Claims
- 1. A composition comprising a compound of Formula (I):
- 2. A composition comprising a compound of Formula (I):
- 3. The composition of claim 2 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cyCloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 4. The composition of claim 2 wherein L is a direct bond or C1-8alkandiyl.
- 5. The composition of claim 2 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 6. A composition comprising a compound of Formula (I):
- 7. The composition of claim 6 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 8. The composition of claim 6 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 9. The composition of claim 6 wherein L is a direct bond or C1-8alkandiyl.
- 10. The composition of claim 6 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; and isoquinolinyl-N-oxide.
- 11. A composition comprising a compound of Formula (I):
- 12. The composition of claim 11 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 13. The composition of claim 11 wherein L is a direct bond or C1-8alkandiyl.
- 14. The composition of claim 11 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 15. A composition comprising a compound of Formula (I):
- 16. The composition of claim 15 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 17. The composition of claim 15 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 18. The composition of claim 15 wherein L is a direct bond or C1-8alkandiyl.
- 19. The composition of claim 15 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 20. A composition comprising a compound of Formula (I):
- 21. The composition of claim 20 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 22. The composition of claim 20 wherein L is a direct bond or C1-8alkandiyl.
- 23. The composition of claim 20 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 24. A composition comprising a compound of Formula (I):
- 25. The composition of claim 24 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 26. The composition of claim 24 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 27. The composition of claim 24 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 28. The composition of claim 24 wherein L is a direct bond or C1-8alkandiyl.
- 29. The composition of claim 24 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 30. A composition comprising a compound of Formula (I):
- 31. The composition of claim 30 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 32. The composition of claim 30 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 33. The composition of claim 30 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 34. The composition of claim 30 wherein L is a direct bond or C1-8alkandiyl.
- 35. The composition of claim 30 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 36. A composition comprising a compound of Formula (I):
- 37. The composition of claim 36 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 38. The composition of claim 36 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 39. The composition of claim 36 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 40. The composition of claim 36 wherein L is a direct bond or C1-8alkandiyl.
- 41. The composition of claim 36 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 42. A composition comprising a compound of Formula (I):
- 43. The composition of claim 42 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 44. The composition of claim 42 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 45. The composition of claim 42 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 46. The composition of claim 42 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 47. A composition comprising a compound of Formula (I):
- 48. The composition of claim 47 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 49. The composition of claim 47 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 50. The composition of claim 47 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 51. The composition of claim 47 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 52. A composition comprising a compound of Formula (I):
- 53. The composition of claim 52 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 54. The composition of claim 52 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 55. The composition of claim 52 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 56. The composition of claim 52 wherein L is a direct bond or C1-8alkandiyl.
- 57. A composition comprising a compound of Formula (I):
- 58. The composition of claim 57 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 59. The composition of claim 57 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 60. The composition of claim 57-wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 61. The composition of claim 57 wherein L is a direct bond or C1-8alkandiyl.
- 62. A composition comprising a compound of Formula (I):
- 63. The composition of claim 62 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 64. The composition of claim 62 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 65. The composition of claim 62 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 66. The composition of claim 62 wherein L is a direct bond or C1-8alkandiyl.
- 67. A composition comprising a compound of Formula (I):
- 68. The composition of claim 67 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 69. The composition of claim 67 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 70. The composition of claim 67 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 71. The composition of claim 67 wherein L is a direct bond or C1-8alkandiyl.
- 72. A composition comprising a compound of Formula (I):
- 73. The composition of claim 72 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 74. The composition of claim 72 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 75. The composition of claim 72 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 76. The composition of claim 72 wherein L is a direct bond or C1-8alkandiyl.
- 77. The composition of claim 72 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 78. A composition comprising a compound of Formula (I):
- 79. The composition of claim 78 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 80. The composition of claim 78 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 81. The composition of claim 78 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 82. The composition of claim 78 wherein L is a direct bond or C1-8alkandiyl.
- 83. The composition of claim 78 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 84. A composition comprising a compound of Formula (I):
- 85. The composition of claim 84 wherein R1 is a substituent independently selected from the group consisting of hydrogen; hydroxy; fluoro; chloro; and C1-8alkanyloxy.
- 86. The composition of claim 84 wherein R1 is a substituent independently selected from the group consisting of fluoro; chloro; and C1-8alkanyloxy.
