Claims
- 1. A compound of the formula:
- 2. A compound of claim 1 wherein A is selected from pyridyl, furyl, imidazolyl, pyrrolyl, thienyl or indanyl.
- 3. A compound of claim 1 wherein A is 3-pyridyl.
- 4. A compound of claim 1 wherein A is substituted.
- 5. A compound of claim 1 wherein A is substituted with one or more substitutents selected from alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO2, —CO2R6, —COR6, —OR6, —SR6, —SOR6, —SO2R6, —CONR7R8, —NRN(R7R8), —N(R7R8), or W—Y—(CH2)n—Z wherein R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or
R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; W is O, NR6, or is absent; Y is —(CO)— or —(CO2)—, or is absent; Z is alkyl of 1 to 4 carbon atoms, —CN, —CO2R6, COR6, —CONR7R8, —OCOR6, —NR6COR7, —OCONR6, —OR6, —SR6, —SOR6, —SO2R6, SR6N(R7R8), —N(R7R8) or phenyl; and n is 1 to6.
- 6. A compound of claim 1 wherein A is substituted with one or more substitutents independently selected from halogen or alkyl of 1 to 6 carbon atoms.
- 7. A compound of claim 1 wherein one or more of R9-R12 is independently selected from halogen, methyl, methoxy, and cyano.
- 8. A compound of claim 1 wherein each of R1-R9 is hydrogen.
- 9. A compound of claim 1 wherein G is furyl or thiadiazole.
- 10. A compound of claim 1 wherein G is 1,2,3 thiadiazole.
- 11. A compound of claim 1 wherein G is 2-furyl.
- 12. A compound of claim 1 wherein X is a bond.
- 13. A compound of claim 1 wherein X is lower alkyl.
- 14. A compound of claim 1 selected from:
Furan-2-carboxylic acid [4-(3-pyridin-2-yl-thioureido)-phenyl]-amide; Furan-2-carboxylic acid [4-(3-pyridin-4-yl-thioureido)-phenyl]-amide; Furan-2-carboxylic acid [4-(3-pyridin-3-yl-thioureido)-phenyl]-amide; [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(6-chloro-pyridin-3-yl)-thioureido]-phenyl}-amide; Furan-2-carboxylic acid [4-(3-pyrimidin-4-yl-thioureido)-phenyl]-amide; [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-pyridin-3-yl)-thioureido]-phenyl }-amide; [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-bromo-pyridin-3-yl)-thioureido]-phenyl}-amide; [1,2,3]Thiadiazole-4-carboxylic acid (4-[3-(1-tert-butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-amide; Furan-2-carboxylic acid {4-[3-(1-tert-butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-amide; [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-trifluoromethyl-pyridin-3-yl)-thioureido]-phenyl}-amide; Furan-2-carboxylic acid [4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-amide; [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-amide; [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-indan-1-yl-thioureido)-phenyl]-amide; Furan-2-carboxylic acid [4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-amide; [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-amide; 2-Fluoro-N-[4-(3-pyridin-3-yl-thioureido)-phenyl]-benzamide; 2-Fluoro-N-[4-(3-pyridin-2-yl-thioureido)-phenyl]-benzamide; 2-Fluoro-N-[4-(3-pyridin-4-yl-thioureido)-phenyl]-benzamide; 2-Fluoro-N-[4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-benzamide; 2-Fluoro-N-[4-[3-(1H-indazol-5-yl)-thioureido]-phenyl}-benzamide; N-{4-[3-(1-tert-Butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-2-fluoro-benzamide; 2-Fluoro-N-[4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-benzamide; 2-Fluoro-N-{4-[3-(1-furan-2-yl-ethyl)-thioureido]-phenyl}-benzamide; 2-Fluoro-N-{4-[3-(1-pyridin-4-yl-ethyl)-thioureido]-phenyl}-benzamide; 2-Fluoro-N-(4-{3-[1-(1-methyl-1H-pyrrol-2-yl)-ethyl]-thioureido}-phenyl)-benzamide; and 2-Fluoro-N-{4-[3-(1-thiophen-3-yl-ethyl)-thioureido]-phenyl}-benzamide; and pharmaceutical salts thereof.
- 15. A pharmaceutical composition comprising a compound of of the formula:
- 16. A method of inhibiting the replication of a herpes virus comprising contacting a compound of the formula:
- 17. The method of claim 16 wherein the herpes virus is human cytomegalovirus.
- 18. The method of claim 16 wherein the herpes virus is herpes simplex virus.
- 19. The method of claim 16 wherein the herpes virus is varicella zoster virus.
- 20. A method of treating a patient suffering from a herpes virus infection comprising administering to the patient a therapeutically effective amount of a compound having the formula:
- 21. The method of claim 20 wherein the herpes virus is human cytomegalovirus.
- 22. The method of claim 20 wherein the herpes virus is herpes simplex virus.
- 23. The method of claim 20 where the herpes virus is varicella zoster virus.
BACKGROUND OF THE INVENTION
[0001] This application claims the benefit of U.S. Provisional Application Nos. 60/150,698, 60/155,240, 60/155,192, and 60/150,692, and U.S. Application Nos. 09/208,540, 09/208,164, 09/208,561 each of which was filed Dec. 9, 1998. These applications are herein incorporated by reference in their entireties.
Provisional Applications (7)
|
Number |
Date |
Country |
|
60150698 |
Dec 1998 |
US |
|
60155240 |
Dec 1998 |
US |
|
60155192 |
Dec 1998 |
US |
|
60150692 |
Dec 1998 |
US |
|
60228808 |
Dec 1998 |
US |
|
60228805 |
Dec 1998 |
US |
|
60228809 |
Dec 1998 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09444896 |
Nov 1999 |
US |
Child |
09804510 |
Mar 2001 |
US |