Claims
- 1. A Pharmaceutical composition for the treatment of elevated serum cholesterol, elevated serum free fatty acid levels, elevated serum lipids and/or impaired BSP clearance containing as an active component thereof an effective amount of the compound homocysterine thiolactone nicotinamide: ##STR4## and a non-toxic, pharmacologically acceptable salt thereof.
- 2. A method of treating elevated serum cholesterol, elevated serum free fatty acid levels, elevated serum lipids and/or impaired BSP clearance which comprises administering to animals, having such malfunction, effective amounts of the composition of claim 1.
RELATED APPLICATIONS
This application is a divisional of application Ser. No. 668,498 filed Mar. 19, 1976 now U.S. Pat. 4,021,433 and which is a Continuation-in-Part of patent application Ser. No. 451,694 filed Mar. 15, 1974 and herewith abandoned.
This invention relates to the novel homocysteine thiolactone of nicotinamide and its salts and more particularly to its synthesis, utility and modes for its useful administration.
The compound: homocysteine thiolactone of nicotinamide having the formula: ##STR2## and its pharmacologically acceptable salts have useful pharmacological activity related to liver function and indicated therapeutic activity in lowering cholesterol, free fatty acid, and triglyceride, plasma levels and in improving BSP clearance in conditions where such effects are indicated.
US Referenced Citations (2)
| Number |
Name |
Date |
Kind |
|
3155672 |
Pasini et al. |
Nov 1964 |
|
|
3758485 |
Biniecki et al. |
Sep 1973 |
|
Divisions (1)
|
Number |
Date |
Country |
| Parent |
668498 |
Mar 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
| Parent |
451694 |
Mar 1974 |
|
Patent Grant
4100289