- 87. The composition of claim 84 wherein R2 is independently selected from the group consisting of hydrogen; C2-8alkenyl; C1-8alkylidenyl; C1-8alkylidynyl; C3-8cycloalkanyl; phenyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; naphthyl optionally substituted with one to three substituents independently selected from the group consisting of fluoro, chloro, bromo, hydroxy, C1-8alkanyl, C1-8alkanyloxy, phenyl(C1-8)alkanyloxy, and fluorinated alkanyl; and a heteroaryl optionally substituted with one to three substituents independently selected from the group consisting of C1-6alkanyl and halogen wherein said heteroaryl is pyridyl, pyrimidyl, furyl, thienyl or imidazolyl.
- 88. The composition of claim 84 wherein L is a direct bond or C1-8alkandiyl.
- 89. The composition of claim 84 wherein R3 is selected from the group consisting of naphthyl substituted with hydroxyl; quinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro; quinolinyl-N-oxide; isoquinolinyl optionally substituted with one or more substituents selected from the group consisting of methyl and chloro and isoquinolinyl-N-oxide.
- 90. A composition comprising a compound of Formula (Ia):
- 91. A composition comprising a compound of Formula (Ia):
- 92. A composition comprising a compound of Formula (Ia):
- 93. A composition comprising a compound of Formula (Ia):
- 94. A pharmaceutical composition comprising a compound, salt or solvate according to claim 1 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 95. A veterinary composition comprising a compound, salt or solvate according to claim 1 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 96. A method of treating or preventing a disease or condition in a mammal which disease or condition is affected by the modulation of one or more vanilloid receptors, which method comprises administering to a mammal in need of such treatment or prevention a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 97. A method for preventing or treating a chronic-pain causing disease or condition, an acute-pain causing disease or condition, or a pulmonary dysfunction comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 98. A method for preventing or treating a disease or condition, wherein said disease or condition causes inflammatory pain, burning pain, itch urinary incontinence, or chronic obstructive pulmonary disease, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 99. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 1.
- 100. The method of claim 97 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 101. The method of claim 97 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 102. The method of claim 97 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 103. A kit comprising in one or more containers an amount of the composition of claim 1 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 104. A pharmaceutical composition comprising a compound, salt or solvate according to claim 90 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 105. A veterinary composition comprising a compound, salt or solvate according to claim 90 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 106. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 90.
- 107. The method of claim 104 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 108. The method of claim 104 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 109. The method of claim 104 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 110. A kit comprising in one or more containers an amount of the composition of claim 90 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
- 111. A pharmaceutical composition comprising a compound, salt or solvate according to claim 91 admixed with a pharmaceutically acceptable carrier, excipient or diluent.
- 112. A veterinary composition comprising a compound, salt or solvate according to claim 91 admixed with a veterinarily acceptable carrier, excipient or dilluent.
- 113. A method for preventing or treating a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, posffebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma, said method comprising the step of administering to a mammal in need of such treatment a therapeutically effective amount of a compound, salt or solvate of claim 91.
- 114. The method of claim 111 wherein said therapeutically effective amount comprises a dose range of from about 0.001 mg to about 1,000 mg.
- 115. The method of claim 111 wherein said therapeutically effective amount comprises a dose range of from about 0.1 mg to about 500 mg.
- 116. The method of claim 111 wherein said therapeutically effective amount comprises a dose range of from about 1 mg to about 250 mg.
- 117. A kit comprising in one or more containers an amount of the composition of claim 91 effective to treat or prevent a disease or condition selected from the group consisting of osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine, headache, toothache, burn, sunburn, snake bite (in particular, venomous snake bite), spider bite, insect sting, neurogenic bladder, benign prostatic hypertrophy, interstitial cystitis, urinary tract infection, cough, asthma, chronic obstructive pulmonary disease, rhinitis, contact dermatitis/hypersensitivity, itch, eczema, anxiety, panic disorders, inflammatory bowel diseases, pharyngitis, mucositis, enteritis, cellulites, peripheral neuropathy, bilateral peripheral neuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminal neuralgia, causalgia, sciatic neuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limb pain, bony fractures, post-operative ileus, irritable bowel syndrome, Crohn's Disease, ulcerative colitis, cholecystitis, pancreatitis, postmastectomy pain syndrome, oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, optic neuritis, postfebrile neuritis, migrating neuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstrual cramps, cancer, and trauma.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This applicaiton claims priority to U.S. Provisional Application No. 60/381,575, filed May 17, 2003.
Provisional Applications (1)
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Number |
Date |
Country |
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60381575 |
May 2002 |
US |