Claims
- 1. A compound of the formula ##STR17## wherein X and Y are the same or different and each can be hydrogen, halogen, trifluoromethyl, loweralkoxy, loweralkyl, loweralkanoyl, loweralkylthio, loweralkylsulfonyl, loweralkylsulfinyl, amino, hydroxy or nitro; R.sup.1 is hydrogen, straight or branched chain loweralkyl, cyano cycloalkylloweralkyl wherein the cycloalkyl ring contains from 3 to 6 carbon atoms, phenoxycarbonyl of the formula ##STR18## alkoxycarbonyl, loweralkenyl or loweralkynyl; R.sup.2 is a straight or branched chain loweralkyl; and n is an integer of from 2 to 4; or a physiologically tolerable acid addition salt thereof.
- 2. A compound as defined in claim 1 wherein R.sup.1 is hydrogen or straight or branched chain loweralkyl and R.sup.2 is straight or branched chain loweralkyl.
- 3. A compound as defined in claim 2 wherein n is 2, X is hydrogen, and Y is hydrogen, halogen, or SCH.sub.3.
- 4. The compound as defined in claim 1 which is 2-chloro-10,11-dihydro-11-[.beta.-(dimethylamino)ethylthio]dibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 5. The commpound defined in claim 1 which is 10,11-dihydro-10-[.beta.-(dimethylamino)ethylthio]dibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 6. The compound as defined in claim 1 which is 11-[.beta.-(ethylamino)ethylthio]-10,11-dihydro-4-nitrodibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 7. The compound as defined in claim 1 which is 8-chloro-10,11-dihydro-10-[.beta.-(dimethylamino)ethylthio]-2-methyldibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 8. The compound as defined in claim 1 which is 2-chloro-10,11-dihydro-11-[.beta.-(mehtylamino)ethylthio]dibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 9. The compound as defined in claim 1 which is 2-fluoro-10,11-dihydro-11-[.beta.-(dimethylamino)ethylthio]dibenzo[b,f]theipin or a physiologically tolerable acid addition salt thereof.
- 10. The compound as defined in claim 1 which is 2-fluoro-10,11-dihydro-11-[(.beta.-methylaminoethyl)thio]dibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 11. The compound as defined in claim 1 which is 10,11-dihydro-10-[.beta.-(methylamino)ethylthio]dibenzo[b,f]thiepin or a physiologically tolerable acid addition salt thereof.
- 12. A pharmaceutical composition for treating pain, depression or convulsions which comprises between 0.5 and about 70% by weight of a compound defined in claim 1 and a pharmaceutically acceptable carrier therefor.
- 13. A method of treating depression which comprises administering to a patient suffering from depression a pharmaceutically effective amount of a compound defined in claim 1.
- 14. A method of treating pain which comprises administering to a patient in pain a pharmaceutically effective amount of a compound defined in claim 1.
- 15. A method of treating convulsions which comprises administering to a patient susceptible to convulsions a pharmaceutically effective amount of a compound defined in claim 1.
- 16. A method of treating depression which comprises administering to a patient suffering from depression a pharmaceutically effective amount of a compound defined in claim 3.
- 17. A method of treating pain which comprises administering to a patient in pain a pharmaceutically effective amount of a compound defined in claim 3.
- 18. A method of treating convulsions which comprises administering to a patient susceptible to convulsions a pharmaceutically effective amount of a compound defined in claim 3.
Parent Case Info
This is a division of application Ser. No. 546,642, filed Oct. 28, 1983, issued as U.S. Pat. No. 4,668,695 on May 26, 1987, which is a continuation of application Ser. No. 350,531, filed Feb. 24, 1982, now abandoned, which is a continuation-in-part of application Ser. No. 174,487, filed Aug. 1, 1980, now abandoned, which is continuation of application Ser. No. 085,751, filed Oct. 17, 1979, now abandoned, which is a continuation-in-part of application Ser. No. 860,082, filed Dec. 13, 1977, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3704245 |
Umio et al. |
Nov 1972 |
|
Non-Patent Literature Citations (1)
Entry |
Bartl et al., Collection Czechoslov. Chem. Communication, vol. 43, 1978, pp. 2427-2435. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
546642 |
Oct 1983 |
|
Continuations (3)
|
Number |
Date |
Country |
Parent |
350531 |
Feb 1982 |
|
Parent |
85751 |
Oct 1979 |
|
Parent |
860082 |
Dec 1977 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
174487 |
Aug 1980 |
|