AEROSOLIZABLE PRODUCT

TECHNICAL FIELD

The present disclosure relates to an aerosolizable product, containers in which are contained the aerosolizable product and to electronic aerosol provision systems such as electronic aerosol delivery systems (e.g. e-cigarettes) incorporating said product.

BACKGROUND

Electronic vapor provision systems such as e-cigarettes generally contain a reservoir of liquid which is to be vaporized, typically containing nicotine. When a user inhales on the device, a heater is activated to vaporize a small amount of liquid, which is therefore inhaled by the user.

The use of e-cigarettes in the UK has grown rapidly, and it has been estimated that there are now almost three million people using them in the UK.

Current vaping products use liquids which are wicked to a heater that generates an aerosol, and this aerosol delivers nicotine and flavor. Current e-cigarette formulations typically utilize glycerol and/or propylene glycol as the liquid. In these systems, liquid can leak both in the device and in the bottles during storage and handling. Additionally, users of combustible cigarettes are accustomed to “punctuated” patterns of use, whereby successive sessions are punctuated by the exhaustion of the combustible cigarette. Consumers wishing to transition to using liquid based systems may experience a more continuous profile of use since such liquid based systems typically provide a longer lasting substrate source which spans the period associated with many conventional punctuated sessions. As a result, users may struggle to transition to the non-punctuated session of use which long lasting liquid systems deliver.

SUMMARY

In one aspect there is provided an aerosolizable product comprising an aerosol forming material; and a substrate material, wherein the substrate material is at least calcium carbonate;

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides an aerosolizable product comprising

(a) an aerosol forming material; and

(b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate,

wherein the aerosolizable product is a solid form.

The present invention further provides an aerosolizable product comprising

(a) an aerosol forming material; and

(b) a substrate material, wherein the substrate material is at least calcium carbonate;

wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The present invention further provides a dosage form of an aerosolizable product, wherein the dosage form comprises

(a) active agent in an amount of 0.001 to 1 grams;

(b) an aerosol forming material; and

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides a dosage form of an aerosolizable product, wherein the dosage form comprises

(a) active agent in an amount of 0.001 to 1 grams;

(b) an aerosol forming material; and

wherein the aerosolizable product is a solid form.

The present invention further provides a dosage form of an aerosolizable product, wherein the dosage form comprises

(a) active agent in an amount of 0.001 to 1 grams;

(b) an aerosol forming material; and

wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable nicotine product.

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and

(b) a substrate material, wherein the substrate material is at least calcium carbonate; wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product;

(ii) heating the aerosolizable product.

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate;

wherein the aerosolizable product is a solid form;

(ii) heating the aerosolizable product.

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product;

(ii) heating the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a substrate material, wherein the substrate material is at least calcium carbonate, to form an initial mixture, wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product; and

(ii) processing the initial mixture to form the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) processing the initial mixture to form the aerosolizable product

wherein the aerosolizable product is a solid form.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a substrate material, wherein the substrate material is at least calcium carbonate, to form an initial mixture, wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product; and

(ii) processing the initial mixture to form the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium

wherein the aerosolizable product is a solid form.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The present invention further provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a substrate material, wherein the substrate material is at least calcium carbonate

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a solid substrate material, wherein the solid substrate material is at least calcium carbonate

wherein the aerosolizable product is a solid form.

The present invention further provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The present invention further provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate

wherein the aerosolizable product is a solid form.

The present invention further provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;

wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

DETAILED DESCRIPTION

As discussed herein the present invention provides an aerosolizable product comprising

(a) an aerosol forming material; and (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate, wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

In this regard, the term “aerosolizable product” refers to a combination of one or more materials, at least one of which is capable of forming a condensation aerosol following heating to an appropriate temperature. Thus, it is not necessary for all components of the aerosolizable product of the present invention to be “aerosolized”.

The solid products of the present invention and the substrate materials of the present invention can substantially sustain their physical shape when unsupported by external means, e.g. packaging etc. Thus, they are considered to be solid, solid-like, in solid form or in solid-like form.

We have found that by use of a calcium carbonate substrate such that the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product, it is possible to form a substrate having a substantially solid form which is able to hold aerosol forming materials such as glycerol. As a result, problems associated with leakage and user acceptance of the prior art may be overcome. The substrate may also be used to hold an active agent, such as nicotine, and flavor which are released using heating along with the visible vapor from the aerosol forming material (e.g. glycerol or other humectants). By controlling the surface area of the calcium carbonate relative to the amount of aerosol forming material present in the aerosolizable product it is possible to avoid the issues of leakage and also create a single session for vaping which ends when the aerosolizable product runs out of aerosol forming material (since this then necessitates a change of the entire aerosolizable product).

