TREA

Alkyl Dimethyl Organosilane Quaternaries in Persistent Systems and Methods

Follow

Information

  • Patent Application
  • 20200375190
  • Publication Number
    20200375190
  • Date Filed
    July 31, 2018
    6 years ago
  • Date Published
    December 03, 2020
    4 years ago
Information
Abstract
The technology described herein includes methods and uses for quaternary ammonium, specifically an organosilane quaternary ammonium or quat, and particularly AIVIOSILQ™ quat to provide persistent disinfectant and anti-microbial protection. Uses include skin (derma) and medical applications.
Description
BACKGROUND

Benzyl ammonium quaternary chlorides (BAC) are effective antimicrobial compounds. Current BAC formulations been found to be most effective as antimicrobial agents as mixtures of various alkyl dimethyl chain lengths. Other well-known quaternary ammonium compounds or “quats” are known to have disinfectant properties and are used in various settings. Quat-based disinfectants and sanitizers may be used on skin and hard non-porous surfaces to kill and prevent the spread of infectious agents including bacteria, viruses, fungus, algae, and the like. Quat-based disinfectants may be used in healthcare, hospitality, schools, agriculture, as well as various other locations and settings where killing and reducing the spread of infectious agents is desired.


Many skin and surface disinfectants are capable of disinfecting or treating immediately; however, the effectiveness is short lived and at times immediately goes away after application. Therefore, skin and surface treatments, along with disinfected surfaces that keep a persistent or long-term state of effectiveness are desirable.







DETAILED DESCRIPTION

Described herein are uses, systems and methods for the use of a quatemary ammonium or “quat”, and in particular, octadecyldimethyl (3-trihydroxypropyl) ammonium chloride, or the trademarked AMOSILQTM “quat”.


The AMOSILQ™ “quat” may be applied or be used in various forms such as the following described implementations. For example:


USE FOR SKIN AND SURFACES
ALCOHOL AND ORGANOSILANE COMBO ON SKIN:





    • Increased binding, homogeneity (minimal to no domain formation once dry) and antimicrobial efficacy of self-assembled organosilane quaternary based polymeric barrier on skin due to the presence of varying percentages of ethanol and isopropyl alcohol. Example formulation ranges includes up to 70% alcohol in solution, and organosilane quaternary of up to 10% in solution, based on solubility in given formulation and amount required for desired antimicrobial efficacy. Formulation is also based on ranges within both hand and surface applications.

    • Better binding and be more effective as an antimicrobial in the presence of ethanol and or isopropyl alcohol. This combined effect could result in higher/broader spectrum of kill rates both in solution and once the organosilane quatemary binds to the surface. Once dried, the organosilane quaternary compound forms an organized antimicrobial layer capable of weakening/destroying the cell membrane of the target organism. Alcohol works to denature all proteins once the membrane has been compromised. Together, the overall antimicrobial efficacy can be enhanced. Alcohol also increases the stability and drying time of the self-assembled polymeric nano-barriers formed, thus enhancing binding, antimicrobial efficacy and decreasing domain formation on the surface.

    • These functions can also be applied to non-living porous and non-porous substrates

    • Surfaces can include metal, glass, plastics, rubber, ceramics and fabrics including cellulose, cotton, acetates, nylon, etc.





Applications:





    • DUAL FUNCTIONING HAND WASH AND RUB PRODUCT:
      • Formulation can act as both an antiseptic hand wash and rub (hand sanitizer without water). This can be a two-step process from the same bottle. Step one) Wash hands with product to remove unwanted grim. Step 2) Pump and rub on hands for long lasting antimicrobial protection

