Claims
- 1. An amide selected from the group consisting of a compound of the formula:
- 2. An amide of claim 1 wherein said compound is
- 3. A compound of claim 2 wherein R1 and R2 are independently halo or lower alkyl sulfonyl and R3 is a 5 to 7-membered ring which is cyclopentyl, cyclohexyl, cyclohexenyl, or a six-membered heterocycloalkyl having one heteroatom selected from oxygen and sulfur.
- 4. A compound of claim 3 wherein the heteroatom is oxygen.
- 5. The amide of claim 4 wherein R5 is methyl.
- 6. The amide of claim 5 where X is oxygen.
- 7. The amide of claim 6 wherein R1 and R2 are independently chloro or methyl sulfonyl.
- 8. The amide of claim 7 wherein R1 and R2 are chloro.
- 9. The amide of claim 8 which is 1-[cyclopentyloxy-(3,4-dichloro-phenyl)-acetyl]-3-methyl-urea.
- 10. The amide of claim 8 which is 1-[cyclohexyloxy-(3,4-dichloro-phenyl)-acetyl]-3-methyl-urea.
- 11. The amide of claim 8 which is 1-[(cyclohex-2-enyloxy)-(3,4-dichloro-phenyl)-acetyl]-3-methyl-urea.
- 12. The amide of claim 8 which is 1-[(3,4-dichloro-phenyl)-(tetrahydro-pyran-4-yloxy)-acetyl]-3-methyl-urea.
- 13. The amide of claim 7 wherein R1 is chloro and R2 is methyl sulfonyl.
- 14. The amide of claim 13 which is 1-[(3-chloro-4-methanesulfonyl-phenyl)-cyclopentyloxy-acetyl]-3-methyl-urea.
- 15. The amide of claim 13 which is 1-[(3-chloro-4-methanesulfonyl-phenyl)-(cyclohex-2-enyloxy)-acetyl]-3-methyl-urea.
- 16. The amide of claim 1 wherein said compound is
- 17. The amide of claim 16 wherein R1 and R2 are independently halo or lower alkyl sulfonyl, and R3 is a 5 to 7-membered ring which is cyclopentyl, cyclohexyl, cyclohexenyl, or a six-membered heterocycloalkyl having one heteroatom selected from oxygen and sulfur.
- 18. The amide of claim 17 wherein the heteroatom is oxygen.
- 19. The amide of claim 18 wherein R6 is thiazolyl or pyridinyl.
- 20. The amide of claim 19 wherein R1 and R2 are independently chloro or methyl sulfonyl.
- 21. The amide of claim 20 where X is oxygen.
- 22. The amide of claim 21 wherein R1 and R2 are chloro.
- 23. The amide of claim 22 wherein R6 is thiazolyl.
- 24. The amide of claim 23 which is 2-(3,4-dichloro-phenyl)-2-(tetrahydro-pyran-4-yloxy)-N-thiazol-2-yl-acetamide.
- 25. The amide of claim 23 which is 2-cyclopentyloxy-2-(3,4-dichloro-phenyl)-N-thiazol-2-yl-acetamide.
- 26. The amide of claim 23 which is 2-cyclohexyloxy-2-(3,4-dichloro-phenyl)-N-thiazol-2-yl-acetamide.
- 27. The amide of claim 23 which is 2-(cyclohex-2-enyloxy)-2-(3,4-dichloro-phenyl)-N-thiazol-2-yl-acetamide.
- 28. The amide of claim 22 wherein R6 is pyridinyl.
- 29. The amide of claim 28 which is 2-cyclopentyloxy-2-(3,4-dichloro-phenyl)-N-pyridin-2-yl-acetamide.
- 30. The amide of claim 21 wherein R1 is chloro and R2 is methyl sulfonyl.
- 31. The amide of claim 30 which is 2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxy-N-thiazol-2-yl-acetamide.
- 32. The amide of claim 30 which is 2-(3-chloro-4-methanesulfonyl-phenyl)-2-(cyclohex-2-enyloxy)-N- thiazol-2-yl-acetamide.
- 33. The amide of claim 20 wherein X is sulfur, sulfonyl or carbonyl.
- 34. The amide of claim 33 wherein R1 and R2 are chloro.
- 35. The amide of claim 34 wherein R3 is cyclopentyl.
- 36. The amide of claim 35 which is 3-cyclopentyl-2-(3,4-dichloro-phenyl)-3-oxo-N-thiazol-2-yl-propionamide.
- 37. The amide of claim 35 which is 2-cyclopentanesulfonyl-2-(3,4-dichloro-phenyl)-N-thiazol-2-yl-acetamide.
- 38. The amide of claim 35 which is 2-cyclopentylsulfanyl-2-(3,4-dichloro-phenyl)-N-thiazol-2-yl-acetamide.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is related to U.S. Provisional Ser. No. 60/219,872, filed Jul. 20, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60219872 |
Jul 2000 |
US |