Claims
- 1. A compound of formula in amorphous form substantially free of crystalline form.
- 2. A pharmaceutical composition, which is free of ionic polymers, comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 3. A method of making a compound of claim 1 comprising:(a) dissolving crystalline compound of formula I, free of ionic polymers, in an organic solvent; and (b) precipitating the desired amorphous compound of formula I from the solution of step (a).
- 4. The method of claim 3 wherein the organic solvent used in step (a) is selected from the group consisting of ethanol, methanol, acetone, dimethyl sulfoxide, N,N-dimethylacetamide, N,N-dimethylformamide, N-methylpyrrolidone, diethylene glycol ethyl ether, glycofural, propylene carbonate, tetrahydrofuran, polyethylene glycols, and propylene glycols.
- 5. The method of claim 4 wherein the organic solvent used in step (a) is dimethylacetamide.
- 6. The method of claim 3 wherein precipitation in step (b) is effected by adding the solution of step (a) to a cold aqueous solution.
- 7. The method of claim 6 wherein the temperature of the aqueous solution is from about 2° C. to about 10° C.
- 8. The method of claim 7 wherein the pH of the aqueous solution is one in which the compound of formula I in amorphous form is not soluble.
- 9. The method of claim 8 wherein the pH of the aqueous solution is from about 2 to about 7.
Parent Case Info
This application claims priority to prior provisional application Ser. No. 60/237,563, filed on Oct. 3, 2000 claimed under 35 U.S.C. § 119(e).
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Kind |
5057614 |
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Oct 1991 |
A |
6048887 |
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Apr 2000 |
A |
RE36736 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0 988 863 |
Mar 2000 |
EP |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/237563 |
Oct 2000 |
US |