Claims
- 1. A compound having the following structural formula: ##STR62## wherein AA is an amino acid or a chain of two or more amino acids, excluding the N-terminus and C-terminus from said amino acid or chain of two or more amino acids;
- R.sub.1 is hydrogen or an alkyl group having 1 to 8 carbon atoms;
- R.sub.2 is selected from the group consisting of:
- (i) an aliphatic hydrocarbon having from 1 to about 20 carbon atoms, and ##STR63## wherein R.sub.4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms; and
- R.sub.3 is selected from the group consisting of:
- (i) hydrogen; and ##STR64## wherein R.sub.5 is hydrogen or a nitro group.
- 2. The compound of claim 1 wherein R.sub.1 is hydrogen.
- 3. The compound of claim 1 wherein R.sub.2 is an alkyl group having from 7 to 16 carbon atoms.
- 4. The compound of claim 1 wherein ##STR65## wherein R.sub.4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms.
- 5. The compound of claim 4 wherein R.sub.4 is an alkenyl group having from 2 to 4 carbon atoms.
- 6. The compound of claim 5 wherein R.sub.4 is an alkenyl group having 2 carbon atoms.
- 7. The compound of claim 1 wherein R.sub.3 is hydrogen.
- 8. The compound of claim 1 wherein R.sub.3 is: ##STR66## wherein R.sub.5 is hydrogen or nitro.
- 9. The compound of claim 8 wherein R.sub.5 is hydrogen.
- 10. The compound of claim 8 wherein R.sub.5 is nitro.
- 11. The compound of claim 1 wherein said compound is 1, 12-[di-arginyl-phenylalanyl] diaminododecane.
- 12. A compound having the following structural formula: ##STR67## wherein AA is an amino acid or a chain of two or more amino acids, excluding the N-terminus and C-terminus from said amino acid or chain of two or more amino acids;
- R.sub.1 is hydrogen or an alkyl group having 1 to 8 carbon atoms;
- R.sub.2 is selected from the group consisting of:
- (i) an aliphatic hydrocarbon having from 7 to 16 carbon atoms, and ##STR68## wherein R.sub.4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms; and
- R.sub.3 is selected from the group consisting of:
- (i) hydrogen; and ##STR69## wherein R.sub.5 is hydrogen or a nitro group.
- 13. The compound of claim 12 wherein R.sub.1 is hydrogen.
- 14. The compound of claim 12 wherein R.sub.2 is an alkyl group having from 7 to 16 carbon atoms.
- 15. The compound of claim 12 wherein ##STR70## wherein R.sub.4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms.
- 16. The compound of claim 15 wherein R.sub.4 is an alkenyl group having from 2 to 4 carbon atoms.
- 17. The compound of claim 16 wherein R.sub.4 is an alkenyl group having 2 carbon atoms.
- 18. The compound of claim 17 wherein R.sub.3 is hydrogen.
- 19. The compound of claim 12 wherein R.sub.3 is: ##STR71## wherein R.sub.5 is hydrogen or nitro.
- 20. The compound of claim 19 wherein R.sub.5 is hydrogen.
- 21. The compound of claim 12 wherein AA is a phenylalanine residue without the C-terminus and N-terminus.
- 22. The compound of claim 21 wherein said compound has the following structural formula: ##STR72##
- 23. The compound of claim 22 wherein R.sub.3 is hydrogen.
- 24. The compound of the claim 22 wherein R.sub.3 is: ##STR73## wherein R.sub.5 is hydrogen or nitro.
- 25. The compound of claim 18 wherein R.sub.5 is hydrogen.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 199,553, filed Feb. 22, 1994, now abandoned which is a C-I-P of U.S. Ser. No. 004,313, filed Jan. 14, 1993, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (4)
Number |
Date |
Country |
O394684A1 |
Oct 1990 |
EPX |
0432432 |
Jun 1991 |
EPX |
2015651 |
Oct 1970 |
DEX |
7136605 |
Oct 1971 |
JPX |
Non-Patent Literature Citations (4)
Entry |
Abstract of Japanese patent A7136605. |
Abstract of German patent DE2015691. |
PCT Search Report, International Application No. PCT/US94/00335, mailed May 23, 1994. |
Reynolds et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 259, No. 2, pp. 626-632 (1991). |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
199553 |
Feb 1994 |
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Parent |
04313 |
Jan 1993 |
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