Patent Application
20240164951
Adhesive tape is utilized for many different purposes. One important usage of adhesive tape is for application to wearable devices, including medical devices. For instance, adhesive tape can be used to attach sensors of glucose monitoring medical devices to human skin in order to monitor a subject for the treatment of diabetes.
Currently available adhesive tapes for medical devices have limited duration when used with an attached medical device. For example, current adhesive tapes can have a fixed thickness of adhesive material, which can impede the ability of the tape to stick to the user's skin. As a result, medical devices must be undesirable re-applied to the skin multiple times and can impact the effectiveness of the monitoring by the devices. Further, adhesive tapes should be able to support the weight of a medical device and ensure accurate sensor readings on the user.
Accordingly, the present disclosure provides improved adhesive tape compositions for application with medical devices, for instance wearable medical devices. As described herein, the adhesive tape compositions can advantageously provide prolonged duration of use with wearable devices. Furthermore, the adhesive tape compositions are breathable and provide bi-directional stretch properties, which allows for secure attachment to the skin of a user and at the same time follows the movements of the user to provide longer periods of use for medical devices.
The detailed description particularly refers to the accompanying figures in which:
In an illustrative aspect, an adhesive tape composition 10 is provided. The adhesive tape composition comprises i) a fabric 12 and ii) an adhesive 14 as shown in
In an embodiment, a blend of polyurethane resin with polyethylene or other polypropylene resins can be utilized. Polyurethane is generally known in the art as providing desirable properties such as flexibility and breathability. However, other polymer composite materials (e.g., those based on polyester or polyolefins) can achieve breathability by processing or by incorporating functional additives. For instance, inorganic additives can be utilized with the embodiments of the present disclosure as a backing fabric or as a film of the adhesive tape.
In an aspect, fabrics comprising polyurethane can provide high moisture vapor transmission rate (MVTR) values, which allows for breathability of the tape and desirably permits for longer wear time on a user's skin and prevention of skin irritation. In an embodiment, the fabric is configured for bi-directional stretching.
Various fabrics are contemplated for the adhesive tape compositions of the present disclosure. For instance, a fabric can be obtained from Mativ Holdings, Inc. (Alpharetta, Georgia, U.S.A.).
The fabric can have various properties of certain ranges, including any of the following:
In an embodiment, the fabric comprises a front side and a back side, wherein the adhesive extends between and interconnects the back side of the fabric and the removable liner. In an embodiment, the fabric is embossed to provide an embossed fabric. In an embodiment, the fabric is embossed on the front side to provide an embossed fabric. In an embodiment, the fabric is embossed on the back side to provide an embossed fabric. In an embodiment, the fabric is embossed on the front side and on the back side to provide an embossed fabric.
The embossed fabric includes a non-embossed portion and an embossed portion that is arranged to extend away from the non-embossed portion. On the embossed fabric, the non-embossed portion and the embossed portion provide two different depths of thickness. This concept is shown by
In an embodiment, the embossed fabric can have a depth of the outer layer of the fabric that is not in contact with the adhesive. This is shown as “A” in
In an embodiment, the embossed fabric has a depth of the inner layer of the fabric that is in contact with the adhesive. This is shown as “B” in
Further, as shown as “C” in
In an embodiment, one or more repositories are present on the embossed fabric. The repositories, for instance, can be present as a result of the embossment to place various “pockets” in the embossed fabric. For instance, a repository can form on the embossed portion of the embossed fabric. For instance, a repository can form on the non-embossed portion of the embossed fabric. In an embodiment, the repositories of the embossed fabric are of variable thicknesses. As used herein, a “variable” thickness can refer to a non-random design, for instance variability that follows a pattern on a fabric. For instance, variability can refer to the pattern as a result of embossment of the embossed fabric.
