ALKENYLGUANINE ANALOGS--A NEW CLASS OF ANTIVIRAL AGENT

Information

• Research Project
• 2073264

• ApplicationId

  2073264

• Core Project Number

  R43AI036788

• Full Project Number

  1R43AI036788-01A1

• Serial Number

  36788

• FOA Number

• Sub Project Id

• Project Start Date

  9/1/1995 - 29 years ago

• Project End Date

  4/30/1996 - 28 years ago

• Program Officer Name

• Budget Start Date

  9/1/1995 - 29 years ago

• Budget End Date

  4/30/1996 - 28 years ago

• Fiscal Year

  1995

• Support Year

  1

• Suffix

  A1

• Award Notice Date

  8/15/1995 - 29 years ago

Organizations

• ARONEX PHARMACEUTICALS, INC. C/O ANTIGENICS, INC

The specific aims of this proposal are to develop certain structure activity relationships with respect to a novel class of antiviral agents and to conduct preliminary experiments designed to define the mechanism of action for these drugs. Preliminary studies have established that certain alkenes, when attached to a guanine congener, provide potential antiviral agents with improved therapeutic indices against debilitating, human, DNA viral infections (human cytomegalovirus, herpes simplex virus). It is proposed to synthesize additional derivatives of the lead active compounds wherein certain structural variations will be made in the unsaturated hydrocarbon moiety. A study and comparison of the antiviral activity of these additional derivatives will be used to construct a hypothetical model of the structural features suggesting the most promising drug candidate. Information from simultaneous studies on the mechanism of antiviral action of these drugs will be incorporated into the development of the model. PROPOSED COMMERCIAL APPLICATION: A large commercial market can be identified for new, and/or novel, antiviral agents against DNA viruses.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG7

• Study Section Name

• Organization Name

  ARONEX PHARMACEUTICALS, INC.

• Organization Department

• Organization DUNS

• Organization City

  THE WOODLANDS

• Organization State

  TX

• Organization Country

  UNITED STATES

• Organization Zip Code

  77380

• Organization District

  UNITED STATES