Analyzer-based Phase-Contrast Orthopedic Imaging

Information

  • Research Project
  • 10269477
  • ApplicationId
    10269477
  • Core Project Number
    R01EB023969
  • Full Project Number
    3R01EB023969-03S1
  • Serial Number
    023969
  • FOA Number
    PA-18-591
  • Sub Project Id
  • Project Start Date
    7/15/2018 - 5 years ago
  • Project End Date
    3/31/2022 - 2 years ago
  • Program Officer Name
    ZUBAL, IHOR GEORGE
  • Budget Start Date
    3/1/2021 - 3 years ago
  • Budget End Date
    3/31/2021 - 3 years ago
  • Fiscal Year
    2021
  • Support Year
    03
  • Suffix
    S1
  • Award Notice Date
    2/15/2021 - 3 years ago

Analyzer-based Phase-Contrast Orthopedic Imaging

The proposed project concerns with evaluation of an analyzer-based phase contrast imaging (ABI), for orthopedic imaging. ABI is a modality that uses x-ray refraction to produce dramatic improvements in imaging of the soft tissues. ABI has been well documented to produce extraordinary images at synchrotron facilities. We have developed a breakthrough approach, now included into our full scale prototype that can deliver images under 10sec. This prototype is design for breast imaging. The goal of the proposed project supplement will be to evaluate its output in an expert reader study for orthopedic imaging application and also assess if the system cost can be reduced. ABI imaging offers many important potential benefits: 1) ABI has very high inherent soft- tissue image contrast due to the physics of x-ray refraction and strong scatter rejection, promising to provide clear visualization of bonnie structure as well as soft tissue which includes muscles, ligament and tendons; 2) currently ABI is a planar-imaging method like radiography, but can also be used in computed tomography (CT) modes; 3) ABI has no need for injected contrast agent; 4) ABI has potential to reduce radiation dose; 5) the image detail seen in ABI may ultimately eliminate the need follow CT or MRI imaging. The main elements in this supplement will define the project's specific aims as follows: 1. Evaluate existing imaging system using ex vivo foot and thumb specimens using expert orthopedic surgeons and radiologist. 2) Optimize system cost by evaluating if a smaller (therefore cheaper) detector and crystals can be used without performance reduction.

IC Name
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
  • Activity
    R01
  • Administering IC
    EB
  • Application Type
    3
  • Direct Cost Amount
    98217
  • Indirect Cost Amount
    43255
  • Total Cost
    141472
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    286
  • Ed Inst. Type
    BIOMED ENGR/COL ENGR/ENGR STA
  • Funding ICs
    NIBIB:141472\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
  • Study Section Name
  • Organization Name
    ILLINOIS INSTITUTE OF TECHNOLOGY
  • Organization Department
    ENGINEERING (ALL TYPES)
  • Organization DUNS
    042084434
  • Organization City
    CHICAGO
  • Organization State
    IL
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    606163717
  • Organization District
    UNITED STATES