Claims
- 1. An aluminum-zirconium octachlorohydrate having a metal (Al+Zr) to chloride molar ratio of 0.90 to 1.00.
- 2. An aluminum-zirconium octachlorohydrate having the formula AlnZr(OH)[3n+4−m(n+1)](Cl)[m(n+1)]-(Gly)q wherein n is 6.0 to 10.0, m is 1.00 to 1.11, and q is about 0.8 to about 4.0.
- 3. The aluminum-zirconium octachlorohydrate of claim 2 wherein q is about 1.0 to 2.0.
- 4. The aluminum-zirconium octachlorohydrate of claim 3 wherein m is about 1.02 to about 1.11.
- 5. The aluminum-zirconium octachlorohydrate of claim 3 wherein m is about 1.04 to about 1.11.
- 6. The aluminum-zirconium octachlorohydrate of claim 3 which, when analyzed by HPLC as a 10% aqueous solution using conditions capable of resolving the aluminum into at least four successive peaks (labeled peaks 2 to 5), exhibits an HPLC peak 5 area of at least 45% and an HPLC peak 4 to peak 3 area ratio of at least 0.4, wherein substantially all of the aluminum is found in peaks 3, 4 and 5.
- 7. The aluminum-zirconium octachlorohydrate of claim 2 made with a zirconium hydroxychloride of the formula Zr(OH)4-bClb wherein b is 2.2 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.45 and 0.25.
- 8. The aluminum-zirconium octachlorohydrate of claim 1 made with a zirconium hydroxychloride of the formula Zr(OH)4-bClb wherein b is about 3.4 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.29 and 0.25.
- 9. The aluminum-zirconium octachlorohydrate of claim 2, 3, 4, 5 or 6 made with a zirconium hydroxychloride of the formula Zr(OH)4-bClb wherein b is about 3.4 to 4.0 so that the Zr:Cl ratio in said zirconium hydroxychloride is between 0.29 and 0.25.
- 10. The aluminum-zirconium octachlorohydrate of claim 1, 2, 3, 4, 5, 6 or 7 in solid powder form.
- 11. An aqueous composition comprising water and, dissolved therein, an aluminum-zirconium octachlorohydrate according to claim 1, 2, 3, 4 or 7.
- 12. The aqueous composition of claim 11 comprising about 8% to about 45% (USP) of said aluminum-zirconium octachlorohydrate.
- 13. A composition comprising a liquid polyhydric alcohol and, dissolved therein, an aluminum-zirconium octachlorohydrate according to claim 1, 2, 3, 4 or 7.
- 14. The composition of claim 13 comprising about 8% to about 45% (USP) of said aluminum-zirconium octachlorohydrate.
- 15. A clear antiperspirant gel composition comprising a water-in-oil emulsion having a water phase and an oil phase, wherein the water phase comprises an aqueous composition according to claim 11.
- 16. A topical antiperspirant composition comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of an aluminum-zirconium octachlorohydrate according to claims 1, 2, 3, 4 or 7.
- 17. The topical antiperspirant composition of claim 16 wherein said carrier is an anhydrous carrier and said aluminum-zirconium octachlorohydrate is in solid powder form suspended in said anhydrous carrier.
- 18. The topical antiperspirant composition of claim 17 wherein said anhydrous carrier comprises a silicone.
- 19. The topical antiperspirant composition of claim 16 in the form of a liquid, lotion, cream, gel, soft-solid, or solid stick.
- 20. A method of reducing perspiration from human skin comprising applying to human skin a topical antiperspirant composition according to claim 16.
- 21. A method of reducing perspiration from human skin comprising applying to human skin an aluminum-zirconium octachlorohydrate according to claim 1, 2, 3, 4 or 7.
- 22. A method of preparing an aluminum-zirconium chlorohydrate of the formula AlnZr(OH)[3n+4−m(n+1)](Cl)[m(n+1)]-(Gly)q wherein n is 2.0 to 10.0, m is 1.00 to 1.11, and q is about 0.8 to about 4.0, which method comprises mixing an aqueous solution of an aluminum chlorohydrate of the formula A12(OH)6-aCla wherein a is about 1 to about 2, with an aqueous solution comprising glycine and a zirconium hydroxychloride of the formula Zr(OH)4-bClb wherein b is 2.2 to 4.0, each of said aluminum chlorohydrate and zirconium hydroxychloride being present in an amount to provide an Al:Zr molar ratio of 2.0 to 10.0, and, if necessary, adjusting the metal (Al+Zr) to chloride ratio (M:Cl) to 0.90 to 1.00 by addition of an appropriate amount of aqueous HCL.
- 23. The method of claim 22 wherein b is about 3.4 to 4.0 in said zirconium hydroxychloride.
- 24. The method of claim 22 wherein said aluminum antiperspirant salt has an HPLC peak 4 to peak 3 area ratio of at least 0.5 with at least 70% of the aluminum contained in peaks 3 and 4.
- 25. The method of claim 22, 23 or 24 which additionally comprises drying said solution to obtain said aluminum-zirconium chlorohydrate in solid form.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation of application Ser. No. 09/696,271 filed Oct. 25, 2000, now U.S. Pat. No. 6,436,381.
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Continuations (1)
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Number |
Date |
Country |
Parent |
09/696271 |
Oct 2000 |
US |
Child |
10/138476 |
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US |