The present invention relates to systems and methods to provide visual field of view characterization (diagnostic) and vision restoration therapy to subjects including patients with vision impairment. In particular, the invention is directed toward positioning users and a source of visual stimuli to ensure accurate diagnostic testing and therapy.
Stimulating the vision system of a subject with vision impairments may improve their visual performance of patients. For example, as documented in U.S. Pat. No. 6,464,356, and US Published Patent Application No. 2005/0213033, which are hereby incorporated by reference herein in their entirety, presenting visual stimuli to the areas of a human's visual system may allow improvement in the user's vision. Such a procedure may be carried out on a personal computer for home use, the therapy performed in sessions on a daily schedule for a set period of time (e.g., an hour).
The location and orientation of a user's head relative to a display, used to present visual stimuli, needs to be identified each time therapy is performed to properly stimulate the correct zones in a user's visual field. Previous therapeutic regimens relied upon a user fixing their gaze in a particular location. The natural tendency of persons to move after being in an unsupported, fixed position for a relatively long period of time may cause misalignment of the visual stimuli relative to a user's visual field. Such misalignment may limit the effectiveness of a therapeutic session. Even if a user attempts to remain stationary relative to a display, identifying the proper position may be difficult, especially for individual users outside of a clinical setting. In addition, the amount of time required to properly align the relative position of the display with a user's visual field can be substantial.
Because devices for visual field testing and therapy tend to be bulky, they are typically used in dedicated facilities. However, it may be inconvenient to transport a patient to such a facility. It may therefore be desirable to use such a device in non-dedicated facilities such as a home, rehabilitation center, or hospital room. Additionally, positional adjustment of the subject relative to the source of stimulus may be overly time consuming or difficult.
In illustrative embodiments of the present invention, an adjustable device provides visual testing or treatment to a subject. The device has a computer display mounted on a base. A head support assembly includes a chinrest and aids in the positioning of the head of a subject with respect to the display. The head support assembly is joined to the base, and thus to the display, via an articulated arm. The chinrest will resist a given downward force of the head. During transport, the head support assembly is foldable toward the display to create a more compact and portable device.
In related embodiments, the chinrest and display may be adjustable in multiple ways. For example, the elevation of the chinrest relative to the fixation center of the display may be adjustable. The lateral position of the chinrest may be adjustable. The elevation of the chinrest and the elevation of the display may be adjustable with respect to the base, and may be adjusted simultaneously to maintain their relative elevations, while adjusting the absolute elevation to conform with a subject's height or comfort. The positions of the chinrest and display may be adjusted manually. The positions may also be adjusted automatically. For example, an eye-tracker can be used to determine the best position for the chinrest relative to the display and the device can use that information to adjust the position of the chinrest and/or display. In embodiments, positioning of the chinrest and display can be done manually, or electromechanically. A memory storage device may be used to store positional information associated with a given subject. In response to an input of information identifying the subject, the device may then automatically adjust to reproduce the stored positional settings associated with the subject.
In a further embodiment, in order to increase the safety of operating the device, the chinrest supports the head of the subject by supplying only a limited upward, countering force. Application of a force in excess of a threshold force value will cause the downward collapse of the chinrest. As a result, the device is less likely to be toppled.
In further related embodiments, a computer may be integrated into the device or otherwise operatively coupled to the device via wired or wireless (e.g., radio frequency) connections. The computer directs the presentation of stimuli and records user responses to the stimuli. A variety of input devices may be used, including a mouth-actuated switch, a microphone, a finger actuated switch, a foot actuated switch, a joystick, a mouse, a trackpad, a trackball, and an accelerometer-based device.
In a yet another embodiment, the head support assembly includes a sensor that is operatively coupled to the computer and detects the presence of the head of a subject. As a result, the computer will compensate for the so-detected presence or absence of the subject and thereby avoid the accumulation of spurious data from a non-present subject. For example, the removal of the subject's head may trigger a pause condition and the detected return of the patient's head may trigger a resumption of a program of visual testing or therapy.
