Patent Application
20130217746
The present invention relates to aqueous agrochemical concentrates, as well as methods of making and using the aqueous agrochemical concentrates.
Bioactive agrochemicals are usually sold as concentrated formulations and prior to use they are diluted with water and subsequently applied to plants, e.g. by spraying. Such formulations may include ingredients in addition to the agrochemical active ingredient to improve the product, e.g. to assist with dispersion of the active in water, to improve plant up-take of the active, to improve the bioactivity of the active, or to improve shelf-life etc.
There are a number of different types of formulation that are commonly used with bioactive agrochemicals. These include soluble concentrates (SL), emulsifiable concentrates (EC), suspension concentrates (SC), oil-in-water emulsions (EW), water-dispersible powders (WP), water-dispersible granules (WG), suspoemulsions (SE) and microcapsule suspensions (CS).
Some types of formulation, particularly formulations other than emulsifiable concentrates, benefit greatly from the presence of an adjuvant, i.e. an agent used to enhance the bioperformance (activity) of the bioactive agrochemical. Adjuvants can vary in complexity from simple surfactants to multi-component blended oils. Some adjuvants, such as alcohol ethoxylates, display liquid crystalline behaviour at high concentrations in water (WO 2005/013692). It can be difficult to formulate agrochemical concentrates containing such adjuvants at high concentrations due to the high viscosity of the liquid crystalline phases. The liquid crystalline phases can be cubic, hexagonal or lamellar phases, with different phases forming at different concentrations and different temperatures. The cubic and hexagonal phases are highly viscous, the lamellar phase is less viscous but we have found that this is still viscous enough to give problems with pourability, rinsability from the container and/or dilution into water for spray application.
WO 2005/013692 describes use of hydrotropes to address the problem of adjuvants exhibiting liquid crystalline behaviour. Hydrotropes are generally considered to be molecules that solubilise hydrophobic compounds in water. Typically, hydrotropes are amphiphiles and consist of a hydrophilic part and a small hydrophobic part. Addition of hydrotropes can disrupt the liquid crystalline phases but use of many hydrotropes often results in a solution that is still highly viscous.
WO 2005/048707 describes the use of particular water soluble solvent to act as anti-gel forming and anti-caking agent for aqueous suspension concentrate compositions comprising polyoxyalkylene alkyl ethers. The anticaking agents are described as glycol based aqueous solvents such as ethylene glycol, diethylene glycol, dipropylene glycol and propylene glycol, with dipropylene glycol being preferred. However, we have found that use of such glycol solvents can result in a solution that is still highly viscous.
For agrochemical concentrates comprising adjuvants that exhibit liquid crystalline behaviour in water it can be important to reduce the viscosity of the agrochemical concentrate in order to provide good pourability, good rinsability from the container and/or for ease of dilution into water for spray application.
It has now surprisingly been found that aryl sulphonates and particular alcohols can disrupt these liquid crystalline phases, leading to a liquid phase of a much lower viscosity.
Accordingly, in a first aspect the invention provides a method of reducing the viscosity of an aqueous agrochemical concentrate comprising a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l; the method comprising including, e.g. adding, b) a compound selected from:
The aryl sulphonate, aliphatic mono alcohol, aliphatic polyol or aryl alcohol may be considered as viscosity reducing agents, e.g. they may disrupt liquid crystalline phases of the adjuvant, thereby reducing the viscosity of the concentrate. Preferably, such viscosity reducing agents are capable of maintaining the adjuvant in the liquid phase in water, e.g. the viscosity reducing agent is capable of preventing the adjuvant from adopting liquid crystalline phases when mixed with water. The liquid crystalline phases may be considered to be gel phases. For example, at particular concentrations of adjuvant, usually high concentrations, the presence of the viscosity reducing agent will maintain the adjuvant in the liquid phase whereas in the absence of the viscosity reducing agent the adjuvant will be a gel, e.g. liquid crystalline gel. The aryl sulphonate, aliphatic mono alcohol, aliphatic polyol or aryl alcohol are highly effective at reducing the viscosity of the liquid phase.
In one embodiment the invention provides a method of reducing the viscosity of an aqueous agrochemical concentrate comprising an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine comprising including an aryl sulphonate in the aqueous agrochemical concentrate, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l, and wherein the aqueous agrochemical concentrate comprises an agrochemical active ingredient.
In a further embodiment the invention provides a method of reducing the viscosity of an aqueous agrochemical concentrate comprising an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine comprising including an aliphatic mono alcohol in the aqueous agrochemical concentrate, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l, and wherein the aqueous agrochemical concentrate comprises an agrochemical active ingredient.
In a further embodiment the invention provides a method of reducing the viscosity of an aqueous agrochemical concentrate comprising an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine comprising including an aliphatic polyol comprising at least four contiguous carbon atoms in the aqueous agrochemical concentrate, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l and wherein the aqueous agrochemical concentrate comprises an agrochemical active ingredient.
In yet a further embodiment the invention provides a method of reducing the viscosity of an aqueous agrochemical concentrate comprising an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine including an aryl alcohol in the aqueous agrochemical concentrate, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l, and wherein the aqueous agrochemical concentrate comprises an agrochemical active ingredient.
In a further aspect, the invention provides an aqueous agrochemical concentrate comprising
a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine; wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) a compound selected from
In one embodiment, the invention provides an aqueous agrochemical concentrate comprising
a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine; wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) an aryl sulphonate; and
c) an agrochemical active ingredient.
In a further embodiment, the invention provides an aqueous agrochemical concentrate comprising
a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine; wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) an aliphatic mono alcohol; and
c) an agrochemical active ingredient.
