Claims
- 1. A pharmaceutical composition having .beta.-adrenergic stimulant activity in dosage unit form comprising a pharmaceutical carrier and an effective amount of a chemical compound of the formula: ##SPC4##
- or a pharmaceutically acceptable acid addition salt of said compound, wherein:
- R is straight or branched chain lower alkyl of from 1 to 5 carbon atoms;
- R.sub.1 is branched chain lower alkyl of from 3 to 5 carbon atoms, cycloalkyl or cycloalkylmethyl, the cycloalkyl moiety having from 3 to 6 carbon atoms, or ##SPC5##
- R.sub.2 is hydrogen, methyl or ethyl;
- R.sub.3 and R.sub.4 are hydrogen, hydroxy, or methoxy, and
- R.sub.5 is hydrogen or methyl.
- 2. A pharmaceutical composition according to claim 1 in which R is methyl.
- 3. A pharmaceutical composition according to claim 2 in which R.sub.2 is hydrogen.
- 4. A pharmaceutical composition according to claim 3 in which R.sub.1 is t-butyl, being the compound .alpha.-(t-butylaminomethyl)-4-hydroxy-3-(methylsulfonylmethyl)benzyl alcohol.
- 5. A pharmaceutical composition in accordance with claim 1 in which said compound is in the form of a hydrochloride salt.
- 6. The method of producing .beta.-adrenergic stimulant activity which comprises administering internally to animals requiring bronchodilation an amount sufficient to produce said activity a chemical compound of the formula: ##SPC6##
- or a pharmaceutically acceptable acid addition salt of said compound, wherein:
- R is straight or branched chain lower alkyl of from 1 to 5 carbon atoms;
- R.sub.1 is branched chain lower alkyl of from 3 to 5 carbon atoms, cycloalkyl or cycloalkylmethyl, the cycloalkyl moiety having from 3 to 6 carbon atoms, or ##SPC7##
- R.sub.2 is hydrogen, methyl or ethyl;
- R.sub.3 and R.sub.4 are hydrogen, hydroxy, or methoxy, and
- R.sub.5 is hydrogen or methyl.
- 7. The method according to claim 6 in which R is methyl.
- 8. The method according to claim 7 in which R.sub.2 is hydrogen.
- 9. The method according to claim 8 in which R.sub.1 is t-butyl, being the compound .alpha.-(t-butylaminomethyl)-4-hydroxy-3-(methylsulfonylmethyl)benzyl alcohol.
- 10. A method in accordance with claim 6 in which said compound is in the form of a hydrochloride salt.
Parent Case Info
This is a division of application Ser. No. 359,063 filed May 10 1973 which is a continuation in part of Ser. No. 236,177 filed March 20 1972 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3775479 |
Bruderer et al. |
Nov 1973 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
359063 |
May 1973 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
236177 |
Mar 1972 |
|