Claims
- 1. A [2,4,5-cis]-dioxane of the formula I:
- wherein A.sup.1 and A.sup.2 form a direct link; R.sup.2 is hydrogen or (1-4C) alkyl; R.sup.3 together with R.sup.1 forms vinylene; R.sup.4 and R.sup.5 are independently selected from hydrogen, halogeno, (1-4C)alkyl, (1-4C)alkoxy, nitro, cyano, trifluoromethyl, hydroxy, (1-4C)alkanoylamino and (2-4C)alkanoyloxy, or R.sup.4 and R.sup.5 together form (1-4C)alkylenedioxy attached to adjacent carbon atoms in Q when the latter completes a benzene ring; Y is vinylene; n is 1; m is 2; Q, in conjunction with its adjoining carbon atoms, completes a benzene or pyridine ring; and Z is carboxy, 1(H)-tetrazol-5yl, or a group of the formula --CO.NH.SO.sub.2 R.sup.6 wherein R.sup.6 is (1-6C)alkyl, benzyl or phenyl, the latter two of which are unsubstituted or bear a halogeno, (1-4C)alkyl, (1-4C)alkoxy, nitro, cyano or trifluoromethyl substituent, or a pharmaceutically acceptable salt thereof.
- 2. A compound as claimed in claim 1 wherein R.sup.2 is hydrogen, methyl, ethyl; R.sup.4 and R.sup.5 are independently selected from hydrogen, fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, hydroxy, nitro, cyano, trifluoromethyl, formamido, acetamido, acetoxy and propionyloxy, or R.sup.4 and R.sup.5 together form methylenedioxy or ethylenedioxy attached to adjacent carbon atoms in Q when the latter completes a benzene ring; R.sup.6 is methyl, ethyl, propyl, isopropyl, benzyl or phenyl, the latter two of which are unsubstituted or bear a fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, nitro, cyano or trifluoromethyl substituent; n is 1; and m is 2.
- 3. A naphthyl compound of the formula IIb ##STR2## wherein R.sup.2 is hydrogen or (1-4C)alkyl; R.sup.4 and R.sup.5 are independently selected from hydrogen, halogeno, (1-4C)alkyl, (1-4C)alkoxy, hydroxy, nitro, cyano and trifluoromethyl, or R.sup.4 and R.sup.5 together form methylenedioxy; p is 2; and Z is carboxy, 1(H)-tetrazol-5-yl or a group of the formula --CO.NH.SO.sub.2 R.sup.6 wherein R.sup.6 is (1-6C)alkyl, benzyl or phenyl, the latter two of which are unsubstituted or bear a halogeno, (1-4C)alkyl, (1-4C)alkoxy, nitro, cyano or trifluoromethyl substituent; or a pharmaceutically acceptable salt thereof.
- 4. A compound as claimed in claim 3 wherein R.sup.2 is hydrogen, methyl, ethyl; R.sup.4 and R.sup.5 are independently selected from hydrogen, fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, hydroxy, nitro, cyano and trifluoromethyl, or R.sup.4 and R.sup.5 together form methylenedioxy attached to adjacent carbon atoms; R.sup.6 is methyl, ethyl, propyl, isopropyl, benzyl, or phenyl, the latter two of which are unsubstituted or bear a fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, nitro, cyano or trifluoromethyl substituent.
- 5. A salt as claimed in claim 3 or 1 which is selected from alkali metal, alkaline earth metal, aluminum or ammonium salts, and from salts with organic amines and quaternary bases, forming physiologically acceptable cations.
- 6. The compound 4(Z)-6-([2,4,5-cis]-4-o-hydroxyphenyl-2-(2-naphthyl)-1,3-dioxan-5-yl)hexenoic acid and the pharmaceutically acceptable salts thereof.
- 7. A method of antagonizing one or more of the actions of thromboxane A.sub.2 in a warm-blooded animal requiring such treatment which comprises administering to the said animal an effective amount of a compound of formula I or IIb, or a pharmaceutically acceptable salt thereof, as defined in claim 3 or 1.
- 8. A pharmaceutical composition for use in antagonizing one or more of the actions of thromboxane A.sub.2 in a warm-blooded animal which comprises an effective amount of a compound of formula I or IIb, or a pharmaceutically acceptable salt thereof, as claimed in claim 3 or 1 together with a pharmaceutically acceptable diluent or carrier.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8511896 |
May 1985 |
GBX |
|
8531893 |
Dec 1985 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 06/861,335, filed May 9, 1986, now U.S. Pat. No. 4,824,858.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4567197 |
Brewster et al. |
Jan 1986 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
0094239 |
Nov 1983 |
EPX |
0142323 |
May 1985 |
EPX |
0142324 |
May 1985 |
EPX |
0145260 |
Jun 1985 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
861335 |
May 1986 |
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