. (maize)

phosphinothricin acetyltransferase (PAT) from

Streptomyces hygroscopicus.

A-131
BT11
Syngenta Seeds,
Insect-resistant and herbicide-tolerant maize produced

Zea mays

(X4334CBR,
Inc.
by inserting the cry1Ab gene from Bacillus thuringiensis
L. (maize)

X4734CBR)

subsp. kurstaki, and the phosphinothricin N-

acetyltransferase (PAT)-encoding gene from

S. viridochromogenes.

A-132
BT11 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

MIR604
Inc.
produced by conventional cross-breeding of parental
L. (maize)

lines BT11 (OECD unique identifier: SYN-BTØ11-1)

and MIR604 (OECD unique identifier: SYN-IR6Ø5-5).

Resistance to the European Corn Borer and tolerance to

the herbicide glufosinate ammonium (Liberty) is derived

from BT11, which contains the cry1Ab gene from

Bacillus thuringiensis subsp. kurstaki, and the

phosphinothricin N-acetyltransferase (PAT)-encoding

gene from S. viridochromogenes. Corn rootworm-

resistance is derived from MIR604 which contains the

mcry3A-gene from Bacillus thuringiensis.

A-133
BT11 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

MIR604 ×
Inc.
produced by conventional cross-breeding of parental
L. (maize)

GA21

lines BT11 (OECD unique identifier: SYN-BTØ11-1),

MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and

GA21 (OECD unique identifier: MON- Ø Ø Ø21-9).

Resistance to the European Corn Borer and tolerance to

the herbicide glufosinate ammonium (Liberty) is derived

from BT11, which contains the cry1Ab gene from

Bacillus thuringiensis subsp. kurstaki, and the

phosphinothricin N-acetyltransferase (PAT)-encoding

gene from S. viridochromogenes. Corn rootworm-

resistance is derived from MIR604 which contains the

mcry3A gene from Bacillus thuringiensis. Tolerance to

glyphosate herbicide is derived from GA21 which

contains a modified EPSPS gene from maize.

A-134
CBH-351
Aventis
Insect-resistant and glufosinate ammonium herbicide-

Zea mays

CropScience
tolerant maize developed by inserting the genes
L. (maize)

encoding Cry9C protein from Bacillus thuringiensis

subsp. tolworthi and phosphinothricin acetyltransferase

(PAT) from Streptomyces hygroscopicus.

A-135
DAS-06275-8
DOW
Lepidopteran insect-resistant and glufosinate ammonium

Zea mays

AgroSciences
herbicide-tolerant maize variety produced by inserting
L. (maize)

LLC
the cry1F gene from Bacillus thuringiensis var. aizawai

and the phosphinothricin acetyltransferase (PAT) from

Streptomyces hygroscopicus.

A-136
DAS-59122-7
DOW
Corn rootworm-resistant maize produced by inserting

Zea mays

AgroSciences
the cry34Ab1 and cry35Ab1 genes from the PS149B1
L. (maize)

LLC and
strain of Bacillus thuringiensis. The PAT-encoding gene

Pioneer Hi-Bred
from Streptomyces viridochromogenes was introduced

International
as a selectable marker; US 2006-070139

Inc.

A-137
DAS-59122-7 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

NK603
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)

LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-

Pioneer Hi-Bred
59122-7) with NK603 (OECD unique identifier: MON-

International
ØØ6Ø3-6). Corn rootworm-resistance is derived from

Inc.
line DAS-59122-7 which contains the cry34Ab1 and

cry35Ab1 genes from the PS149B1 strain of Bacillus

thuringiensis. Tolerance to glyphosate herbicide is

derived from NK603.

A-138
DAS-59122-7 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

TC1507 ×
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)

NK603
LLC and
lines DAS-59122-7 (OECD unique identifier: DAS-

Pioneer Hi-Bred
59122-7) and TC1507 (OECD unique identifier DAS-

International
Ø15Ø7-1) with NK603 (OECD unique identifier: MON-

Inc.
ØØ6Ø3-6). Corn rootworm-resistance is derived from

line DAS-59122-7, which contains the cry34Ab1 and

cry35Ab1 genes from the PS149B1 strain of Bacillus

thuringiensis. Lepidopteran resistance and tolerance to

glufosinate ammonium herbicide are derived from

TC1507. Tolerance to glyphosate herbicide is derived

from NK603.

A-139
DAS-Ø15Ø7-1 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

MON-ØØ6Ø3-6
AgroSciences
derived from conventional cross-breeding of the parental
L. (maize)

LLC
lines 1507 (OECD identifier: DAS-Ø15Ø7-1) and

NK603 (OECD identifier: MON-ØØ6Ø3-6).

A-140
DBT418
Dekalb Genetics
Insect-resistant and glufosinate ammonium herbicide-

Zea mays

Corporation
tolerant maize developed by inserting genes encoding
L. (maize)

Cry1AC protein from Bacillus thuringiensis subsp

kurstaki and phosphinothricin acetyltransferase (PAT)

from Streptomyces hygroscopicus.

A-141
DK404SR
BASF Inc.
Somaclonal variants with a modified acetyl-CoA-

Zea mays

carboxylase (ACCase) were selected by culture of
L. (maize)

embryos on sethoxydim-enriched medium.

A-142
DP-098140-6

Glyphosate tolerance/ALS inhibitor tolerance;

Zea mays

WO 2008/112019
L. (maize)

A-143
DP-Ø9814Ø-6
Pioneer Hi-Bred
Maize line 98140 was genetically engineered to express

Zea mays

(Event 98140)
International
the GAT4621 (glyphosate acetyltransferase) and ZM-
L. (maize)

Inc.
HRA (modified maize version of a acetolactate synthase)

proteins. The GAT4621 protein, encoded by the gat4621

gene, confers tolerance to glyphosate-containing

herbicides by acetylating glyphosate and thereby

rendering it non-phytotoxic. The ZM-HRA protein,

encoded by the zm-hra gene, confers tolerance to the

ALS-inhibiting class of herbicides.

A-144
Event 3272
Syngenta Seeds,
Maize line expressing a heat-stable alpha-amylase gene

Zea mays

Inc.
amy797E for use in the dry-grind ethanol production
L. (maize)

process. The phosphomannose isomerase gene from

E. coli was used as a selectable marker.

A-145
EXP1910IT
Syngenta Seeds,
Tolerance to the imidazolinone herbicide imazethapyr,

Zea mays

Inc. (formerly
induced by chemical mutagenesis of the acetolactate
L. (maize)

Zeneca Seeds)
synthase (ALS) enzyme using ethyl methanesulfonate(EMS).

A-146
FI117

Glyphosate resistance; U.S. Pat. No. 6,040,497

Zea mays

L. (maize)

A-147
GA21
Monsanto
Induction, by gene-gun bombardment, of a modified 5-

Zea mays

Company
enolpyruvylshikimate-3-phosphate synthase (EPSPS), an
L. (maize)

enzyme involved in the shikimate biosynthesis pathway

for the production of the aromatic amino acids.

A-148
GAT-ZM1

Glufosinate tolerance; WO 01/51654

Zea mays

L. (maize)

A-149
GG25

Glyphosate resistance; U.S. Pat. No. 6,040,497

Zea mays

L. (maize)

A-150
GJ11

Glyphosate resistance; U.S. Pat. No. 6,040,497

Zea mays

L. (maize)

A-151
IT
Pioneer Hi-Bred
Tolerance to the imidazolinone herbicide imazethapyr,

Zea mays

International
was obtained by in vitro selection of somaclonal
L. (maize)

Inc.
variants.

A-152
LY038
Monsanto
Altered amino acid composition, specifically elevated

Zea mays

Company
levels of lysine, through the introduction of the cordapA
L. (maize)

gene, derived from Corynebacterium glutamicum,

encoding the enzyme dihydrodipicolinate synthase

(cDHDPS); U.S. Pat. No. 7,157,281

A-153
MIR162

Insect resistance; WO 2007142840

Zea mays

L. (maize)

A-154
MIR604
Syngenta Seeds,
Corn rootworm-resistant maize was produced by

Zea mays

Inc.
transformation with a modified cry3A gene. The
L. (maize)

phosphomannose isomerase gene from E. coli was used

as a selectable marker; (Cry3a055); EP 1 737 290

A-155
MIR604 ×
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

GA21
Inc.
produced by conventional cross-breeding of parental
L. (maize)

lines MIR604 (OECD unique identifier: SYN-IR60Ø5-5)

and GA21 (OECD unique identifier: MON- ØØØ21-9).

Corn rootworm-resistance is derived from MIR604

which contains the mcry3A gene from Bacillus

thuringiensis. Tolerance to glyphosate herbicide is

derived from GA21.

A-156
MON80100
Monsanto
Insect-resistant maize produced by inserting the cry1Ab

Zea mays

Company
gene from Bacillus thuringiensis subsp. kurstaki. The
L. (maize)

genetic modification affords resistance to attack by the

European Corn Borer.

A-157
MON802
Monsanto
Insect-resistant and glyphosate herbicide-tolerant maize

Zea mays

Company
produced by inserting the genes encoding the Cry1Ab
L. (maize)

protein from Bacillus thuringiensis and the 5-

enolpyruvylshikimate-3-posphate synthase (EPSPS)

from the CP4 strain of A. tumefaciens.

