Claims
- 1. A method for treating an inflammatory or immune disease, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
- 2. The method of claim 1, wherein D is of formula (II),
- 3. The method of claim 1, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, —N═, —N—, —S—, or a single bond; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylamino, diarylamino, —C(O)—NRbRb′, or —C(O)—Rb; or R1 and R2 together are C5-C8 cycloalkyl or C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C3-C8 heterocyclolkyl, C5-C8 heterocycloalkenyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NO2, —C(O)—NRcRc′, —C(O)—Rc, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═, —S—, or a single bond; if R6 is deleted, X2— is —N═, —S—, or a single bond; if R7 is deleted, X3— is —N═, —S—, or a single bond; and if R8 is deleted, X4— is —N═, —S—, or a single bond; B is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, or heteroaryl; or B and A together are C5-C7 heterocycloalkyl or heteroaryl; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; or D and A together are C5-C7 heterocycloalkyl or heteroaryl; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, C5-C8 cycloalkenyl, C5-C8 heterocycloalkenyl, aryl, or heteroaryl.
- 4. The method of claim 3, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, or —N═; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, or C1-C6 alkylthio; or R1 and R2 together are C5-C8 cycloalkyl or C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═; if R6 is deleted, X2— is —N═; if R7 is deleted, X3— is —N═; and if R8 is deleted, X4— is —N═; A is C1-C12 alkyl optionally containing 1-6 heteroatoms, C2-C12 alkenyl optionally containing 1-6 heteroatoms, C2-C12 alkynyl optionally containing 1-6 heteroatoms, aryl, C1-C10 alkylsulfonyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 alkylaryl optionally containing 1-6 heteroatoms, or C2-C20 arylalkyl optionally containing 1-6 heteroatoms; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, aryl, or heteroaryl.
- 5. The method of claim 4, wherein A is C1-C12 alkyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 arylalkyl, or A and B together are heteroaryl.
- 6. The method of claim 5, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, or halogen; and B is H or B and A together are heteroaryl.
- 7. The method of claim 4, wherein D is of formula (II),
- 8. The method of claim 7, wherein A is C1-C12 alkyl.
- 9. The method of claim 7, wherein A is C1-C12 alkyl containing 1-6 heteroatoms and optionally substituted with sulfonyl, C1-C6 alkylsulfonyl, arylsulfonyl, or heteroarylsulfonyl.
- 10. The method of claim 7, wherein A is C2-C20 alkylaryl optionally containing 1-6 heteroatoms.
- 11. The method of claim 7, wherein A is aryl, or A and B together are heteroaryl.
- 12. The method of claim 8, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H, C1-C8 alkyl, or aryl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H or C1-C8 alkyl; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H, C1-C8 alkyl, or aryl; or R1′ and R2′together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 13. The method of claim 9, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 14. The method of claim 10, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen.
- 15. The method of claim 11, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H or C1-C8 alkyl; B is H; or B and A together are heteroaryl; each of X1′—, X2′—, X3′—, and X4—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H or C1-C8 alkyl.
- 16. A compound of formula (I):
- 17. The compound of claim 16, wherein D is of formula (II),
- 18. The compound of claim 16, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, —N═, —N—, —S—, or a single bond; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylamino, diarylamino, —C(O)—NRbRb′, or —C(O)—Rb; or R1 and R2 together are C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C3-C8 heterocycloalkyl, C5-C8 heterocycloalkenyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NO2, —C(O)—NRcRc′, —C(O)—Rc, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═, —S—, or a single bond; if R6 is deleted, X2— is —N═, —S—, or a single bond; if R7 is deleted, X3— is —N═, —S—, or a single bond; and if R8 is deleted, X4— is —N═, —S—, or a single bond; B is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, or heteroaryl; or B and A together are heteroaryl; D is H, aryl, heteroaryl, C3-C8 heterocycloalkyl, or C1-C8 alkyl; or D and A together are heteroaryl; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, C5-C8 cycloalkenyl, C5-C8 heterocycloalkenyl, aryl, or heteroaryl.
- 19. The compound of claim 18, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, or —N═; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, or C1-C6 alkylthio; or R1 and R2 together are C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═; if R6 is deleted, X2— is —N═; if R7 is deleted, X3— is —N═; and if R8 is deleted, X4— is —N═; A is C1-C12 alkyl optionally containing 1-6 heteroatoms, C2-C12 alkenyl optionally containing 1-6 heteroatoms, C2-C12 alkynyl optionally containing 1-6 heteroatoms, aryl, C1-C10 alkylsulfonyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 alkylaryl optionally containing 1-6 heteroatoms, or C2-C20 arylalkyl optionally containing 1-6 heteroatoms; D is H, aryl, heteroaryl, C3-C8 heterocycloalkyl, or C1-C8 alkyl; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, aryl, or heteroaryl.
