Claims
- 1. A compound having the formula: ##STR8## wherein R.sub.1 is hydrogen, halo, nitro, amino, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy; R.sub.2 is hydrogen, fluorine, chlorine, bromine, lower alkyl, lower alkoxy amino, nitro, or trifluoromethyl; R.sub.3 is hydroxy, lower alkoxy, amino, (lower)alkylamino, hydroxy(lower)alkyl amino, N-(lower)alkanoylamino(lower)alkoxy, N-arylcarbamoyl(lower)alkylthio, N,N-di(lower)alkylamino-N'-(lower)alkylamino, (lower)alkyl-N-(lower)alkanoylamino, cyano(lower)alkylamino, prolino, cysteino or piperidino(lower)alkylamino; X is CH or N, and where the dotted lines represent optional double bonds in the 5,6- and 7,8 positions, or a pharmacologically acceptable salt thereof.
- 2. The compound of claim 1, having the name .alpha.-(2-benzothiazolylthio)benzeneacetic acid.
- 3. The compound of claim 1, having the name .alpha.-(5-chlorobenzothiazol-2-ylthio)benzeneacetic acid.
- 4. The compound of claim 1, which is the sodium salt of .alpha.-(5-chlorobenzothiazol-2-ylthio)benzeneacetic acid.
- 5. The compound of claim 1, having the name .alpha.-(5-chlorobenzothiazol-2-ylthio)-.alpha.-(p-chlorophenyl)acetic acid.
- 6. The compound of claim 1, having the name .alpha.-(p-chlorophenyl)-.alpha.-(benzothiazol-2-ylthio)acetic acid.
- 7. The compound of claim 1, having the name .alpha.-(5-chloro-2-benzothiazolylthio)benzene acetic acid, ethyl ester.
- 8. The compound of claim 1, having the name .alpha.-(5-chlorobenzothiazol-2-ylthio)-.alpha.-phenylacetamide.
- 9. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]-N-(2-hydroxyethyl)benzeneacetamide.
- 10. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]benzene acetic acid, [2-(acetylamino)ethyl]ester.
- 11. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]benzeneethanethioic acid S-[2-(2-naphthalenylamino)-2-oxoethyl]ester.
- 12. The compound of claim 1, having the name .alpha.-[(5-chlorothiazolo[5,4-b]pyridin-2-yl)thio]-.alpha.-phenylacetic acid.
- 13. The compound of claim 1, having the name .alpha.-[(5-chlorothiazolo[5,4-b]pyridin-2-yl)thio]-.alpha.-(p-chlorophenyl)acetic acid.
- 14. The compound of claim 1, having the name .alpha.-phenyl-.alpha.-[(4,5,6,7-tetrahydrobenzothiazol-2-yl)thio]acetic acid.
- 15. The compound of claim 1, having the name .alpha.-[(6-nitro-2-benzothiazolyl)thio]benzeneacetic acid.
- 16. The compound of claim 1, having the name 4-chloro-.alpha.-[(5-chloro-2-benzothiazolyl)thio]benzeneacetamide.
- 17. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]-N-methylbenzeneacetamide.
- 18. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]-N-[2-(dimethylamino)ethyl]benzeneacetamide.
- 19. The compound of claim 1, having the name N-[[(5-chloro-2-benzothiazolyl)thio]phenylacetyl]glycine, ethyl ester.
- 20. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]-N-(cyanomethyl)benzeneacetamide.
- 21. The compound of claim 1, having the name 1-[[(2-benzothiazolyl)thio]phenylacetyl]-L-proline.
- 22. The compound of claim 1, having the name 1-[[(5-chloro-2-benzothiazolyl)thio]phenylacetyl)-L-proline.
- 23. The compound of claim 1, having the name .alpha.-[(5-chloro-2-benzothiazolyl)thio]-N-[2-(1-piperidinyl)ethyl]benzeneacetamide.
- 24. The compound of claim 1, having the name N-[[(5-chloro-2-benzothiazolyl]thio]phenylacetyl]-L-cysteine.
Parent Case Info
This is a continuation-in-part of U.S. Ser. No. 273,826 filed June 15, 1981 now abandoned, which is a continuation in part of U.S. Ser. No. 130,483 filed Mar. 31, 1980 now U.S. Pat. No. 4,275,065 which is a continuation-in-part of U.S. Ser. No. 050,847 filed June 21, 1979, and now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4294839 |
Doll et al. |
Oct 1981 |
|
Non-Patent Literature Citations (1)
Entry |
Potts, K., et al., J. Org. Chem., 43(13), 2697-2700, (1978). |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
273826 |
Jun 1981 |
|
Parent |
130483 |
Mar 1980 |
|
Parent |
50847 |
Jun 1979 |
|