A-158
MON809
Pioneer Hi-Bred
Resistance to European Corn Borer (Ostrinia nubilalis)

Zea mays

International
by introduction of a synthetic cry1Ab gene. Glyphosate
L. (maize)

Inc.
resistance via introduction of the bacterial version of a

plant enzyme, 5-enolpyruvylshikimat-3-phosphate

synthase (EPSPS).

A-159
MON810
Monsanto
Insect-resistant maize produced by inserting a truncated

Zea mays

Company
form of the cry1Ab gene from Bacillus thuringiensis
L. (maize)

subsp. kurstaki HD-1. The genetic modification affords

resistance to attack by the European Corn Borer (ECB);

US 2004-180373

A-160
MON810 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant maize

Zea mays

MON88017
Company
derived from conventional cross-breeding of the parental
L. (maize)

lines MON810 (OECD identifier: MON-ØØ81Ø-6) and

MON88017 (OECD identifier: MON-88Ø17-3).

European Corn Borer (ECB) resistance is derived from a

truncated form of the cry1Ab gene from Bacillus

thuringiensis subsp. kurstaki HD-1, present in MON810.

Corn rootworm-resistance is derived from the cry3Bb1

gene from the EG4691 strain of Bacillus thuringiensis

subspecies kumamotoensis present in MON88017.

Glyphosate tolerance is derived from a 5-

enolpyruvylshikimate-3-phosphate synthase (EPSPS)-

encoding gene from the CP4 strain of Agrobacterium

tumefaciens present in MON88017.

A-161
MON832
Monsanto
Introduction, by gene-gun bombardment, of glyphosate

Zea mays

Company
oxidase (GOX) and a modified 5-enolpyruvylshikimate-
L. (maize)

3-phosphate synthase (EPSPS), an enzyme involved in

the shikimate biosynthesis pathway for the production of

the aromatic amino acids.

A-162
MON863
Monsanto
Corn rootworm-resistant maize produced by inserting

Zea mays

Company
the cry3Bb1 gene from Bacillus thuringiensis subsp.
L. (maize)

kumamotoensis.

A-163
MON87460

Drought tolerance; water deficit tolerance; WO

Zea mays

2009/111263
L. (maize)

A-164
MON88017
Monsanto
Corn rootworm-resistant maize produced by inserting

Zea mays

Company
the cry3Bb1 gene from the EG4691 strain of Bacillus
L. (maize)

thuringiensis subsp. kumamotoensis. Glyphosate

tolerance was derived by inserting a 5-

enolpyruvylshikimate-3-phosphate synthase (EPSPS)-

encoding gene from the CP4 strain of Agrobacterium

tumefaciens; WO 2005059103

A-165
MON89034
Monsanto
Maize event expressing two different insecticidal

Zea mays

Company
proteins from Bacillus thuringiensis providing resistance
L. (maize)

to a number of lepidopteran pests; insect resistance

(Lipidoptera-Cry1A.105-Cry2Ab); WO 2007140256

A-166
MON89034 ×
Monsanto
Stacked insect-resistant and glyphosate-tolerant maize

Zea mays

MON88017
Company
derived from conventional cross-breeding of the parental
L. (maize)

lines MON89034 (OECD identifier: MON-89 Ø34-3)

and MON88017 (OECD identifier: MON-88Ø17-3).

Resistance to lepidopteran insects is derived from two

cry genes present in MON89043. Corn rootworm-

resistance is derived from a single cry gene and

glyphosate tolerance is derived from a 5-

enolpyruylshikimate-3-phosphate synthase (EPSPS)-

encoding gene from Agrobacterium tumefaciens present

in MON88017.

A-167
MON-ØØ6Ø3-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

6 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)

ØØ81Ø-6

parental lines NK603 (OECD identifier: MON-ØØ6Ø3-

6) and MON810 (OECD identifier: MON-Ø81Ø-6).

A-168
MON-ØØ81Ø-
Monsanto
Stacked insect-resistant and increased lysine-content

Zea mays

6 × LY038
Company
maize hybrid derived from conventional cross-breeding
L. (maize)

of the parental lines MON810 (OECD identifier: MON-

ØØ81Ø-6) and LY038 (OEC identifier: REN-ØØØ38-

3).

A-169
MON-ØØ863-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

5 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)

ØØ6Ø3-6

parental lines MON863 (OECD identifier: MON-

ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-

6).

A-170
MON-ØØ863-
Monsanto
Stacked insect-resistant maize hybrid derived from

Zea mays

5 × MON
Company
conventional cross-breeding of the parental lines
L. (maize)

ØØ81Ø-6

MON863 (OECD identifier: MON-Ø863-5) und

MON810 (OECD identifier: MON-ØØ81Ø-6)

A-171
MON-ØØ863-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

5 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)

Ø81Ø-6 ×

stacked hybrids MON-ØØ863-5 × MON-ØØ81Ø-6 and

MON-ØØ6Ø3-6

NK603 (OECD identifier: MON-ØØ6Ø3-6).

A-172
MON-ØØØ21-
Monsanto
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

9 × MON-
Company
hybrid derived from conventional cross-breeding of the
L. (maize)

ØØ81Ø-6

parental lines GA21 (OECD identifier: MON-ØØØ21-9)

and MON810 (OECD identifier: MON-ØØ81Ø-6).

A-173
MS3
Bayer Crop-
Male sterility caused by expression of the barnase

Zea mays

Science
ribonuclease gene from Bacillus amyloliquefaciens; PPT
L. (maize)

(Aventis
resistance was obtained via PPT acetyltransferase (PAT).

CropScience

(AgrEvo))

A-174
MS6
Bayer Crop-
Male sterility caused by expression of the barnase

Zea mays

Science
ribonuclease gene from Bacillus amyloliquefaciens; PPT
L. (maize)

(Aventis
resistance was attained via PPT acetyltransferase (PAT).

CropScience

(AgrEvo))

A-175
NK603
Monsanto
Introduction by gene-gun bombardment of a modified 5-

Zea mays

Company
enolpyruvylshikimate-3-phosphate synthase (EPSPS), an
L. (maize)

enzyme involved in the shikimate biosynthesis pathway

for the production of the aromatic amino acids.

A-176
PV-ZMGT32

Glyphosate tolerance; US 2007-056056

Zea mays

(NK603)

L. (maize)

A-177
PV-ZMGT32

Glyphosate tolerance; US 2007292854

Zea mays

(nk603)

L. (maize)

A-178
PV-ZM1R13

Insect resistance (Cry3Bb); US 2006-095986

Zea mays

(MON863)

L. (maize)

A-179
SYN-BTØ11-
Syngenta Seeds,
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

1 × MON-
Inc.
produced by conventional cross-breeding of parental
L. (maize)

ØØØ21-9

lines BT11 (OECD unique identifier: SYN-BTØ11-1)

and GA21 (OECD unique identifier: MON-ØØØ21-9).

A-180
T14, T25
Bayer
Glufosinate herbicide-tolerant maize produced by

Zea mays

CropScience
inserting the phosphinothricin N-acetyltranferase (PAT)-
L. (maize)

(Aventis
encoding gene from the aerobic actinomycete

CropScience

Streptomyces viridochromogenes.

(AgrEvo))

A-181
TC1507
Mycogen (c/o
Insect-resistant and glufosinate ammonium

Zea mays

Dow
herbicide-tolerant maize produced by inserting the cry1F
L. (maize)

AgroSciences);
gene from Bacillus thuringiensis var. aizawai and the

Pioneer (c/o
phosphinothricin N-acetyltransferase-encoding gene

Dupont)
from Streptomyces viridochromogenes.

A-182
TC1507 ×
DOW
Stacked insect-resistant and herbicide-tolerant maize

Zea mays

DAS-59122-7
AgroSciences
produced by conventional cross-breeding of parental
L. (maize)

LLC and
lines TC1507 (OECD unique identifier: DAS-Ø15Ø7-1)

Pioneer Hi-Bred
with DAS-59122-7 (OECD unique identifier: DAS-

International
59122-7). Resistance to lepidopteran insects is derived

Inc.
from TC1507 due to the presence of the cry1F gene from

Bacillus thuringiensis var. aizawai. Corn rootworm-

resistance is derived from line DAS-59122-7 which

contains the cry34b1 and cry35Ab1 genes from

Bacillus. Thuringiensis strain PS149B1. Tolerance to

glufosinate ammonium herbicide is derived from

TC1507 from the phosphinothricin N-acetyltransferase-

encoding gene from Streptomyces viridochromogenes.

A-183
VIP1034

Insect resistance; WO 03/052073

Zea mays

L. (maize)

In one embodiment of the invention the plants B-1 to B-129 of table B, in total or in part, or propagation material of said plants, is treated or contacted with the active ingredient combinations of the invention, alone or in the form of compositions comprising an active ingredient combination.

TABLE B

Non-exhaustive list of transgenic plants to carry out the invention from the APHIS database of the

United States Department of Agriculture (USDA). The database can be found on:

http://www.aphis.usda.govianimal_welfarelefoia/index.shtml.