In other embodiments, the device may include antiglare components such as an antiglare hood or a glare detector. For ease of portability, the device may have a handle attached to the display.
In further embodiments, a device for administering testing or therapy procedures includes a display that is foldably connected to a base and has a head support assembly that is foldably connected to the display via an articulated arm The head support assembly may also be foldably connected to the arm. The device may be lockable is a folded and/or unfolded state. An actuator may be used to lock and/or unlock the device in order to switch configurations between a folded and unfolded mode.
The foregoing features of the invention will be more readily understood by reference to the following detailed description, taken with reference to the accompanying drawings, in which:
Illustrative embodiments of the invention described herein are directed toward devices and methods to evaluate and to treat a subject (i.e., a patient) to compensate for impairment of vision. A display presents visual stimuli that are viewed by the subject, the stimuli resulting in evaluation and/or treatment of the impaired vision of the subject. Embodiments provide a device that has a positionable head support assembly that includes a chinrest and supports the head of a subject relative to a display so that the subject's visual field can be precisely stimulated for visual field testing or therapy. Embodiments include features that allow the device facilitate adjustment, and make the device safer and more convenient to use, including features that allow the device to be folded for ease of transport. As a result, the device is well suited to use at a non-dedicated clinical setting such as a hospital room, doctor's office or the home of a subject. A padded case may be provided to pack the folded device in for secure shipping or carrying.
The device 100 includes a head support assembly 105 that is used to position a subject's head in front of a computer display 104. The display 104 is supported on a base 106, and may be held above the base by a stem (item 250 of
The base 106 is designed to support the device and prevent it from toppling. Although the base 106 may take many forms, a U-shaped base minimizes weight, yet resists the downward force created when a subject rests their head in the head support assembly 105. This safety arrangement may make advantageously prevent unexpected forward tilting and toppling of the device 100. The base may be passive, or have built in circuitry and controls.
The computer display 104 is used to present stimuli (e.g. fixation and peripheral stimuli) to a subject. For maximum portability, the display may be a flat-panel type display, such as an LCD display (color or monochrome), although plasma displays or other types of displays may be equally well suited. The housing of the display 104 may include various controls; for example, buttons to control the elevation of the display, buttons to pause and resume operation of the testing or therapy. The display housing 104 may also contain an integrated microphone and/or video camera, which may be used as input devices for responding to displayed stimulus or to communicate with a remote clinical professional. Other input devices (not shown) for responding to displayed stimulus may also be associated with the display 104 or base 106; for example, a retractable mouse, or clipped-on wireless input device.
The display 104 may also include an antiglare feature such as an attachment points for a light-shielding hood (not shown), or an antiglare sensor system that notifies a subject or helper of the presence of excessive stray light. This antiglare sensor would ensure that the screen readability is not degraded to the point of affecting diagnostic or therapy. Should the sensor detect a glare condition exceeding a predetermined threshold, the device could halt or prevent the start of diagnostic or therapy activities until the detected glare is reduced or eliminated, e.g., by repositioning the device or by changing the ambient light conditions. For example, a camera, photodiode or other photosensor may be integrated into the head support assembly or the display to measure light impinging on or reflected from the surface of the display 104.
In some embodiments, the device 100 may include firmware, controls and an interface so that a second display (not shown), a keyboard (not shown), and a pointing device (e.g. a mouse, not shown) can be connected to it. These additional components allow a clinical professional to monitor or alter a diagnostic or therapeutic procedure. The information presented on the screen of the peripheral display can duplicate the screen 104 as seen by the subject (a mirror view). The clinical professional may also configure the computer to supplement or replace the mirror view with statistical data, graphs and other information related to the diagnostic or therapy underway. The clinical professional can use the keyboard or pointing device to modify the diagnostic or therapy sequence, insert comments to a therapy log associated with a computer-medium patient file, and make any other changes to the operating mode of the device 100.