In an embodiment, the adhesive is present in the one or more repositories of the embossed fabric. The adhesive can be present in the one or more repositories in the embossed fabric that are formed as a result of the embossment. In an embodiment, as shown as “D” in
Various adhesives are contemplated for the adhesive tape compositions of the present disclosure. For instance, an adhesive can comprise, consist essentially of, or consist of a solvent-based acrylic adhesive, an acrylic-rubber hybrid adhesive, a rubber based adhesive, a polyurethane adhesive, or a silicon adhesive. Further, an adhesive can comprise, consist essentially of, or consist of a solids-based acrylic adhesive, an acrylic-rubber hybrid adhesive, a rubber based adhesive, a polyurethane adhesive, or a silicon adhesive, up to 100% solids. In one aspect, an adhesive can be indicated for long term skin wear. In an embodiment, the adhesive is an acrylic. In an embodiment, the adhesive is of medical grade.
For instance, an adhesive such as Aroset S488 can be obtained from Bostik, Inc. (Wauwatosa, Wisconsin, U.S.A.). For instance, an adhesive such as Durotack DT AH 115 can be obtained from Henkel (Düsseldorf, Germany). For instance, an adhesive such as BTX-110 can be obtained from Toyo Ink (Tokyo, Japan).
The adhesive of the adhesive tape composition can have various properties of certain ranges, including any of the following:
In an embodiment, the adhesive tape composition has a thickness between 8 to 20 mils (without including the removable liner) as measured by PSTC 133 Test Methods. In other embodiments, the adhesive tape composition can have a thickness, without including the removable liner, of greater than or equal to 8 mils, of greater than or equal to 8.2 mils, of greater than or equal to 8.4 mils, of greater than or equal to 8.6 mils, of greater than or equal to 8.8 mils, of greater than or equal to 9 mils, of greater than or equal to 9.2 mils, of greater than or equal to 9.4 mils, of greater than or equal to 9.6 mils, of greater than or equal to 9.8 mils, of greater than or equal to 10 mils, of greater than or equal to 10.2 mils, of greater than or equal to 10.4 mils, of greater than or equal to 10.6 mils, of greater than or equal to 10.8 mils, of greater than or equal to 11 mils, of greater than or equal to 11.2 mils, of greater than or equal to 11.4 mils, of greater than or equal to 11.6 mils, of greater than or equal to 11.8 mils, of greater than or equal to 12 mils, of greater than or equal to 12.2 mils, of greater than or equal to 12.4 mils, of greater than or equal to 12.6 mils, of greater than or equal to 12.8 mils, of greater than or equal to 13 mils, of greater than or equal to 13.2 mils, of greater than or equal to 13.4 mils, of greater than or equal to 13.6 mils, of greater than or equal to 13.8 mils, of greater than or equal to 14 mils, of greater than or equal to 14.2 mils, of greater than or equal to 14.4 mils, of greater than or equal to 14.6 mils, of greater than or equal to 14.8 mils, of greater than or equal to 15 mils, of greater than or equal to 15.2 mils, of greater than or equal to 15.4 mils, of greater than or equal to 15.6 mils, of greater than or equal to 15.8 mils, of greater than or equal to 16 mils, of greater than or equal to 16.2 mils, of greater than or equal to 16.4 mils, of greater than or equal to 16.6 mils, of greater than or equal to 16.8 mils, of greater than or equal to 17 mils, of greater than or equal to 17.2 mils, of greater than or equal to 17.4 mils, of greater than or equal to 17.6 mils, of greater than or equal to 17.8 mils, of greater than or equal to 18 mils, of greater than or equal to 18.2 mils, of greater than or equal to 18.4 mils, of greater than or equal to 18.6 mils, of greater than or equal to 18.8 mils, of greater than or equal to 19 mils, of greater than or equal to 19.2 mils, of greater than or equal to 19.4 mils, of greater than or equal to 19.6 mils, of greater than or equal to 19.8 mils, or of greater than or equal to 20 mils, including any and all ranges therebetween two stated thicknesses.