EA final

Extension of

Transformation
conclusion &

No.
Petition
Petition***
Institution
Plant
Event or Line
determination

B-1
10-070-01p

Virginia Tech
Peanut
Sclerotinia
N70, P39 and

blight-resistant
W171

B-2
09-349-01p

Dow
Soya bean
2,4-D- and
DAS-68416-4

AgroSciences

glufosinate

tolerance

B-3
09-328-01p

Bayer Crop
Soya bean
glyphosate and
FG72

Science

isoxaflutole

tolerance

B-4
09-233-01p

Dow
Maize
2,4-D and ACCase-
DAS-40278-9

inhibitor tolerance

B-5
09-201-01p

Monsanto
Soya bean
improved fatty acid
MON-87705-6

profile

B-6
09-183-01p

Monsanto
Soya bean
stearidonic acid
MON-87769

production

B-7
09-082-01p

Monsanto
Soya bean
Lepidoteran
MON 87701

resistance

B-8
09-063-01p

Stine Seed
Maize
Glyphosate
HCEM485

tolerance

B-9
09-055-01p

Monsanto
Maize
Drought tolerance
MON 87460

B-10
09-015-01p

BASF Plant
Soya bean
Imidazlinon
BPS-CV127-9

Science, LLC

tolerance
Soya bean

B-11
08-366-01p

ArborGen
Eucalyptus
Freeze tolerance,
ARB-FTE?-08

fertility altered

B-12
08-340-01p

Bayer
Cotton
Glufosinate
T304-40XGHB119

tolerance, insect

resistance

B-13
08-338-01p

Pioneer
Maize
Male sterility,
DP-32138-1

fertility restored,

visual marker

B-14
08-315-01p

Florigene
Rose
Altered flower
IFD-52401-4 and

color
IFD-52901-9

B-15
07-108-01p

Syngenta
Cotton
Lepidopteran
COT67B

resistance

B-16
06-354-01p

Pioneer
Soya bean
High oleic acid
DP-305423-1

B-17

content

B-18
05-280-01p

Syngenta
Maize
Termostable
3272

B-19

alpha-arnylase

B-20
04-110-01p

Monsanto &
Alfalfa
Glyphosate
J101, J163

B-21

Forage Genetics

tolerance

B-22

B-23

B-24
03-104-01p

Monsanto &
Creeping
Glyphosate
ASR368

B-25

Scotts
bentgrass
tolerance

B-26

B-27

B-28

B-29

B-30
07-253-01p

Syngenta
Maize
Lepidopteran
MIR-162 Maize

B-31

resistance

B-32
07-152-01p

Pioneer
Maize
Glyphosate &
DP-098140-6

B-33

imidazolinone

tolerance

B-34
04-337-01p

Univeristy of
Papaya
Papaya ringspot
X17-2

B-35

Florida

virus-resistant

B-36
06-332-01p

Bayer
Cotton
Glyphosate
GHB614

B-37

CropScience

tolerance

B-38
06-298-01p

Monsanto
Maize
European Corn
MON 89034

B-39

Borer resistance

B-40
06-271-01p

Pioneer
Soya bean
Glyphosate &
356043

B-41

acetolactate
(DP-356043-5)