Due to the material properties, it is possible through compression and if required the addition of binders (such as CMC) to form a consumable which may be handled as a solid in a pill/pellet/small particle (balls/agglomerated) form.

Due to the size required for a single session of vaping (8-10 puffs), a consumable may be formed into a small solid <1 g. Due to the size of the solid, this may be loaded into a device which may have a much smaller heater (oven) than currently known in the art. A small oven is advantageous since it reduces the power consumption compared to a larger oven and also reduces the size requirement of the device. Further, since the aerosolizable product being heated is a discrete unit, rather than being part of a generally continuous bulk, it liquid, less power may be required to generate a vapor. Also, after use, the substrate used to hold the aerosol generating material will comprise chalk waste which will be easy to dispose of with little worry of environmental impact.

For ease of reference, these and further aspects of the present invention are now discussed under appropriate section headings. However, the teachings under each section are not necessarily limited to each particular section.

Calcium Carbonate

As discussed herein the present invention provides an aerosolizable product comprising (a) an aerosol forming material; and (b) a substrate material, wherein the substrate material is at least calcium carbonate, wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product. In this aspect of the present invention, the calcium carbonate may be present in the product in any suitable amount, provided of course that the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

In this regard, it is noted that calcium carbonate can have a range of specific surface areas. For example, typical calcium carbonate can have a specific surface area (according to the BET method) of around 7 to 9 m²/g. However, it is possible to “functionalize” the calcium carbonate such that its surface area is increased. Indeed, functionalized calcium carbonates may have a specific surface area (according to the BET method) of around 70 m²/g. Therefore, in one aspect, the calcium carbonate used in the aerosolizable product has a specific surface area of at least 5 m²/g based on the weight of the calcium carbonate.

As discussed herein the present invention provides an aerosolizable product comprising (a) an aerosol forming material; and (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate, wherein the aerosolizable product is a solid form. In this aspect of the present invention, the calcium carbonate may be present in the product in any suitable amount, provided of course that a solid substrate material is formed.

In one aspect the substrate is present in an amount of at least 10 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 20 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 30 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 40 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 50 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 60 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 70 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 80 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 85 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of at least 95 wt. % based on the aerosolizable product.

In one aspect the substrate is present in an amount of no greater than 99 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of no greater than 95 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of no greater than 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of no greater than 85 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of no greater than 80 wt. % based on the aerosolizable product.

In one aspect the substrate is present in an amount of from 10 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 20 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 30 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 40 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 50 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 60 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 70 to 90 wt. % based on the aerosolizable product. In one aspect the substrate is present in an amount of from 80 to 90 wt. % based on the aerosolizable product.

The substrate may be formed wholly or in part from calcium carbonate. In one aspect calcium carbonate is present in an amount of at least 50 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 60 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 70 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 80 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 85 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 90 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 95 wt. % based on the substrate. In one aspect calcium carbonate is present in an amount of at least 99 wt. % based on the substrate. In one aspect the substrate material consists essentially of calcium carbonate. In one aspect the substrate material consists of calcium carbonate.

In one aspect the calcium carbonate is present in an amount of at least 10 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 20 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 30 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 40 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 50 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 60 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 70 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 85 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 95 wt. % based on the aerosolizable product.

In one aspect the calcium carbonate is present in an amount of no greater than 99 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of no greater than 95 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of no greater than 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of no greater than 85 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of no greater than 80 wt. % based on the aerosolizable product.

In one aspect the calcium carbonate is present in an amount of from 10 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 20 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 30 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 40 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 50 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of at least 95 wt. % based on the aerosolizable product.

In one aspect the calcium carbonate is present in an amount of from 10 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 20 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 30 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 40 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 50 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 60 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 70 to 90 wt. % based on the aerosolizable product. In one aspect the calcium carbonate is present in an amount of from 80 to 90 wt. % based on the aerosolizable product.

As discussed herein the present invention further provides an aerosolizable product comprising (a) an aerosol forming material; and (b) a substrate material, wherein the substrate material is at least calcium carbonate; wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product. Each of the above embodiments which require the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product, equally apply to this aspect of the invention.

Aerosol Forming Material

The one or more aerosol forming materials may be present in any suitable amount in the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 1 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 5 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 10 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 15 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 20 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of at least 25 wt. % based on the aerosolizable product.

In one aspect the one or more aerosol forming materials is present in a total amount of from 1 to 30 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of from 5 to 30 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of from 10 to 30 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of from 15 to 30 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of from 20 to 30 wt. % based on the aerosolizable product. In one aspect the one or more aerosol forming materials is present in a total amount of from 25 to 30 wt. % based on the aerosolizable product.