In a further embodiment, the invention provides an aqueous agrochemical concentrate comprising
a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine; wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l.
b) an aliphatic polyol comprising at least four contiguous carbon atoms; and
c) an agrochemical active ingredient.
Sometimes a high adjuvant concentration is desirable in order to increase the efficacy of the agrochemical active ingredient, or a high loaded formulation is more convenient for the end-user. For example, the adjuvant may be present in the aqueous agrochemical concentrate at at least 100 g/l, at least 180 g/l, or at least 230 g/l. For example, the adjuvant may be −50-800 g/l of the aqueous agrochemical concentrate, e.g. 100-500 g/l, e.g. 150-400 g/l.
The adjuvant may be present in the aqueous agrochemical concentrate at a concentration such that it exhibits liquid crystalline behaviour in the absence of the viscosity reducing agent, e.g. at 5° C.
The adjuvant may be an alkoxylated aliphatic acid, alkoxylated aliphatic alcohol, alkoxylated aliphatic amide or alkoxylated aliphatic amine, which aliphatic acid, aliphatic alcohol, aliphatic amide or aliphatic amine has a C8-C20 alkyl or C8-C20 alkenyl group. For example, the adjuvant may have the formula I:
R1—(CO)p—Z—[—R2O—]q—R3 (I)
wherein
Z is O, NH, or N(—[—R2O—]q—R3) providing that Z is O or NH when p is 1;
R1 is C8-C20 alkyl or C8-C20 alkenyl;
each R2 is independently C2-C4 alkyl;
R3 is hydrogen or C1-C8 alkyl; p is 0 or 1; and
q is 2 to 40.
Preferably Z is O. Preferably, R3 is C1-C8 alkyl, more preferably butyl. We have found that “end capping” the adjuvant with butyl is advantageous since a lower level of viscosity can be achieved with the same amount of viscosity reducing agent, compared to the corresponding uncapped adjuvant. Without being bound by theory, one explanation for this result could be that butyl “end capping” the adjuvant disrupts the packing of the adjuvant molecules in the liquid crystalline phase or the packing of the adjuvant molecules with the viscosity reducing agent. A “capped adjuvant” is one where R3 is not H.
More preferably, the adjuvant is one wherein: Z is O, R1 is C8-C20 alkyl or C8-C20 alkenyl; R2 is ethyl; R3 is C1-C8 alkyl; p is 0; and q is 2 to 40.
More preferably, the adjuvant is one wherein: Z is O, R1 is C16-C20 alkyl or C16-C20 alkenyl; R2 is ethyl; R3 is butyl; p is 0; and q is 5 to 30.
Usually the adjuvant in the aqueous agrochemical concentrate will be a blend of the molecules, e.g. in which Z, R1, R2, R3, q and p may have different values. For example, at least 50, 60, 70, 80, 90, or even 100% of the adjuvant molecules in the concentrate may be molecules according to formula I. For example, at least 50, 60, 70, 80, 90, or even 100% of the adjuvant molecules may be molecules in which R3 is C1-C8 alkyl. In particular, there will usually be a distribution of alkylene oxide chain lengths. Preferably the average value of q is 10 to 25, more preferably 18 to 22, even more preferably about 20. The term “average” refers to the mode average. At least 50, 60, 70, 80, 90, or even 100% of the adjuvant molecules in the concentrate may be molecules in which: Z is O, R1 is C16-C20 alkyl or C16-C20 alkenyl; R2 is ethyl; R3 is butyl; p is 0; and q is an average of 18-22
Adjuvants of the present invention may be prepared by conventional techniques, e.g. as described in WO 03/022048.
In one embodiment the viscosity reducing agent is an aryl sulphonate. The aryl sulphonate may be a compound of formula II:
A-SO3− (II)
wherein A is phenyl optionally substituted by one or more groups independently selected from C1-C8 alkyl, C1-C8 haloalkyl, hydroxy and halogen. Preferably, A is phenyl optionally substituted by one to three groups independently selected from C1-C8 alkyl, C1-C8 haloalkyl, hydroxy and halogen. More preferably, A is phenyl optionally substituted by one to three C1-C8 alkyl, more preferably optionally substituted by one or two C1-C4 alkyl.
Examples of particular aryl sulphonates for use as viscosity reducing agents are toluene sulphonate, xylene sulphonate and cumene sulphonate:
Most preferred is cumene sulphonate, e.g. ammonium cumene sulphonate.
In a further embodiment the viscosity reducing agent is an aliphatic mono alcohol, i.e. a compound containing one hydroxy group. The aliphatic mono alcohol may be a compound of formula III:
R4—OH (III)
wherein R4 is C4-C16 alkyl optionally substituted by C3-C8 cycloalkyl, or C3-C8 cycloalkyl optionally substituted by C1-C8 alkyl. Preferably, R4 is C4-C16 alkyl or C3-C6 cycloalkyl, even more preferably C4-C12 alkyl or C5-C6 cycloalkyl, most preferably C4-C8 alkyl or cyclohexanol. Examples of particular aliphatic mono alcohols for use as viscosity reducing agents are n-hexanol, 2-ethyl hexanol, n-butanol, cyclohexanol, and n-octanol.
In a further embodiment the aliphatic mono alcohol is a compound of formula III in which R4 is propyl, preferably isopropyl.
