Claims
- 1. A regime or regimen for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising administering to an individual subject in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 2. The regime or regimen as defined by claim 1, for inducing/stimulating the growth of human head hair, eyebrows, eyelashes, beard hairs, moustache hairs or pubic hairs and/or retarding the loss and/or increasing the density thereof.
- 3. A regime or regimen for inducing/stimulating the growth of human head hair and/or retarding the loss and/or increasing the density thereof, comprising topically applying onto the hair and/or scalp of an individual in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 4. A regime or regimen for treating androgenic alopecia, comprising administering to an individual in need of such treatment, a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 5. A regime or regimen for caring for and/or making up human eyelashes, comprising topically applying thereon a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 6. The regime or regimen as defined by claim 1, wherein formula (I), R1 and R2, which may be identical or different, are each: OH, OCH3, OCH2—CH3,
- 7. The regime or regimen as defined by claim 1, wherein formula (I), R1 and R2, are respectively in the 2 and 3 or 2 and 4 positions of the pyridine ring.
- 8. The regime or regimen as defined by claim 1, comprising administering a salt of said at least one pyridinedicarboxylic acid compound of formula (I), selected from the group consisting of the double salt of sodium or of potassium, zinc (Zn2+), calcium (Ca2+), copper (Cu2+), iron (Fe2+), strontium (Sr2+), magnesium (Mg2+) and manganese (Mn2+) salts, triethanolamine, monoethanolamine, diethanolamine, hexadecylamine, N,N,N′,N′-tetrakis(2-hydroxypropyl)-ethylenediamine or tris(hydroxymethyl)aminomethane salts, hydroxides, carbonates and chlorides.
- 9. The regime or regimen as defined by claim 1, comprising administering a thus effective amount of:
pyridine-2,4-dicarboxylic acid or its zinc or sodium salt, pyridine-2,3-dicarboxylic acid or its zinc or sodium salt, dimethyl pyridine-2,4-dicarboxylate, dimethyl pyridine-2,3-dicarboxylate, diethyl pyridine-2,4-dicarboxylate, diethyl pyridine-2,3-dicarboxylate, diisopropyl pyridine-2,4-dicarboxylate, 2,4-di(n-propylamido) pyridine, di(acetyloxymethyl) pyridine-2,4-dicarboxylate, diethyl pyridine-2,5-dicarboxylate, dimethyl pyridine-2,5-dicarboxylate, 2,4-di(2-hydroxyethylamido)pyridine, 2,4-di(3-hydroxypropylamido)pyridine, or mixture thereof.
- 10. The regime or regimen as defined by claim 1, said at least one pyridinedicarboxylic acid compound of formula (I) comprising an ester.
- 11. The regime or regimen as defined by claim 9, comprising administering a thus effective amount of diethyl pyridine-2,4-dicarboxylate.
- 12. A cosmetic/pharmaceutical composition of matter suited for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 13. A topically applicable cosmetic/pharmaceutical composition of matter suited for inducing/stimulating the growth of human keratinous fibers and/or retarding the loss and/or increasing the density thereof, comprising a thus effective amount of at least one pyridinedicarboxylic acid compound having the following structural formula (I), or salt thereof:
- 14. The topically applicable cosmetic/pharmaceutical composition as defined by claim 13, formulated as a hair cream or lotion, shampoo, hair conditioner, or mascara.
- 15. The cosmetic/pharmaceutical composition as defined by claim 12, formulated as an aqueous, alcoholic or aqueous/alcoholic solution or suspension.
- 16. The cosmetic/pharmaceutical composition as defined by claim 12, further comprising at least one hydrophilic or lipophilic gelling agent or thickener, hydrophilic or lipophilic additive, preservative, antioxidant, solvent, fragrance, filler, odor absorber, electrolyte, neutralizing agent, UV blocking agent, film-forming polymer, cosmetic and pharmaceutical active principle eliciting a therapeutic effect on the skin or keratinous fibers, colorant, substance P, CGRP or bradykinin antagonist, NO-synthase inhibitor, or mixture thereof.
- 17. The cosmetic/pharmaceutical composition as defined by claim 12, further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or limits the loss thereof.
- 18. The cosmetic/pharmaceutical composition as defined by claim 12, further comprising at least one:
hormone; antibacterial agent; calcium antagonist agent; microorganism extract; agent which modulates cutaneous differentiation and/or proliferation; agent which modulates bacterial adhesion to the skin and/or mucous membranes; agent for combating parasites; antifungal; antiviral agent; steroidal or nonsteroidal anti-inflammatory agent; anaesthetic agent; antipruriginous agent; keratolytic agent; agent for combating free radicals; antiseborrheic; antidandruff agent; anti-acne agent; vasodilator; agent which reduces hair loss; anti-androgen agent; steroidal or nonsteroidal inhibitor of reductases; potassium channel agonist; FP receptor agonist; or mixture thereof.
- 19. The topically applicable cosmetic/pharmaceutical composition as defined by claim 13, further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or which limits the loss thereof, selected from the group consisting of aminexil, minoxidil, latanoprost, travoprost, and mixtures thereof.
- 20. The cosmetic/pharmaceutical composition as defined by claim 12, further comprising at least one other active agent which promotes the regrowth of human keratinous fibers and/or which limits the loss thereof, selected from the group consisting of aminexil, an FP receptor, a vasodilator, and mixtures thereof.
- 21. The cosmetic/pharmaceutical composition as defined by claim 12, comprising from 10−3% to 10% by weight of said at least one pyridinedicarboxylic acid compound of formula (I), or salt thereof.
- 22. The cosmetic/pharmaceutical composition as defined by claim 12, comprising from 10−2% to 5% by weight of said at least one pyridinedicarboxylic acid compound of formula (I), or salt thereof.
- 23. The cosmetic/pharmaceutical composition as defined by claim 12, formulated for administration by injection.
- 24. The cosmetic/pharmaceutical composition as defined by claim 12, formulated for administration by ingestion.
Priority Claims (1)
Number |
Date |
Country |
Kind |
02/04527 |
Apr 2002 |
FR |
|
CROSS-REFERENCE TO PRIORITY/PROVISIONAL APPLICATIONS
[0001] This application claims priority under 35 U.S.C. §119 of FR-02/04527, filed Apr. 11, 2002, and of provisional application Serial No. 60/372,414, filed Apr. 16, 2002, both hereby expressly incorporated by reference. This application is also a continuation of said '414 provisional.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60372414 |
Apr 2002 |
US |