In an embodiment, the head support assembly 105 has a chinrest 102, and a forehead band 108 supported by two posts 111. In use, a subject will rest their chin upon the chinrest 102, and their forehead against the forehead band 108. The chinrest 102 and forehead band 105 may be curved to increase comfort and ensure reproducible alignment. The head support assembly 105 may be folded onto the arm 110 prior to transport and storage. For example, the assembly may rotate around an axis defined by the first articulation 103. If the arm 110 is also foldable against the display, then the overall volume defined by the folded device 100 will be lower if the head support assembly 105 folds outwardly, i.e., rotates away from the display 104. In this case, a limit (not shown) may prevent the head support assembly 105 from rotating past an upright position, yet allow folding backward for storage. Optionally, a locking mechanism may be included to lock the head support assembly 105 in an extended and/or folded position.
In an embodiment, the elevation of the chinrest 102 with respect to the center of the screen of the display 104 is fixed and not adjustable. This elevation is chosen such that once the chin of a patient is positioned within the chin rest, the eyes of this patient are in line with the center of the screen with a maximum vertical error of +/−3.00 inches.
In another embodiment, the distance from the chin to the surface of the flat screen may also be fixed and not adjustable. This fixed distance has a value between 5 inches and 20 inches. The choice of this fixed distance is based on the width of the image presented on the screen and the desire to achieve a lateral field of view angle for each eye of between about 30 degrees and 60 degrees, depending on diagnostic and therapy objectives.
To effect therapy specific to a particular lateral portion of the visual field, it may be advantageous to offset the subject's head laterally in relation to the display. Accordingly, in an embodiment, the head support assembly 105 may contain a mechanism to allow lateral repositioning of the head support assembly 105 relative to the display 104. The mechanism may utilize a trigger to release an articulating mechanism at the base of the arm 110. Release may be effected via, for example, a cable, or via a cable attached to a solenoid locking mechanism associated with the second articulating mechanism 107 at the base of the arm. Such actuation controls may be located on the head support assembly 105. The left or right lateral adjustment may be limited, e.g., to an offset of between about 1 to 4 inches. Alternately, head support assembly 105 may be laterally positioned by sliding the assembly 105 along a track, or with a lead screw mechanism.
The head support assembly 105 may optionally include sensors (not shown) that detect the presence or absence of the subject's head. During unattended stimulation procedures, it may be difficult to ascertain whether the subject remains consistently positioned with their chin located within the chinrest 102. For example, the subject could move or take a brief break while continuing actuation of the input device. In addition, the subject's head may be misaligned. As a result, spurious negative data may be accumulated. In an embodiment, one or more detectors may be placed within the chinrest 102, or other location, to detect the chin of the subject, and may detect proper alignment of the chin and/or forehead of the subject. In the event that these detectors sense that the subject's chin is no longer properly within the head support assembly 105, compensatory action may be taken. Examples of compensatory actions include testing or therapy may be automatically paused, annotating an associated patient therapy file, ignoring data from a time period, repeating part of the procedure, or combination thereof. As a result, accumulation of spurious data from a non-present subject is prevented. If paused, the procedure may be automatically resumed when the detectors sense that the subject's chin is has returned to the chinrest, or manually resumed once the patient restarts the therapy by pressing on an input device keys. Those skilled in the art know that multiple forms of detectors could be used for this purpose including: optical detectors, (e.g., visible and infrared light detectors), thermal sensors, ultrasonic detectors, pressure detectors within the chin rest, force sensors, strain gauges, and conductance sensors, to name a few.