As discussed herein, the aerosolizable product comprises an aerosol forming material. As will be appreciated by one skilled in the art, that the aerosolizable product comprises an aerosol forming material means that the aerosolizable product contains at least one aerosol forming material. References herein to an aerosol forming material may be read to relate to at least one aerosol forming material.

The aerosol forming material may be selected from water, polyhydric alcohols, such as glycerol, propylene glycol and triethylene glycol, for example, or esters such as triethyl citrate or triacetin, or high boiling point hydrocarbons, or non-polyols, such as glycols, sorbitol or lactic acid, for example. The aerosol forming material may be selected from polyhydric alcohols, such as glycerol, propylene glycol and triethylene glycol, for example, or esters such as triethyl citrate or triacetin, or high boiling point hydrocarbons, or non-polyols, such as glycols, sorbitol or lactic acid, for example. In one aspect, the aerosol forming material is selected from polyhydric alcohols (such as glycerol, propylene glycol and triethylene glycol), esters (such as triethyl citrate and triacetin), high boiling point hydrocarbons, non-polyols (such as glycols, sorbitol and lactic acid), and mixtures thereof [preferably wherein the aerosol forming material is selected from glycerol, propylene glycol, and mixtures thereof].

The aerosol forming material may be selected from water, triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof. The aerosol forming material may be selected from triethylene glycol, triethyl citrate, triacetin, glycols, sorbitol, lactic acid, glycerol, propylene glycol, and mixtures thereof.

In one aspect, the aerosol forming material is selected from water, glycerol, propylene glycol, and mixtures thereof. In one aspect, the aerosol forming material is selected from glycerol, propylene glycol, and mixtures thereof.

In one aspect the aerosol forming material is at least water. In this aspect, a further aerosol forming material may be present or may not be present. In a further aspect, the aerosol forming material comprises water and at least one aerosol forming material other than water. In one aspect, the one or more aerosol forming materials is mixture of (a) water and (b) glycerol, propylene glycol or a mixture thereof.

The aerosol forming material(s) may be present in any suitable amount in the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 5 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 10 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 15 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 20 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 25 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of at least 30 wt. % based on the aerosolizable product.

In one aspect the aerosol forming material is present in a total amount of from 5 to 30 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 10 to 30 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 15 to 30 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 20 to 30 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 25 to 30 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 5 to 25 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 5 to 20 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 5 to 15 wt. % based on the aerosolizable product. In one aspect the aerosol forming material is present in a total amount of from 5 to 10 wt. % based on the aerosolizable product.

As discussed herein, in one aspect the aerosol forming material is at least glycerol. The glycerol may be present in any suitable amount in the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 5 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 10 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 15 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 20 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 25 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of at least 30 wt. % based on the aerosolizable product.

In one aspect the glycerol is present in a total amount of from 5 to 30 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 10 to 30 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 15 to 30 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 20 to 30 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 25 to 30 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 5 to 25 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 5 to 20 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 5 to 15 wt. % based on the aerosolizable product. In one aspect the glycerol is present in a total amount of from 5 to 10 wt. % based on the aerosolizable product.

As discussed herein, in one aspect the aerosol forming material is at least propylene glycol. The propylene glycol may be present in any suitable amount in the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 5 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 10 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 15 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 20 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 25 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of at least 30 wt. % based on the aerosolizable product.

In one aspect the propylene glycol is present in a total amount of from 5 to 30 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 10 to 30 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 15 to 30 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 20 to 30 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 25 to 30 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 5 to 25 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 5 to 20 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 5 to 15 wt. % based on the aerosolizable product. In one aspect the propylene glycol is present in a total amount of from 5 to 10 wt. % based on the aerosolizable product.

As discussed herein, in one aspect the aerosol forming material is at least water. The water may be present in any suitable amount in the aerosolizable product. In one aspect the water is present in a total amount of at least 5 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of at least 10 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of at least 15 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of at least 20 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of at least 25 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of at least 30 wt. % based on the aerosolizable product.

In one aspect the water is present in a total amount of from 5 to 30 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 10 to 30 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 15 to 30 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 20 to 30 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 25 to 30 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 5 to 25 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 5 to 20 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 5 to 15 wt. % based on the aerosolizable product. In one aspect the water is present in a total amount of from 5 to 10 wt. % based on the aerosolizable product.

Surface area of solid substrate per gram of aerosol forming material

As has been explained above, it has been found that by controlling the surface area of the calcium carbonate relative to the amount of aerosol forming material present in the aerosolizable product it is possible to avoid the issues of leakage (since a substantially solid aerosolizable product is formed) and also create a single session for vaping which ends when the aerosolizable product runs out of aerosol forming material.

