Claims
- 1. A process for the production of compounds of formula I in whichR1 denotes hydrogen or methyl R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms, provided that when R2 denotes methyl or isobutyl, —(CH2)n—R4 is not (all-cis-4,7,10,13)-octadecatetraenyl or an unbrancehed chain with 14 carbon atoms R3 denotes hydrogen or lower alkyl n denotes 0-12 R4 denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, provided that when R4 denotes alkyl, —(CH2)n—R4 is not an unbranched alkyl chain with 8, 10, 12, 14 or 16 carbon atoms as well as pharmacologically acceptable salts and optical isomers thereof; said process comprising reacting a compound of formula II in which R1, R2, and R3 have the above meanings either with (a) a compound of formula III in which R4 and n have the above meanings and X represents an activating group or (b) with a compound of formula IV R4—(CH2)n+1—CN (IV) in which R4 and n have the above meanings.
- 2. The process of claim 1, wherein the compounds obtained are converted into other compounds of formula I.
- 3. The process of claim 1, wherein the compounds obtained are converted into pharmacologically acceptable salts.
- 4. The process of claim 1, wherein the compounds obtained are converted into optical isomers.
- 5. Compounds of formula I in whichR1=hydrogen or methyl R2=lower straight-chained or branched alkyl with 1 to 10 carbon atoms, with the proviso that when R2 is isopropyl, then —(CH2)n—R4 may not be an unbranched chain with 6 or 10 carbon atoms, when R2 is methyl, then R1 is hydrogen, and (CH2)4—R4 may not be (all-cis-3, 6, 9, 12)-octadecatetranenyl, (all-cis-4,7,10,13)-octadecatetraene or an unbranched chain with 14 carbon atoms, and when R2 is isobutyl, then (CH2)4—R4 may not be (all-cis-4,7,10,13)-octadecatetraene, R3=hydrogen n=0-12 R4=alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, with the proviso that when R4 is alkyl, —(CH2)4—R4 may not be an unbranched alkyl chain with 6, 8, 10, 12 14 or 16 carbon atoms, as well as pharmacologically acceptable salts and optical isomers thereof.
- 6. A pharmaceutical compostion containing at least one compound of formula I in whichR1 denotes hydrogen or methyl R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms, with the proviso that when R2 is isopropyl, then —(CH2)n—R4 may not be an unbranched chain with 6 or 10 carbon atoms, and when R2 is methyl, then R1 is hydrogen, and —(CH2)4—R4 may not be (all-cis-3, 6, 9, 12)-octadecatetranenyl, or an unbranched chain with 14 carbon atoms R3 denotes hydrogen [or lower alkyl]n denotes 0-12 R4 denotes alkyl, alkenyl or alkinty with 6 to 24 carbon atoms, which the proviso that when R4 is alkyl, then —(CH2)4—R4 may not be an unbranched alkyl chain with 6, 8, 10, 12 14 or 16 carbon atoms, in addition to common carrier and auxiliary substances.
- 7. A method for treating osteoporosis in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of a composition of claim 6.
- 8. A method for treating osteoporosis in a patient in need of such treatment, comprising administering to said patient, a therapeutically effective amount of a compound of claim 5.
Priority Claims (1)
| Number |
Date |
Country |
Kind |
| 195 44 635 |
Nov 1995 |
DE |
|
Parent Case Info
This is a continuation application of U.S. patent application Ser. No. 09/069,000, filed on Dec. 14, 1998, which is a 371 of PCT/EP96/05212 filed Nov. 26, 1996 the disclosure of which is hereby incorporated by reference.
Foreign Referenced Citations (1)
| Number |
Date |
Country |
| 9412466 |
Jun 1994 |
WO |
Continuations (1)
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Number |
Date |
Country |
| Parent |
09/069000 |
|
US |
| Child |
09/407981 |
|
US |
Patent Grant
6444832
