Claims
- 1. A compound of the formula ##STR24## wherein R is --CH.sub.2 --SR', R' is selected from the group consisting of 1-methyl-tetrazolyl and 2-methyl-1,3,4-thiadiazolyl, R.sub.1 is hydrogen, R.sub.2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, A is selected from the group consisting of hydrogen, an alkali metal cation, an equivalent of an alkaline earth metal or magnesium, and a non-toxic, pharmaceutically acceptable organic amine base cation and OR.sub.2 is in the syn position.
- 2. A compound of claim 1 wherein R.sub.2 is methyl and A is hydrogen.
- 3. A compound of claim 1 which is the syn isomer of 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyl-tetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid.
- 4. A compound of claim 1 which is syn isomer of 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid.
- 5. A compound of claim 1 which is syn isomer of sodium 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylate.
- 6. A compound of claim 1 which is syn isomer of sodium 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyl-tetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylate.
- 7. An antibiotic composition comprising an antibiotically effective amount of at least one compound of claim 1 and an inert pharmaceutical carrier.
- 8. A composition of claim 7 wherein the active compound is selected from the group consisting of the syn isomer of 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyl-tetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid and its sodium salt.
- 9. A composition of claim 7 wherein the active compound is selected from the group consisting of the syn isomer of 7-[{2-(2-amino-4-thiazolyl) 2-methoxyiminoacetyl}amino]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid and its sodium salt.
- 10. A method of treating bacterial infections in warm-blooded animals comprising administering internally to warm-blooded animals an antibiotically effective amount of at least one compound of claim 1.
- 11. The method of claim 10 wherein the compound is the syn isomer of 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyltetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid.
- 12. The method of claim 10 wherein the compound is syn isomer of 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(2-methyl-1,3,4-thiadiazolyl-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylic acid.
- 13. The method of claim 10 wherein the compound is syn isomer of sodium 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylate.
- 14. The method of claim 10 wherein the compound is syn isomer of sodium 7-[{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetyl}amino]-3-[(1-methyl-tetrazol-5-yl)-thiomethyl]-ceph-3-eme-4-carboxylate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
76 08690 |
Mar 1976 |
FRX |
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PRIOR APPLICATION
This application is a division of our copending, commonly assigned U.S. patent application Ser. No. 796,315 filed May 12, 1977, now U.S. Pat. No. 4,102,893, which in turn is a continuation-in-part of our copending application Ser. No. 781,344 filed Mar. 25, 1977, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4024137 |
Cook et al. |
May 1977 |
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4098888 |
Ochiai et al. |
Jul 1978 |
|
4166115 |
Takaya et al. |
Aug 1979 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
796315 |
May 1977 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
781344 |
Mar 1977 |
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