Claims
- 1. A method for preventing development of hepatic fibrosis or cirrhosis or fatty liver comprising administering to a subject in need thereof an effective amount of at least one adenosine A2A receptor antagonist.
- 2. The method according to claim 1 wherein the adenosine A2A receptor antagonist is selected from the group consisting of adenosine, 2-phenylaminoadenosine, 2-p-2-carboxyethylphenylamino-5′-N-ethylcarboxamidoadenosine, 5-N-ethylcarboxamidoadenosine, 5′-N-cyclopropyladenosine, 5′-N-methylcarboxamidoadenosine, 8-(3-chlorostyryl) caffeine, PD-1259444,
1,3-diprbpyl phenylxanthine and 4-{2-[7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-a][1,3,5]-triazin-5-ylamino]ethyl}phenol (ZM 241385) 8-styryl derivatives of 1,3-7-alkylxanthines of the following formula: 4Wherein R1 and R3 can be methyl, ethyl, propyl, or allyl; R7 is H, methyl, or C1-C8 alkyl; R∝ is hydrogen; and compounds of the following formula: 5wherein is m-Br or p-SO3H 6
- 3. A method for treating hepatic fibrosis or cirrhosis or fatty acids comprising administering to a subject in need thereof an effective amount of at least one adenosine A2A receptor antagonist or at least one adenosine uptake promotor.
- 4. The method according to claim 3 wherein the adenosine A2A receptor antagonist is selected from the group consisting of
- 5. The method according to claim 4 wherein the adenosine A2A receptor antagonist is selected from the group consisting of 8-(3-chlorostyryl) caffeine and 4-{2-[7-amino-2-(2-furyl)(1,2,4)triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl}phenol, also known as ZM 241385.
- 6. A method for preventing development of hepatic fibrosis, cirrhosis, or fatty liver comprising administering to a subject in need thereof an effective amount of at least one agent which inhibits stimulation of the adenosine A2A receptor.
- 7. A method for treating hepatic fibrosis or cirrhosis or fatty liver comparing administering to a subject in need thereof an effective amount of at least one agent which inhibits stimulation of the A2A receptor.
REFERENCE TO OTHER APPLICATIONS
[0001] The present application claims priority from provisional application Ser. No. 60/181,546, filed Feb. 10, 2000, the entire contents of which are hereby incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60181546 |
Feb 2000 |
US |