synthase tolerance

B-42
06-234-01p
98-329-01p
Bayer
Rice
phosphinothricin
LLRICE601

B-43

CropScience

tolerance

B-44
06-178-01p

Monsanto
Soya bean
Glyphosate
MON 89788

B-45

tolerance

B-46
04-362-01p

Syngenta
Maize
Corn
MIR604

B-47

rootworm-protected

B-48

B-49
04-264-01p

ARS
Plum
Plum Pox
C5

B-50

virus-resistant

B-51
04-229-01p

Monsanto
Maize
High lysine content
LY038

B-52

B-53
04-125-01p

Monsanto
Maize
Corn rootworm-
88017

B-54

resistance

B-55
04-086-01p

Monsanto
Cotton
Glyphosate
MON 88913

B-56

tolerance

B-57

B-58
03-353-01p

Dow
Maize
Corn rootworm-
59122

B-59

resistance

B-60
03-323-01p

Monsnato
Sugar beet
Glyphosate
H7-1

B-61

tolerance

B-62
03-181-01p
00-136-01p
Dow
Maize
Lepidopteran
TC-6275

B-63

resistance &

phosphinothricin

tolerance

B-64
03-155-01p

Syngenta
Cotton
Lepidopteran
COT 102

B-65

resistance

B-66
03-036-01p

Mycogen/Dow
Cotton
Lepidopteran
281-24-236

B-67

resistance

B-68
03-036-02p

Mycogen/Dow
Cotton
Lepidopteran
3006-210-23

B-69

resistance

B-70
02-042-01p

Aventis
Cotton
Phosphinothricin
LLCotton25

tolerance

B-71
01-324-01p
98-216-01p
Monsanto
Oilseed
Glyphosate
RT200

rape
tolerance

B-72
01-206-01p
98-278-01p
Aventis
Oilseed
Phosphinothricin-
MS1 & RF1/RF2

rape
tolerance &

pollination control

B-73
01-206-02p
97-205-01p
Aventis
Oilseed
Phosphinothricin
Topas 19/2

rape
tolerance

B-74
01-137-01p

Monsanto
Maize
Corn rootworm-
MON 863

resistance

B-75
01-121-01p

Vector
Tobacco
Reduced nicotine
Vector 21-41

content

B-76
00-342-01p

Monsanto
Cotton
Lepidopteran
Cotton Event

resistance
15985

B-77
00-136-01p

Mycogen c/o
Maize
Lepidopteran
Line 1507

Dow & Pioneer

resistance &

phosphinothricin

tolerance

B-78
00-011-01p
97-099-01p
Monsanto
Maize
Glyphosate
NK603

tolerance

B-79
99-173-01p
97-204-01p
Monsanto
Patato
PLRV & CPB
RBMT22-82

resistance

B-80
98-349-01p
95-228-01p
AgrEvo
Maize
Phosphinothricin
M86

tolerance and male

sterility

B-81
98-335-01p

U. of
Flax
Tolerant to soil
CDC Triffid

Saskatchewan

residues of

sulfonylurea

herbicide

B-82
98-329-01p

AgrEvo
Rice
Phosphinothricin
LLRICE06,

tolerance
LLRICE62

B-83
98-278-01p

AgrEvo
Oilseed
Phosphinothricin
MS8 & RF3

rape
tolerance &

pollination control

B-84
98-238-01p

AgrEvo
Soya bean
Phosphinothricin
GU262

tolerance

B-85
98-216-01p

Monsanto
Oilseed
Glyphosate
RT73

rape
tolerance

B-86
98-173-01p

Novartis Seeds
Beet
Glyphosate
GTSB77

& Monsanto

tolerance

B-87
98-014-01p
96-068-01p
AgrEvo
Soya bean
Phosphinothricin
A5547-127

tolerance

B-88
97-342-01p

Pioneer
Maize
Male sterility &
676, 678, 680

phosphinothricin

tolerance

B-89
97-339-01p

Monsanto
Potato
CPB & PVY
RBMT15-101,

resistance
SEMT15-01,

SEMT15-15

B-90
97-336-01p

AgrEvo
Beet
Phosphinothricin
T-120-7

tolerance

B-91
97-287-01p

Monsanto
Tomato
Lepidopteran
5345

resistance

B-92
97-265-01p

AgrEvo
Maize
Phosphinothricin
CBH-351

tolerance &

Lepidopteran

resistance

B-93
97-205-01p

AgrEvo
Oilseed
Phosphinothricin
T45

rape
tolerance

B-94
97-204-01p

Monsanto
Potato
CPB & PLRV
RBMT21-129 &

resistance
RBMT21-350

B-95
97-148-01p

Bejo
Cichorium
Male sterility
RM3-3, RM3-4,

intybus

RM3-6

B-96
97-099-01p

Monsanto
Maize
Glyphosate
GA21

tolerance

B-97
97-013-01p

Calgene
Cotton
Bromoxynil
Events 31807 &

tolerance &
31808

Lepidopteran

resistance

B-98
97-008-01p

Du Pont
Soya bean
Oil profile altered
G94-1, G94-19,

G-168

B-99
96-317-01p

Monsanto
Maize
Glyphosate
MON802

tolerance & ECB

resistance

B-100
96-291-01p

DeKalb
Maize
European Corn
DBT418

Borer resistance

B-101
96-248-01p
92-196-01p
Calgene
Tomato
Fruit ripening
1 additional

altered
FLAVRSAVR line

B-102
96-068-01p

AgrEvo
Soya bean
Phosphinothricin
W62, W98,

tolerance
A2704-12, A2704-21,

A5547-35

B-103
96-051-01p

Cornell U
Papaya
PRSV resistance
55-1, 63-1

B-104
96-017-01p
95-093-01p
Monsanto
Maize
European Corn
MON809 &

Borer resistance
MON810

B-105
95-352-01p

Asgrow
Summer
CMV, ZYMV,
CZW-3

squash
WMV2 resistance

B-106
95-338-01p

Monsanto
Potato
CPB resistance
SBT02-5 & -7,

ATBT04-6 & -27,

-30, -31, -36

B-107
95-324-01p

Agritope
Tomato
Fruit ripening
35 1 N

altered

B-108
95-256-01p

Du Pont
Cotton
Sulfonylurea
19-51a

resistance

B-109
95-228-01p

Plant Genetic
Maize
Male Sterile
MS3

Systems

B-110
95-195-01p

Northrup King
Maize
European Corn
Bt11

Borer resistance

B-111
95-179-01p
92-196-01p
Calgene
Tomato
Fruit ripening
2 additional

altered
FLAVRSAVR-

lines

B-112
95-145-01p

DeKalb
Maize
Phosphinothricin
B16

tolerance

B-113
95-093-01p

Monsanto
Maize
Lepidopteran
MON 80100

resistance

B-114
95-053-01p

Monsanto
Tomato
Fruit ripening
8338

altered

B-115
95-045-01p

Monsanto
Cotton
Glyphosate
1445, 1698

tolerance

B-116
95-030-01p
92-196-01p
Calgene
Tomato
Fruit ripening
20 additional

altered
FLAVRSAVR

lines

B-117
94-357-01p

AgrEvo
Maize
Phosphinothricin
T14, T25

tolerance

B-118
94-319-01p

Ciba Seeds
Maize
Lepidopteran
Event 176

resistance

B-119
94-308-01p

Monsanto
Cotton
Lepidopteran
531, 757, 1076

resistance

B-120
94-290-01p

Zeneca &
Tomato
Fruit
B, Da, F

Petoseed

polygalacturonase

level decreased

B-121
94-257-01p

Monsanto
Potato
Coleopteran
BT6, BT10, BT12,

resistance
BT16, BT17,

BT18, BT23

B-122
94-230-01p
92-196-01p
Calgene
Tomato
Fruit ripening
9 additional

altered
FLAVRSAVR

lines

B-123
94-228-01p

DNA Plant Tech
Tomato
Fruit ripening
1345-4

altered

B-124
94-227-01p
92-196-01p
Calgene
Tomato
Fruit ripening
Line N73 1436-

altered
111

B-125
94-090-01p

Calgene
Oilseed
Oil profile altered
Pcgn3828-

rape

212/86-18 & 23

B-126
93-258-01p

Monsanto
Soya bean
Glyphosate
40-3-2

tolerance

B-127
93-196-01p

Calgene
Cotton
Bromoxynil
BXN

tolerance

B-128
92-204-01p

Upjohn
Summer
WMV2 & ZYMV
ZW-20

squash
resistance

B-129
92-196-01p

Calgene
Tomato
Fruit ripening
FLASVR SAVR

altered

Abbreviations used in this table:

CMV—cucumber mosaic virus,

CPB—Colorado potato beetle,

PLRV—potato leafroli Virus,

PRSV—papaya ringspot virus,

PVY—potato virus Y,

WMV2—watermelon mosaic Vials 2

ZYMV—zucchini yellow mosaic virus

In one embodiment the plants which comprise a transgenic event as per D-1 to D-48 of table D or express such a trait, in whole or in part, or propagation material of these plants, are or is contacted or treated with the active ingredient combinations of the invention, alone or in the form of compositions which comprise an active ingredient combination.

TABLE D

Non-exhaustive list of transgenic events and traits the invention

can be worked on, with reference to patent applications.

No.
Plant species
Transgenic event
Trait
Patent reference

D-1
Maize
PV-ZMGT32 (NK603)
Glyphosate tolerance
US 2007-056056

D-2
Maize
MIR604
Insect resistance (Cry3a055)
EP-A 1 737 290

D-3
Maize
LY038
High lysine content
U.S. Pat. No. 7,157,281

D-4
Maize
3272
Self-processing maize
US 2006-230473

(alpha-amylase)

D-5
Maize
PV-ZMIR13 (MON863)
Insect resistance (Cry3Bb)
US 2006-095986

D-6
Maize
DAS-59122-7
Insect resistance
US 2006-070139

(Cry34Ab1/Cry35Ab1)

D-7
Maize
TC1507
Insect resistance (Cry1F)
U.S. Pat. No. 7,435,807

D-8
Maize
MON810
Insect resistance (Cry1Ab)
US 2004-180373

D-9
Maize
VIP1034
Insect resistance
WO 03/052073

D-10
Maize
B16
Glufosinate resistance
US 2003-126634

D-11
Maize
GA21
Glyphosate resistance
U.S. Pat. No. 6,040,497

D-12
Maize
GG25
Glyphosate resistance
U.S. Pat. No. 6,040,497

D-13
Maize
GJ11
Glyphosate resistance
U.S. Pat. No. 6,040,497

D-14
Maize
FI117
Glyphosate resistance
U.S. Pat. No. 6,040,497

D-15
Maize
GAT-ZM1
Glufosinate tolerance
WO 01/51654

D-16
Maize
DP-098140-6
Glyphosate tolerance/ALS-
WO 2008/112019

inhibitor tolerance

D-17
Wheat
Event 1

Fusarium resistance
CA 2561992

(trichothecene 3-O-

acetyltransferase)

D-18
Sugar beet
T227-1
Glyphosate tolerance
US 2004-117870

D-19
Sugar beet
H7-1
Glyphosate tolerance
WO 2004-074492

D-20
Soya bean
MON89788
Glyphosate tolerance
US 2006-282915

D-21
Soya bean
A2704-12
Glufosinate tolerance
WO 2006/108674

D-22
Soya bean
A5547-35
Glufosinate tolerance
WO 2006/108675

D-23
Soya bean
DP-305423-1
High oleic acid/ALS-
WO 2008/054747

inhibitor tolerance

D-24
Rice
GAT-OS2
Glufosinate tolerance
WO 01/83818

D-25
Rice
GAT-OS3
Glufosinate tolerance
US 2008-289060

D-26
Rice
PE-7
Insect resistance (Cry1Ac)
WO 2008/114282

D-27
Oilseed rape
MS-B2
Male sterility
WO 01/31042

D-28
Oilseed rape
MS-BN1/RF-BN1
Male sterility/restoration
WO 01/41558

D-29
Oilseed rape
RT73
Glyphosate resistance
WO 02/36831

D-30
Cotton
CE43-67B
Insect resistance (Cry1Ab)
WO 2006/128573

D-31
Cotton
CE46-02A
Insect resistance (Cry1Ab)
WO 2006/128572

D-32
Cotton
CE44-69D
Insect resistance (Cry1Ab)
WO 2006/128571

D-33
Cotton
1143-14A
Insect resistance (Cry1Ab)
WO 2006/128569

D-34
Cotton
1143-51B
Insect resistance (Cry1Ab)
WO 2006/128570

D-35
Cotton
T342-142
Insect resistance (Cry1Ab)
WO 2006/128568

D-36
Cotton
event3006-210-23
Insect resistance (Cry1Ac)
WO 2005/103266

D-37
Cotton
PV-GHGT07 (1445)
Glyphosate tolerance
US 2004-148666

D-38
Cotton
MON88913
Glyphosate tolerance
WO 2004/072235

D-39
Cotton
EE-GH3
Glyphosate tolerance
WO 2007/017186

D-40
Cotton
T304-40
Insect resistance (Cry1Ab)
WO2008/122406

D-41
Cotton
Cot202
Insect resistance (VIP3)
US 2007-067868

D-42
Cotton
LLcotton25
Glufosinate resistance
WO 2007/017186

D-43
Cotton
EE-GH5
Insect resistance (Cry1Ab)
WO 2008/122406

D-44
Cotton
event 281-24-236
Insect resistance (Cry1F)
WO 2005/103266

D-45
Cotton
Cot102
Insect resistance (Vip3A)
US 2006-130175

D-46
Cotton
MON 15985
Insect resistance
US 2004-250317

(Cry1A/Cry2Ab)

D-47
Bentgrass
Asr-368
Glyphosate tolerance
US 2006-162007

D-48
Aubergine
EE-1
Insect resistance (Cry1Ac)
WO 2007/091277

In one embodiment the plants which comprise a transgenic event as per E-1 to E-50 of table E or express such a trait, in whole or in part, or propagation material of these plants, are or is contacted or treated with the active ingredient combinations of the invention, alone or in the form of compositions which comprise an active ingredient combination.

TABLE E

Non-exhaustive list of transgenic events and traits and their trade names.

No.
Trade name
Plant
Company
Genetically modified properties
Additional information

E-1
Roundup

Beta vulgaris

Monsanto
Glyphosate tolerance

Ready ®
(sugar beet)
Company

E-2
InVigor ®

Brassica napus

Bayer
Canola rape was genetically modified with the

(Argentine
CropScience
following result:

canola rape)

Ø expression of a gene which confers tolerance

to the herbicide glyfosinate ammonium;

Ø introduction of a novel hybrid breeding system

for canola rape which is based on genetically

modified male-sterility (MS) and fertility-

restorer (RF) lines;

Ø expression of a gene for resistance to

antibiotics.