In one aspect, the calcium carbonate has a specific surface area (according to the BET

[Brunauer-Emmett-Teller] method) of at least 5 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 7 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of 7 to 9 m²/g.

In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 70 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 72 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 80 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 85 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 90 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 95 m²/g. In one aspect the calcium carbonate has a specific surface area (according to the BET method) of at least 100 m²/g.

The specific surface area of the calcium carbonate may be measured in accordance with ISO 9277:2010(en) “Determination of the specific surface area of solids by gas adsorption—BET method”

Aerosolizable Product

The aerosolizable product of the present invention may contain one or more further components. These components may be selected depending on the nature of the formulation. In one aspect, the aerosolizable product further comprises an active agent. By “active agent” it is meant an agent which has a biological effect on a subject when the vapor is inhaled. The one or more active agents may be selected from nicotine, botanicals, and mixtures thereof. The one or more active agents may be of synthetic or natural origin. The active could be an extract from a botanical, such as from a plant in the tobacco family. An example active is nicotine.

In one aspect, the active agent is at least nicotine. Nicotine may be provided at any suitable amount depending on the desired dosage to be inhaled by the user. In one aspect nicotine is present in an amount of no greater than 6 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 6 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 6 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 6 wt % based on the total weight of the aerosolizable vproduct. In one aspect nicotine is present in an amount of from 1.8 to 6 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 5 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 5 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 5 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1.8 to 5 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of no greater than 4 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 4 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 4 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 4 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1.8 to 4 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of no greater than 3 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 3 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 3 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 3 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1.8 to 3 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of no greater than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of no greater than 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.5 to 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.5 to 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of less than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of less than 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to less than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.4 to less than 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.5 to less than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.5 to less than 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to less than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 0.8 to less than 1.8 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to less than 1.9 wt % based on the total weight of the aerosolizable product. In one aspect nicotine is present in an amount of from 1 to less than 1.8 wt % based on the total weight of the aerosolizable product.

In one aspect, the product includes tobacco and/or a tobacco extract.

When the product is in a solid form, it may be formed into any suitable shape. For example, solid forms may be provided to allow for different surface areas and more airflow paths through/around the material. Such shapes may be hollow centers (single or multiple holes), surface textures/channels/ridges (for less contact to hot surfaces of ovens and increased airflow around the consumable) and loose spheres/agglomerated particles which could fill different heating apparatus e.g. different shaped ovens.

When the product is in a solid form, the product is typically prepared by combining calcium carbonate with one or more liquids such as the aerosol forming material to form a material capable of being compressed into multiple solid forms. Alternatively, a solid form of calcium carbonate may be prepared into which the liquids are introduced. In either aspect, the present invention allows for the material to be compressed into a suitable form such as a pellet or pill form.

Alternatively, when higher levels of liquids are required, a paste like or putty like material (for example containing a liquid loading between 20-30%) may be prepared. This semi solid material may be delivered in any suitable manner. For example, it may be added to an aerosol generation system as a paste or putty from a tube. The semi solid systems of the present invention allow for higher aerosol formation and the ability to fill different shapes. The solid systems of the present invention have the advantage that they allow for clear airflow paths for drawing the vapor generated and reduce the amount of system cleaning required.

As will be understood by one skilled in the art, a putty is malleable. A putty may deform but not be free flowing under gravity. A putty may change shape under its own mass but under its own mass should not change shape dimensionally in any orientation by more than 10 percent over a 24 hour period.

In a further embodiment of the present invention, the aerosolizable product may be delivered in a form which is then further contained to provide a discreet product. For example, solid product such as loose powder, particles, agglomerates, spheronized material, pills or pellets may be contained within a perforated or porous wrap. This wrap is typically constructed of materials suitable for exposure to temperature ranges up to 300° C. Suitable materials are perforated metal foil, metal mesh, porous or perforated papers and fiber constructed fleece materials. The use of a porous outer wrap is advantageous since it minimizes direct contact with the aerosolizable product. Additionally the use of a porous outer wrap minimizes the risk of dust being released and potentially being inhaled.

In one aspect, the aerosolizable product further comprises a binder. The binder agents may be selected from Microcrystalline cellulose (MCC), Carboxymethyl cellulose (CMC) and mixtures thereof.

