Claims
- 1. Compounds of the general formula (I) ##STR8## wherein R.sup.1 is a hydrogen atom or a C.sub.1-6 alkyl group;
- W is a straight or branched C.sub.1-7 alkylene group;
- X is cis or trans --CH.dbd.CH--;
- Y is a saturated heterocyclic amino group (attached to the cyclopentane ring via the nitrogen atom) selected from piperidino, morpholino and thiamorpholino; and R.sup.2 is a phenylalkyl group in which the alkyl portion contains 1-3 carbon atoms and the phenyl is substituted by phenyl (C.sub.1-3) alkyl, phenyl, or (C.sub.1-3) alkoxyphenyl, and the physiologically acceptable salts and solvates thereof.
- 2. Compounds as claimed in claim 1 in which R.sup.1 is a hydrogen atom.
- 3. Compounds as claimed in claim 1 in which X is cis --CH.dbd.CH-- and W is --CH.sub.2 CH.sub.2 --.
- 4. Compounds as claimed in claim 1 in which:
- R.sup.1 is a hydrogen atom,
- W is --CH.sub.2 CH.sub.2 --,
- X is cis --CH.dbd.CH--,
- Y is morpholino or piperidino, and
- R.sup.2 is benzyl in which the phenyl group is substituted by phenyl or methoxyphenyl, and the physiologically acceptable salts and solvents thereof.
- 5. [1.alpha.(z),2.beta.,3.beta.,5.alpha.]-(.+-.)-7-[5[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid and the physiolgically acceptable salts and solvates thereof.
- 6. The 1R-isomer of the compound as claimed in claim 5.
- 7. A pharmaceutical composition comprising an antithrombotic effective amount of a compound as claimed in claim 1 together with one or more pharmaceutical carriers.
- 8. A composition as claimed in claim 7 wherein said compound is [1.alpha.(Z),2.beta.,3.beta.,5.alpha.]-(.+-.)-7-(5-[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid and the physiologically acceptable salts and solvates thereof.
- 9. A composition as claimed in claim 7 wherein said compound is [1R-[1.alpha.(Z),2.beta.,3.beta.,5.alpha.]]-(+)-7-[5-[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid, hydrochloride.
- 10. A composition as claimed in claim 7 in the form of a tablet or capsule.
- 11. A method for the treatment or prevention of occlusive vascular diseases which comprises administering to the patient an effective amount of a compound as claimed in claim 1 or a physiologically acceptable salt or solvate thereof.
- 12. A method as claimed in claim 11 wherein said compound is [1.alpha.(Z),2.beta.,3.beta.,5.alpha.]-(.+-.)-7-[5-[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid and the physiologically acceptable salts and solvates thereof.
- 13. A method as claimed in claim 12 wherein said compound is [1R-[1.alpha.(Z), 2.beta.,3.beta.,5.alpha.]]-(+)-7-[[(1,1'-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid, hydrochloride.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8113238 |
Apr 1981 |
GBX |
|
8120459 |
Jul 1981 |
GBX |
|
Parent Case Info
This is a continuation of application Ser. No. 750,655, filed Jul. 1, 1985, now abandoned, which is a continuation of application Ser. No. 584,300 filed Mar. 5, 1984, now abandoned, which in turn is a continuation of application Ser. No. 437,332, filed Oct. 28, 1982, now abandoned, which is a continuation-in-part of application Ser. No. 372,823, filed Apr. 28, 1982, now abandoned.
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0044711 |
Jan 1982 |
EPX |
Non-Patent Literature Citations (6)
Entry |
Floyd et al., Tetrahedron Letters, No. 32, (1972), pp. 3269-3272. |
Miller et al., Prostaglandins, 11, (1976), pp. 77-84. |
Anderson et al., Advances in Prostaglandins & Thromboxane Research, vol. 1, pp. 271, 275, 283 and 288, (1976). |
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Continuations (3)
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Number |
Date |
Country |
Parent |
750655 |
Jul 1985 |
|
Parent |
584300 |
Mar 1984 |
|
Parent |
437332 |
Oct 1982 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
372823 |
Apr 1982 |
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