E-3
Liberty Link ®

Brassica napus

BayerCrop-
Phosphinotricin tolerance

(Argentine
Science

canola rape)

E-4
Roundup

Brassica napus

Monsanto
Glyphosate tolerance

Ready ®
(canola rape)
Company

E-5
Clearfield ®
(Canola rape)
BASF
Non-GMO, imazamox tolerance

Corporation

E-6
Optimum ™

Glycine max

Pioneer Hi-
Glyphosate and ALS herbicide tolerance

GAT ™
L. (soya bean)
Bred

International,

Inc

E-7
Roundup

Glycine max

Monsanto
Glyphosate tolerance

Ready ®
L. (soya bean)
Company

E-8
Roundup

Glycine max

Monsanto
Glyphosate tolerance

RReady2Yiel ™
L. (soya bean)
Company

E-9
STS ®

Glycine max

DuPont
Sulfonylurea tolerance

L. (soya bean)

E-10
YIELD

Glycine max

Monsanto

GARD ®
L. (soya bean)
Company

E-11
AFD ®

Gossypium

Bayer
The lines include, for example, AFD5062LL,

hirsutum

CropScience
AFD5064F, AFD 5065B2F; AFD seed is available

L. (cotton)

in a wide range of varieties with integrated

technology such as, for example, the Bollgard ®,

Bollgard II, Roundup Ready, Roundup

Ready Flex and LibertyLink ® technologies

E-12
Bollgard II ®

Gossypium

Monsanto
MON 15985 event: Cry2(A)b1; Cry1A(c)

hirsutum

Company

L. (cotton)

E-13
Bollgard ®

Gossypium

Monsanto
Cry 1Ac

hirsutum

Company

L. (cotton)

E-14
FiberMax ®

Gossypium

Bayer

hirsutum

CropScience

L. (cotton)

E-15
Liberty Link ®

Gossypium

Bayer
Phosphinotricin tolerance

hirsutum

CropScience

L. (cotton)

E-16
Nucotn 33B

Gossypium

Delta Pine
Bt toxin in the lines from Delta Pine: CrylAc

hirsutum

and Land

L. (cotton)

E-17
Nucotn 35B

Gossypium

Delta Pine
Bt toxin in the lines from Delta Pine: CrylAc

hirsutum

and Land

L. (cotton)

E-18
Nucotn ®

Gossypium

Delta Pine
Bt toxin in the lines from Delta Pine

hirsutum

and Land

L. (cotton)

E-19
PhytoGen ™

Gossypium

PhytoGen Seed
Comprises varieties which contain, for

hirsutum

Company, Dow
example, Roundup Ready flex, Widestrike

L. (cotton)
AgroSciences

LLC

E-20
Roundup

Gossypium

Monsanto
Glyphosate tolerance

Ready Flex ®

hirsutum

Company

L. (cotton)

E-21
Roundup

Gossypium

Monsanto
Glyphosate tolerance

Ready ®

hirsutum

Company

L. (cotton)

E-22
Widestrike ™

Gossypium

Dow
Cry1F and Cry1Ac
Monsanto/Dow

hirsutum

AgroSciences

L. (cotton)
LLC

E-23
YIELD

Gossypium

Monsanto

http://www.garstseed.com/

GARD ®

hirsutum

Company

GarstClient/Technology/

L. (cotton)

agrisure.aspx

E-24
Roundup

Medicago

Monsanto
Glyphosate tolerance

Ready ®

sativa (alfalfa)
Company

E-25
Clearfield ®

Oryza sativa

BASF
Non-GMO, imazamox tolerance

(rice)
Corporation

E-26
NewLeaf ®

Solanum

Monsanto
Resistance to infection by potato leafroll virus

tuberosum

Company
(PLRV) and feeding damage by the Colorado

L. (potato)

beetle Leptinotarsa decemlineata

E-27
NewLeaf ®

Solanum

Monsanto
Resistance to infection by potato leafroll virus
http://www.dowagro.com/

plus

tuberosum

Company
(PLRV) and feeding damage by the Colorado
phytogen/index.htm

L. (potato)

beetle Leptinotarsa decemlineata

E-28
Protecta ®

Solanum

tuberosum

L. (potato)

E-29
Clearfield ®
Sunflower
BASF
Non-GMO, imazamox tolerance

Corporation

E-30
Roundup

Triticum

Monsanto
Glyphosate tolerance, NK603

Ready ®

aestivum

Company

(wheat)

E-31
Clearfield ®
Wheat
BASF
Non-GMO, imazamox tolerance

Corporation

E-32
Agrisure ®

Zea mays

Syngenta
These include Agrisure CB/LL (BT 11 event plus

(Family)
L. (maize)
Seeds, Inc.
phosphinotricin tolerance as the result of

GA21 event); Agrisure CB/LL/RW (Bt 11 event,

modified synthetic Cry3A gene, phosphinotricin

tolerance as the result of GA21 event);

Agrisure GT (glyphosate tolerance); Agrisure

GT/CB/LL(glyphosate tolerance and

phosphinotricin tolerance as the result of

GA21 event, Bt 11 event); Agrisure 3000GT

(CB/LL/RW/GT: glyphosate and phosphinotricin

tolerance as the result of GA21 event;

Bt 11 event, modified synthetic Cry3A gene);

