Claims
- 1. A compound of the formula ##STR131## wherein X is an imino acid of the formula ##STR132## n is an integer of from 4 to 8; n' is zero or one;
- R.sub.2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl;
- R.sub.1 and R.sub.6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR133## wherein R.sub.14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and
- R.sub.15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or
- R.sub.14 and R.sub.15 taken together are --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.dbd.CH--, or ##STR134## and when either or both of R.sub.1 and R.sub.6 are hydrogen a basic addition salt or an amino acid addition salt thereof.
- 2. A compound of claim 1 wherein n is 4 to 7.
- 3. A compound of claim 1 wherein R.sub.1 is hydrogen or alkali metal.
- 4. The compound of claim 1 wherein n is 6, R.sub.1 is hydrogen, n' is 0, and R.sub.2 is hydrogen.
- 5. The lithium salt of the compound of claim 3.
- 6. The compound of claim 4 wherein R.sub.1 is hydrogen or ##STR135##
- 7. The compound of claim 1 wherein R.sub.6 is hydrogen or ##STR136## wherein R.sub.14 is hydrogen, methyl, cyclopentyl or cyclohexyl and R.sub.15 is lower alkyl of 1 to 4 carbons or phenyl.
- 8. The compound of claim 1 wherein X is ##STR137##
- 9. The compound of claim 1 wherein X is ##STR138##
- 10. The compound of claim 1 wherein X is ##STR139##
- 11. A pharmaceutical composition useful for treating hypertension comprising a pharmaceutically acceptable carrier and an effective amount of one or more compounds of claim 1 or pharmaceutically acceptable salts thereof.
- 12. The method of treating hypertension in a mammalian specie comprising administering an effective amount of the composition of claim 11.
Parent Case Info
This is a division of application Ser. No. 398,052, filed July 14, 1982, now U.S. Pat. No. 4,444,765.
US Referenced Citations (14)
Foreign Referenced Citations (4)
Number |
Date |
Country |
868532 |
Oct 1978 |
BEX |
2027025 |
Feb 1980 |
GBX |
2028327 |
Mar 1980 |
GBX |
2039478 |
Aug 1980 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Mauger et al., "Analogs and Homologs of Proline and Hydroxyproline", Chem. Review, vol. 66, pp. 47-86, (1966). |
Divisions (1)
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Number |
Date |
Country |
Parent |
398052 |
Jul 1982 |
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