Claims
- 1. A 1-acyl-2-oxindole-3-carboxamide compound of the formula ##STR10## and the pharmaceutically-acceptable base salts thereof; wherein X and Y are each selected from the group consisting of hydrogen, fluoro, chloro, bormo, trifluoromethyl and alkyl having 1 to 4 carbons;
- R.sup.1 is selected from the group consisting of heterocyclic, mono-methyl heterocyclic, furymethyl and thienylmethyl; wherein said heterocyclic is selected form the group consisting of pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl and isoxazolyl;
- and R.sup.2 is alkyl having 1 to 6 carbons.
- 2. A compound according to claim 1, wherein R.sup.1 is furylmethyl or thienylmethyl.
- 3. A compound according to claim 2, wherein R.sup.2 is methyl.
- 4. A compound according to claim 1, wherein R.sup.1 is said heterocyclic or said mono-methyl heterocyclic.
- 5. The compound according to claim 3, wherein X and Y are each hydrogen and R.sup.1 is 2-thienylmethyl.
- 6. The compound according to claim 4, wherein X is 5-chloro, Y is hydrogen and R.sup.1 is 2-pyridyl.
- 7. A pharmaceutical composition, which comprises a pharmaceutically-acceptable carrier and a 1-acyl-2-oxindole-3-carboxamide compound according to claim 1, and wherein the weight ratio of the pharmaceutically-acceptable carrier to the 1-acyl-2-oxindole-3-carboxamide compound is in the range from 1:4 to 4:1.
- 8. A method of eliciting an analgesic response in a mammalian subject, which comprises administering to said mammalian subject an analgesic response eliciting amount of a 1-acyl-2-oxindole-3-carboxamide compound according to claim 1.
- 9. A method of treating an inflammatory disease in a mammalian subject, which comprises administering to said mammalian subject an inflammatory disease treating amount of a 1-acyl-2-oxindole-3-carboxamide compound according to claim 1.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a division of application Ser. No. 07/014,120, filed Feb. 2, 1987, now U.S. Pat. No. 4,730,004 which is a continuation in part of application Ser. No. 06/821,296 filed Jan. 22, 1986, now abandoned, which is a continuation in part of application Ser. No. 06/753,200, filed July 9, 1985, now abandoned.
US Referenced Citations (5)
Non-Patent Literature Citations (2)
Entry |
Tacconi, et al., Tetrahedron, 27, (1971) pp. 561-579. |
C.A., 51: 5044a (1957), Kisteneva. |
Divisions (1)
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Number |
Date |
Country |
Parent |
14120 |
Feb 1987 |
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Continuation in Parts (2)
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Number |
Date |
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821296 |
Jan 1986 |
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Parent |
753200 |
Jul 1985 |
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