- 20. The method of claim 19, wherein A is C1-C12 alkyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 arylalkyl, or A and B together are heteroaryl.
- 21. The method of claim 20, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, or halogen; and B is H or B and A together are heteroaryl.
- 22. The compound of claim 21, wherein the compound is compound 68 or compound 70.
- 23. The compound of claim 19, wherein D is of formula (II),
- 24. The compound of claim 23, wherein A is C1-C12 alkyl.
- 25. The compound of claim 23, wherein A is C1-C12 alkyl containing 1-6 heteroatoms and optionally substituted with sulfonyl, C1-C6 alkylsulfonyl, arylsulfonyl, or heteroarylsulfonyl.
- 26. The compound of claim 23, wherein A is C2-C20 alkylaryl optionally containing 1-6 heteroatoms.
- 27. The compound of claim 23, wherein A is aryl, or A and B together are heteroaryl.
- 28. The compound of claim 24, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H, C1-C8 alkyl, or aryl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H or C1-C8 alkyl; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H, C1-C8 alkyl, or aryl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 29. The compound of claim 28, wherein the compound is one of the compounds 1-3, 5, 11-12, 19, 23, 30, and 53-55.
- 30. The compound of claim 25, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H; each of X1′—, X2′—, X3—, and X4—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 31. The compound of claim 30, wherein the compound is one of compounds 31, 41-44, and 51.
- 32. The compound of claim 26, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—,independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen.
- 33. The compound of claim 32, wherein the compound is one of compounds 38 and 59-63.
- 34. The compound of claim 27, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H or C1-C8 alkyl; B is H; or B and A together are heteroaryl; each of X1′—, X2′—, X3′—, and X4—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H or C1-C8 alkyl.
- 35. The compound of claim 34, wherein the compound is compound 36.
- 36. A compound of formula (I):
- 37. The compound of claim 36, wherein D is of formula (II),
- 38. The compound of claim 36, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, —N═, —N—, —S—, or a single bond; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylamino, diarylamino, —C(O)—NRbRb′, or —C(O)—Rb; or R1 and R2 together are C5-C8 cycloalkyl or C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C3-C8 heterocycloalkyl, C5-C8 heterocycloalkenyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NO2, —C(O)—NRcRc′, —C(O)—Rc, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═, —S—, or a single bond; if R6 is deleted, X2— is —N═, —S—, or a single bond; if R7 is deleted, X3— is —N═, —S—, or a single bond; and if R8 is deleted, X4— is —N═, —S—, or a single bond; B is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, or heteroaryl; or B and A together are heteroaryl; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; or D and A together are heteroaryl; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, C5-C8 cycloalkenyl, C5-C8 heterocycloalkenyl, aryl, or heteroaryl.
- 39. The compound of claim 38, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, or —N═; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, or C1-C6 alkylthio; or R1 and R2 together are C5-C8 cycloalkyl or C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═; if R6 is deleted, X2— is —N═; if R7 is deleted, X3— is —N═; and if R8 is deleted, X4— is —N═; A is C1-C12 alkyl optionally containing 1-6 heteroatoms, C2-C12 alkenyl optionally containing 1-6 heteroatoms, C2-C12 alkynyl optionally containing 1-6 heteroatoms, aryl, C1-C10 alkylsulfonyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 alkylaryl optionally containing 1-6 heteroatoms, or C2-C20 arylalkyl optionally containing 1-6 heteroatoms; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, is H, aryl, or heteroaryl.
- 40. The method of claim 39, wherein A is C1-C12 alkyl.
- 41. The method of claim 40, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H or C1-C8 alkyl; B is H; and D is H, heteroaryl, or —C(O)—Rd.
- 42. The compound of claim 41, wherein the compound is compound 72 or compound 73.
- 43. The compound of claim 39, wherein D is of formula (II),
- 44. The compound of claim 43, wherein A is C1-C12 alkyl.
- 45. The compound of claim 43, wherein A is C1-C12 alkyl containing 1-6 heteroatoms and optionally substituted with sulfonyl, C1-C6 alkylsulfonyl, arylsulfonyl, or heteroarylsulfonyl.
- 46. The compound of claim 44, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C ; each of R1′ and R2′, independently, is H or C1-C8 alkyl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, or C1-C6 alkoxy.
- 47. The compound of claim 46, wherein the compound is one of compounds 25-28 and 57-58.
- 48. The compound of claim 45, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H or C1-C8 alkyl; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H or C1-C8 alkyl.
