Claims
- 1. An apparatus for measuring reflectance from a porous matrix containing a reagent that reacts with an analyte suspected of being present in a liquid sample applied to a surface in said porous matrix, where said sample can migrate through said porous matrix and react with said reagent if said analyte is present in said sample, which comprises:
- a housing;
- an internal chamber in said housing;
- means for accessing said internal chamber, whereby said porous matrix can be inserted in or removed from said internal chamber through said means for accessing;
- means for excluding external light from entering said internal chamber through said means for accessing;
- means for retaining said porous matrix in said internal chamber, wherein said porous matrix is retained with a first surface accessable for applying said liquid sample through said means for accessing;
- means for illuminating a second surface of said porous matrix when said porous matrix is retained in said internal chamber, wherein said second surface is different from said first surface;
- means for detecting intensity of light reflected from said second surface of said porous matrix when said porous matrix is retained in said internal chamber and illuminated by said means for illuminating, wherein said means for detecting produces an output related to said intensity, said means for detecting intensity being adapted to provide a series of outputs;
- control means for processing said outputs, said control means including means for comparing outputs in said series and determining whether said outputs decrease by a predetermined difference sufficient to indicate that said sample of body fluid has reached said second surface, wherein said predetermined decrease in outputs causes said control means to initiate a timing period which results in a measurement reading being taken from said surface at a predetermined time after said second timing period is initiated without having determined the time at which said sample of body fluid was initially applied to said porous matrix; and
- means for reporting said measurement reading.
- 2. The apparatus of claim 1, wherein said apparatus further comprises a self-contained electronic power supply operationally connected to said means for illuminating, means for detecting, control means, and means of reporting.
- 3. The apparatus of claim 1, wherein said means for illuminating and means for detecting light together comprise: 1)two light sources of different wavelengths and a single light detector; or 2) a polychromatic light source and two detectors restricted to detecting different wavelegths of light, wherein one of said wavelengths measures a product absorbance and the other of said wavelengths measures a background absorbance.
- 4. The apparatus of claim 3, wherein the first wavelength of light is from 690 to 710 nm and the second wavelength of light is from 625 to 645 nm.
- 5. The apparatus of claim 1, wherein said control means is further capable of collecting and storing a background detector current reading in the absence of light reflected from said porous matrex.
- 6. The apparatus of claim 5, further comprising a power supply, wherein said control means further comprises means for automatically collecting and comparing sequential reflectance readings from said means for detecting when power is supplied to said control means in an analyte detection mode; means for initiating a timing circuit upon detection of said decrease in reflectance; means for collecting a reaction reflectance reading at a predetermined interval after said drop in reflectance; means for calculating a value for concentration of analyte in said liquid being analyzed from said reaction reflectance reading; and means for transferring said value to said reporting means.
- 7. The apparatus of claim 6, wherein said control means further comprise means for collecting and storing a base reflectance reading from said matrix when power is supplied to said control means in a base reflectance mode prior to said analyte detection mode and means for subtracting said base reflectance reading from said reaction reflectance reading prior to calculation by said control means of said value.
Parent Case Info
This is a division of application Ser. No. 07/896,418, filed Aug. 13, 1986, now U.S. Pat. No. 4,935,346.
US Referenced Citations (8)
Non-Patent Literature Citations (2)
Entry |
N. Tietz (ed.), Textbook of Clinical Chemistry, (W. B. Saunders Philadelphia) pp. 267-269 (1986). |
"Blood Glucose Monitors", in Health Devices, vol. 17, No. 9, pp. 253, 257-258 (Sep. 1988). |
Divisions (1)
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Number |
Date |
Country |
Parent |
896418 |
Aug 1986 |
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