In a further embodiment the viscosity reducing agent is an aliphatic polyol, i.e. an alcohol containing more than one hydroxy group. The aliphatic polyol may be an aliphatic diol of the formula IV
R5—OH (IV)
wherein R5 is C4-C16 alkyl optionally substituted by C3-C8 cycloalkyl, or C3-C8 cycloalkyl optionally substituted by C1-C8 alkyl, and wherein R5 is substituted by one additional hydroxy. Preferably, R5 is C4-C16 alkyl or C3-C6 cycloalkyl, even more preferably C4-C12 alkyl or C5-C6 cycloalkyl, most preferably C4-C8 alkyl or cyclohexanol, likewise in each case substituted by one additional hydroxy. Examples of particular aliphatic diols for use as viscosity reducing agents are 2-ethyl 1,3 hexanediol, 1,2 pentanediol and 2-methyl 2,4 pentanediol (also known as hexylene glycol).
In a further embodiment the viscosity reducing agent is an aryl alcohol. The aryl alcohol may be a compound of formula V
B—OH (V)
wherein B is phenyl optionally substituted by one or more groups independently selected from C1-C4 alkyl, C1-C4 haloalkyl, carboxyl, sulphonyl, hydroxy and halogen. Preferably, B is phenyl optionally substituted by at least carboxyl or sulphonyl, more preferably carboxyl. Preferably, the viscosity reducing agent is salicylate.
Where possible the viscosity reducing agent may be provided in salt form or unprotonated form. Suitable salts will be apparent to the person skilled in the art, e.g. alkali metal salts, e.g. sodium and potassium salts, and ammonium salts. The viscosity reducing agent could also be added to the formulation in the acidic form, forming the salt in-situ e.g. with a basic surfactant or a basic active ingredient.
The term “optionally substituted” as used herein means substituted or not substituted. Alkyl and alkenyl groups as defined herein may be straight chains or branched chains.
The aqueous agrochemical concentrate is preferably a suspension concentrate (SC) formulation, e.g. an aqueous suspension of finely divided insoluble solid particles of the agrochemical active ingredient. SC formulations may be prepared by ball or bead milling a solid agrochemical active ingredient in a suitable medium to produce a fine particle suspension of the agrochemical active ingredient. The particle size is typically from 0.2-15 microns, for example from 0.5 to 5 microns median diameter. The agrochemical active ingredient may be combined with other formulation ingredients and added to water, or it may be added to water already containing other formulation ingredients. The order of addition of ingredients to the aqueous agrochemical concentrate is generally not critical, although it is preferable to add the viscosity reducing agent into the aqueous phase (optionally containing the active ingredient) before the addition of the adjuvant in order to speed up dissolution of the adjuvant.
The agrochemical composition may contain other ingredients found in commercial agrochemical concentrate formulations, e.g. surfactants, dispersants, polymers, wetting agents, other adjuvants stabilizers, pH modifiers, anti-freeze agents, suspending agents, emulsifiers, antifoam agents, pH stabilising agents, preservatives and the like.
The agrochemical active ingredient may be any agrochemical active ingredient, including pesticides, plant growth regulators, safeners, etc. A pesticide is for example a herbicide, fungicide or insecticide.
As examples of herbicides suitable for formulation as a concentrate there may be mentioned mesotrione, fomesafen, tralkoxydim, napropamide, amitraz, propanil, pyrimethanil, dicloran, tecnazene, toclofos methyl, flamprop M, 2,4-D, MCPA, mecoprop, clodinafop, clodinafop-propargyl, cyhalofop-butyl, diclofop methyl, haloxyfop, quizalofop-P, indol-3-ylacetic acid, 1-naphthylacetic acid, isoxaben, tebutam, chlorthal dimethyl, benomyl, benfuresate, dicamba, dichlobenil, benazolin, triazoxide, fluazuron, teflubenzuron, phenmedipham, acetochlor, alachlor, metolachlor, pretilachlor, thenylchlor, alloxydim, butroxydim, clethodim, cyclodim, sethoxydim, tepraloxydim, pendimethalin, dinoterb, bifenox, oxyfluorfen, acifluorfen, fluoroglycofen-ethyl, bromoxynil, ioxynil, imazamethabenz-methyl, imazapyr, imazaquin, imazethapyr, imazapic, imazamox, flumioxazin, flumiclorac-pentyl, picloram, amodosulfuron, chlorsulfuron, nicosulfuron, rimsulfuron, triasulfuron, triallate, pebulate, prosulfocarb, molinate, atrazine, simazine, cyanazin, ametryn, prometryn, terbuthylazine, terbutryn, sulcotrione, isoproturon, linuron, fenuron, chlorotoluron and metoxuron.
As examples of fungicides suitable for formulation as a concentrate, in addition to those mentioned elsewhere, there may be mentioned azoxystrobin, trifloxystrobin, kresoxim methyl, famoxadone, metominostrobin and picoxystrobin, cyprodanil, carbendazim, thiabendazole, dimethomorph, vinclozolin, iprodione, dithiocarbamate, imazalil, prochloraz, fluquinconazole, epoxiconazole, flutriafol, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, hexaconazole, paclobutrazole, propiconazole, tebuconazole, triadimefon, triticonazole, fenpropimorph, tridemorph, fenpropidin, mancozeb, metiram, chlorothalonil, thiram, ziram, captafol, captan, folpet, fluazinam, flutolanil, carboxin, metalaxyl, bupirimate, ethirimol, dimoxystrobin, fluoxastrobin, orysastrobin, metominostrobin and prothioconazole.
