Claims
- 1. Amorphous 3[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid, sodium salt.
- 2. A compound of claim 1 having a solubility in de-ionized water at 25.degree. C. of 55 mg/mL.
- 3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 4. The pharmaceutical composition of claim 3 additionally comprising an effective amount of a second active ingredient selected from the group consisting of non-steroidal anti-inflammatory drugs; peripheral analgesic agents; cyclooxygenase inhibitors; leukotriene antagonists; leukotriene biosynthesis inhibitors; H.sub.1 - or H.sub.2 -receptor antagonists; antihistaminic agents; prostaglandin antagonists; and ACE antagonists.
- 5. A pharmaceutical composition according to claim 4 wherein the second active ingredient is a non-steroidal anti-inflammatory drug.
- 6. A pharmaceutical composition of claim 5, wherein the weight ratio of said compound of claim 1 to said second active ingredient ranges from about 1000:1 to 1:1000.
- 7. A method of preventing the synthesis, the action, or the release of SRS-A or leukotrienes in a mammal which comprises administering to said mammal an effective amount of a compound of claim 1.
- 8. The method of claim 7 wherein the mammal is man.
CROSS-REFERENCE
This is a CIP of U.S. Ser. No. 793,087, Nov. 15, 1991, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0419049 |
Mar 1991 |
EPX |
Non-Patent Literature Citations (3)
Entry |
Suryanarayanan & Mitchell, Inter. J. of Pharm., 24, 1-4 (1985). |
Byrn, S. R., Solid State Chem. of Drugs, pp. 10-11, Acad. Press. 1982. |
List of Amorphous Pharmaceuticals, Chem. Abst., 1967-1990. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
793087 |
Nov 1991 |
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