As shown in
To compensate for the height of the subject and or the distance between their eyes and chin, the arm 110 and hinge 103 may be together slidably positionable along the height of the stem 250. A spring-loaded handle 240, has a tab that extend into a slot 210 in the stem 250 to secure the arm 110 elevation in one of multiple pre-defined positions. The positions of the slots 210 may be chosen to correspond to a given distribution of eye to chin distances of the population (e.g., to cover 3 standard deviations of distances as determined from the analytical data contained in Baidai. et. al., “Relationship between Anthropometric and Cephalometric Measurements and Proportions of the Face of Healthy Young White Adult Men and Women,”J. of Craniofacial Surgery 14(2): 154-161, March 2003). To unlock and reposition the arm 110, a user pulls the handle 230 to rotate the handle 230 around a handle hinge 275 and disengage the tab of the handle 230 from a slot 210. The user then releases the handle 230 and raises or lowers the handle 210; a handle spring 240 will force the re-engagement of the tab into a new slot.
In some embodiments, the device 100 may be folded at more than one of the first, second and third articulations to make it more compact for ease of transportation. For instance, a folding sequence may include:
In a related embodiment, as a safety feature, the chinrest arm 110 folding articulation 107 may collapse toward the base 106 in response an excessive downward vertical load applied to the chin rest. This safety feature prevents the toppling-over of the entire device when an excessive load is applied to the chin rest. For example, a clutch mechanism can be factory preset to any load exceeding a threshold of between 1.0 lb. and 200 lb. Upon collapse of the chinrest arm, it is possible for the patient to reposition the arm in its preset position by simply lifting the arm and re-engaging the clutch mechanism.
To maximize patient comfort, the display 104 and head support assembly 105 may be elevated or lowered vertically, to bring the chinrest 102 to the elevation suitable to provide each patient with maximum comfort during use of the device 100.
The device 100 may be manually adjustable or may include one or more motorized parts for automatic positional adjustment.
The drive mechanism includes a leadscrew 440/drive nut 430 mechanism powered by a DC motor 410 with a gearbox reduction 420. A current sensor may be placed in the circuit powering the DC motor to sense the end-of travel of the drive mechanism in either direction. When a stall condition occurs (end-of travel) the resulting increased motor current is detected and the energy supplied to the motor in that direction is terminated. The rotation speed of the motor may be monitored so that the amount of energy supplied to the motor is automatically adjusted (i.e. pulsed width modulation) to achieve a similar speed when the display 104 and head support assembly 105 is traveling upward or downward. There is an increased load on the motor assembly when the display/chin rest assembly travels upward than downward so the speed detector and resulting energy adjustments operate as load-compensator.
As a safety feature, if the display/chin rest assembly 105 encounters an interference (e.g., a human limb between the display 104 and base 106 of device 100) when the display 104 and head support assembly 105 travel downward, the DC motor current will increase and the motor rotation speed will decrease and may diminish to zero. Detection of either or both conditions will result in stoppage of the motor, and may be followed by an immediate displacement of the drive mechanism in the opposite direction for a distance sufficient to relieve pressure on the interference and allow its removal. Those skilled in the art know that a DC motor/gearbox/leadscrew/drive nut implementation for the device 100 is only one possible implementation among many; a rack and pinion, pneumatic, hydraulic, solenoid and ratchet system or linear motor, among others, could be used for the drive mechanism of the device 100.
Embodiments of the present invention may include one or more of the following drive features:
In a related embodiment, the device 100 may automatically set the relationship between the chinrest 102 and the display 104. For example, a patient could adjust the chinrest position manually or electromechanically and the display 104, equipped with an eye tracker system, automatically brings the center of the screen exactly in line with the eyes of the patient for any position of the chin rest. Accordingly, the device 100 will automatically compensate for patient-to-patient variability in eye to chin distance.
In a clinic, setting the same device 100 may be used by multiple patients each day and it may save time to record the spatial location of the chinrest 102 and of the display 104 in a memory device that is specific to each patient. After completing the initial adjustments of chin rest and screen during initial diagnostic or therapy, the spatial coordinates may be automatically stored in the memory of the MSD (memory Storage Device) specific to the patient, along with the therapy profile and patient identification information already present in this MSD. The next time the patient uses a device 100 (the same device or other device of the same type) the device may read the spatial coordinates from the patient MSD, and will automatically pre-position the chinrest and screen as soon as the MSD is inserted in the VRT device. Upon completion of this pre-positioning, the patient can still fine-tune these adjustments using [up] and [down] manual controls at his disposal to reflect a different chair or seating position. Alternatively, the stored positional information may be used to aid in manual adjustment of the device.