As examples of insecticides suitable for formulation as a concentrate there may be mentioned thiamethoxam, imidacloprid, acetamiprid, clothianidin, dinotefuran, nitenpyram, fipronil, abamectin, emamectin, bendiocarb, carbaryl, fenoxycarb, isoprocarb, pirimicarb, propoxur, xylylcarb, asulam, chlorpropham, endosulfan, heptachlor, tebufenozide, bensultap, diethofencarb, pirimiphos methyl, aldicarb, methyl, cyprmethrin, bioallethrin, deltamethrin, lambda cyhalothrin, cyhalothrin, cyfluthrin, fenvalerate, imiprothrin, permethrin, halfenprox and tefluthrin.
In one embodiment the agrochemical active ingredient is fungicide from the class of succinate dehydrogenase inhibitors (SDHI). The class of fungicides known as succinate dehydrogenase inhibitors is an art-recognised class with a mode of action that targets the enzyme succinate dehydrogenase (SDH, so-called complex II in the mitochondrial respiration chain), which is a functional part of the tricarboxylic cycle and linked to the mitochondrial electron transport chain. SDH consists of four subunits (A, B, C and D) and it is understood, without being bound by theory, that the binding site of ubiquinone (and of SDHIs) is formed by the subunits B, C and D. SDHI fungicides have been grouped under FRAC (Fungicide Resistance Action Committee) code number 7. See www.frac.info.
The SDHI class of fungicides includes phenyl benzamides, e.g. benodanil, flutolanil and mepronil; pyridinyl-ethyl-benzamides, e.g. fluopyram, furan-carboxamides, e.g. fenfuram, oxathin-carboxamides, e.g. carobxin oxycarboxin; thiazole-carboxamides, e.g. thifluzamide; pyrazole carboxamides, e.g. bixafen, furametpyr, isopyrazem, penflufen, penthiopyrad and sedaxane; and pyridine carboxamides, e.g. boscalid.
Preferably the SDHI fungicide is a compound of formula VII
wherein R2 is CF3, CF2H or CFH2,
A is thienyl, phenyl, or ethylene each optionally substituted by one to three groups independently selected from halogen, methyl and methoxy,
B is a direct bond, cyclopropylene, an annelated bicyclo[2.2.1]heptane- or bicyclo[2.2.1]heptene ring, and
D is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkyl, C1-C6 alkylidene, C1-C6 haloalkylidene, phenyl or phenyl optionally substituted by one to three substituents independently selected from halogen and trihalomethylthio.
The compound of formula VII is preferably a compound of formula VIII (Isopyrazam), a compound of formula IX (Sedaxane), a compound of formula X, a compound of formula XI (Penthiopyrad), a compound of formula XII (Bixafen), a compound of formula XIII (Fluxapyroxad), a compound of formula XIV, or a compound of formula XV.
Isopyrazam, Sedaxane, Penthiopyrad, Fluxapyroxad and Bixafen are known fungicides. The compound of formula X is known, e.g. from WO 2007/048556, the compound of formula XIV is known e.g. from WO 2010/000612, the compound of formula XV is known e.g. from WO 2008/053044. The compound of formula VII is preferably Isopyrazam.
When the agrochemical active ingredient is an SDHI fungicide the viscosity reducing agent is preferably an aryl sulphonate, e.g. as described above. We have found that use of these viscosity reducing agents in combination with Isopyrazam reduces crystal growth in the aqueous agrochemical concentrate compared to concentrates using other viscosity reducing agents.
The aqueous agrochemical concentrate comprises the agricultural active ingredient in an amount to allow application of the agrochemical active ingredient at an effective rate. The “effective rate” can be experimentally determined and depends on the type of agrochemical active ingredient used. The concentration of the active ingredient in the concentrate could be also designed for ease of dilution by the end-user, e.g. to allow application at the desired number of litres of product per hectare. The concentration of the active ingredient in the concentrate could also be designed to reduce packaging and transportation costs. For example, the agrochemical active ingredient may be up to 700 g/l, e.g. 10-500 g/l, e.g. 50-300 g/l.
The aqueous agrochemical concentrate comprises an effective amount of the viscosity reducing agent, e.g. a concentration such that the viscosity of the aqueous agrochemical concentrate comprising the adjuvant is reduced compared to the absence of the agent. An effective amount of the viscosity reducing agent may be experimentally determined.
For example, when the viscosity reducing agent is an aryl sulphonate or an aryl alcohol, it may be present in the aqueous agrochemical concentrate at at least 1 g/l, at least 5 g/l, at least 10 g/l, at least 20 g/l, at least 30 g/l, at least 50 g/l, at least 100 g/l. The aryl sulphonate or aryl alcohol may be present in the range from 1-500 g/l, from 10-400 g/l, from 10-200 g/l, from 10-150 g/l.
For example, when the viscosity reducing agent is an aliphatic alcohol, it may be present in the aqueous agrochemical concentrate at at least 1 g/l, at least 5 g/l, at least 10 g/l, at least 20 g/l, at least 30 g/l, at least 50 g/l, at least 100 g/l I. The alcohol may be present in the range from 1-500 g/l, from 10-400 g/l, from 10-200 g/l, from 10-150 g/l.
When the aqueous agrochemical concentrate comprises a suspending agent it will contain an effective amount of the suspending agent. This may be experimentally determined.
The proportion of adjuvant relative to active ingredient can readily be selected by one skilled in the art to meet the intended utility. Typically the w/w ratio of adjuvant to active ingredient will range from 1:50 and 200:1 and preferably from 1:5 to 20:1.
