AMORPHOUS SELENIUM IMAGING FOR TOMOTHERAPY

Information

  • Research Project
  • 2717570
  • ApplicationId
    2717570
  • Core Project Number
    R43CA079383
  • Full Project Number
    1R43CA079383-01
  • Serial Number
    79383
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/5/1998 - 26 years ago
  • Project End Date
    3/4/2001 - 23 years ago
  • Program Officer Name
    TORRES-ANJEL, MANUEL J.
  • Budget Start Date
    9/5/1998 - 26 years ago
  • Budget End Date
    3/4/2001 - 23 years ago
  • Fiscal Year
    1998
  • Support Year
    1
  • Suffix
  • Award Notice Date
    9/4/1998 - 26 years ago
Organizations

AMORPHOUS SELENIUM IMAGING FOR TOMOTHERAPY

Tomotherapy has the potential to provide much better radiation therapy because it combines optimized radiotherapy treatment planning, intensity modulated radiation delivery and tomographic verification. TomoTherapy, Inc. is developing a commercial tomotherapy system, but we are missing a key enabling technology: a detector for optimized megavoltage computed tomography. This technology will allow more conformal dose distributions to be verifiably delivered. A key enabling technology for tomotherapy is megavoltage computed tomography. Existing computed tomography imaging systems do not have optimal performance for tomotherapy applications. This proposal explores the use of thin film amorphous selenium (a-Se) imaging for use in tomotherapy. Critical issues to be investigated in Phase I are feasibility, linearity, stability and temporal response of the system. A preliminary design for a prototype will be developed. In Phase II we will design the thin film arrays and readout electronics, fabricate a prototype detector and evaluate its performance for tomotherapy. This is the key enabling technology to allow tomotherapy to enter the marketplace. PROPOSED COMMERCIAL APPLICATIONS: Tomotherapy is a promising new method to verifiably deliver highly conformal dose distributions for cancer therapy. The total market for radiotherapy delivery equipment is hundreds of millions of dollars per year. One of the key technologies for enabling tomotherapy is a Computed Tomography-like megavoltage detector. Amorphous selenium imaging technology is highly promising for this application.

IC Name
NATIONAL CANCER INSTITUTE
  • Activity
    R43
  • Administering IC
    CA
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    394
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG7
  • Study Section Name
  • Organization Name
    TOMOTHERAPY
  • Organization Department
  • Organization DUNS
  • Organization City
    MIDDLETON
  • Organization State
    WI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    53562
  • Organization District
    UNITED STATES