In some embodiments, the fabric can have a thickness (as measured by PSTC 133 Test Methods) of greater than or equal to 3 mils, of greater than or equal to 3.2 mils, of greater than or equal to 3.4 mils, of greater than or equal to 3.6 mils, of greater than or equal to 3.8 mils, of greater than or equal to 4 mils, of greater than or equal to 4.2 mils, of greater than or equal to 4.4 mils, of greater than or equal to 4.6 mils, of greater than or equal to 4.8 mils, of greater than or equal to 5 mils, of greater than or equal to 5.2 mils, of greater than or equal to 5.4 mils, of greater than or equal to 5.6 mils, of greater than or equal to 5.8 mils, of greater than or equal to 6 mils, of greater than or equal to 6.1 mils, of greater than or equal to 6.2 mils, of greater than or equal to 6.3 mils, of greater than or equal to 6.4 mils, of greater than or equal to 6.5 mils, of greater than or equal to 6.6 mils, of greater than or equal to 6.7 mils, of greater than or equal to 6.8 mils, of greater than or equal to 6.9 mils, of greater than or equal to 7 mils, of greater than or equal to 7.1 mils, of greater than or equal to 7.2 mils, of greater than or equal to 7.3 mils, of greater than or equal to 7.4 mils, of greater than or equal to 7.5 mils, of greater than or equal to 7.6 mils, of greater than or equal to 7.7 mils, of greater than or equal to 7.8 mils, of greater than or equal to 7.9 mils, of greater than or equal to 8 mils, of greater than or equal to 8.1 mils, of greater than or equal to 8.2 mils, of greater than or equal to 8.3 mils, of greater than or equal to 8.4 mils, of greater than or equal to 8.5 mils, of greater than or equal to 8.6 mils, of greater than or equal to 8.7 mils, of greater than or equal to 8.8 mils, of greater than or equal to 8.9 mils, of greater than or equal to 9 mils, of greater than or equal to 9.2 mils, of greater than or equal to 9.4 mils, of greater than or equal to 9.6 mils, of greater than or equal to 9.8 mils, of greater than or equal to 10 mils, of greater than or equal to 10.2 mils, of greater than or equal to 10.4 mils, of greater than or equal to 10.6 mils, of greater than or equal to 10.8 mils, of greater than or equal to 11 mils, of greater than or equal to 11.2 mils, of greater than or equal to 11.4 mils, of greater than or equal to 11.6 mils, of greater than or equal to 11.8 mils, or of greater than or equal to 12 mils, including any and all ranges therebetween two stated thicknesses. The same ranges apply to the embossed fabric, the embossed portion of the embossed fabric, and the non-embossed portion of the embossed fabric as described herein.
In some embodiments, the adhesive can have a maximum thickness (as measured by PSTC 133 Test Methods) of greater than or equal to 1 mils, of greater than or equal to 1.2 mils, of greater than or equal to 1.4 mils, of greater than or equal to 1.6 mils, of greater than or equal to 1.8 mils, of greater than or equal to 2 mils, of greater than or equal to 2.2 mils, of greater than or equal to 2.4 mils, of greater than or equal to 2.6 mils, of greater than or equal to 2.8 mils, of greater than or equal to 3 mils, of greater than or equal to 3.1 mils, of greater than or equal to 3.2 mils, of greater than or equal to 3.3 mils, of greater than or equal to 3.4 mils, of greater than or equal to 3.5 mils, of greater than or equal to 3.6 mils, of greater than or equal to 3.7 mils, of greater than or equal to 3.8 mils, of greater than or equal to 3.9 mils, of greater than or equal to 4 mils, of greater than or equal to 4.1 mils, of greater than or equal to 4.2 mils, of greater than or equal to 4.3 mils, of greater than or equal to 4.4 mils, of greater than or equal to 4.5 mils, of greater than or equal to 4.6 mils, of greater than or equal to 4.7 mils, of greater than or equal to 4.8 mils, of greater than or equal to 4.9 mils, of greater than or equal to 5 mils, of greater than or equal to 5.1 mils, of greater than or equal to 5.2 mils, of greater than or equal to 5.3 mils, of greater than or equal to 5.4 mils, of greater than or equal to 5.5 mils, of greater than or equal to 5.6 mils, of greater than or