The aqueous agrochemical concentrates of the invention may contain more than one type of adjuvant, more than one type of viscosity reducing agent, and/or more than one type of agrochemical active ingredient. In particular, the aqueous agrochemical concentrate may include more than one viscosity reducing agent, e.g. it may contain an aryl sulphonate and an alcohol, in particular an aryl sulphonate and an aliphatic alcohol, e.g. an aryl sulphonate and an aliphatic mono alcohol. A preferred combination is cumene sulphonate and 2-ethylhexanol.
The aqueous agrochemical concentrate may be various suitable formulation types, e.g. a suspension concentrate, a mixture of a suspension concentrate and soluble liquid, a mixture of a suspension concentrate and capsule suspension. Preferably, the aqueous agrochemical concentrate is a suspension concentrate formulation.
In a further aspect, the invention provides use of a compound selected from:
In one embodiment the compound is an aryl sulphonate, e.g. as described above. In another embodiment the compound is an aliphatic mono alcohol, e.g. as described above. In another embodiment the compound is an aliphatic polyol, e.g. as described above. In another embodiment the compound is an aryl alcohol, e.g. as described above.
Preferably, the adjuvant is one as defined above. Preferably, the agrochemical active ingredient is a fungicide, more preferably a fungicide from the SDHI class of fungicides, even more preferably Isopyrazam.
In a further aspect, the invention provides a method comprising diluting the aqueous agrochemical concentrate in a spray tank.
In a further aspect the invention provides a method of controlling or preventing infestation of plants by phytopathogenic microorganisms by application of an aqueous agrochemical composition comprising
a) an adjuvant selected from an alkoxylated aliphatic acid, an alkoxylated aliphatic alcohol, an alkoxylated aliphatic amide and an alkoxylated aliphatic amine; wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) a compound selected from
Preferably the adjuvant is one as defined above. Preferably, the agrochemical active ingredient is a fungicide, more preferably a fungicide from the SDHI class of fungicides, even more preferably Isopyrazam.
Anti-settling agents are added to formulations to prevent the separation of components on long-term storage. Such anti-settling/structuring agents typically increase the viscosity of the formulation. However, as the formulation often has to be poured by the end user it is desirable for the stabilising structure to be easily broken by shear. In a suspension concentrate formulation the anti-settling agent is usually a swelling clay such as bentonite (sodium montmorillonite) which may be mixed with a water-soluble polymers to achieve synergistic rheological effects. The water-soluble polymer is usually a cellulose derivative or polysaccaharide such as Xanthan gum (Chemistry and Technology of Agrochemical Formulations, D A Knowles, Kluwer Academic Publishers 1998). However, we have found that commonly used suspending agents such as Bentopharm, Kelzan, Aerosil 200, Bentone SD-3, Bentone 1000, Jaguar HP120, Hydroxy propyl cellulose, are ineffective at high adjuvant concentration.
We have now surprisingly found that attapulgite clay is highly effective as a suspending agent with alkoxylated adjuvants, e.g. those that display liquid crystalline behaviour at high concentrations in water.
Accordingly, in a further aspect, the invention provides a method of suspending an agrochemical active ingredient in an aqueous agrochemical concentrate, which aqueous agrochemical concentrate comprises
a) an adjuvant, which adjuvant is an alkoxylated fatty acid, an alkoxylated fatty alcohol, an alkoxylated fatty amide or an alkoxylated fatty amine, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) an agrochemical active ingredient;
Attapulgite is a hydrous magnesium aluminum silicate clay mineral with a unique structure made up of colloidal particles that are needle-like in shape. It is recognised as a distinct clay mineral. Attapulgite is described for example in Wolford, Journal of ASTM International, 2007, Vol. 4, No. 10, pages 1-4 (paper ID JAI100396), and in Haden. W. L. Haden, Jr. Attapulgite: Properties and uses: in Clays and Clay Minerals, Proc. IOth Natl. Conf., Austin, Tex., 1961
Sometimes a high adjuvant concentration is desirable in order to increase the efficacy of the agrochemical active ingredient, or a high loaded formulation is more convenient for the end-user. For example, the adjuvant may be present in the aqueous agrochemical concentrate at at least 100 g/l, at least 180 g/l, or at least 230 g/l. For example, the adjuvant may be 50-800 g/l of the agrochemical concentrate, e.g. 100-500 g/l, e.g. 150-400 g/l.
The adjuvant may be an alkoxylated aliphatic acid, alkoxylated aliphatic alcohol, alkoxylated aliphatic amide or alkoxylated aliphatic amine as described above.
Preferably, the aqueous agrochemical concentrate comprises a viscosity reducing agent. The viscosity reducing agent may be a hydrotrope, e.g. as described in WO 2005/013692. Hydrotropes are generally considered to be molecules that solubilise hydrophobic compounds in water. Typically, hydrotropes are amphiphiles and consist of a hydrophilic part and a small hydrophobic part. Hydrotropes, e.g. those described in WO 2005/013692, include anionic benzoates, anionic benzosulphonates, anionic phosphates and phosphonates, anionic benzophosphates, arylphosphates and phosphonates, neutral phenols such as catechol and resorcinol, aliphatic glycolsulfates, alicyclic bile salts, aliphatic carboxylates, aromatic carboxylates, naphthalene sulphonates, alkynaphthalene sulphonates, polymeric naphthalene sulphonates and their copolymers, aryl sulphonates and carboxylates and their polymers and copolymers, naphthalene and alkylnaphthalene phosphates and phosphonates and their polymers and copolymers, glycol and glycerol ethers and the amino acid proline. Preferably, the viscosity reducing agent is selected from an aryl sulphonate, an aliphatic alcohol, an aryl alcohol, as described above. We have found that molecules from these classes function as viscosity reducing agents with the adjuvants of the invention and are highly effective at reducing the viscosity of the liquid phase.