The binder may be provided at any suitable amount depending on the product. In one aspect the binder is present in a total amount of from 0.01 to 5 wt. % based on the aerosolizable product. In one aspect the binder is present in a total amount of from 0.1 to 5 wt. % based on the aerosolizable product. In one aspect the binder is present in a total amount of from 0.1 to 3 wt. % based on the aerosolizable product. In one aspect the binder is present in a total amount of from 0.5 to 3 wt. % based on the aerosolizable product. In one aspect the binder is present in a total amount of from 0.5 to 2 wt. % based on the aerosolizable product. In one aspect the binder is present in a total amount of from 1 to 2 wt. % based on the aerosolizable product.

Dosage Form

As discussed herein, the present invention further provides a dosage form of an aerosolizable nicotine product, wherein the dosage form comprises (a) active agent, such as nicotine, in an amount of 0.001 to 1 grams; (b) an aerosol forming material; and (c) a solid substrate material, wherein the solid substrate material is at least calcium carbonate wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

As discussed herein, the present invention further provides a dosage form of an aerosolizable product, wherein the dosage form comprises

(a) active agent in an amount of 0.001 to 1 grams;

(b) an aerosol forming material; and

wherein the aerosolizable product is a solid form.

As discussed herein, the present invention further provides a dosage form of an aerosolizable nicotine product, wherein the dosage form comprises (a) active agent, such as nicotine, in an amount of 0.001 to 1 grams; (b) an aerosol forming material; and (c) a substrate material, wherein the substrate material is at least calcium carbonate; wherein the calcium carbonate is present in an amount of at least 30 wt. % based on the aerosolizable nicotine product.

In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.8 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.8 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.6 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.4 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.2 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.001 to 0.1 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.02 to 0.1 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.03 to 0.1 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.04 to 0.1 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.05 to 0.1 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.01 to 0.09 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.01 to 0.08 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.01 to 0.07 grams. In one aspect the active agent, such as nicotine, is present in an amount of 0.01 to 0.06 grams.

The dosage form may be prepared from an aerosolizable product as defined herein.

Process

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and

(ii) heating the aerosolizable product.

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate;

wherein the aerosolizable product is a solid form;

(ii) heating the aerosolizable product.

The present invention further provides a process for forming an aerosol, the process comprising the steps of:

(i) providing an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product;

(ii) heating the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(ii) processing the initial mixture to form the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) processing the initial mixture to form the aerosolizable product

wherein the aerosolizable product is a solid form.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(ii) processing the initial mixture to form the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium

wherein the aerosolizable product is a solid form.

The present invention further provides a process for preparing an aerosolizable product, the process comprising the steps of:

(i) contacting an aerosol forming material and a solid substrate material, wherein the solid substrate material is at least calcium carbonate, to form an initial mixture; and

(ii) compressing the initial mixture to form an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The process of the present invention may comprises additional steps either before the steps listed, after the steps listed or between one or more of the steps listed.

In one aspect, configurations are envisaged in which the aerosolizable product of the present invention can be heated in line with flavor matrices such as flavor capsules or tobacco. The aerosol may be passed from the aerosolizable product through the flavor or tobacco matrix which may also be heated in an independent zone. As discussed herein, it is also possible to include the tobacco (or other organic media) within the calcium carbonate containing solid substrate material of the present invention.

Further Aspects

The c product may be contained or delivered by any means. In one aspect the present invention further provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a substrate material, wherein the substrate material is at least calcium carbonate

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

In a further aspect the present invention provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a solid substrate material, wherein the solid substrate material is at least calcium carbonate

wherein the aerosolizable product is a solid form.

In a further aspect the present invention provides a contained aerosolizable product comprising

(a) a container; and

(b) an aerosolizable product comprising

- (i) an aerosol forming material; and
- (ii) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The container may be any suitable container, for example to allow for the storage or delivery of the aerosolizable product. For example, the container may be a single dose pack or may be a multi dose pack. The container may be a blister pack or may be a dispenser. In one aspect the container is configured for engagement with an electronic vapor provision system. The container may be configured to become fluidly in communication with an electronic vapor provision system so that aerosolizable product may be delivered to the electronic vapor provision system. As described above, the present disclosure relates to a container which may be used in an electronic vapor provision system, such as an e-cigarette. Throughout the following description the term “e-cigarette” is used; however, this term may be used interchangeably with electronic vapor provision system.

As discussed herein, the container of the present invention is typically provided for the delivery of an aerosolizable product to or within an e-cigarette. The aerosolizable product may be held within an e-cigarette or may be sold as a separate container for subsequent use with or in an e-cigarette. As understood by one skilled in the art, e-cigarettes may contain a unit known as a detachable cartomiser which typically comprises a reservoir of aerosolizable product, a wick material and a device for vaporizing the aerosolizable product. In some e-cigarettes, the cartomiser is part of a single-piece device and is not detachable. In one aspect the container is a cartomiser or is part of a cartomiser. In one aspect the container is not a cartomiser or part of a cartomiser and is a container, such as a tank, which may be used to deliver aerosolizable product to or within an e-cigarette.

