Claims
- 1. A compound of the formula: ##STR2## in which R is represented by a substituent selected from the group consisting of
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH.sub.2 -CH.sub.3,
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH(CH.sub.3).sub.2,
- -CO-CH.dbd.CH-CH.dbd.CH-CH-CH.sub.2 -CH.sub.2 -CH(CH.sub.3).sub.2,
- -CO(CH.sub.2).sub.6 -CH.sub.3,-CO(CH.sub.2).sub.5 CH(CH.sub.3).sub.2 and
- -CO(CH.sub.2).sub.6 CH(CH.sub.3).sub.2, a pharmaceutically acceptable acid addition salt thereof, or a mixture of said compounds present in any proportion.
- 2. A compound of claim 1 wherein
- R is represented by:
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH.sub.2 -CH.sub.3,
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH(CH.sub.3).sub.2 or
- -CO-CH.dbd.CH-CH.dbd.CH-CH.sub.2 -CH.sub.2 -CH(CH.sub.3).sub.2
- or a pharmaceutically acceptable acid addition salt thereof.
- 3. A compound of claim 1 wherein R is represented by:
- -CO(CH.sub.2).sub.6 -CH.sub.3' -CO(CH.sub.2).sub.5 CH(CH.sub.3).sub.2 or
- -CO(CH.sub.2).sub.6 CH(CH.sub.3).sub.2
- or a pharmaceutically acceptable acid addition salt thereof.
- 4. A topical pharmaceutical formulation for the treatment of wound infection or acne comprising an antibacterially effective amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
- 5. A method for combatting infectious diseases in mammals comprising administering an antibacterially effective amount of a compound of claim 1 to a mammal in need thereof.
- 6. A method of claim 5 wherein the infectious disease is a wound infection or acne and the compound is topically administered.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8808658 |
Apr 1988 |
GBX |
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Parent Case Info
This is a continuation of application Ser. No. 08/315,030, filed Sep. 28, 1994, now abandoned, which is a continuation of application Ser. No. 08/210,119, filed Mar. 17, 1994, now abandoned, which is a continuation of Ser. No. 08/073,252, filed Jun. 7, 1993, now abandoned, which is a continuation of Ser. No. 07/880,613, filed May 8, 1992, now abandoned, which is a divisional of Ser. No. 07/670,378, filed Mar. 14, 1991, now abandoned, which is a continuation of 07/336,262, filed Apr. 11, 1989, now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4303646 |
Cavalleri et al. |
Dec 1981 |
|
4427656 |
Cavalleri et al. |
Jan 1984 |
|
4661470 |
Malabarba et al. |
Apr 1987 |
|
5108988 |
Ciabatti et al. |
Apr 1992 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0259870 |
Mar 1988 |
EPX |
Non-Patent Literature Citations (3)
Entry |
Morita et al., J.C.S. Chem. Comm. pp. 874-875 (1978). |
Cavalleri et al., The Journal of Antibiotics, vol. XXXVII, No. 4, pp. 309-317 (Apr. 1984). |
Cavalleri et al., The Journal of Antibiotics, vol. XL, No. 1, pp. 49-59 (Jan. 1987). |
Divisions (1)
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Number |
Date |
Country |
Parent |
670378 |
Mar 1991 |
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Continuations (5)
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Number |
Date |
Country |
Parent |
315030 |
Sep 1994 |
|
Parent |
210119 |
Mar 1994 |
|
Parent |
73252 |
Jun 1993 |
|
Parent |
880613 |
May 1992 |
|
Parent |
336262 |
Apr 1989 |
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