Claims
- 1. An ambiphilic cream base consisting essentially of:
- (a) water, and lipids or lipid-like substances forming a fatty phase.
- (b) oil-in-water and water-in-oil emulsifiers, and
- (c) glycerol, sorbitol or mixtures thereof,
- wherein each of the components is present in an amount effective to provide an ambiphilic cream, and provided that the ambiphilic cream contains no glycerol monostearate or propylene glycol.
- 2. An ambiphilic cream base according to claim 1, wherein glycerol is present at 1 to 20 percent by weight of the ambiphilic cream base.
- 3. An ambiphilic cream base according to claim 1, wherein glycerol is present at 5 to 15 percent by weight of the ambiphilic cream base.
- 4. An ambiphilic cream base according to claim 1, wherein glycerol is present at about 10 percent by weight of the ambiphilic cream base.
- 5. An ambiphilic cream base according to claim 1 wherein the water-in-oil emulsifier is at least one higher aliphatic alcohol or a mixture thereof with a partial ester of glycerol with a higher aliphatic alcohol.
- 6. An ambiphilic cream base according to claim 5, wherein the partial ester is glycerol monostearate.
- 7. An ambiphilic cream base according to claim 6, wherein the water-in-oil emulsifier is present at 5 to 16 percent by weight of the ambiphilic cream base.
- 8. An ambiphilic cream base according to claim 6, wherein the water-in-oil emulsifier is present at 8 to 12 percent by weight of the ambiphilic cream base.
- 9. An ambiphilic cream base according to claim 6, wherein the water-in-oil emulsifier is present at about 10 percent by weight of the ambiphilic cream base.
- 10. An ambiphilic cream base according to claim 1, further comprising stabilizers, spreading agents, emollients, humectants, crystallization inhibitors, hydrocolloids, or mixtures thereof.
- 11. An ambiphilic cream base according to claim 1 wherein the water content is 25 to 55 weight percent, the content of glycerol, sorbitol, or mixtures thereof is 1 to 20 weight percent, and the content of isopropyl myristate is 20 to 50 weight percent relative to the total weight of the ambiphilic cream base.
- 12. An ambiphilic cream base according to claim 1, further comprising an effective amount of a compatible water-soluble or fat-soluble active pharmaceutical.
- 13. An ambiphilic cream base consisting essentially of:
- (a) water;
- (b) isopropyl myristate as a component of a fatty phase;
- (c) oil-in-water and water-in-oil emulsifiers; and optionally,
- (d) glycerol, sorbitol, or mixtures thereof;
- wherein each component is present in an amount effective to provide an ambiphilic cream, and provided that the ambiphilic cream contains no propylene glycol.
- 14. An ambiphilic cream base according to claim 1, wherein the lipids or lipid-like substances forming the fatty phase are liquid paraffin, vaseline, octyldodecanol, medium-chain-length triglycerides or mixtures thereof.
- 15. An ambiphilic cream base according to claim 13 wherein liquid paraffin, vaseline, octyldodecanol, medium-chain-length triglycerides or mixtures thereof are included as components of the fatty phases.
- 16. An ambiphilic cream base according to claim 13 wherein the water-in-oil emulsifier is at least one higher aliphatic alcohol or a mixture thereof with a partial ester of glycerol with a higher aliphatic alcohol.
- 17. An ambiphilic cream base according to claim 16, wherein the partial ester is glycerol monostearate.
Priority Claims (1)
Number |
Date |
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88105632 |
Apr 1988 |
EPX |
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Parent Case Info
This application is a continuation of United States application Ser. No. 07/333,388 filed Mar. 31, 1989, abandoned.
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4246285 |
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Jan 1981 |
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4424234 |
Alderson et al. |
Jan 1984 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0226337 |
Jun 1987 |
EPX |
Non-Patent Literature Citations (2)
Entry |
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Continuations (1)
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Number |
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333388 |
Mar 1989 |
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