Claims
- 1. A compound selected from those formula (I): ##STR24## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl group optionally substituted with a hydroxyl group,
- R.sub.2 and R.sub.3 form, with the nitrogen atom to which they are attached a morpholino group,
- X denotes a hydrogen atom,
- Y denotes a hydroxyl group,
- Z denotes a hydrogen atom, and
- T denotes a hydrogen atom or lower alkyl group,
- the term lower indicating that the groups so described have 1 to 6 carbon atoms inclusive,
- their stereoisomers, their quaternary ammonium salts and their addition salts with a pharmaceutically, acceptable acid.
- 2. A compound as claimed in claim 1 which is 3-methyl-6-(1-hydroxy-3-morpholinopropyl)benzoxazolinone, or an addition salt thereof with a pharmaceutically, acceptable acid.
- 3. A pharmaceutical composition suitable for alleviation of pain containing, as active analgestic principle, at least one compound as claimed in claim 1, in combination with one or more pharmaceutically, acceptable, nontoxic, inert vehicles or excipients.
- 4. A pharmaceutical composition as claimed in claim 3, wherein the compound is 3-methyl-6-(1-hydroxy-3-morpholinopropyl)benzoxazolinone or an addition salt thereof with a pharmaceutically-acceptable acid,
- 5. A method for treating a living animal body afflicted with pain, comprising the step of administering to the said living animal an effective analgesic amount of a compound selected from those of formula (I): ##STR25## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl group optionally substituted with a hydroxyl group,
- R.sub.2 and R.sub.3 form, with the nitrogen atom to which they are attached a morpholino group,
- X denotes a hydrogen atom,
- Y denotes a hydroxyl group,
- Z denotes a hydrogen atom, and
- T denotes a hydrogen atom or lower alkyl group, the term "lower" indicating that the groups so described have 1 to 6 carbon atoms, inclusive,
- their stereoisomers, their quaternary ammonium salts, and their addition salts with a pharmaceutically-acceptable acid, which is suitable for the alleviation of said condition.
- 6. A method as claimed in claim 5, wherein the compound is 3-methyl-6-(1-hydroxy-3-morpholinopropyl)benzoxazolinone or an addition salt thereof with a pharmaceutically-acceptable acid.
Priority Claims (1)
Number |
Date |
Country |
Kind |
89 02554 |
Feb 1989 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending U.S. application Ser. No. 07/485,057, filed Feb. 26, 1990, now U.S. Pat. No. 5,132,305.
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Number |
Name |
Date |
Kind |
4558060 |
Caignard |
Dec 1985 |
|
4960778 |
Lesieur et al. |
Oct 1990 |
|
5034401 |
Frost et al. |
Jul 1991 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0390673 |
Oct 1990 |
EPX |
2491471 |
Apr 1982 |
FRX |
82-11186 |
Apr 1982 |
WOX |
Non-Patent Literature Citations (1)
Entry |
European Journal of Medicinal Chemistry-Chimica Therapeutica for Jan.-Feb., 1976, vol. 11, No. 1, pp. 33-42. |
Divisions (1)
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Number |
Date |
Country |
Parent |
485057 |
Feb 1990 |
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