Claims
- 1. A method for the treatment of algesia comprising orally or parenterally administering to a patient in need of such treatment an analgesic effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof. ##STR126## wherein Z represents the carbon and hydrogen atoms necessary to complete a substituted or unsubstituted, saturated or unsaturated, 5- to 7-membered ring; R.sup.1, R.sup.2 and R.sup.3 may be the same or different and represent a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, lower alkoxy, amino, lower alkyl substituted amino, acylamido, sulfamido, halogen and nitro; A represents a moiety selected from the group consisting of formulas: ##STR127## provided that when Z represents the atoms necessary to complete a 2,3,4,5-tetrahydro-1-benzoxepin ring, R.sup.1 may not equal hydrogen, amino, or alkylamino and R.sup.2 may not equal hydrogen or halogen; when Z represents the atoms necessary to complete a 2,2-dimethyl-2,3-dihydrobenofuran ring, R.sup.1, R.sup.2 and R.sup.3 may not simultaneously equal hydrogen and when R.sup.2 is fluorine, R.sup.1 and R.sup.3 may not equal hydrogen; and when Z represents the atoms necessary to complete a 2,2-dimethyl or a 2,2-diethyl, 3,4-dihydrobenzopyran ring, R.sup.2 may not equal fluorine or chlorine when R.sup.1 and R.sup.3 are hydrogen; provided that when Z represents the atoms necessary to complete a 2,3,4,5-tetrahydro-1-benzoxepin ring, R.sup.1 may not equal hydrogen amino, or alkylamino and R.sup.2 may not equal hydrogen or halogen; when Z represents the atoms necessary to complete a 2,2-dimethyl-2,3-dihydrobenzofuran ring, R.sup.1, R.sup.2 and R.sup.3 may not simultaneously equal hydrogen and when R.sup.2 is fluorine, R.sup.1 and R.sup.3 may not equal hydrogen; and when Z represents the atoms necessary to complete a 2,2-dimethyl or a 2,2-diethyl 3,4-dihydrobenzopyran ring, R.sup.2 may not equal fluorine or chlorine when R.sup.1 and R.sub.3 are hydrogen.
- 2. The method of claim 1 wherein Z represents the atoms necessary to complete an unsubstituted dihydrofuran ring.
- 3. The method of claim 1 wherein one of R.sup.1 and R.sup.2 is amino.
- 4. The method of claim 1 wherein R.sup.1 is amino, R.sup.2 is chloro and R.sup.3 is hydrogen.
- 5. The method of claim 1 wherein R.sup.1 is amino, R.sup.2 is chloro and R.sup.3 is hydrogen.
- 6. The method of claim 1 wherein said compound is represented by the formula VIII ##STR128## where A, R.sup.1, R.sup.2 and R.sup.3 are defined as in claim 1 and R.sup.9 is hydrogen, lower alkyl, cycloalkyl or phenyl.
- 7. The method of claim 1 wherein said compound is represented by the formula (IX) ##STR129## where A, R.sup.1, R.sup.2 and R.sup.3 are defined as in claim 1 and R.sup.9 A and R.sup.9 B are independently hydrogen, lower alkyl, cycloalkyl or phenyl.
- 8. The method of claim 4 wherein said compound has the R-isomer configuration.
- 9. The method of claim 5 wherein said compound has the R-isomer configuration.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of U.S. application Ser. No. 07/614,773 filed Nov. 16, 1990 which, in turn, is a comtinuation of U.S. application Ser. No. 07/582,716 filed Sept. 14, 1990, which in turn is a continuation of U.S. application Ser. No. 402,952 filed Sept. 5, 1989, which in turn is a continuation-in-part of U.S. application Ser. No. 868,899 filed May 23, 1986 (now U.S. Pat. No. 4,888,353), which in turn is a continuation-in-part of U.S. application Ser. No. 835,006 filed Feb. 28, 1986 (now abandoned), which in turn is a continuation-in-part of U.S. application Ser. No. 564,641 filed Dec. 22, 1983 (now abandoned).
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4797406 |
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0124783 |
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EPX |
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EPX |
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EPX |
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Non-Patent Literature Citations (1)
Entry |
Medline Search "5HT.sub.3 Antagonists and Analgesia" (1985-1991). |
Continuations (2)
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Number |
Date |
Country |
Parent |
582716 |
Sep 1990 |
|
Parent |
402952 |
Sep 1989 |
|
Continuation in Parts (4)
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Number |
Date |
Country |
Parent |
614773 |
Nov 1990 |
|
Parent |
868899 |
May 1986 |
|
Parent |
835006 |
Feb 1986 |
|
Parent |
564641 |
Dec 1983 |
|