Agrisure GT/RW (glyphosate tolerance, modified

synthetic Cry3A gene); Agrisure RW (modified

synthetic Cry3A gene); future traits

E-33
BiteGard ®

Zea mays

Novartis Seeds
cry1A(b) gene

L. (maize)

E-34
Bt-Xtra ®

Zea mays

DEKALB
cry1Ac gene

L. (maize)
Genetics

Corporation

E-35
Clearfield ®

Zea mays

BASF
Non-GMO, imazamox tolerance

L. (maize)
Corporation

E-36
Herculex ®

Zea mays

Dow

(Familie)
L. (maize)
AgroSciences

LLC

E-37
IMI ®

Zea mays

DuPont
Imidazolinone tolerance

L. (maize)

E-38
KnockOut ®

Zea mays

Syngenta
SYN-EV176-9: cry1A(b) gene

L. (maize)
Seeds, Inc,

E-39
Mavera ®

Zea mays

Renessen
High lysine
http://www.dowagro.com/

L. (maize)
LLC

widestrike/

E-40
NatureGard ®

Zea mays

Mycogen
cry1A(b) gene

L. (maize)

E-41
Roundup

Zea mays

Monsanto
Glyphosate tolerance
http://www.starlinkcorn.com/

Ready ®
L. (maize)
Company

starlinkcorn.htm

E-42
Roundup

Zea mays

Monsanto
Glyphosate tolerance

Ready ®2
L. (maize)
Company

E-43
SmartStax

Zea mays

Monsanto
Combination of eight genes

L. (maize)
Company

E-44
StarLink ®

Zea mays

Aventis
Cry9c gene

L. (maize)
CropScience −>

Bayer

CropScience

E-45
STS ®

Zea mays

DuPont
Sulfonylurea tolerance

L. (maize)

E-46
YIELD

Zea mays

Monsanto
Mon810, Cry1Ab1; resistance to the
http://www.dowagro.com/

GARD ®
L. (maize)
Company
European Corn Borer
herculex/about/herculexfamily/

E-47
YieldGard ®

Zea mays

Monsanto
Mon810 × Mon863, dual resistance to

Plus
L. (maize)
Company
European Corn Borer and corn rootworm

E-48
YieldGard ®

Zea mays

Monsanto
Mon863, Cry3Bb1, resistance to corn

Rootworm
L. (maize)
Company
rootworm

E-49
YieldGard ®

Zea mays

Monsanto
Stacked traits

VT
L. (Maize)
Company

E-50
YieldMaker ™

Zea mays

DEKALB
Contains Roundup Ready 2 technology,

L. (Maize)
Genetics
YieldGard VT, YieldGard Corn Borer,

Corporation
YieldGard Rootworm and YieldGard Plus

Transgenic crop plants that can be treated in accordance with the invention are preferably plants which comprise transformation events (transformation-integration events) or a combination of transformation events (transformation-integration events) and which, for example, are listed in the databases for various national or regional registration authorities, including event 1143-14A (cotton, insect control, not filed, described in WO2006/128569); event 1143-51B (cotton, insect control, not filed, described in WO2006/128570); event 1445 (cotton, herbicide tolerance, not filed, described in US2002120964 or WO2002/034946); event 17053 (rice, herbicide tolerance, filed as PTA-9843, described in WO2010/117737); event 17314 (rice, herbicide tolerance, filed as PTA-9844, described in WO2010/117735); event 281-24-236 (cotton, insect control-herbicide tolerance, filed as PTA-6233, described in WO2005/103266 or US2005216969); event 3006-210-23 (cotton, insect control herbicide tolerance, filed as PTA-6233, described in US2007143876 or WO2005/103266); event 3272 (maize, quality trait, filed as PTA-9972, described in WO2006098952 or US2006230473); event 40416 (maize, insect control-herbicide tolerance, filed as ATCC PTA-11508, described in WO2011/075593); event 43A47 (maize, insect control-herbicide tolerance, filed as ATCC PTA-11509, described in WO2011/075595); event 5307 (maize, insect control, filed as ATCC PTA-9561, described in WO2011/077816); event ASR-368 [bent grass, herbicide tolerance, filed as ATCC PTA-4816, described in US2006162007 or WO2004053062]; event B16 (maize, herbicide tolerance, not filed, described in US2003126634); event BPS-CV127-9 (soya bean, herbicide tolerance, filed as NCIMB No. 41603, described in WO2010/080829); event CE43-67B (cotton, insect control, filed as DSM ACC2724, described in US2009217423 or WO2006/128573); event CE44-69D (cotton, insect control, not filed, described in US20100024077); event CE44-69D (cotton, insect control, not filed, described in WO2006/128571); event CE46-02A (cotton, insect control, not filed, described in WO2006/128572); event COT102 (cotton, insect control, not filed, described in US2006130175 or WO2004039986); event COT202 (cotton, insect control, not filed, described in US2007067868 or WO2005054479); event COT203 (cotton, insect control, not filed, described in WO2005/054480); event DAS40278 (maize, herbicide tolerance, filed as ATCC PTA-10244, described in WO2011/022469); event DAS-59122-7 (maize, insect control-herbicide tolerance, filed as ATCC PTA 11384, described in US2006070139); event DAS-59132 (maize, insect control-herbicide tolerance, not filed, described in WO2009/100188); event DAS68416 (soya bean, herbicide tolerance, filed as ATCC PTA-10442, described in WO2011/066384 or WO2011/066360); event DP-098140-6 (maize, herbicide tolerance, filed as ATCC PTA-8296, described in US2009137395 or WO2008/112019); event DP-305423-1 (soya bean, quality trait, not filed, described in US2008312082 or WO2008/054747); event DP-32138-1 (maize, hybrid system, filed as ATCC PTA-9158, described in US20090210970 or WO2009/103049); event DP-356043-5 (soya bean, herbicide tolerance, filed as ATCC PTA-8287, described in US20100184079 or WO2008/002872); event EE-1 (aubergine, insect control, not filed, described in WO2007/091277); event FI117 (maize, herbicide tolerance, filed as ATCC 209031, described in US2006059581 or WO1998/044140); event GA21 (maize, herbicide tolerance, Hied as ATCC 209033, described in US2005086719 or WO1998/044140); event GG25 (maize, herbicide tolerance, filed as ATCC 209032, described in US2005188434 or WO1998/044140); event GHB119 (cotton, insect control-herbicide tolerance, filed as ATCC PTA-8398, described in WO2008/151780); event GHB614 (cotton, herbicide tolerance, filed as ATCC PTA-6878, described in US2010050282 or WO2007/017186); event GJ11 (maize, herbicide tolerance, filed as ATCC 209030, described in US2005188434 or WO1998/044140); event GM RZ13 (sugar beet, virus resistance, filed as NCIMB-41601, described in WO2010/076212); event H7-1 (sugar beet, herbicide tolerance, filed as NCIMB 41158 or NCIMB 41159, described in US2004172669 or WO2004/074492); event JOPLIN 1 (wheat, fungus resistance, not filed, described in US2008064032); event LL27 (soya bean, herbicide tolerance, filed as NCIMB41658, described in WO2006/108674 or US2008320616); event LL55 (soya bean, herbicide tolerance, filed as NCIMB 41660, described in WO2006/108675 or US2008196127); event LLcotton25 (cotton, herbicide tolerance, filed as ATCC PTA-3343, described in WO2003013224 or US2003097687); event LLRICE06 (rice, herbicide tolerance, filed as ATCC-23352, described U.S. Pat. No. 6,468,747 or WO2000/026345); event LLRICE601 (rice, herbicide tolerance, filed as ATCC PTA-2600, described in US20082289060 or WO2000/026356); event LY038 (maize, quality trait, filed as ATCC PTA-5623, described in US2007028322 or WO2005061720); event MIR162 (maize, insect control, filed as PTA-8166, described in US2009300784 or WO2007/142840); event MIR604 (maize, insect control, not filed, described in US2008167456 or WO2005103301); event MON 15985 (cotton, insect control, filed as ATCC PTA-2516, described in US2004-250317 or WO2002/100163); event MON810 (maize, insect control, not filed, described in US2002102582); event MON863 (maize, insect control, filed as ATCC PTA-2605, described in WO2004/011601 or US2006095986); event MON87427 (maize, pollination control, filed as ATCC PTA-7899, described in WO2011/062904); event MON87460 (maize, stress tolerance, filed as ATCC PTA-8910, described in WO2009/111263 or US20110138504); event MON87701 (soya bean, insect control, filed as ATCC PTA-8194, described in US2009130071 or WO2009/064652); event MON87705 (soya bean, quality trait-herbicide tolerance, filed as ATCC PTA-9241, described in US20100080887 or WO2010/037016); event MON87708 (soya bean, herbicide tolerance, filed as ATCC PTA9670, described in WO2011/034704); event MON87754 (soya bean, quality feature, filed as ATCC PTA-9385, described in WO2010/024976); event MON87769 (soya bean, quality trait, filed as ATCC PTA-8911, described in US20110067141 or WO2009/102873); event MON88017 (maize, insect control-herbicide tolerance, filed as ATCC PTA-5582, described in US2008028482 or WO2005/059103); event MON88913 (cotton, herbicide tolerance, filed as ATCC PTA-4854, described in WO2004/072235 or US2006059590); event MON89034 (maize, insect control, filed as ATCC PTA-7455, described in WO2007/140256 or US2008260932); event MON89788 (soya bean, herbicide tolerance, filed as ATCC PTA-6708, described in US2006282915 or WO2006/130436); event MS11 (oilseed rape, pollination control-herbicide tolerance, filed as ATCC PTA-850 or PTA-2485, described in WO2001/031042); event MS8 (oilseed rape, pollination control-herbicide tolerance, filed as ATCC PTA-730, described in WO2001/041558 or US2003188347); event NK603 (maize, herbicide tolerance, filed as ATCC PTA-2478, described in US2007-292854); event PE-7 (rice, insect control, not filed, described in WO2008/114282); event RF3 (oilseed rape, pollination control-herbicide tolerance, filed as ATCC PTA-730, described in WO2001/041558 or US2003188347); event RT73 (oilseed rape, herbicide tolerance, not filed, described in WO2002/036831 or US2008070260); event T227-1 (sugar beet, herbicide tolerance, not filed, described in WO2002/44407 or US2009265817); event T25 (maize, herbicide tolerance, not filed, described in US2001029014 or WO2001/051654); event T304-40 (cotton, insect control-herbicide tolerance, filed as ATCC PTA-8171, described in US2010077501 or WO2008/122406); event T342-142 (cotton, insect control, not filed, described in WO2006/128568); event TCI507 (maize, insect control-herbicide tolerance, not filed described in US2005039226 or WO2004/099447); event VIP1034 (maize, insect control-herbicide tolerance, filed as ATCC PTA-3925, described in WO2003/052073); event 32316 (maize, insect control-herbicide tolerance, filed as PTA-11507, described in WO2011/084632); event 4114 (maize, insect control-herbicide tolerance, filed as PTA-11506, described in WO2011/084621).

The plants listed can be treated in accordance with the invention in a particularly advantageous manner with the inventive active ingredient mixture. The preferred ranges stated above for the mixtures also apply to the treatment of these plants. Particular emphasis is given to the treatment of plants with the mixtures specifically mentioned in the present text.

The control of animal pests, especially of nematodes, by treating the seed of plants has been known for a long time and is the subject of continual improvements. However, in the treatment of seed, a number of problems are encountered which cannot always be resolved in a satisfactory manner. Thus, it is desirable to develop methods for protecting the seed and the germinating plant which at least significantly reduce, or make superfluous, the additional application of crop protection agents after sowing or after the emergence of the plants. It is additionally desirable to optimize the amount of active ingredient employed in such a way as to provide maximum protection for the seed and the germinating plant from attack by animal pests, especially nematodes, but without damaging the plant itself by the active ingredient used. In particular, methods for the treatment of seed should also take into consideration the intrinsic insecticidal properties of transgenic plants in order to achieve optimum protection of the seed and the germinating plant with a minimum of crop protection agents being employed.

The present invention therefore also relates especially to a method for the protection of seed and germinating plants from attack by animal pests, especially by nematodes, and also to a method for increasing yields, by treating the seed with an inventive composition.

The invention likewise relates to the use of the inventive compositions for the treatment of seed for protecting the seed and the germinating plant from animal pests, especially from nematodes, and also for increasing yields.

The invention further relates to seed which has been treated with an inventive composition for protection from animal pests, especially nematodes.

One of the advantages of the present invention is that the particular systemic properties of the inventive compositions mean that treatment of the seed with these compositions not only protects the seed itself, but also the resulting plants after emergence, from animal pests, especially nematodes. In this manner, the immediate treatment of the crop at the time of sowing or shortly thereafter can be dispensed with.

It is also considered to be advantageous that the inventive mixtures can also be used for transgenic seed in particular.

Formulations

The active ingredient combinations can be converted to the customary formulations such as solutions, emulsions, wettable powders, suspensions, powders, dusts, pastes, soluble powders, granules, suspension-emulsion concentrates, natural and synthetic materials impregnated with active ingredient, and microencapsulations in polymeric materials, for the foliar and soil applications.

These formulations are produced in a known manner, for example by mixing the active ingredients with extenders, that is, liquid solvents and/or solid carriers, optionally with the use of surfactants, that is, emulsifiers and/or dispersants, and/or foam formers.

If the extender used comprises water, it is also possible, for example, to use organic solvents as cosolvents. The following are essentially suitable as liquid solvents: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulfoxide, and water.

Suitable solid carriers are:

for example ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals such as highly disperse silica, alumina and silicates; suitable solid carriers for granules are: for example crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, or else synthetic granules of inorganic and organic meals, and granules of organic material such as sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam formers are: for example nonionic and anionic emulsifiers such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulfonates, alkyl sulfates, arylsulfonates, or else protein hydrolysates: suitable dispersants are: for example lignosulfite waste liquors and methylcellulose.

Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, or else natural phospholipids such as cephalins and lecithins and synthetic phospholipids can be used in the formulations. Other possible additives are mineral and vegetable oils.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The formulations generally contain between 0.1 and 95 wt % of active ingredient, preferably between 0.5 and 90%.

The inventive active ingredient combinations may be present in commercially standard formulations and in the use forms, prepared from these formulations, as a mixture with other active ingredients, such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth-regulating substances or herbicides. The insecticides include, for example, phosphates, carbamates, carboxylates, chlorinated hydrocarbons, phenylureas and substances produced by microorganisms, etc.