equal to 5.7 mils, of greater than or equal to 5.8 mils, of greater than or equal to 5.9 mils, of greater than or equal to 6 mils, of greater than or equal to 6.1 mils, of greater than or equal to 6.2 mils, of greater than or equal to 6.3 mils, of greater than or equal to 6.4 mils, of greater than or equal to 6.5 mils, of greater than or equal to 6.6 mils, of greater than or equal to 6.7 mils, of greater than or equal to 6.8 mils, of greater than or equal to 6.9 mils, of greater than or equal to 7 mils, of greater than or equal to 7.1 mils, of greater than or equal to 7.2 mils, of greater than or equal to 7.3 mils, of greater than or equal to 7.4 mils, of greater than or equal to 7.5 mils, of greater than or equal to 7.6 mils, of greater than or equal to 7.7 mils, of greater than or equal to 7.8 mils, of greater than or equal to 7.9 mils, of greater than or equal to 8 mils, of greater than or equal to 8.1 mils, of greater than or equal to 8.2 mils, of greater than or equal to 8.3 mils, of greater than or equal to 8.4 mils, of greater than or equal to 8.5 mils, of greater than or equal to 8.6 mils, of greater than or equal to 8.7 mils, of greater than or equal to 8.8 mils, of greater than or equal to 8.9 mils, of greater than or equal to 9 mils, of greater than or equal to 9.2 mils, of greater than or equal to 9.4 mils, of greater than or equal to 9.6 mils, of greater than or equal to 9.8 mils, or of greater than or equal to 10 mils, including any and all ranges therebetween two stated thicknesses. Furthermore, the adhesive can be present at two or more different thicknesses as described above when it is present in the embossed portion and/or the non-embossed portion of an embossed fabric.
In some embodiments, the removable liner can have a thickness of greater than or equal to 1 mils, of greater than or equal to 1.2 mils, of greater than or equal to 1.4 mils, of greater than or equal to 1.6 mils, of greater than or equal to 1.8 mils, of greater than or equal to 2 mils, of greater than or equal to 2.2 mils, of greater than or equal to 2.4 mils, of greater than or equal to 2.6 mils, of greater than or equal to 2.8 mils, of greater than or equal to 3 mils, of greater than or equal to 3.1 mils, of greater than or equal to 3.2 mils, of greater than or equal to 3.3 mils, of greater than or equal to 3.4 mils, of greater than or equal to 3.5 mils, of greater than or equal to 3.6 mils, of greater than or equal to 3.7 mils, of greater than or equal to 3.8 mils, of greater than or equal to 3.9 mils, of greater than or equal to 4 mils, of greater than or equal to 4.1 mils, of greater than or equal to 4.2 mils, of greater than or equal to 4.3 mils, of greater than or equal to 4.4 mils, of greater than or equal to 4.5 mils, of greater than or equal to 4.6 mils, of greater than or equal to 4.7 mils, of greater than or equal to 4.8 mils, of greater than or equal to 4.9 mils, of greater than or equal to 5 mils, of greater than or equal to 5.1 mils, of greater than or equal to 5.2 mils, of greater than or equal to 5.3 mils, of greater than or equal to 5.4 mils, of greater than or equal to 5.5 mils, of greater than or equal to 5.6 mils, of greater than or equal to 5.7 mils, of greater than or equal to 5.8 mils, of greater than or equal to 5.9 mils, of greater than or equal to 6 mils, of greater than or equal to 6.1 mils, of greater than or equal to 6.2 mils, of greater than or equal to 6.3 mils, of greater than or equal to 6.4 mils, of greater than or equal to 6.5 mils, of greater than or equal to 6.6 mils, of greater than or equal to 6.7 mils, of greater than or equal to 6.8 mils, of greater than or equal to 6.9 mils, of greater than or equal to 7 mils, of greater than or equal to 7.1 mils, of greater than or equal to 7.2 mils, of greater than or equal to 7.3 mils, of greater than or equal to 7.4 mils, of greater than or equal to 7.5 mils, of greater than or equal to 7.6 mils, of greater than or equal to 7.7 mils, of greater than or equal to 7.8 mils, of greater than or equal to 7.9 mils, or of greater than or equal to 8 mils, including any and all ranges therebetween two stated thicknesses.
