Claims
- 1. A compound of the formula: ##STR40## wherein R represents alkyl having 2 to 6 carbon atoms, alkenyl having 2 to 6 carbon atoms, alkynyl having 2 to 6 carbon atoms, or --(CH.sub.2).sub.m --R.sup.3 wherein R.sup.3 represents cycloalkyl of 3 to 5 carbons atoms and m is 1 or 2;
- R.sup.1 represents alkyl having 1 to 4 carbon atoms;
- R.sup.2 represents hydrogen or alkyl having 1 to 5 carbon atoms;
- R.sup.4 represents alkyl having 1 to 6 carbon atoms;
- n is an integer from 1 to 5;
- p is an integer from 0 to 6;
- Y represents NH; and
- Z represents hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently hydrogen or alkyl having 1 to 4 carbon atoms, or SR.sup.6 wherein R.sup.6 is, hydrogen, benzyl or alkyl having 1 to 4 carbon atoms;
- and the stereoisomers and pharmaceutically acceptable salts thereof.
- 2. A compound according to claim 1 of the formula ##STR41## wherein R represents alkyl having 2 to 4 carbon atoms, alkenyl having 3 to 4 carbon atoms, or cyclopropylalkyl wherein the alkyl moiety has 1 to 2 carbon atoms;
- R.sup.1 represents methyl or ethyl;
- R.sup.2 represents hydrogen or alkyl having 1 to 3 carbon atoms;
- n is an integer from 1 to 3;
- p is an integer from 0 to 4;
- Y represents NH; and
- Z represents hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, NH.sub.2 or SR.sup.6 wherein R.sup.6 is, hydrogen, benzyl, or alkyl having 1 to 4 carbon atoms; and the stereoisomers and pharmaceutically acceptable salts thereof.
- 3. A compound according to claim 1 of the formula ##STR42## wherein R represents propyl, 2-propenyl, or cyclopropylmethyl;
- p is an integer from 0 to 2;
- Y represents NH; and
- Z represents hydrogen, NH.sub.2, alkyl having 1 to 2 carbon atoms, alkoxy having 1 to 2 carbon atoms, or SR.sup.6 wherein R.sup.6 is hydrogen, benzyl or methyl; and the stereoisomers and pharmaceutically acceptable salts thereof.
- 4. A compound according to claim 3 which is 3,4dihydro-7-[3-[3-methoxy-4-[2-[(phenylmethyl)-thio]-1H-imidazol-4yl]-2-propylphenoxy]propoxy]-8propyl-2H-1-benzopyran-2-carboxylic acid.
- 5. A compound according to claim 3 which is 3,4-dihydro-7-[3-[4-(1H-imidazol-4-yl)-3-methoxy-2-propylphenoxy]propoxy-8-propyl-2H-1-benzopyran-2-carboxylic acid.
- 6. A pharmaceutical composition for treating leukotriene B.sub.4 mediated conditions comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 7. A pharmaceutical composition for treating inflammatory diseases comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 8. A method of treating leukotriene B.sub.4 mediated conditions comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 9. A method of treating inflammatory diseases comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 10. A method according to claim 9 wherein the inflammatory disease is rheumatoid arthritis.
- 11. A method according to claim 9 wherein the inflammatory disease is psoriasis.
- 12. A method according to claim 9 wherein the inflammatory disease is inflammatory bowel disease.
- 13. A method according to claim 9 wherein the inflammatory disease is gout.
- 14. A method according to claim 9 wherein the inflammatory disease is asthma.
- 15. A method according to claim 9 wherein the inflammatory disease is multiple sclerosis.
Parent Case Info
This is a division, of application Ser. No. 07/759,272, filed Sep. 13, 1991, which is a divisional of U.S. Ser. No. 07/521,777 filed on May 10, 1990, now U.S. Pat. No. 5,073,562.
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Divisions (2)
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Number |
Date |
Country |
Parent |
759272 |
Sep 1991 |
|
Parent |
521777 |
May 1990 |
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