    • OVER THE COUNTER SKIN APPLICATIONS
      • TOPICAL ANTIMICROBIAL: HEALTHCARE, FIRST AID AND CONSUMER ANTISEPTICS
        • Purposes:
          • Consumer hand rub
          • Consumer hand wash
          • First aid hand rub
          • First aid hand wash
          • Patient preoperative skin preparation
          • Healthcare professional hand rub
          • Healthcare professional hand wash
          • Surgical hand scrub
          • Surgical hand rub
        • Potential forms:
          • Liquid
          • Gel
          • Spray
          • Foam
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Alcohol, ethanol, ethyl alcohol
          • Benzalkonium chloride
          • Benzethonium chloride
          • Chlorhexidine gluconate
          • Chloroxylenol
          • Iodine tincture USP
          • Iodine topical solution USP
          • Isopropyl alcohol
          • Mercufenol chloride
          • Combinations:
          •  Calomel, oxyquinoline benzoate, triethanolamine, and phenol derivative
          •  Mercufenol chloride and secondary amyltricresols in 50 percent alcohol
      • TOPICAL SKIN PROTECTANT AND ANTIMICROBIAL FOR DIAPER RASH
        • Purpose:
          • Helps treat and prevent diaper rash
          •  Antimicrobial
          •  Helps protect minor skin irritation due to diaper rash and helps seal out wetness
        • Potential forms:
          • Spray
          • Cream
          • Ointment
          • Powder
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Alkyldimethyl Benzylammonium chloride
          • Allantoin (5-ureidohydantoin)
          • Aluminum acetate
          • Aluminum hydroxide
          • Amylum
          • Balsam peru
          • Benzethonium chloride
          • Benzocaine
          • Bicarbonate of soda
          • Bismuth subnitrate
          • Boric acid
          • Calamine
          • Calcium carbonate
          • Camphor
          • Casein
          • Cod liver oil
          • Cysteine hydrochloride
          • Dibucaine
          • Diperodon hydrochlorid
          • Glycerin
          • Hexachlorophene
          • 8-hydroxyquinoline
          • Iron oxide
          • Lanolin
          • Menthol
          • Methapyrilene
          • Methionine
          • Methylbenzethonium chloride
          • Oil of eucalyptus
          • Oil of lavender
          • Oil of peppermint
          • Oil of white thyme
          • Panthenol
          • Para-chloromercuriphenol
          • Petrolatum
          • Phenol
          • Pramoxine hydrochloride
          • Salicylic acid
          • Silicone
          • Sorbitan monosterate
          • Talc
          • Tetracaine
          • Vitamin A
          • Vitamin A palmitate
          • Vitamin D
          • Vitamin D2
          • Vitamin E
          • White petrolatum
          • Zinc oxide
          • Zinc stearate
      • TOPICAL FIRST AID ANTIBIOTIC DRUG PRODUCTS
        • Purpose:
          • Help prevent infection in minor cuts, scrapes, and bums
        • Potential forms:
          • Cream
          • Ointment
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Bacitracin ointment
          • Bacitracin zinc
          • Chlortetracycline hydrochloride
          • Neomycin sulfate
          • Tetracycline hydrochloride
          • Oxytetraclyine hydrochloride
      • TOPICAL ANTIFUNGAL DRUG PRODUCTS
        • Purpose:
          • Inhibits the growth and reproduction of fungal cells and deceases the number of fungi present
          • To treat athletes foot, jock itch ringworm
        • Potential forms:
          • Cream
          • Gel
          • Aerosol
        • Potential active ingredients that can be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Clioquinol
          • Haloprogin
          • Miconazole nitrate
          • Povidone-iodine
          • Tolnaftate
          • Undecylenic acid
          • Calcium undecylenate
          • Copper undecylenate
          • Zinc undecylenate
      • TOPICAL ACNE DUG PRODUCTS
        • Purpose:
          •  Acne medication, acne treatment
          •  Formulation form:
          •  Lotion
          •  Cream
          •  Ointment
          •  Gel
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Resorcinol
          • Resorcinol monoacetate
          • Salicylic acid
          • Sulfur
      • TOPICAL SKIN PROTECTANT: DEODORANT
        • Purpose:
          •  antiseptic, antiperspirant
        • Formulation form:
          • Solid
          • Gel
          • Liquid
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Sodium stearate
          • Sodium chloride
          • Stearyl alcohol
          • Potassium alum
          • Aluminum Zirconium
          • Aluminum Chlorohydrate
          • Aluminum chloride
      • TOPICAL: DENTAL
        • Purpose:
          • Antiseptic, Anti-gingivitis, anti-plaque, anti-cavity
        • Formulation form:
          • Liquid
          • Spray
          • Paste
          • Gel
        • Potential active ingredients to be combined with organosilane quaternary ammonium compound such as (3-(Trimethoxysil)Propyl)OctadecyDimethylAmmonium Chloride:
          • Sodium fluoride
          • Sodium monofluorophoshate
          • Hydrogen peroxide
          • Stannoud fluoride
          • Cetylpyridinium chloride
          • Thymol
          • Menthol
          • Eucalyptol
          • Methyl salicylate