In an embodiment, the adhesive tape composition is configured for attachment to a medical device. In an embodiment, the medical device is a glucose monitoring device. In an embodiment, the medical device is a medical diagnostic device. In an embodiment, the medical device is a smart wearable device. For these embodiments, it is contemplated that the medical device utilizes adhesive tape for attachment of the device to skin. Without being bound by any theory, the medical device can be attached to skin via adhesive tape for a prolonged time period without incurring edge lifting or adhesive oozing around the perimeter of the adhesive tape.
Furthermore, in some embodiments, the adhesive tape can be evaluated prior to use in order to analyze its biomedical or biocompatibility. For instance, the adhesive tape can under testing such as cytotoxicity, irritation, and sensitization prior to use according to the present disclosure.
Various removable liners are contemplated for the adhesive tape compositions of the present disclosure. For instance, a removable liner such as Grade 52564 80 #(lb/ream basis weight) super-calendered kraft (SCK) white paper liner can be obtained from Loparex (Cary, North Carolina, U.S.A.). Other removable liners can be obtained, for example, from MPI, Ahlstrom, MTI, and Mondi.
For instance, a removable liner can have a basis weight of between 42 to 96 lb/ream, preferably 60 to 80 lb/ream. In an embodiment, the removable liner is one side siliconized. In an embodiment, the removable liner is double side siliconized. In an embodiment, the removable liner is a poly-coated liner.
In an illustrative aspect, a medical tape composition is provided. The medical tape composition comprises i) a fabric and ii) means for coupling a medical device to an occupant. In an embodiment, the means for coupling comprises an adhesive.
In an embodiment, the means for coupling is adapted for placement on the occupant for at least 1 day without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 2 days without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 3 days without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 5 days without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 7 days without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 10 days without detaching. In an embodiment, the means for coupling is adapted for placement on the occupant for at least 14 days without detaching.
In an embodiment, the medical device is a glucose monitoring device.
In an embodiment, the fabric is a non-woven fabric. In an embodiment, the fabric is a breathable fabric. In an embodiment, the fabric comprises polyurethane. In an embodiment, the fabric is configured for bi-directional stretching.
In an embodiment, the fabric comprises a front side and a back side, wherein, the adhesive extends between and interconnects the back side of the fabric and the removable liner. In an embodiment, the fabric is embossed on the front side to provide an embossed fabric. In an embodiment, the fabric is embossed on the back side to provide an embossed fabric. In an embodiment, the fabric is embossed on the front side and on the back side to provide an embossed fabric.
In an embodiment, one or more repositories are present on the embossed fabric. In an embodiment, the repositories of the embossed fabric are of variable thicknesses. In an embodiment, the adhesive is present in the one or more repositories of the embossed fabric.
The following numbered embodiments are contemplated and are non-limiting:
An exemplary adhesive tape composition can be formed as follows. Adhesive was uniformly coated on the siliconized side of an 80 lb basis weight SCK paper release liner using steel coating rollers at the thickness of 3.5 mil. This was air dried for 15 minutes then dried at 70° C. for 15 minutes, followed by the final drying step at 121° C. for 15 minutes. Dried adhesive on the liner was then laminated on the adhesive side of the 75 gsm, wherein both sides were embossed polyurethane fabric under laminating pressure of 20 psa.