In one aspect the container is part of an e-cigarette. In one aspect the present invention further provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;

wherein the total surface area of the calcium carbonate present in the aerosolizable product is at least 25 m²per gram of aerosol forming material present in the aerosolizable product.

In a further aspect the present invention provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a solid substrate material, wherein the solid substrate material is at least calcium carbonate

wherein the aerosolizable product is a solid form.

In a further aspect the present invention provides an electronic aerosol provision system comprising:

(i) an aerosolizer for aerosolizing an aerosolizable product for inhalation by a user of the electronic aerosol provision system;

(ii) a power supply comprising a cell or battery for supplying power to the aerosolizer; and

(iii) an aerosolizable product comprising

- (a) an aerosol forming material; and
- (b) a substrate material, wherein the substrate material is at least calcium carbonate;
- wherein the calcium carbonate is present in an amount of at least 80 wt. % based on the aerosolizable product.

The invention will now be described with reference to the following non-limiting example.

Examples

Samples of aerosolizable product were prepared in accordance with the details of Table 1.

Materials Used were

Calcium Carbonate (CC): Pumex Calcitec, Calcitec Puro v/100 99%<500 micron

Microcrystalline cellulose (MCC): Avicel® PH Microcrystalline Cellulose

Carboxymethyl cellulose (CMC): Carboxymethyl cellulose sodium

Functionalised Calcium Carbonate (FCC): a Calcium Carbonate product having the following properties

Property
Test Method
Values
Unit

Calcium carbonate
XRF(0014)
52.5
%

Particle-size distribution D50
Malvern MS 2000
6.7
μm

Particle-size distribution D98
Malvern MS 2000
19
μm

Specific Surface Area (BET)
ISO 9277
70
m²/g

Blancheur CIE L•
ISO 11664-4
97.1

Sieve residue at 45 μm
ISO 787/7
0.00
%

The specific surface area of the calcium carbonate may be measured in accordance with ISO 9277:2010(en) “Determination of the specific surface area of solids by gas adsorption—BET method”

TABLE 1

CC

Surface area

Glycerol
Glycerol
Binder
Binder

Nicotine
Nicotine
Flavor
Flavor

surface area
Sample
per g of

Sample
Ingredients/Description
CC (%)
CC (g)
(%)
(g)
(%)
(g)
Water (%)
Water (g)
(%)
(g)
(%)
(g)
QTzY (g)
(m2/g)
CC area
aerosol

S16
MCC test
65.04
8
26.83
3.3
8.13
1
0
0
0
0
0
0
12.3
8
64
19.39

(Avicel PH-102)

S15
MCC test
66.67
8
25
3
8.33
1
0
0
0
0
0
0
12
8
64
21.33

(Avicel PH-102)

S14
MCC test
66.67
8
24.5
2.94
8.33
1
0
0
0
0
0.5
0.06
12
8
64
21.77

(Avicel PH-102) plus

Zamony flavor

S3
25% Glycerol,
75
7.5
25
2.5
0
0
0
0
0
0
0
0
10
8
60
24

75% CC

S17
Dual binder
65
6.5
20
2
10
1
5
0.5
0
0
0
0
10
8
52
26

test 50% MCC/50%

CMC

S12
CMC binder test
70
7
20
2
10
1
0
0
0
0
0
0
10
8
56
28

(7H3SF)-no water

S19
MCC/CMC/CC/Vype
70.07
7.02
19.95
2
9.98
1
0
0
0
0
0
0
10.01
8
56.12
28.1

blended Tobacco 12 mg

S1
20% Cirro Currant
80
8
20
2
0
0
0
0
0
0
0
0
10
8
64
32

Affairs 70/30

Glycerol/Propylene

glycol (6 mg/ml nic),

80% CC Calcium

Carbonate

S18
Dual binder test
70
7
15
1.5
10
1
5
0.5
0
0
0
0
10
8
56
37.33

50% MCC/50% CMC

S25
FCC/CMC/Glycerol
30
0.3
50
0.5
20
0.2
0
0
0
0
0
0
1
70
21
42

S26
FCC/CMC/Glycerol
40
0.4
55
0.55
5
0.05
0
0
0
0
0
0
1
70
28
50.91

S27
FCC/CMC/Glycerol
40
0.4
50
0.5
10
0.1
0
0
0
0
0
0
1
70
28
56

S8
CMC Binder
70
7
10
1
20
2
0
0
0
0
0
0
10
8
56
56

S28
FCC/CMC/Glycerol
40
0.4
45
0.45
15
0.15
0
0
0
0
0
0
1
70
28
62.22

S11
CMC binder
66.67
8
8.33
1
8.33
1
16.67
2
0
0
0
0
12
8
64
64

test (7H35F)