If positional corrections are made, the revised spatial coordinates of the chin rest and screen are updated in the MSD. The expression “memory storage device” (MSD) used herein should be taken broadly and is not intended to describe solely storage devices making use of the USB port (or other ports) found on most computers. In some embodiments of this invention, the patient storage device may take forms other than MSD such as “wallet card with a built in computer.” An MSD may be any storage device containing patient specific data, whether this devices needs to be physically connected to the device for its data to be used by the device, or whether this patient-specific storage device can communicate wirelessly and bi-directionally with the VRT device using techniques such as RFID.
This chinrest position and therapy information can also be stored in the memory of the device itself 100 and can be retrieved, along with therapy data by entering a subject identifier code. For example, the subject identifier code may be input using an input device, including a biometric identification system, e.g., a fingerprint or retinal scanner.
In another embodiment, the chinrest position and therapy information can be stored on a remote computer server, and could be retrieved from any device using its internet access upon entry by the patient of a specific I.D. or upon presentation of a proper biometric identifier such as the tip of a finger placed on a fingerprint scanner located on the device 100 or coupled to the device 100.
The device 100 may be designed to be connected to the internet using a phone connection (dial-up), or wide-band high speed connection (e.g., Ethernet, cable, DSL, 3G, or WiMax). For instance, the device could include an internal modem. This internet connection can be used for the following purposes:
In some embodiments, one or more input devices may be provided for the patient to indicate that they have observed a visual stimulus on the screen. The base plate 106 of the device 100 may be equipped with an input device on each side. These input devices can be equipped with one up to ten pushbutton switches. A wired or wireless input device can also be used as an alternative to the base plate input devices. The above mentioned input devices are all coupled to the computer of the device 100 and can be used concurrently and simultaneously if desired and in any combination. A variety of other input device types may be used; for example, a mouth-actuated switch (e.g., blowing air in a tube to actuate a pressure sensitive switch), a microphone, a finger actuated switch, a foot actuated switch, a joystick, a mouse, a trackpad, a trackball, and an accelerometer-based device. The device 100 is capable of recording to memory locally or remotely (e.g., via internet link) which input device (type and specific identifier code) was used for a specific therapy or diagnostic.
An input device coupled to the computer of the device 100 may also be equipped with a pause button to allow a subject to interrupt the therapy when necessary, and then to resume this therapy by pushing the pause button once more, or if desired, by pressing any other key on one of the input device. During a pause, the display 104 can present a message reminding the patient that the therapy has been paused and that she needs to take a specific action to either resume or terminate the therapy.
In alternative embodiments, the disclosed methods for relative positioning of a subject and a display may be implemented as a computer program product for use with a computer system. Such implementations may include a series of computer instructions fixed either on a tangible medium, such as a computer readable medium (e.g., a diskette, CD-ROM, ROM, or fixed disk) or transmittable to a computer system, via a modem or other interface device, such as a communications adapter connected to a network over a medium. The medium may be either a tangible medium (e.g., optical or analog communications lines) or a medium implemented with wireless techniques (e.g., microwave, infrared or other transmission techniques). The series of computer instructions embodies all or part of the functionality previously described herein with respect to the system. Those skilled in the art should appreciate that such computer instructions can be written in a number of programming languages for use with many computer architectures or operating systems.
