Claims
- 1. A compound having the formula ##STR37## wherein for the l isomer or racemic mixtures containing it ##STR38## or N.sub.3 ; B is NH.sub.2,
- u is 1 or 2;
- R.sub.3 is H, alkyl of 1-10 carbon atoms, or cycloalkyl of 3-8 carbon atoms;
- R.sub.4 is H, alkyl of 1-4 carbon atoms, alkenyl of 2-4 carbon atoms, cycloalkyl of 3-4 carbon atoms, or OR.sub.5 ;
- R.sub.5 is alkyl of 1-4 carbon atoms;
- X is O or S;
- R.sub.6 is H or alkyl of 1-4 carbon atoms;
- n is 1-3; and
- R.sub.1 and R.sub.2 taken together are H and N(R.sub.6).sub.2 ; or a pharmaceutically suitable salt thereof; provided that:
- (1) when n is 2, then X is not S; and
- (2) when n is 3, then X is not O.
- 2. A compound of claim 1 wherein B is ##STR39## where R.sub.4 is H, CH.sub.3, or OR.sub.5.
- 3. A compound of claim 1 wherein n is 1 or 2.
- 4. A compound of claim 1 wherein:
- (a) B is ##STR40## where R.sub.4 is H, CH.sub.3, or OR.sub.5 ; and (b) n is 1 or 2.
- 5. A compound of claim 1 wherein B is ##STR41##
- 6. A compound of claim 4 wherein n is 1.
- 7. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 1.
- 8. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 2.
- 9. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 3.
- 10. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 4.
- 11. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 5.
- 12. A pharmaceutical composition consisting essentially of a pharmaceutically suitable carrier and an antibacterial amount of a compound of claim 6.
- 13. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 1.
- 14. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 2.
- 15. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 3.
- 16. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 4.
- 17. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 5.
- 18. A method of treating a bacterial infection in a mammal comprising administering to the mammal an antibacterial amount of a compound of claim 6.
Parent Case Info
This application is a division of application Ser. No. 07/233,828 filed Aug. 19, 1988, now Pat. No. 4,921,869 issued May 1, 1990, which is a division of Ser. No. 07/106358 filed Oct. 9, 1987 Pat. No. 4,801,600, issued Jan. 31, 1989.
US Referenced Citations (8)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0127902 |
Dec 1984 |
EPX |
0184170 |
Jun 1986 |
EPX |
2094299 |
Sep 1982 |
GBX |
Divisions (2)
|
Number |
Date |
Country |
Parent |
233828 |
Aug 1988 |
|
Parent |
106358 |
Oct 1987 |
|