Where possible the viscosity reducing agent may be provided in salt form or unprotonated form. Suitable salts will be apparent to the person skilled in the art, e.g. alkali metal salts, e.g. sodium and potassium salts, and ammonium salts. The viscosity reducing agent could also be added to the formulation in the acidic form, forming the salt in-situ e.g. with a basic surfactant or a basic active ingredient.
Preferably the agrochemical concentrate is a suspension concentrate as described above.
The agrochemical composition may contain other ingredients found in commercial agrochemical concentrate formulations, e.g. surfactants, dispersants, polymers, wetting agents, other adjuvants stabilizers, pH modifiers, anti-freeze agents, suspending agents, emulsifiers, antifoam agents, pH stabilising agents, preservatives and the like.
The aqueous agrochemical concentrate preferably comprises an agrochemical active ingredient. The agrochemical active ingredient may be any agrochemical active ingredient, including pesticides, plant growth regulators, safeners, etc. A pesticide is for example a herbicide, fungicide or insecticide. These are described above.
In one embodiment the agrochemical active ingredient is fungicide from the class of succinate dehydrogenase inhibitors (SDHI) as described above.
The aqueous agrochemical concentrate comprises the agricultural active ingredient in an amount to allow application of the agrochemical active ingredient at an effective rate as described above.
The aqueous agrochemical concentrate may comprise an effective amount of the viscosity reducing agent as described above.
The aqueous agrochemical concentrate comprising attapulgite comprise an effective amount of attapulgite. This may be experimentally determined. For example, the attapulgite may be present in the aqueous agrochemical concentrate at a concentration of 1-40 g/l, e.g. 1-20 g/l, 5-20 g/l, e.g. 7-20 g/l. Preferably the attapulgite will be present in the aqueous agrochemical concentrate at at least 1 g/l, at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 g/l.
The agrochemical concentrates of the invention may contain more than one type of adjuvant, more than one type of viscosity reducing agent, and/or more than one type of agrochemical active ingredient.
In a further aspect, the invention provides an aqueous agrochemical concentrate comprising
a) an adjuvant, which adjuvant is an alkoxylated fatty acid, an alkoxylated fatty alcohol, an alkoxylated fatty amide or alkoxylated fatty amine, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) attapulgite;
c) an agrochemical active ingredient;
Preferably, the aqueous agrochemical concentrate also comprises c) a viscosity reducing agent that is capable of preventing the adjuvant from adopting a liquid crystalline phase when mixed with water. Preferably, the agrochemical active ingredient is a fungicide, more preferably a fungicide from the SDHI class of fungicides, even more preferably Isopyrazam.
In a further aspect, the invention provides use of attapulgite as a suspending agent in an aqueous agrochemical concentrate, which aqueous agrochemical concentrate comprises
a) an adjuvant, which adjuvant is an alkoxylated fatty acid, an alkoxylated fatty alcohol, an alkoxylated fatty amide or an alkoxylated amine, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l;
b) an agrochemical active ingredient.
Preferably, the aqueous agrochemical concentrate also comprises c) a viscosity reducing agent that is capable of preventing the adjuvant from adopting a liquid crystalline phase when mixed with water. Preferably, the agrochemical active ingredient is a fungicide, more preferably a fungicide from the SDHI class of fungicides, even more preferably Isopyrazam.
In a further aspect, the invention provides a method comprising diluting in a spray tank the aqueous agrochemical concentrate.
In a further aspect, the invention provides a method of controlling or preventing infestation of plants by plant pests by application of an aqueous agrochemical composition to the plants, plant parts or locus thereof, comprising
a) an adjuvant, which adjuvant is an alkoxylated fatty acid, an alkoxylated fatty alcohol, an alkoxylated fatty amide or an alkoxylated fatty amine;
b) attapulgite; and
c) an agrochemical active ingredient;
wherein the method comprises providing the agrochemical composition by diluting an aqueous agrochemical concentrate, wherein the concentration of adjuvant in the aqueous agrochemical concentrate is at least 50 g/l.
Preferably, the aqueous agrochemical concentrate also comprises d) a viscosity reducing agent that is capable of preventing the adjuvant from adopting a liquid crystalline phase when mixed with water. Preferably, the agrochemical active ingredient is a fungicide, more preferably a fungicide from the SDHI class of fungicides, even more preferably Isopyrazam.
The terms alkoxylated fatty acid, alkoxylated fatty alcohol, alkoxylated fatty amide and alkoxylated fatty amine are used interchangeably with alkoxylated aliphatic acid, alkoxylated aliphatic alcohol, alkoxylated aliphatic amide and alkoxylated aliphatic amine respectively.
The present invention will now be described by way of the following non-limiting Examples. Those skilled in the art will promptly recognize appropriate variations from the procedures both as to reactants and as to reaction conditions and techniques.
All references mentioned herein are incorporated by reference in their entirety. All aspects and preferred features of the invention may be combined with each other, except where this is evidently not possible.
The composition of products used in the Examples was as follows:
Eltesol AC60 contains ammonium cumene sulphonate, 60% w/w (“Eltesol” is a trade mark). Eltesol ST90 contains sodium toluene sulphonate 90% w/w.
Dowfax 2A1 and Dowfax 3B2 contain alkyl substituted diphenyl oxide disulphonate surfactants (in Dow trade literature described as having hydrotropic and surfactant properties in one molecule) (“Dowfax” is a trade mark).