Furthermore, such instructions may be stored in any memory device, such as semiconductor, magnetic, optical or other memory devices, and may be transmitted using any communications technology, such as optical, infrared, microwave, or other transmission technologies. It is expected that such a computer program product may be distributed as a removable medium with accompanying printed or electronic documentation (e.g., shrink wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the network (e.g., the Internet or World Wide Web). Of course, some embodiments of the invention may be implemented as a combination of both software (e.g., a computer program product) and hardware. Still other embodiments of the invention are implemented as entirely hardware, or entirely software (e.g., a computer program product).
The described embodiments of the invention are intended to be merely exemplary and numerous variations and modifications will be apparent to those skilled in the art. All such variations and modifications are intended to be within the scope of the present invention as defined in the appended claims.
Number | Name | Date | Kind |
---|---|---|---|
1463847 | Shilling | Aug 1923 | A |
2213484 | Briggs | Sep 1940 | A |
3883234 | Lynn et al. | May 1975 | A |
4260227 | Munnerlyn et al. | Apr 1981 | A |
4408846 | Balliet | Oct 1983 | A |
4429961 | Sheingorn | Feb 1984 | A |
4533221 | Trachtman | Aug 1985 | A |
4660945 | Trachtman | Apr 1987 | A |
4679920 | Takashi et al. | Jul 1987 | A |
4971434 | Ball | Nov 1990 | A |
4995717 | Damato | Feb 1991 | A |
5050982 | Meissner | Sep 1991 | A |
5088810 | Galanter et al. | Feb 1992 | A |
5139323 | Schillo | Aug 1992 | A |
5147284 | Fedorov et al. | Sep 1992 | A |
5191367 | Salibello et al. | Mar 1993 | A |
5206671 | Eydelman et al. | Apr 1993 | A |
5241332 | Farrell | Aug 1993 | A |
5305027 | Patterson | Apr 1994 | A |
5321445 | Fossetti | Jun 1994 | A |
5325136 | Salibello et al. | Jun 1994 | A |
5363154 | Galanter et al. | Nov 1994 | A |
5455643 | Ki-Ho | Oct 1995 | A |
5534953 | Schmielau | Jul 1996 | A |
5539481 | Vax | Jul 1996 | A |
5539482 | James et al. | Jul 1996 | A |
5550602 | Braeuning | Aug 1996 | A |
5565949 | Kasha, Jr. | Oct 1996 | A |
5883692 | Agonis et al. | Mar 1999 | A |
5912723 | Maddess | Jun 1999 | A |
5946075 | Horn | Aug 1999 | A |
5991085 | Rallison et al. | Nov 1999 | A |
6062687 | Lofgren-Nisser | May 2000 | A |
6286960 | Tomita | Sep 2001 | B1 |
6321338 | Porras et al. | Nov 2001 | B1 |
6359601 | Maguire, Jr. | Mar 2002 | B1 |
6364486 | Ball et al. | Apr 2002 | B1 |
6386706 | McClure et al. | May 2002 | B1 |
6406437 | Zur et al. | Jun 2002 | B1 |
6431708 | Krebs | Aug 2002 | B2 |
6443977 | Jaillet | Sep 2002 | B1 |
6464356 | Sabel et al. | Oct 2002 | B1 |
6519703 | Joyce | Feb 2003 | B1 |
6540355 | Couture | Apr 2003 | B1 |
6592221 | Stregova | Jul 2003 | B1 |
6742892 | Liberman | Jun 2004 | B2 |
