Claims
- 1. A liquid aerosol formulation adapted to form a vaporization aerosol, comprising ethanol and cromolyn sodium, the liquid aerosol formulation being propellant free.
- 2. The liquid aerosol formulation of claim 1, further comprising a surfactant having a hydrophilic-lipophilic balance of below 15 or below 10.
- 3. The liquid aerosol formulation of claim 1, wherein the surfactant is lecithin, sorbitan trioleate, oleic acid, polyoxyethylene laurel ether or mixtures thereof.
- 4. The liquid aerosol formulation of claim 1, further comprising up to 30 volume % of a low volatility liquid such as propylene glycol.
- 5. A propellant-free aerosol containing aerosol particles entrained in a vapor, wherein substantially all of the aerosol particles consist essentially of cromolyn sodium and surfactant and the vapor consists essentially of a carrier.
- 6. The aerosol of claim 5, wherein the surfactant is lecithin, sorbitan trioleate, oleic acid, polyoxyethylene laurel ether or mixtures thereof.
- 7. The aerosol of claim 5, wherein the aerosol particles further comprise a low volatility liquid such as propylene glycol.
- 8. An aerosol generating device, comprising:
a liquid source of a liquid aerosol formulation comprising ethanol and cromolyn sodium; a flow passage in fluid communication with the liquid source; and a heater disposed to heat liquid aerosol formulation in a heated portion of the flow passage to produce a vapor which admixes with air to produce an aerosol containing cromolyn sodium and optionally a surfactant and/or low volatility liquid such as propylene glycol.
- 9. A method of generating an aerosol, comprising:
(a) supplying a liquid aerosol formulation comprising ethanol, cromolyn sodium, optional surfactant and optional low volatility liquid from a liquid source to a flow passage; (b) heating liquid aerosol formulation in a heated portion of the flow passage to produce a vapor; and (c) admixing the vapor with air to produce an aerosol containing cromolyn sodium and optionally a surfactant and/or low volatility liquid such as propylene glycol.
- 10. The method of claim 9, wherein the liquid aerosol formulation further includes propylene glycol in an amount effective to prevent clogging of the flow passage.
- 11. A method of generating an aerosol, comprising:
(a) supplying a liquid aerosol formulation comprising a carrier, cromolyn sodium, optional surfactant and optional low volatility liquid to a flow passage; (b) heating the liquid aerosol formulation in a heated portion of the flow passage to produce a vapor; and (c) admixing the vapor with air to produce an aerosol.
- 12. A liquid aerosol suspension adapted to form a vaporization aerosol, comprising a high volatility carrier and a second component, the liquid aerosol formulation being propellant free and containing a zwitterionic and/or non-ionic surfactant.
- 13. A method of generating an aerosol, comprising:
(a) supplying a liquid aerosol suspension comprising a high volatility carrier and a second component to a flow passage and a zwitterionic and/or non-ionic surfactant; (b) heating the liquid aerosol suspension in a heated portion of the flow passage to produce a vapor; (c) admixing the vapor with air to produce an aerosol.
- 14. The method of claim 13, wherein the carrier comprises ethanol and the second component comprises cromolyn sodium.
- 15. The method of claim 13, wherein aerosol particles of the aerosol have a mass median aerodynamic diameter of about 0.5 to 5 microns.
- 16. The method of claim 13, wherein the liquid aerosol suspension further includes a low volatility liquid.
- 17. The method of claim 16, wherein the aerosol includes the surfactant and the low volatility liquid.
- 18. The method of claim 13, wherein the liquid aerosol suspension includes ethanol and propylene glycol, the heating vaporizes at least part of the ethanol and the vapor is jetted from the flow passage as a mist of aerosol particles containing non-vaporized liquid propylene glycol.
- 19. The method of claim 13, wherein the flow passage is a capillary sized flow passage.
- 20. A method of treating asthma in a subject in need thereof, comprising administering the aerosol produced according to the method of claim 13.
Parent Case Info
[0001] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Application No. 60/468,266 entitled AEROSOLIZATION OF AN ETHANOL-BASED SUSPENSION BY THE CAPILLARY AEROSOL GENERATOR filed on May 7, 2003, the entire content of which is hereby incorporated by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60468266 |
May 2003 |
US |