Claims
- 1. A composition comprising:
- crystalline MTiOXO.sub.4 having an analyte receptor immobilized on a surface of said crystalline MTiOXO.sub.4 ;
- wherein M is selected from the group consisting of K, Rb, Tl, and NH.sub.4, and X is P or As; provided that when M is NH.sub.4, X is P.
- 2. The composition of claim 1, wherein M is K and X is P.
- 3. The composition of claim 1, wherein the analyte receptor is a bioreceptor.
- 4. The composition of claim 3, wherein the bioreceptor is immunoreactive.
- 5. The composition of claim 4, wherein the bioreceptor is an antibody.
- 6. The composition of claim 1, wherein the analyte receptor is immobilized directly to the crystalline MTiOXO.sub.4.
- 7. The composition of claim 1, wherein the analyte receptor is immobilized to the crystalline MTiOXO.sub.4 via an immobilization matrix.
- 8. A process for the detection of an analyte, comprising the step of:
- (a) immobilizing a receptor having specific binding affinity for said analyte onto a surface of crystallline MTiOXO.sub.4,
- wherein M is selected from the group consisting of K, Rb, Tl, and NH.sub.4 ; and X is P or As; provided that when M is NH.sub.4, X is P;
- (b) contacting the surface of the crystalline MTiOXO.sub.4 with a solution containing the analyte to be detected, whereby the analyte will bind to the immobilized receptor;
- (c) applying electromagnetic energy to the crystalline MTiOXO.sub.4, whereby acoustic waves characterized by a frequency are generated; and
- (d) measuring the frequency of said acoustic waves; whereby by detecting a change in the frequency of said waves the presence of analyte is detected.
- 9. A process for the detection of an analyte, comprising the steps of:
- (a) immobilizing a receptor having specific binding affinity for said analyte onto a surface of crystalline MTiOXO.sub.4,
- wherein M is selected from the group consisting of K, Rb, Tl, and NH.sub.4 ; and X is P or As; provided that when M is NH.sub.4, X is P;
- (b) contacting the surface of the crystalline MTiOXO.sub.4 with a solution containing the analyte to be detected, whereby the analyte will bind to the immobilized receptor;
- (c) applying electromagnetic radiation to the crystalline MTiOXO.sub.4 ; and
- (d) measuring the optical properties of the crystalline MTiOXO.sub.4 ; whereby by detecting a change in said optical properties the presence of analyte is detected.
- 10. The process of claim 8 or 9, wherein M is K and X is P.
- 11. The process of claim 8 or 9, wherein the receptor is a bioreceptor.
- 12. The process of claim 8 or 9, wherein the bioreceptor is immunoreactive.
- 13. The process of claim 8 or 9, wherein the bioreceptor is a nucleic acid.
- 14. The process of claim 8 or 9, wherein the receptor is immobilizing directly onto the surface of the crystalline MTiOXO.sub.4.
- 15. The process of claim 8 or 9, wherein the receptor is immobilized to the crystalline MTiOXO.sub.4 via an immobilization matrix.
Parent Case Info
This is a continuation of application Ser. No. 08/069,906, filed Jun. 1, 1993, now abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0215669 |
Mar 1987 |
EPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
69906 |
Jun 1993 |
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