Claims
- 1. An aminobenzoic acid derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof: ##STR74## wherein R.sup.1 represents a group represented by the formula: ##STR75## wherein A and B each represents a group represented by the formula: ##STR76## wherein R.sup.8 represents hydrogen, hydroxyl or lower alkoxy; R.sup.2 represents hydrogen, lower alkyl or arylalkyl, provided that when R.sup.8 is hydrogen R.sup.2 is not hydrogen or alkyl;
- R.sup.9 represents alkynyl;
- R.sup.10 represents amino, acylamino or alkylamino; and
- R.sup.11 represents halogen.
- 2. An aminobenzoic acid derivative or a pharmacologically acceptable salt thereof as set forth in claim 1, wherein R.sup.9 is a group represented by the formula: ##STR77##
- 3. An aminobenzoic acid derivative or a pharmacologically acceptable salt thereof as set forth in claim 2, wherein R.sup.10 is amino and R.sup.11 is chlorine.
- 4. The aminobenzoic acid derivative according to claim 1, wherein R.sup.2 is a propyl or isopropyl group.
- 5. A pharmacological composition comprising a pharmacologically effective amount of the compound as defined in claim 1 or a pharmacologically acceptable salt thereof, and a pharmacologically acceptable carrier.
- 6. A pharmacological composition comprising a pharmacologically effective amount of the compound as defined in claim 4 or a pharmacologically acceptable salt thereof, and a pharmacologically acceptable carrier.
- 7. A method for preventing or therapeutically treating a disease against which serotonin antagonism or an acetylcholine release accelerating action is efficacious which comprises administering a pharmacologically effective amount of the compound as defined in claim 1 to a subject who suffers or will suffer from said disease.
- 8. A method for preventing or therapeutically treating a disease against which serotonin antagonism or an acetylcholine release accelerating action is efficacious which comprises administering a pharmacologically effective amount of the compound as defined in claim 4 to a subject who suffers or will suffer from said disease.
- 9. The method as claimed in claim 7, in which gastrointestinal function is increased.
- 10. The method as claimed in claim 7, in which antiemetic or an oxiolytic is effective or an irritable bowel syndrome is prevented or treated.
Priority Claims (1)
Number |
Date |
Country |
Kind |
5-189693 |
Jul 1993 |
JPX |
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Parent Case Info
This application is a continuation of application Ser. No. 08/275,704, filed on Jul. 18, 1994, now U.S. Pat. No. 5,512,579, the entire contents of which are hereby incorporated by reference.
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Continuations (1)
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Number |
Date |
Country |
Parent |
275704 |
Jul 1994 |
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