MEDICAL DEVICE COATINGS







      • The application of organosilane compound alone or in combination with other coatings for enhanced, long lasting, non-leaching antimicrobial properties polymeric nano-barriers formed, thus enhancing binding, antimicrobial efficacy and decreasing domain formation on the surface.

      • Length of antimicrobial protection depends on application, exposure to living system parameters (heat, chemistry, flow), surface cleaning agents and overall exposure to abrasion

      • Organosilane can be embedded during manufacturing of devices, coated post production or applied in clinical setting

      • Additional favorable biological interfacing properties also possible including reduced inflammation and immune response after implantation







DISPOSABLE DEVICE PACKAGING
NON-SURGICAL/NON-IMPLANT ABLE DEVICES





    • Personal Protective Equipment
      • Gloves
      • Personnel hair, nose and mouth protectors
      • Scrubs and gowns
      • Goggles

    • Wound care
      • Bandages/ wraps

    • Orthopedic
      • Braces/casting

    • Exam room equipment

    • Laboratory equipment

    • Diagnostic modality components

    • EMS/patient transport equipment





SURGICAL EQUIPMENT





    • Surgical tools

    • Surgical tool packaging

    • Surgical furniture





IMPLANTABLE DEVICES





    • Stents

    • Pacemakers

    • Bladder catheters

    • Central venous catheters

    • Fracture fixation devices

    • Dental implants

    • Joint prostheses

    • Vascular grafts

    • Cardiac pacemakers

    • Mammary implants

    • Mechanical heart valves




Claims
  • 1. A method of using an organosilane quaternary ammonium comprising: combining the organosilane quaternary ammonium with ethanol and/or isopropyl alcohol into a solution; andapplying the combined solution on skin and/or surfaces.
  • 2. A method of using a quaternary ammonium solution as a hand wash and disinfectant rub comprising: combining a quaternary ammonium in a solution to be used as the hand wash and disinfectant rub.
  • 3. A method of using an organosilane quaternary ammonium in a topical application comprising: using the organosilane quaternary ammonium in one or more of the following:Consumer hand rubConsumer hand washFirst aid hand rubFirst aid hand washPatient preoperative skin preparationHealthcare professional hand rubHealthcare professional hand washSurgical hand scrubSurgical hand rub
  • 4. The method of using an organosilane quaternary ammonium in a topical application of claim 3, wherein the topical application is in the form of one of the following: LiquidGelSprayFoam
  • 5. The method of using an organosilane quaternary ammonium in a topical application of claim 3, wherein the topical application is combined with one of the following: a. Alcohol, ethanol, ethyl alcoholb. Benzalkonium chloridec. Benzethonium chlorided. Chlorhexidine gluconatee . Chloroxylenolf. Iodine tincture USPg. Iodine topical solution USPh . Isopropyl alcoholi. Mercufenol chloridej . Combinations: i. Calomel, oxyquinoline benzoate, triethanolamine, and phenol derivativeii. Mercufenol chloride and secondary amyltricresols in 50 percent alcohol
  • 6. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium in a topical solution to prevent diaper rash and seal out moisture
  • 7. The method of claim 6, wherein the topical solution is in the form of a spray, cream, ointment, or powder.
  • 8. The method of claim 6, wherein the topical solution is combined with one of the following: Alkyldimethyl Benzylammonium chlorideAllantoin (5-ureidohydantoin)Aluminum acetateAluminum hydroxideAmylumBalsam peruBenzethonium chlorideBenzocaineBicarbonate of sodaBismuth subnitrateBoric acidCalamineCalcium carbonateCamphorCaseinCod liver oilCysteine hydrochlorideDibucaineDiperodon hydrochloridGlycerinHexachlorophene8-hydroxyquinolineIron oxideLanolinMentholMethapyrileneMethionineMethylbenzethonium chlorideOil of eucalyptusOil of lavenderOil of peppermintOil of white thymePanthenolPara-chloromercuriphenolPetrolatumPhenolPramoxine hydrochlorideSalicylic acidSiliconeSorbitan monosterateTalcTetracaineVitamin AVitamin A palmitateVitamin DVitamin D2Vitamin EWhite petrolatumZinc oxideZinc stearate