Dowfax 2A1 contains a branched C12 diphenyl oxide disulphonate, sodium salt, 45% w/w
Dowfax 3B2 contains a linear C10 diphenyl oxide disulphonate, sodium salt, 45% w/w
Berol AG 6202 contains 2-ethylhexyl polyglucoside, 65% w/w (“Berol” is a trade mark).
Berol AG 6206 contains hexyl polyglucoside, 75% w/w
MeadWestvaco Diacid H-240 from MeadWestvaco contains the compound:
(“MeadWestvaco” is a trade mark).
MeadWestvaco Diacid H-240 contains a C21 dibasic fatty acid, potassium salt, 40-45% w/w
MeadWestvaco H240 is described as containing a hydrotrope in MeadWestvaco trade literature.
Rhodopol 23 contains standard grade xantham gum (antisettling agent) (“Rhodopol” is a trade mark).
Atlox 4913 is polymethyl methacrylate-polyethylene glycol graft copolymer (dispersant) (“Atlox” is a trade mark).
Soprophor 4D384 is Tristyrylphenol-16 EO, ammonium sulphate (dispersant) (“Soprophor” is a trade mark).
Aerosol OTB is 85% w/w sodium dioctyl sulfosuccinate, 15% w/w sodium benzoate (wetter).
Jaguar HP120 contains hydroxypropyl guar gum (anti-settling agent) (“Jaguar” is a trade mark).
Amistar BIW is a commercial product containing azoxystrobin (“Amistar” is a trade mark).
The concentrations of hydrotropes quoted throughout the examples are the actual concentrations of the hydrotropes used, they are not the use concentrations of the products as supplied. The actual concentration quoted in the example can be converted into a product concentration using the concentration listed above for each of the hydrotropes.
An oeyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant and various hydrotropes were added to water, mixed by rolling and then the solutions were equilibrated in an oven at 40° C. for a few days. The adjuvant was added at 40% w/v and the hydrotropes were added at the concentrations quoted in Table 1. The viscosity of the liquid solutions was measured using a Bohlin Gemini rheometer fitted with a C14 concentric cylinder geometry in controlled strain rate mode. The viscosity at a shear rate of 100 s−1 was measured over a temperature range from 5° C. to 40° C. using a temperature increase of 1° C./minute.
The results at 5° C. are shown in Table 1. The 40% w/v oeyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant solution without hydrotrope forms a highly viscous liquid crystalline gel at 5° C. This sample was too viscous to determine an accurate measure of the viscosity within the time-frame of the experiment.
All of the hydrotropes listed in Table 1 prevented the formation of the highly viscous liquid crystalline gel at 5° C.
These results show that aryl sulphonates and sodium salicylate are highly effective at reducing the viscosity compared to other types of molecules commonly used as hydrotropes.
Isopyrazam suspension concentrate (SC) formulations were prepared with the compositions shown in Table 2. The Isopyrazam was bead milled in water containing the dispersing agents and the wetting agent to produce a concentrated fine particle suspension. The other formulation ingredients were added after the milling stage and incorporated with a high shear Silverson mixer. The dispersing and wetting agents used in all these compositions were a combination of Atlox 4913, Soprophor 4D384 and Aerosol OTB in a ratio of 18:6:1.
Viscosity data for the compositions 1-5 is shown in Table 3. The viscosity data was measured using Anton-Paar MCR 301 and 501 Rheometers using a CC17 cup and bob geometry. The samples were pre-sheared and left for 30 minutes before the viscosity was measured at 5° C. Composition 1 was too viscous to determine an accurate measure of the viscosity within the time-frame of the experiment.
It can be seen that increasing the concentration of Eltesol AC60 in the Isopyrazam compositions breaks up the highly viscous liquid crystalline gel and leads to a decrease in the viscosity of the suspension concentrate formulation at 5° C.
An oeyl ethoxylate (10 ethoxylate units) butyl end capped adjuvant and the aryl sulphonate Eltesol AC60 were added to water, mixed by rolling, and then the solutions were equilibrated in an oven at 40° C. for a few days. The adjuvant was added at 40% w/v and the Eltesol AC60 was added at the concentrations quoted in Table 4. The viscosity of the solutions containing the oeyl ethoxylate (10 ethoxylate units) butyl end capped adjuvant and the Eltesol AC60 was measured using a Bohlin Gemini rheometer fitted with a C14 concentric cylinder geometry in controlled strain rate mode. The viscosity at a shear rate of 100 s−1 was measured over a temperature range from 5° C. to 40° C. using a temperature increase of 1° C./minute.
The results at 5° C. are shown in Table 4. The 40% w/v oeyl ethoxylate (10 ethoxylate units) butyl end capped adjuvant solution with no Eltesol AC60 present forms a highly viscous gel at 5° C. This sample was too viscous to determine an accurate measure of the viscosity within the timeframe of the experiment. Results are shown in Table 4.
These results show that aryl sulphonates are highly effective at reducing viscosity.
An oeyl ethoxylate (10 ethoxylate units) uncapped adjuvant and the aryl sulphonate Eltesol AC60 were added to water, mixed by rolling and then the solutions were equilibrated in an oven at 40° C. for a few days. The adjuvant was added at 40% w/v and the Eltesol AC60 was added at the concentrations quoted in Table 5. The viscosity of the solution containing the oeyl ethoxylate (10 ethoxylate units) uncapped adjuvant and 20% w/v Eltesol AC60 was measured using a Bohlin Gemini rheometer fitted with a C14 concentric cylinder geometry in controlled strain rate mode. The viscosity at a shear rate of 100 s−1 was measured over a temperature range from 5° C. to 40° C. using a temperature increase of 1° C./minute.
