Claims
- 1. A method for preventing or treating infections
- (A) that are present on the exterior of a human being or animal, and
- (B) that are caused by pathogenic microorganisms which have in their outer layer
- (a) pili, or
- (b) other surface structures exhibiting hydrophobic interaction,
- which method comprises administering to the site of the infection on the exterior of humans or animals a therapeutically effective amount of a modified agarose, said modified agarose being
- (1) water-insoluble,
- (2) cross-linked with glycerol-ether bridges, and
- (3) substituted with palmitoyl groups.
- 2. A method according to claim 1 wherein said exterior of humans or animals includes body cavities having external orifices.
- 3. A method according to claim 1 wherein said agarose is in the form of water-insoluble particles having a size within the range of 0.1-1000 .mu.m.
- 4. A method for preventing or treating infections
- (A) that are present on the exterior of a human being or animal, and
- (B) that are caused by pathogenic microorganisms which have in their outer layer
- (a) pili, or
- (b) other surface structures exhibiting hydrophobic interaction,
- which method comprises administering to the site of the infection on the exterior of humans or animals a therapeutically effective amount of a physiologically acceptable polymer
- (1) that is based on agarose or derivatives thereof, and
- (2) that contains hydrophobic groups,
- (a) which are placed in branches projecting from the agarose base skeleton,
- (b) which are straight, branched or ring-closed, saturated or unsaturated hydrocarbon claims containing at least 8 carbon atoms and at most 30 carbon atoms, and
- (3) having a molecular weight which is sufficiently high to prevent it from readily penetrating cellular membranes.
- 5. A method according to claim 4 wherein the polymer comprises a cross-linked agarose which is substituted with said hydrophobic groups.
- 6. A method according to claim 4 wherein said polymer also exhibits ion-exchange groups.
- 7. A method according to claim 4 wherein said polymer is in the form of water-insoluble particles having a particle size within the limits 0.1-1000 .mu.m.
- 8. A method according to claim 4 wherein said hydrophobic groups are palmitoyl groups.
- 9. A method according to claim 4 wherein said hydrophobic groups are stearoyl groups.
- 10. A method according to claim 4 wherein said exterior of humans or animals includes body cavities having external orifices.
- 11. A method for preventing or treating infections
- (A) that are present on the exterior of a human being or animal, and
- (B) that are caused by pathogenic microorganisms which have in their outer layer
- (a) pili, or
- (b) other surface structures exhibiting hydrophobic interaction,
- which method comprises administering to the site of the infection on the exterior of humans or animals a therapeutically effective amount of a physiologically acceptable polymer
- (1) that is based on one or more polysaccharides or derivatives thereof, and
- (2) that contains hydrophobic groups,
- (a) which are placed in branches projecting from the polymeric base skeleton,
- (b) which are straight, branched or ring-closed, saturated or unsaturated hydrocarbon claims containing at least 8 carbon atoms and at most 30 carbon atoms, and
- (3) having a molecular weight which is sufficiently high to prevent it from readily penetrating cellular membranes.
- 12. A method according to claim 11 wherein said polymer also exhibits ion-exchange groups.
- 13. A method according to claim 11 wherein said polymer is in the form of water-insoluble particles having a particle size within the limits 0.1-1000 .mu.m.
- 14. A method according to claim 11 wherein said hydrophobic groups are palmitoyl or stearoyl groups.
- 15. A method according to claim 11 wherein said exterior of humans or animals include body cavities having external orifices.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7905523 |
Jun 1979 |
SEX |
|
Parent Case Info
This is a continuation of application Ser. No. 402,349, filed July 27, 1982, now abandoned.
US Referenced Citations (20)
Foreign Referenced Citations (5)
Number |
Date |
Country |
386067 |
Feb 1933 |
GBX |
904874 |
Sep 1962 |
GBX |
1090421 |
Nov 1967 |
GBX |
1180960 |
Nov 1970 |
GBX |
1544434 |
Apr 1979 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Smythe, C. et al., Infection and Immunity, vol. 22, pp. 462-472, 1976. |
Martin, G. J., "Ion Exchange and Adsorption Agents in Medicine", Boston, Toronto, pp. 33-35 and 54-57, 195. |
J. Chromatograpy, vol. 101, pp. 281-288, 1974. |
Continuations (1)
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Number |
Date |
Country |
Parent |
402349 |
Jul 1982 |
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