Mixing with other known active ingredients such as herbicides or with fertilizers and growth regulators is also possible.

When used as insecticides, the inventive active ingredient combinations may additionally be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with synergists. Synergists are compounds which enhance the action of the active ingredients, without it being necessary for the synergist added to be active itself.

The active ingredient content of the use forms prepared from the commercially available formulations may vary within wide limits. The active ingredient concentration of the use forms may be from 0.0000001 to 95 wt % of active ingredient, preferably between 0.0001 and 50 wt %.

The compounds are employed in a customary manner appropriate for the use forms.

Use Forms

When the active ingredients of the invention are used for controlling animal pests, more particularly nematodes, the application rates may be varied within a relatively wide range, depending on the mode of application. The application rate of the active ingredients of the invention

- when treating parts of plants, such as leaves, is as follows: from 0.1 to 10 000 g/ha, preferably from 10 to 1000 g/ha, more preferably from 50 to 300 g/ha (if applied by watering or chipping, the application rate may even be reduced, especially if inert substrates such as rock wool or perlite are used);
- in the treatment of seed is as follows: from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of seed, more preferably from 2.5 to 25 g per 100 kg of seed, very preferably from 2.5 to 12.5 g per 100 kg of seed;
- for soil treatment is as follows: from 0.1 to 10 000 g/ha, preferably from 1 to 5000 g/ha.

These application rates are given only by way of example and without limitation for the purposes of the invention.

The active ingredients anchor compositions of the invention can therefore be used to protect plants, within a certain period of time after treatment, against infestation by animal pests, more particularly nematodes. The period of time within which protection of the plant is brought about extends in general over 1 to 28 days, preferably over 1 to 14 days, more preferably over 1 to 10 days, very preferably over 1 to 7 days after the treatment of the plants with the active ingredients, or to up to 200 days after seed treatment.

Foliar Applications

Foliar application is understood to mean the inventive treatment of the plants and plant parts with the active ingredients directly or by action on the environment, habitat or storage space thereof by the customary treatment methods, for example by dipping, spraying, vaporizing, nebulizing, scattering, painting and injecting. Plant parts are understood to mean all above-ground and below-ground parts and organs of the plants, such as shoot, leaf, flower and root, examples including leaves, needles, steins, stalks, flowers, fruit-bodies, fruits and seeds, and also roots, tubers and rhizomes. The plant parts also include harvested plants and vegetative and generative propagation material, for example seedlings, tubers, rhizomes, runners and seeds.

Soil Application

Soil application is understood to mean the control of insects and/or spider mites and/or nematodes by drenching pesticides onto the soil, incorporating them into the soil and m irrigation systems as droplet application onto the soil. Alternatively, the inventive active ingredient combinations can be introduced into the site of the plants in solid form (for example in the form of granules). In the case of paddy rice crops, this may also be accomplished by metering the inventive active ingredient combinations in a solid application form (for example as a granule) into a flooded paddy field.

The invention relates to these application forms to natural (soil) or artificial substrates (for example rock wool, glass wool, quartz sand, pebbles, expanded clay, vermiculite), outdoors or in closed systems (e.g. greenhouses or under film cover) and in annual (e.g. vegetables, potatoes, cotton, beet, ornamental plants) or perennial crops (e.g. citrus plants, fruit, tropical crops, spices, nuts, vines, conifers and ornamental plants). It is additionally possible to deploy the active ingredients by the ultra-low-volume method or to inject the active ingredient formulation or the active ingredient itself into the soil.

Seed Treatment

The inventive active ingredient combinations are suitable especially for protection of seed of any plant variety which is used in agriculture, in greenhouses, in forests or in horticulture from the aforementioned animal pests, especially from nematodes. More particularly, the seed is that of cereals (such as wheat, barley, rye, millet and sorghum, and oats), maize, cotton, soya, rice, potatoes, sunflower, beans, coffee, beet (e.g. sugar beet and fodder beet), peanut, vegetables (such as tomato, cucumber, onions and lettuce), lawns and ornamental plants. Of particular significance is the treatment of the seed of cereals (such as wheat, barley, rye and oats), maize and rice, and the treatment of cotton and soya seed.

In the context of the present invention, the inventive composition is applied on its own or in a suitable formulation to the seed. Preferably, the seed is treated in a state in which it is sufficiently stable that the treatment does not cause any damage. In general, treatment of the seed may take place at any point in time between harvesting and sowing. Typically, the seed used has been separated from the plant and freed from cobs, shells, stalks, coats, hairs or the flesh of the fruits. For example, it is possible to use seed which has been harvested, cleaned and dried to a moisture content of less than 15 wt %. Alternatively, it is also possible to use seed which, after drying, has been treated, for example, with water and then dried again.

When treating the seed, it generally has to be ensured that the amount of the inventive composition applied to the seed and/or the amount of further additives is selected such that the germination of the seed is not adversely affected, and that the resulting plant is not damaged. This must be borne in mind in particular in the ease of active ingredients which may exhibit phytotoxic effects at certain application rates.

The inventive active ingredient combinations/compositions can be applied directly, i.e. without comprising any further components and without having been diluted. In general, it is preferable to apply the compositions to the seed in the form of a suitable formulation. Suitable formulations and methods for the treatment of seed are known to the person skilled in the art and are described, for example, in the following documents: U.S. Pat. Nos. 4,272,417 A, 4,245,432 A, 4,808,430 A, 5,876,739 A, US 2003/0176428 A1, WO 2002/080675 A1, WO 2002/028186 A2.

The active ingredient combinations usable in accordance with the invention can be converted to the customary seed dressing product formulations such as solutions, emulsions, suspensions, powders, foams, slurries and other coating compositions for seed, and ULV formulations.

These formulations are prepared in the known manner by mixing the active ingredients or active ingredient combinations with customary additives, for example customary extenders and also solvents or diluents, dyes, wetters, dispersants, emulsifiers, antifoams, preservatives, secondary thickeners, adhesives, gibberellins, and also water.

The colorants which may be present in the seed dressing product formulations usable in accordance with the invention are all colorants which are customary for such purposes. Both pigments, which are sparingly soluble in water, and colorants, which are soluble in water, may be used. Examples of dyes include those known by the names Rhodamine B, C.I. Pigment Red 112 and C.I. Solvent Red 1.

The wetters which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which are conventionally used for the formulation of active agrochemical ingredients and for promoting wetting. Alkylnaphthalenesulfonates, such as diisopropyl- or diisobutylnaphthalenesulfonates, can be used with preference.

Useful dispersants and/or emulsifiers which may be present in the seed dressing product formulations usable in accordance with the invention are all nonionic, anionic and cationic dispersants which are conventionally used for the formulation of active agrochemical ingredients. Nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants can be used with preference. Suitable nonionic dispersants include, in particular, ethylene oxide/propylene oxide block polymers, alkylphenol polyglycol ethers and tristryrylphenol polyglycol ethers, and their phosphated or sulfated derivatives. Suitable anionic dispersants are, in particular, lignosulfonates, polyacrylic acid salts and arylsulfonate/formaldehyde condensates.

The antifoams which may be present in the seed dressing product formulations usable in accordance with the invention are all foam-suppressing substances conventionally used for the formulation of active agrochemical ingredients. Silicone antifoams and magnesium stearate can be used with preference.

The preservatives which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which can be employed in agrochemical compositions for such purposes. Examples include dichlorophen and benzyl alcohol hemiformal.

The secondary thickeners which may be present in the seed dressing product formulations usable in accordance with the invention are all substances which can be employed in agrochemical compositions for such purposes. Cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and finely divided silica are preferred.

The adhesives which may be present in the seed dressing product formulations usable in accordance with the invention are all customary binders which can be employed in seed dressing products. Preference is given to polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.

The gibberellins which may be present in the seed dressing product formulations usable in accordance with the invention are preferably the gibberellins A1, A3 (=gibberellic acid), A4 and A7, particular preference being given to using gibberellic acid. The gibberellins are known (cf. R. Wegler “Chemie der Pflanzenschutz-und Schadlingsbekämpnmgsmittel” [Chemistry of Plant Protectants and Pesticides], Vol. 2, Springer Verlag, 1970, pp. 401-412).

The seed dressing product formulations usable in accordance with the invention can be employed either directly or after preceding dilution with water for the treatment of a wide range of seeds. For instance, the concentrates or the formulations obtainable therefrom by dilution with water can be used to dress the seed of cereals, such as wheat, barley, rye, oats and triticale, and the seed of maize, rice, rape, peas, beans, cotton, soya, sunflowers and beet, or else a wide variety of different vegetable seeds. The seed dressing product formulations usable in accordance with the invention or the dilute preparations thereof can also be used to dress seed of transgenic plants. In this context, additional synergistic effects may also occur as a consequence of the interaction with the substances formed by expression.

Useful apparatus which can be used to treat seed with the seed dressing product formulations usable in accordance with the invention, or with the preparations prepared therefrom by addition of water, is all mixing apparatus which can typically be used to dress seed. Specifically, the seed dressing procedure is to place the seed into a mixer, add the amount of seed dressing product formulation desired in each case, either as such or after preceding dilution with water, and mix until the formulation has been distributed homogeneously on the seed. If appropriate, this is followed by a drying process.

