Claims
- 1. An amyloid binding diazo compound of the following formula, or a water-soluble non-toxic salt thereof: ##STR13## wherein: I* is a radioactive iodine moiety;
- R.sub.50 is hydrogen or sulfo;
- R.sub.51 is methyl or carboxyl; and
- R.sub.52, R.sub.53 and R.sub.54 each are hydrogen,
- hydroxy, carboxy or lower alkyl
- esters thereof, methyl or methoxy.
- 2. As a compound of claim 1, 2-(4-(1-hydroxy-2-.sup.123 I-phen-4-yldiazo)-phenyl)-6-methylbenzothiazole-7-sulfonic acid or a water-soluble, non-toxic salt thereof.
- 3. As a compound of claim 1, 2-(4-(1-hydroxy-2-.sup.124 I-phen-4-yldiazo)-phenyl)-6-methylbenzothiazole-7-sulfonic acid or a water-soluble, non-toxic salt thereof.
- 4. A method for determining the presence and location of an amyloid deposit in a body area of a patient, comprising intravenous administration of an imaging effective quantity of a compound containing a radioactive iodine group of any one of claims 1, 2 or 3 to the patient, and sensing radiation emitted from the body area.
RELATIONSHIP TO COPENDING APPLICATION
This application is a division of copending application Ser. No. 510,461, filed Apr. 17, 1990, which in turn is a division of copending application Ser. No. 178,402, filed Apr. 6, 1988 now U.S. Pat. No. 4,933,156, which in turn was a continuation-in-part of copending application Ser. No. 035,837, filed Apr. 8, 1987, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4435570 |
Nishimura et al. |
Mar 1984 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
510461 |
Apr 1990 |
|
Parent |
178402 |
Apr 1988 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
35837 |
Apr 1987 |
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