Claims
- 1. A topical pharmaceutical composition comprising the compound of formula I in free base form or acid addition salt form, encapsulated in liposomes, which composition contains phospholipid components which are selected from 1)palmitoyl-oleyl-phosphatidyl-choline, 2)dioleoyl-phosphatidyl-glycerol, 3)dioleoyl-phosphatidyl-serine, 4)a mixture of palmitoyl-oleyl-phosphatidyl-choline and palmitoyl-oleyl-phosphatidyl-glycerol, 5)dimyristoyl-phosphatidyl-choline, or 6) a mixture of dimyristoyl-phosphatidyl-choline and dimyristoyl-phosphatidyl-glycerol,said composition further comprising phosphatidylethanolamine-polyethyleneglycol.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9111611 |
May 1991 |
GB |
|
Parent Case Info
This is a continuation of application Ser. No. 08/628,359 filed Apr. 5, 1996 now abandoned, which is a continuation of application Ser. No. 08/476,147 filed Jun. 7, 1995, now abandoned, which is a continuation of application Ser. No. 07/890,498 filed May 28, 1992, now abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4755534 |
Stuetz |
Jul 1988 |
A |
4812312 |
Lopez-Berestein et al. |
Mar 1989 |
A |
4891208 |
Janoff et al. |
Jan 1990 |
A |
5013556 |
Woodle et al. |
May 1991 |
A |
5049388 |
Knight et al. |
Sep 1991 |
A |
Foreign Referenced Citations (5)
Number |
Date |
Country |
2148711 |
Jun 1986 |
GB |
WO8603938 |
Jul 1986 |
WO |
8603958 |
Jul 1986 |
WO |
WO8702219 |
Apr 1987 |
WO |
WO8707530 |
Dec 1987 |
WO |
Non-Patent Literature Citations (5)
Entry |
Birnbaum J. Amer. Acad. Dermatil. 23, # 4 p 782-785, 1990.* |
T.C. Jones, Journal of Dermatological Treatment 1, Suppl. 2, pp. 29-32 (1990). |
J.E. Birnbaum, Journal of American Academy of Dermatology, vol. 23, (No. 4/Part 2, Suppl.) pp. 782-785 (1990). |
F. Szoka, Ann. Rev. Biophys. Bioeng. 9, pp. 467-508, 1980. |
J.C. Jensen, Clin. and Exper. Derm., vol. 14, pp. 110-113 (1989). |
Continuations (3)
|
Number |
Date |
Country |
Parent |
08/628359 |
Apr 1996 |
US |
Child |
08/881216 |
|
US |
Parent |
08/476147 |
Jun 1995 |
US |
Child |
08/628359 |
|
US |
Parent |
07/890498 |
May 1992 |
US |
Child |
08/476147 |
|
US |