The unique profile of the adhesive tape is formed after laminating step on the boundary of the dried adhesive and the embossed side surface of the fabric. After lamination to the fabric, the adhesive thickness varies along and across the coated web due to visco-elastic nature of the adhesive as it follows the embossing topography of the fabric.
Four prior art adhesive tape compositions that did not include embossment of fabrics were analyzed as shown in Table 1:
Three adhesive tape compositions that included embossment of fabrics were analyzed as shown in Table 2:
The various adhesive tape compositions were analyzed to evaluate bond depth (for embossed side and non-embossed side, as applicable), bond site thickness, unbonded area, surface roughness, and fiber size. The results of the analyses are shown in Table 3.
Adhesive tape compositions 5 and 6 (i.e., those with embossed fabric that was embossed on the front side and the back side and demonstrating variable thickness of adhesive) demonstrated improved skin wear duration compared to the prior art samples 1-4. Adhesive tape compositions 5 and 6 also demonstrated improved support of a medical device when the medical device was attached to the skin of a user using these adhesive tape compositions.
The instant example provides exemplary methods for determining depth of embossed areas and other features of the fabric of adhesive tape compositions. Equipment for the instant example included Hitachi S-3000N Scanning Electron Microscope (with PCI Quartz Software), a Denton vacuum desk V coater with gold/palladium target, Max Pro Freeze Spray, aluminum regular duty single edge blades, and double slotted vise holders.
Preparation steps of the instant example included:
Analysis steps of the instant example included:
The instant example provides analyses of adhesive tape compositions according to the procedures in Example 2. Various measurements of adhesive tape compositions were undertaken for the elements shown in the SEM image of
In particular, the following measurements of exemplary adhesive tape compositions of the present disclosure were made (referencing
A first exemplary adhesive tape composition (10 samples; white fabric) was analyzed under a microscope (WD 15.8 mm, 15 kV, ×120, at 300 μm scale). The thickness values at each element were measured and are shown in Table 5.
A second exemplary adhesive tape composition (10 samples; tan fabric) was analyzed under a microscope (WD 15.8 mm, 15 kV, ×120, at 300 μm scale). The thickness values at each element were measured and are shown in Table 6.
A summary of the analysis of seven exemplary adhesive tape compositions that were evaluated is found in Table 7.
In comparison to the exemplary adhesive tape compositions shown in the SEM images of
The instant example provides analyses of embossment depths of fabrics. An exemplary embossed non-woven fabric sample can be evaluated. Equipment utilized for the instant example included a Hitachi S-3000N scanning electron microscope with PCI quartz software, a Denton vacuum desk V coater with gold/palladium target, a max pro freeze spray, aluminum regular duty single edge blades, and double slotted vise holders.
The fabric sample is taken from the center of the web for fabric rolls at the beginning, middle, and end of the production run. A small section of the sample is frozen by spraying the max pro freeze spray directly on the section of the fabric to be analyzed. The sample is ready for further use immediately after spray freezing.
Thereafter, a cross section of the sample is cut with a razor, making sure to cut through the middle point of the embossed area. A line of the cut to be made is shown by the dashed line in
The cross-sectioned sample is placed with the cut side up in a double slotted vise holder and repeated for additional samples. The holders are placed into the vacuum coater. The samples are coated for 45 seconds and then removed after coating is complete.
For testing, the coated sample are placed in the SEM chamber. Once the SEM chamber has reached the appropriate pressure, the beam is turned on and the sample is set to the following parameters:
About 10 images per sample are obtained to make necessary measurements, often obtaining more than one area from a sample to complete measurements. An example of an original image is shown in
After all images are taken, the emboss depth is measured using calibrated software. All measurements are made at the center of the emboss area using following steps.
This application claims the benefit under 35 USC § 119(e) of U.S. Provisional Application Ser. No. 63/426,806, filed on Nov. 21, 2022, the entire disclosure of which is incorporated herein by reference.
| Number | Date | Country | |
|---|---|---|---|
| 63426806 | Nov 2022 | US |
