Claims
- 1. An amide compound represented by the formula, ##STR190## wherein ring A represents a benzene ring or a naphthalene ring; when ring A is a naphthalene ring, R.sup.1, R.sup.2 and R.sup.3 are all hydrogen atoms, and when ring A is a benzene ring, R.sup.1, R.sup.2 and R.sup.3 are the same or different and independently represent hydrogen, lower alkoxy, halogen, nitro, lower alkyl, halogen-substituted lower alkyl, phenyl, phenoxy, lower alkanoyloxy, hydroxy, lower alkylthio, lower alkyl sulfinyl or lower alkyl sulfonyl;
- R.sup.4 represents a heterocyclic group selected from the group consisting of (1) a lower alkyl-substituted thieno[3,2-d]-pyrimidin-4-yl group, (2) a pyrazolo [1,5-a]-1,3,5-triazin-4-yl group optionally having one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl(lower)alkyl, phenylthiophenyl and halogen, (3) a pyrazolo[3,4-d]pyrimidin-4-yl group which has a lower alkyl group at the 6-position and one of those nitrogen atoms may have a phenyl(lower) alkyl group as a substituent, and (4) a purin-6-yl group which has a lower alkyl group at the 2-position and one of whose nitrogen atoms may have a lower alkyl or phenyl (lower) group as a substituent; and
- R.sup.5 represents a hydrogen atom or a group represented by ##STR191## wherein A, R.sup.1, R.sup.2 and R.sup.3 are as defined above.
- 2. An amide compound according to claim 1 which is represented by the formula of claim 1 wherein ring A represents a benzene ring.
- 3. An amide compound according to claim 2 which is represented by the formula of claim 1 wherein R.sup.4 represents a thieno[3,2-d]pyrimidin-4-yl group substituted by a lower alkyl group at the 2-position, or a pyrazolo[1,5-a]-1,3,5-triazin-4-yl group substituted by a lower alkyl group at the 2-position.
- 4. An amide compound according to claim 3 which is represented by the formula of claim 1 wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and independently represent hydrogen, lower alkoxy, halogen, phenyl, lower alkanoyloxy or lower alkylthio.
- 5. An amide compound according to claim 4 which is selected from the group consisting of N-(2-n-butylpyrazolo[1,5-a]-1,3,5-triazin-4-yl)-3,4,5-trimethoxy benzamide, N-(2-n-butylpyrazolo[1,5-a]-1,3,5-triazin-4-yl)-2,4-dichlorobenzamide, N-(2-n-butylpyrazolo[1,5-a]-1,3,5-triazin-4-yl)-3-chlorobenzamide and N-(2-n-butylthieno[3,2-d]pyrimidin-4-yl)-3,4,5-trimethoxybenzamide.
- 6. An analgesic composition which comprises an amide compound defined in claim 1 and a pharmaceutically acceptable carrier.
- 7. A method for relieving pain, which comprises administering to a patient an effective amount of an amide compound defined in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8-144099 |
Jun 1996 |
JPX |
|
9-073116 |
Mar 1997 |
JPX |
|
Parent Case Info
This application is a 371 of PCT/JP97/01875 filed Jun. 2, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP97/01875 |
6/2/1997 |
|
|
12/2/1998 |
12/2/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/46560 |
11/12/1997 |
|
|
US Referenced Citations (5)
Foreign Referenced Citations (3)
Number |
Date |
Country |
WO 9413676 |
Jun 1994 |
WOX |
WO 9413677 |
Jun 1994 |
WOX |
WO 9533750 |
Dec 1995 |
WOX |