  • 9. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium as a topical first aid antibiotic.
  • 10. The method of claim 9, wherein the topical first aid antibiotic is in the form of a cream or ointment.
  • 11. The method of claim 9, wherein the topical first aid antibiotic includes one of the following: Bacitracin ointmentBacitracin zincChlortetracycline hydrochlorideNeomycin sulfateTetracycline hydrochlorideOxytetraclyine hydrochloride
  • 12. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium as an antifungal.
  • 13. The method of claim 12, wherein the topical first aid antibiotic is in the form of a cream, gel or aerosol.
  • 14. The method of claim 12, wherein the topical first aid antibiotic includes one of the following: ClioquinolHaloproginMiconazole nitratePovidone-iodineTolnaftateUndecylenic acidCalcium undecylenateCopper undecylenateZinc undecylenate
  • 15. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium as a treatment for acne.
  • 16. The method of claim 14, wherein the topical first aid antibiotic is in the form of a lotion, cream, ointment or gel.
  • 17. The method of claim 14, wherein the topical first aid antibiotic includes one of the following: ResorcinolResorcinol monoacetateSalicylic acidSulfur
  • 18. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium as a skin deodorant.
  • 19. The method of claim 18, wherein the topical first aid antibiotic is in the form of a solid, gel, or liquid.
  • 20. The method of claim 18, wherein the topical first aid antibiotic includes one of the following: Sodium stearateSodium chlorideStearyl alcoholPotassium alumAluminum ZirconiumAluminum ChlorohydrateAluminum chloride
  • 21. A method for using an organosilane quaternary ammonium comprising: applying the organosilane quaternary ammonium as a dental product.
  • 22. The method of claim 21, wherein the topical first aid antibiotic is in the form of a liquid, spray, paste or gel
  • 23. The method of claim 21, wherein the topical first aid antibiotic includes one of the following: Sodium fluorideSodium monofluorophoshateHydrogen peroxideStannoud fluorideCetylpyridinium chlorideThymolMentholEucalyptolMethyl salicylate
  • 24. A method for using an organosilane quaternary ammonium comprising: applying to medical device coatings.
  • 25. A method for using an organosilane quaternary ammonium comprising: applying to disposable device packaging.
  • 26. A method for using an organosilane quaternary ammonium comprising: applying to non surgical/non implantable devices.
  • 27. The method of claim 26, wherein the non-surgical/non-implantable devices include one or more of the following: Personal Protective Equipment GlovesPersonnel hair, nose and mouth protectorsScrubs and gownsGogglesWound care Bandages/ wrapsOrthopedic Braces/castingExam room equipmentLaboratory equipmentDiagnostic modality componentsEMS/patient transport equipment
  • 28. A method for using an organosilane quaternary ammonium comprising: applying to surgical equipment.
  • 29. The method of claim 28, wherein the surgical equipment includes one or more of the following: Surgical toolsSurgical tool packagingSurgical furniture
  • 30. A method for using an organosilane quaternary ammonium comprising: applying to implantable devices.
  • 31. The method of claim 30, wherein the surgical equipment includes one or more of the following: StentsPacemakersBladder cathetersCentral venous cathetersFracture fixation devicesDental implantsJoint prosthesesVascular graftsCardiac pacemakersMammary implantsMechanical heart valves
RELATED APPLICATIONS

This application claims the benefit of priority of U.S. Provisional Patent Application Serial No. 62/540,038 filed Aug. 1, 2017, incorporated herein by reference.

PCT Information
Filing Document Filing Date Country Kind
PCT/US2018/044651 7/31/2018 WO 00
Provisional Applications (1)
Number Date Country
62540038 Aug 2017 US