S13
MCC test
61.54
8
7.69
1
7.69
1
23.08
3
0
0
0
0
13
8
64
64

(Avicel PH-102)

S6
10% Glycerol,
88
88
10
10
0
0
0
0
2
2
0
0
100
8
704
70.4

88% Calcium

Carbonate,

2% Nicotine

S5
10% Glycerol,
89
89
10
10
0
0
0
0
1
1
0
0
100
8
712
71.2

89% CC Calcium

Carbonate

1% nicotine,

S2
10% Glycerol,
90
9
10
1
0
0
0
0
0
0
0
0
10
8
72
72

90% CC Calcium

Carbonate

S4
10% Glycerol,
90
90
10
10
0
0
0
0
0
0
0
0
100
8
720
72

90% CC Calcium

Carbonate

S7
5 g S5, 5 g S4, 0.2 g
88.61
8.95
8.91
0.9
0
0
0
0
0.5
0.05
1.98
0.2
10.1
8
71.6
79.56

Gluhan

Flavor

Each of the samples was visually assessed and based on this assessment, a potential delivery form was selected and this form was tested. The results are shown in Table 2.

TABLE 2

Assessment

Sample
(Pass/Fail)
Visual observations
Form testing
Potential form
Device testing

S16
Fail - Difficult to
Worked by hand until

form dough
consistent dough

formed, glycerol

visible on gloves while

working

S15
Fail - Difficult to
Worked by hand until

form dough
consistent dough

formed

S14
Fail - Difficult to
Worked by hand until

form dough
consistent dough

formed

S3
Fail
Paste like
Testing for
Paste/viscous liquid
Glycerol layer

consistency/thick
separation,

visible on top of

liquid
solution

sample

maintained for 2

21 Nov. 2016

days, ongoing

S17
Pass
Loose mix, pellets
Hollow pellets

form and hold form,

slightly soft

S12
Pass
Dough not formed,

material stays loose

when compressed by

hand

S19
Pass
Loose when mixed,

pressed into hollow

pellets. Break easily

immediately after

pressing

S1
Pass
Clumpy and damp
Pill press, forms
Loose large particles/
Pax 2 oven

outer when shook, dry
hard pellet with
pill compressible
vaporizer, max

when re-mixed
some liquid on
(wet and soft)
temperature

surface.

setting. Loose

particles tested

with vapor

generated,

lower than cig-

alike delivery

but consistent

aerosol

generated over

20-30 puffs.

Some flavor

noted in aerosol

S18
Pass
Harder pellet formed
Hollow pellets
Compressed/extruded
Vicod 5 g,

than s17

hollow pellet

form. Output

form very hard.

Softened when

left over time

S25
Pass
Able to thoroughly

mix. Produced large

granules.

Successfully formed a

pill in press. No signs

of liquid escaping the

solid matrix. After

heating, appearance

changed to brown

speckles.

Consumable was

strong and springy

after heating

S26
Pass
Formed large

granules.

Experienced shear

thinning when under

pressure of the pill

press

S27
Pass
Formed small free

flowing granules.

Successfully formed a

pill. Pill structure was

strong. No signs of

liquid escaping the

solid matrix. Lightly

speckled after heating

S8
Pass
Hollow 6 mm
Pellet/extrusion

pellets with 3 mm

hollow core

made, pellets

held shape but

were notably

softer and break

Powder when mixed

down easily.

stayed free flowing

When left over

night in ambient

conditions the

solid form

became softer

but with robust

structure

S28
Pass
Formed a fine powder

once thoroughly

mixed. Free flowing.

Formed a solid pill.

Dry in appearance.

Formed a strong and

dry pill. No signs of

liquid leakage

S11
Pass
Dough made, rollable
Hollow pellet
Drying process
Vicod 5g,

and soft
formed, soft for
would be required
hollow pellet

pelletising but
in manufacturing
form. Output

mimics extrusion.
process
form very hard

Flattened by

and not

hand and left to

possible to

dry

break by hand.