- 49. A pharmaceutical composition comprising a compound of formula (I):
- 50. The composition of claim 49, wherein D is of formula (II),
- 51. The composition of claim 49, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, —N═, —N—, —S—, or a single bond; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylamino, diarylamino, —C(O)—NRbRb′, or —C(O)—Rb; or R1 and R2 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, C3-C8 heterocycloalkyl, C5-C8 heterocycloalkenyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NO2, —C(O)—NRcRc′, —C(O)—Rc, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═, —S—, or a single bond; if R6 is deleted, X2— is —N═, —S—, or a single bond; if R7 is deleted, X3— is —N═, —S—, or a single bond; and if R8 is deleted, X4— is —N═, —S—, or a single bond; B is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, or heteroaryl; or B and A together are C5-C7 heterocycloalkyl or heteroaryl; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; or D and A together are C5-C7 heterocycloalkyl or heteroaryl; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, being H, C5-C8 cycloalkenyl, C5-C8 heterocycloalkenyl, aryl, or heteroaryl.
- 52. The composition of claim 51, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═, —CRa—, or —N═; each of R1 and R2, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, or C1-C6 alkylthio; or R1 and R2 together are C5-C8 cycloalkyl or C5-C8 heterocycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, halogen, or deleted; or R6 and R7 together are C5-C7 cycloalkyl or C5-C7 heterocycloalkyl; provided that if R5 is deleted, X1— is —N═; if R6 is deleted, X2— is —N═; if R7 is deleted, X3— is —N═; and if R8 is deleted, X4— is —N═; A is C-C12 alkyl optionally containing 1-6 heteroatoms, C2-C12 alkenyl optionally containing 1-6 heteroatoms, C2-C12 alkynyl optionally containing 1-6 heteroatoms, aryl, C1-C10 alkylsulfonyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 alkylaryl optionally containing 1-6 heteroatoms, or C2-C20 arylalkyl optionally containing 1-6 heteroatoms; D is H, aryl, heteroaryl, C1-C8 alkyl, C3-C8 heterocycloalkyl, or —C(O)—Rd; and each of Ra, Rb, Rb′, Rc, Rc′, Rd, and Rd′, independently, being H, aryl, or heteroaryl.
- 53. The method of claim 52, wherein A is C1-C12 alkyl, arylsulfonyl, C1-C10 alkylcarbonyl containing 1-6 heteroatoms, C2-C20 arylalkyl, or A and B together are heteroaryl.
- 54. The method of claim 53, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, or halogen; and B is H or B and A together are heteroaryl.
- 55. The composition of claim 52, wherein D is of formula (II),
- 56. The composition of claim 55, wherein A is C1-C12 alkyl.
- 57. The composition of claim 55, wherein A is C1-C12 alkyl containing 1-6 heteroatoms and optionally substituted with sulfonyl, C1-C6 alkylsulfonyl, arylsulfonyl, or heteroarylsulfonyl.
- 58. The composition of claim 55, wherein A is C2-C20 alkylaryl optionally containing 1-6 heteroatoms.
- 59. The composition of claim 55, wherein A is aryl, or A and B together are heteroaryl.
- 60. The composition of claim 56, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H, C1-C8 alkyl, or aryl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H or C1-C8 alkyl; each of X1′—, X2′—, X3′—, and X4—, independently, is —C═; each of R1′ and R2′, independently, is H, C1-C8 alkyl, or aryl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C3-C8 heterocycloalkyl, OH, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 61. The composition of claim 57, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; or R1 and R2 together are C5-C8 cycloalkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; or R1′ and R2′ together are C5-C8 cycloalkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, C1-C6 alkylthio, or halogen.
- 62. The composition of claim 58, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen; B is H; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H, C1-C8 alkyl, C1-C6 alkoxy, aryloxy, or halogen.
- 63. The composition of claim 59, wherein each of X1—, X2—, X3—, and X4—, independently, is —C═; each of R1 and R2, independently, is H or C1-C8 alkyl; each of R5, R6, R7, and R8, independently, is H or C1-C8 alkyl; B is H; or B and A together are heteroaryl; each of X1′—, X2′—, X3′—, and X4′—, independently, is —C═; each of R1′ and R2′, independently, is H or C1-C8 alkyl; each of R3′, R4′, R5′, and R6′, independently, is H or C1-C8 alkyl.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] Pursuant to 35 USC § 119(e), this application claims priority to U.S. Provisional Application Serial No. 60/462,495, filed Apr. 11, 2003, and U.S. Provisional Application Serial No. 60/551,750, filed Mar. 9, 2004, the contents of which are incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60462495 |
Apr 2003 |
US |
|
60551750 |
Mar 2004 |
US |