Claims
- 1. A compound of the formula V:
- 2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 1, or a pharmaceutically acceptable salt thereof.
- 3. A method of treating an individual for a proliferative disorder comprising administering to said individual an effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof.
- 4. A method according to claim 3 wherein the proliferative disorder is selected from the group consisting of hemangiomatosis in new born, secondary progressive multiple sclerosis, chronic progressive myelodegenerative disease, neurofibromatosis, ganglioneuromatosis, keloid formation, Pagets Disease of the bone, fibrocystic disease of the breast, Peronies and Duputren's fibrosis, restenosis and cirrhosis.
- 5. A method according to claim 3 wherein the proliferative disorder is cancer.
- 6. A method according to claim 5 wherein the cancer is selected from the group consisting of ovarian, breast, prostate, lung, renal, colorectal and brain cancers, or the cancer is a leukemia.
- 7. A method of inducing apoptosis of tumor cells in an individual afflicted with cancer comprising administering to said individual an effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof.
- 8. A method according to claim 8 wherein the tumor cells are selected from the group consisting of ovarian, breast, prostate, lung, colorectal, renal and brain tumors.
- 9. A process for preparing a compound of claim 1 comprising reacting a compound of the formula
- 10. An isolated optical isomer of a compound according to claim 1, or pharmaceutically acceptable salt thereof.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent application Ser. No. 09/833,834, filed Apr. 12, 2001 which claimed pursuant to 35 U.S.C. 1119(e) the benefit of the filing date of provisional application Serial No. 60/197,368, filed Apr. 14, 2000. The entire disclosures of the aforesaid applications are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60197368 |
Apr 2000 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09833834 |
Apr 2001 |
US |
Child |
10301332 |
Nov 2002 |
US |