Softened when

left over time

S13
Pass
With no water

material is loose and

brittle if formed into

pellet. Dough made

after water added

S6
Pass
Dry free flowing,
Pills made with
Powder/pill
Pax oven

hold shape when
pill press,

device, temp on

compressed
compressible

high, nicotine

and holds form,

level too high

easy to impact in

auto loader

S5
Pass
Dry free flowing,
Pills made with
Powder/pill
Pax oven

hold shape when
pill press,

device, temp on

compressed
compressible

half, nicotine

and holds form,

high with high

easy to impact in

impact

auto loader

S2
Pass
Dry free flowing,
Pellets made
Powder/pill
Half of one

hold shape when
with hand punch

pellet loaded

compressed
and die. Pills

into pax, vapor

made with pill

generated. One

press,

pill loaded into

compressible

pax, vapor

and holds form,

generated, light

easy to impact in

be consistent

auto loader

delivery. Pill hot

to handle on

exit and breaks

easily when

handled.

S4
Pass
Dry free flowing, hold

Paste/viscous liquid

shape when

compressed. Flakes

visible in mixing need

time to homogenise

S7
Pass
Dry free flowing, hold

Powder/pill

shape when

compressed,

clumping after mixing

Delivery

Pellets were prepared according to Samples S19 and S20 and were placed in an oven based vaporizer (Vicod 5G, http://www.atmosrx.com/Vicod-5G.html) to assess the ability of each product to generate an aerosol. Three repetitions were carried out for each sample. Two tests were run whereby for the first test, pellets were inserted into the device with the oven already at 200° C. (results of Table 3), and for the second test, pellets were inserted into the device and then the oven was heated to 200° C. Airflow was drawn through the device whilst it was turned on and any resulting aerosol captured on a Cambridge Filter Pad (CFP). The CFP (and holder) was weighed before and after the test to check the mass change which is indicative of aerosol formation from the aerosolizable product.

It can be noted from the information in Tables 3 and 4 that heating the aerosolizable product inside the device 200° C. led to an aerosol being generated (due to the various mass changes). Accordingly, it is clear that the present invention allows the preparation of the aerosolizable products which are less prone to leakage (owing to their solid-like nature) and which can provide users with a more punctuated experience compared to liquid based systems.

TABLE 3

Pellet inserted at 200° C.

CFP +

Device
Device

Holder
CFP + Holder
Difference
Weight
Weight
Difference
Pellet
Pellet
Difference

Sample
Weight (g)
Weight after (g)
(g)
(g)
after (g)
(g)
(g)
after (g)
(g)
Notes

s19-1
64.328
64.361
0.034
99.701
99.639
−0.062
0.459
0.370
−0.089
Cream to Brown color change

s19-2
64.995
65.026
0.030
99.744
99.678
−0.066
0.485
0.400
−0.085
Cream to Brown color change

s19-3
63.834
63.864
0.030
99.710
99.652
−0.058
0.434
0.351
−0.084
Cream to Brown color change

s20-1
63.924
63.944
0.020
99.708
99.664
−0.044
0.504
0.451
−0.053
No Color Change

s20-2
63.574
63.599
0.025
99.767
99.724
−0.043
0.555
0.486
−0.069
Part of the pellet broke as it left

device

s20-3
64.593
64.617
0.024
99.764
99.718
−0.046
0.560
0.497
−0.063
No Color Change

CFP—Cambridge Filter Pad

TABLE 4

Pellet inside for heating up to 200° C.

CFP +

Device
Device

Holder
CFP + Holder
Difference
Weight
Weight
Difference
Pellet
Pellet
Difference

Sample
Weight (g)
Weight after (g)
(g)
(g)
after (g)
(g)
(g)
after (g)
(g)
Notes

S19-1
64.6806
64.7088
0.028
99.6748
99.6148
−0.060
0.4666
0.3797
−0.087
Cream to Brown color change

S19-2
64.8805
64.9140
0.034
99.7001
99.6330
−0.067
0.4589
0.3723
−0.087
Cream to Brown color change

S19-3
63.4928
63.5243
0.031
99.6947
99.6353
−0.059
0.4350
0.3521
−0.083
Cream to Brown color change

S20-1
64.0401
640627
0.023
99.7789
99.7338
−0.045
0.5749
0.5076
−0.067
No Color Change

S20-2
63.5779
63.6011
0.023
99.7422
99.3178
−0.424
0.5020
0.4683
−0.034
No Color Change

S20-3
64.5976
6.6191
0.022
99.7677
99.7181
−0.050
0.5460
0.4865
−0.060
Device charging 20 min break,

No Color Change

Various modifications and variations of the present invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in chemistry or related fields are intended to be within the scope of the following claims.

AEROSOLIZABLE PRODUCT

Information

Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

International Classifications

Abstract

Description

Claims

Priority Claims (1)

PRIORITY CLAIM

PCT Information