The results at 5° C. are shown in Table 5. The 40% w/v oeyl ethoxylate (10 ethoxylate units) uncapped adjuvant solutions with no Eltesol AC60 present and with 10% w/v Eltesol AC60 form highly viscous gels at 5° C. These samples were too viscous to determine an accurate measure of the viscosity within the timeframe of the experiment. Results are shown in Table 5.
These results in Examples 3 and 4 show that when the adjuvants are butyl end capped a lower level of viscosity can be achieved with the same amount of aryl sulphonate, compared to the corresponding uncapped adjuvant.
An oeyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant and the aliphatic mono alcohols in Table 6 were added to water, mixed by rolling, and then the solutions were equilibrated in an oven at 40° C. for a few days. The adjuvant was added at 40% w/v and the aliphatic mono alcohols were added at the concentrations quoted in Table 6. The viscosity of the liquid solutions was measured using a Bohlin Gemini rheometer fitted with a C14 concentric cylinder geometry in controlled strain rate mode. The viscosity at a shear rate of 100 s−1 was measured over a temperature range from 5° C. to 40° C. using a temperature increase of 1° C./minute. The results at 5° C. are shown in Table 6.
The 40% w/v oeyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant solution without hydrotrope forms a highly viscous gel at 5° C. This sample was too viscous to determine an accurate measure of the viscosity within the timeframe of the experiment.
These results show that aliphatic mono alcohols are highly effective at reducing the viscosity.
An oeyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant and the diols listed in Table 8 were added to water, mixed by rolling, and then the solutions were equilibrated in an oven at 40° C. for one day. The adjuvant was added at 40% w/v and the diols were added at 10% w/v. The viscosity of the solutions was measured using an Anton-Paar MCR501 rheometer using a CC17 cup and bob geometry. The viscosity at a shear rate of 100 s−1 was measured at 5° C. Results are shown in Table 7.
The 40% w/v oleyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant solution in water forms a highly viscous liquid crystalline gel at 5° C. The solution containing 40% w/v oleyl ethoxylate (20 ethoxylate units) butyl end capped adjuvant in combination with 10% w/v propylene glycol also formed a highly viscous liquid crystalline gel at 5° C. Both of these samples were too viscous to determine an accurate measure of the viscosity within the timeframe of the experiment.
These results show that aliphatic diols are highly effective at reducing the viscosity. In comparison, addition of 10% w/v propylene glycol does not prevent formation of the highly viscous liquid crystalline phase.
Isopyrazam suspension concentrate (SC) formulations were prepared with the compositions shown in Table 8. The Isopyrazam was bead milled in water containing the dispersing agents and the wetting agent to produce a concentrated fine particle suspension. The other formulation ingredients were added after the milling stage and incorporated with a high shear Silverson mixer. The dispersing and wetting agents used in all these compositions were a combination of Atlox 4913, Soprophor 4D384 and Aerosol OTB in a ratio of 18:6:1.
After manufacture 20 ml of formulation was stored in a 28 ml glass vial at 25° C. and the physical stability with time visually inspected. The % height of clear layer compared to the total sample height in a 28 ml vial was measured. Table 9 demonstrates clear differences in physical stability with variation in anti-settling agent. Water was used as the make-up component when volumes of anti-settling systems were varied.
As shown in Table 9 visual inspection indicated that formations stabilised using the common anti-settling sytem of Bentopharm/Kelzan were unstable whereas formulation stabilised using Attapulgite were satisfactorily stable.
Formulations were prepared using the same method as outlined in Example 7.90 g/l of a second active ingredient was added to the Isopyrazam and bead milled to achieve a dispersion of fine particulates. In this example the level of Oleyl ethoxylate 20EO butyl end capped was reduced to 235 g/l. A range of anti-settling systems was incorporated into this mixture and the physical stability measured with time at a standard temperature. The % of clear layer compared to the total sample height in a 28 ml vial was measured.
Table 10 shows the surprising results that only attapulgite prevented significant separation of the formulation over 3 or more weeks stationary storage.
Samples prepared as described in Example 7 using a range of anti-settling agents. Viscosity data for the compositions 1-5 is shown in Table 11. The viscosity data was measured using Anton-Paar MCR 301 and 501 Rheometers using a CC17 cup and bob geometry. The samples were pre-sheared and left for 30 minutes before the viscosity was measured at 25° C.
Table 11 shows only Attapulgite (11 g/l) gives the highly shear thinning rheological profile similar to commercial standard. A shear thinning rhelogical profile is commonly desirable to allow the formulation of both physical stable and pourable, in this particular example it is crucial due to the highly viscous nature of the mixture at low temperature yet highly mobile behaviour at high temperatures.
To make a commercially acceptable product it must be both physically stable and pourable. Pourability can be measured using CI PCA method MT148. As described by this method 500 ml of product was placed in a stopper measuring cylinder and allowed to stand undisturbed for 24 hours at the temperature indicated in the table below (Room temperature or 5° C.). The contained is then emptied at an angle of 45° for 60 seconds and then inverted for 60 seconds. The percentage weight of the residue in the container with respect to the total mass of the original 500 ml is deemed the pourability value. A pourability value of below 5% is deemed acceptable for product registration.
Table 12 shows the results of a commercial standard and two formulations prepared using the method outlined in example 7.
Table 12 demonstrates that these products have acceptable pourability values even at low temperatures.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10188306.4 | Oct 2010 | EP | regional |
| 10188308.0 | Oct 2010 | EP | regional |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/EP2011/068435 | 10/21/2011 | WO | 00 | 4/23/2013 |