6990377 | Gliner et al. | Jan 2006 | B2 |
7004912 | Polat | Feb 2006 | B2 |
7104659 | Grier et al. | Sep 2006 | B2 |
7309128 | Cappo et al. | Dec 2007 | B2 |
20020047987 | Massengill et al. | Apr 2002 | A1 |
20020107960 | Wetherall et al. | Aug 2002 | A1 |
20030090439 | Spitzer et al. | May 2003 | A1 |
20030156254 | Turovetsky | Aug 2003 | A1 |
20030214630 | Winterbotham | Nov 2003 | A1 |
20040012758 | Lin | Jan 2004 | A1 |
20040051848 | Gotze et al. | Mar 2004 | A1 |
20040075811 | Liberman | Apr 2004 | A1 |
20040100616 | Eremeev | May 2004 | A1 |
20040257528 | Miyake et al. | Dec 2004 | A1 |
20050001980 | Spector | Jan 2005 | A1 |
20050041208 | Winterbotham | Feb 2005 | A1 |
20050213033 | Sabel | Sep 2005 | A1 |
20050213034 | Nagayoshi | Sep 2005 | A1 |
20050213035 | Yoshimeki et al. | Sep 2005 | A1 |
20060092377 | Todd et al. | May 2006 | A1 |
20060283466 | Sabel | Dec 2006 | A1 |
20060288258 | Lo et al. | Dec 2006 | A1 |
20060290885 | Covannon et al. | Dec 2006 | A1 |
20070038142 | Todd et al. | Feb 2007 | A1 |
20070171372 | Seal et al. | Jul 2007 | A1 |
Number | Date | Country |
---|---|---|
9305147 | Apr 1994 | DE |
10207839 | Sep 2002 | DE |
115263 | Aug 1984 | EP |
128783 | Dec 1984 | EP |
135736 | Aug 1985 | EP |
0242723 | Oct 1987 | EP |
0537945 | Apr 1993 | EP |
544631 | Jun 1993 | EP |
689822 | Jan 1996 | EP |
775464 | May 1997 | EP |
830839 | Mar 1998 | EP |
1186271 | Mar 2002 | EP |
1236432 | Sep 2002 | EP |
1236433 | Sep 2002 | EP |
1384462 | Jan 2004 | EP |
1402869 | Mar 2004 | EP |
1403680 | Mar 2004 | EP |
1465561 | Feb 1977 | GB |
WO 8000405 | Mar 1980 | WO |
WO 8810088 | Dec 1988 | WO |
WO 9100553 | Jan 1991 | WO |
WO 9110393 | Jul 1991 | WO |
WO 9200037 | Jan 1992 | WO |
WO 9517227 | Jun 1995 | WO |
WO 9700653 | Jan 1997 | WO |
WO 9811819 | Mar 1998 | WO |
WO 9849992 | Nov 1998 | WO |
WO 9952419 | Oct 1999 | WO |
WO 9959461 | Nov 1999 | WO |
WO 0012042 | Mar 2000 | WO |
WO 0036971 | Jun 2000 | WO |
WO 0113859 | Mar 2001 | WO |
WO 0145630 | Jun 2001 | WO |
WO 0147463 | Jul 2001 | WO |
WO 0180808 | Nov 2001 | WO |
WO 0209578 | Feb 2002 | WO |
WO0239754 | May 2002 | WO |
WO 02053072 | Jul 2002 | WO |
WO 03002070 | Jan 2003 | WO |
WO 03002190 | Jan 2003 | WO |
WO 03007944 | Jan 2003 | WO |
WO 03020195 | Mar 2003 | WO |
WO 03041630 | May 2003 | WO |
WO 03065964 | Aug 2003 | WO |
WO 03092482 | Nov 2003 | WO |
WO 03092570 | Nov 2003 | WO |
WO 03098529 | Nov 2003 | WO |
WO 2004066900 | Aug 2004 | WO |
WO 2005004985 | Jan 2005 | WO |
WO 2005037177 | Apr 2005 | WO |
WO 2005044096 | May 2005 | WO |
WO 2005063153 | Jul 2005 | WO |
WO 2005092270 | Oct 2005 | WO |
WO 2005110326 | Nov 2005 | WO |
WO 2005122872 | Dec 2005 | WO |
WO2006002070 | Jan 2006 | WO |
WO 2006006563 | Jan 2006 | WO |
WO 2007109724 | Sep 2007 | WO |
Number | Date | Country | |
---|---|---|---|
20070171372 A1 | Jul 2007 | US |
Number | Date | Country | |
---|---|---|---|
60750867 | Dec 2005 | US |