The application rate of the seed dressing product formulations usable in accordance with the invention can be varied within a relatively wide range. It is guided by the particular content of the active ingredients in the formulations and by the seed. The application rates of the active ingredient combinations are generally between 0.001 and 50 g per kilogram of seed, preferably between 0.01 and 25 g per kilogram of seed.

Calculation Formula for the Mortality of a Combination of Two Active Ingredients

The anticipated effect of a given combination of two active ingredients may be calculated (cf. Colby, S. R., “Calculating Synergistic and Antagonistic Responses of Herbicide Combinations”, Weeds 15, pages 20-22, 1967) as follows:

- if
- X is the mortality, expressed in % of the untreated control, when active ingredient A is used in an application rate of m ppm, or m g/ha
- Y is the mortality, expressed in % of the untreated control, when active ingredient B is used in an application rate of n ppm, or n g/ha
- E is the mortality, expressed in % of the untreated control, when active ingredients A and B are used at application rates of m and n ppm or of m and n g/ha,
- then

$E = X + Y - \frac{X \cdot Y}{100} .$

If the actual insecticide mortality is greater than calculated, then the combination is superadditive in its kill—that is, there is a synergistic effect. In this case the mortality actually observed must be greater than the value for the expected mortality (E) calculated on the basis of the formula given above.

EXAMPLE 1

Myzus Test (Spray Treatment)
Solvent: 78 Parts by Weight of Acetone

- 1.5 parts by weight of dimethylformamide
  
  Emulsifier: 0.5 part by weight of alkylaryl polyglycol ether

A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the staled amounts of solvent and emulsifier and diluting the concentrate with emulsifier-containing water to the desired concentration. A suitable suspension of biological agent is prepared by dissolving the cells, spores or viruses in emulsifier-containing water in the desired concentration.

Chinese cabbage (Brassica pekinensis) leaf disks infested by all stages of the green peach aphid (Myzus persicae) are sprayed with an active ingredient and/or biological agent preparation in the desired concentration.

After the desired lime, the effect in % is ascertained. Here, 100% means that all of the aphids have been killed; 0% means that no aphids have been killed. The mortality figures determined are used for calculation according to the Colby formula (see sheet 1).

In this test, the following combination of fluopyram with a further active ingredient or with a biological agent in accordance with the present specification gave a synergistically boosted activity in comparison to the substances employed individually:

TABLE 1-1

Myzus persicae test

Active ingredient/biological
Concentration

agents
g ai/ha
Mortality in % after 1^d

Fluopyram
1000
0

5●0
●

Imicyafos
67.5
0

found*
calc.**

Fluopyram + imicyafos
1000 + 67.5
100
0

Pyrethrum

100
80

found*
calc.**

Fluopyram + pyrethrum
1000 + 100
100
80

Fluensulfone
2000
0

found*
calc.**

Fluopyram + fluensulfone
500 + 2000
90
0

Paecilomyces lilacinus

5000
●

strain 251

found*
calc.**

Fluopyram + Paecilomyces
1000 + 5000
70
0

lilacinus strain 251

Bacillus amyloliquefaciens

2000
●

strain FZB 42

found*
calc.**

Fluopyram + Bacillus
1000 + 2000
90
0

amyloliquefaciens

Cydia pomonella granulosis
1000
0

virus (CpGV)

found*
calc.**

Fluopyram + Cydia pomonella
1000 + 1000
70
●

granulosis virus (CpGV)

TABLE 1-2

Myzus persicae test

Active ingredient/biological
Concentration

agents
g ai/ha
Mortality in % after 6^d

Fluopyram
1000
0

500
0

Bacillus thuringiensis subsp.
1000
0

tenebrionis

found*
calc.**

Fluopyram. + Bacillus
1000 + 1000
80
0

thuringiensis

subsp. tenebrionis

Azadirachtin
10●
0

found*
calc.**

Fluopyram + azadirachtin
1000 + 100
70
0

Metschnikowia fructicola

1000
0

found*
calc.**

Fluopyram + Metschnikowia
500 + 3000
90
0

fructicola

*found = insecticidal action found,

**calc. = action calculated by the Colby formula

EXAMPLE 2

Spodoptera frugiperda Test (Spray Treatment)

Solvent: 78.0 parts by weight of acetone

- 1.5 parts by weight of dimethylformamide
  
  Emulsifier 0.5 part by weight of alkylaryl polyglycol ether

A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the stated amounts of solvent and emulsifier and diluting the concentrate with emulsifier-containing water to the desired concentration.

Maize (Zea mays; corn) leaf disks are sprayed with an active ingredient preparation of the desired concentration and, after drying off, are populated with caterpillars of the army worm (Spodoptera frugiperda).

After the desired time, the effect in % is ascertained. Here, 100% means that all of the caterpillars have been killed, 0% means that no caterpillar has been killed. The mortality figures determined are used for calculation according to the Colby formula (see sheet 1).

In this test, the following combination of fluopyram and a further active ingredient in accordance with the present specification gave a synergistically boosted activity in comparison to the active ingredients employed individually:

TABLE 2

Spodoptera frugiperda test

Active ingredient/biological
Concentration

agents
g ai/ha
Mortality in % after 2^d

Fluopyram
1000
0

Pyrethrum

100
33

found*
calc.**

Fluopyram + pyrethrum
1000 + 100
50
33

* found = insecticidal action found,

** calc. = action calculated by the Colby formula

EXAMPLE 3
Seed Treatment—Cotton Emergence Test

Seed of cotton (Gossypium hirsutum) is mixed with the desired amount of active ingredient and spores and also water. After drying, 25 seed grains in each case are sown in pots filled with sandy loam.

After 2 days, the effect in % is ascertained on the basis of the cotton plants that have emerged.

The following combinations of fluopyram and biological agents gave a better emergence rate in comparison to the substances employed individually and to the untreated control:

TABLE 3

Cotton emergence

Emergence in % in

Active ingredient/biological
Concentration
comparison to

agents
g ai/kg seed
untreated control

Control (untreated seed)

100

Fluopyram
1
133

0.5
100

Bacillus subtilis strain GB 03
0.078
158

Fluopyram + B. subtilis
0.5 + 0.078
288

strain GB 03

Bacillus amyloliquefaciens

0.15
163

strain FZB 42
0.075
158

Fluopyram. + B. amyloliquefaciens
1.0 + 0.15
225

strain FZB 42
0.5 + 0.075
221

* found = insecticidal action found,

** calc. = action calculated by the Colby formula

EXAMPLE 4

Meloidogyne incognita Test

Solvent: 125.0 parts by weight of acetone

A suitable preparation of active ingredient is prepared by mixing one part by weight of active ingredient with the stated amounts of solvent and diluting the concentrate with water to the desired concentration. A spore suspension is prepared by diluting the spores with water to the desired concentration.

Vessels are filled with sand, active ingredient solution, Meloidogyne incognita egg-and-larvae suspension, and lettuce seeds. The lettuce seeds germinate and the seedlings develop. The galls develop on the roots.

After the desired time, the nematicidal effect is determined on the basis of gall formation in %. Here, 100% means that no galls have been found; 0% means that the number of galls on the treated plants corresponds to the untreated control. The figures ascertained are used for calculation according to the Colby formula (see sheet 1).

In this test, the following combination of fluopyram and biological agents in accordance with the present specification gave a synergistically boosted activity in comparison to the active ingredients employed individually:

TABLE 4

Meloidogyne incognita test

Active ingredient/biological
Concentration

agents
in ppm
Mortality in % after 21^d

Fluopyram
●.0005
0

Metarhizium anisopliae

5
●

strain F52

found*
calc.**

Fluopyram + M. anisopliae
0.0005 + 5
80
0

strain F52

*found = insecticidal action found,

**calc. = action calculated by the Colby formula

EXAMPLE 5

Glycine max—Growth Promotion in Combination with Mycorrhiza

Seed of soya beans (Glycine max) is mixed with the desired amount of active ingredient in water. After drying, the seeds are sown in pots filled with sand and perlite (1:1). For inoculation with arbuscular mycorrhiza fungi, the sand-perlite mixture is mixed beforehand with the Mycorrhiza inoculum (AMykor GmbH; Germany) in a concentration of 25 ml/L. The seed is covered with 3 cm of Lecaton (expanded clay).

Over the following 44 days, the plants are cultivated m a greenhouse in good growth conditions. The pots are watered with a nutrient solution (Hoagland and Arnon, 1950, half-concentrated solution) with a low phosphate concentration (20 μM).

The untreated control plants are cultured without arbuscular mycorrhiza fungi, but under the same conditions.

The growth-promoting effect on shoot and roots is ascertained via the weight of the fresh roots of the treated plant in comparison to the untreated control.

The following combination of active ingredient and biological agents gives increased root growth in comparison to the ingredients and agents applied individually, and to the control:

TABLE 5

Plant growth of soya bean

Root weight in % in

Active ingredient/biological
Concentration
comparison to

agents
mg/seed grain
untreated control

Control
—
100

Fluopyram
0.1
116.90

Arbuscular mycorrhiza fungus
—
133.21

Fluopyram + arbuscular
0.1
137.91

mycorrhiza fungus

	Number	Date	Country
Parent	15845262	Dec 2017	US
Child	16720290		US
Parent	13990586	Sep 2013	US
Child	15845262		US

ACTIVE INGREDIENT COMBINATIONS COMPRISING PYRIDYLETHYLBENZAMIDES AND OTHER ACTIVE INGREDIENTS

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