The present invention relates to an analyzing apparatus structured such as to analyze a sample fed to an analytical tool in accordance with an optical method. More specifically, the present invention relates to an analyzing apparatus provided with a light shielding means for limiting an incoming radiation of an external light into an inner portion of the apparatus.
Conventionally, as a method of measuring a blood sugar level, there is a method using an analytical tool. As one example thereof, there is a method of automatically measuring a blood sugar level in a blood sugar level measuring apparatus by installing an analytical tool to a user in a portable blood sugar level measuring apparatus that can be carried around and dotted sampling blood with respect to the analytical tool (for example, refer to Patent Document 1). Further, there is a structure made such as to measure a blood sugar level by combining a cartridge accommodating a plurality of analytical tools with a blood sugar level measuring apparatus and picking up the analyzing tool from the cartridge in the blood sugar level measuring apparatus (for example, refer to Patent Documents 2 and 3).
On the other hand, as a principle for measuring the blood sugar level, for example, there is a principle utilizing an optical method. In the case that the optical method is utilized in the blood sugar level measurement, the analytical tool is structured such as to be provided with a reagent portion indicating a color in correspondence to a concentration of the blood sugar level, however, the blood sugar level measuring apparatus is structured such as to be provided with a light measuring mechanism for measuring a degree of the color of the reagent portion.
However, since the analytical tool used in the portable blood sugar level measuring apparatus is small, it is necessary to set the light measuring mechanism near a portion (an insertion port) where the analytical tool is installed in the case of employing the optical method in the portable blood sugar level measuring apparatus. Accordingly, there is a risk that the light incoming from the insertion port is received in the light measuring mechanism. If such a matter is generated, the matter affects the result of measurement. Further, since the amount of incoming light via the insertion port is affected by a used environment such as a brightness of a used place, a direction of the insertion port in the blood sugar level measuring apparatus and the like, the amount of incoming light is neither uniform in the measurement nor uniform during the measurement. Accordingly, if it is impossible to suitably suppress the light incoming radiation from the insertion port, it is hard to carry out an accurate blood sugar level measurement.
On the other hand, there is a case that a calibration of the light measuring mechanism is carried out until the insertion of the analytical tool to the blood sugar value measuring apparatus is started, and the sample is fed to the analytical tool. This calibration is carried out by outputting the light from a light source portion of the light measuring mechanism, and comprehending the amount of light received in the light receiving portion of the light measuring mechanism. Accordingly, if the amount of the light incoming from the insertion port is changed in the middle of the calibration, the change affects the result of calibration, and is reflected to a measuring precision as a result.
Further, in the case of measuring the light based on the light transmitting through the analytical tool in the light measuring mechanism, there is a case that the light source portion of the light measuring mechanism employs a light source portion provided with a light emitting device for emitting the light, and a light receiving device for monitoring an output from the light emitting device. In this case, if an amount of the light incoming from the insertion port is changed, the output of the light receiving device is erroneously recognized, and the result of measurement is affected as a result.
Patent Document 1: Japanese Unexamined Patent Publication No. 2003-114213
Patent Document 2: Japanese Unexamined Patent Republication No. 01-63272
Patent Document 3: Japanese Unexamined Patent Publication No. 9-184819
An object of the present invention is to suitably limit an incoming radiation of an external light into an inner portion of an analyzing apparatus via an insertion port and accurately analyze a sample, in the analyzing apparatus structured such as to analyze the sample in accordance with an optical method.
In accordance with the present invention, there is provided an analyzing apparatus including an installation portion having an insertion port and provided for installing an analytical tool; a light measuring mechanism irradiating light to the analytical tool and receiving the light making progress from the analytical tool for analyzing a sample in accordance with an optical method; and a light shielding means for limiting an incoming radiation of an external light from the insertion port, wherein the light shielding means is structured such as to limit the incoming radiation of the external light via the insertion port after starting the insertion of the analytical tool to the installation portion before the light measurement of the analytical tool is finished in the light measuring mechanism.
For example, the light shielding means has a contact member for bringing into contact with the analytical tool, in a state in which the analytical tool is installed to the installation portion.
The contact member is structured such as to have a light shielding portion which comes into contact with the analytical tool and is displaceable in a vertical direction. In this case, the contact member may be structured such as to have a leaf spring portion for pressing to the analytical tool via the light shielding portion.
The analyzing apparatus in accordance with the present invention is structured, for example, such as to pick up the analytical tool from the cartridge accommodating a plurality of analytical tools, and analyze the sample by using the analytical tool, and is structured such as to be further provided with an operation body which is made movable so as to reciprocate relatively with respect to a casing, and a movable body capable of reciprocating between a standby position and a pickup position capable of picking up the analytical tool from the cartridge, working with a reciprocating movement of the operation body, and engaging with the analytical tool accommodated in the cartridge so as to pick up the analytical tool from the cartridge, and provided for accommodating at least a part of the analytical tools in an inner portion of the casing. In this case, the light shielding portion is structured such as to be displaced upward by running on the movable body based on the movement of the movable body.
The movable body is provided such as to coming into contact with the light shielding portion at a time when the light shielding portion runs on, and has a guide surface in which a position becomes higher toward an inserting direction of the analytical tool. On the other hand, the light shielding portion is structured, for example, such that a portion coming into contact with the guide surface is formed as an inclined surface or a curved surface.
The contact member may be structured such that the light shielding portion turns. In this case, the light shielding portion is structured, for example, such that a portion brought into contact with the analytical tool is formed as an inclined surface or a curved surface. The light shielding portion may be energized in a direction of pressing the analytical tool. The light shielding portion is constituted, for example, by an elastic member.
The contact member may be structured such as to include a rubber-like elastic body or a foamed body arranged in an inner portion of the insertion port or at a position which is adjacent to the insertion port.
The contact member in this case is structured, for example, such as to have a penetration space through which the analytical tool is inserted. The penetration space is preferably formed such that at least a partial cross sectional area in an orthogonal direction which is orthogonal to the inserting direction of the analytical tool becomes smaller than a cross sectional area in an orthogonal direction in the analytical tool, and is formed, for example, into a taper shape in which the cross sectional area in the orthogonal direction becomes smaller along the inserting direction. The contact member may be structured such as to have a notch to which the analytical tool is inserted.
The light measuring mechanism is structured, for example, such as to include a light emitting device, a first light receiving device utilized for monitoring an output of the light emitted from the light emitting device, and a second light receiving device receiving the light transmitting the analytical tool, in the light emitted from the light emitting device.
The analytical tool is set, for example, to a state in which the analytical tool partly protrudes from the analyzing apparatus after starting the insertion of the analytical tool to the installation portion before the light measurement of the analytical tool is finished in the light measuring mechanism. The analytical tool may be structured such as to suck the sample fed from the portion protruding from the analyzing apparatus into the inner portion thereof.
A description will be given below of first to fourth embodiments in accordance with the present invention with reference to the accompanying drawings.
First of all, a description will be given of the first embodiment in accordance with the present invention with reference to
An analytical kit 1 shown in
As shown in
The analytical tool 20 corresponding to an accommodated subject in this cartridge 2 is structured such as to analyze the sample in accordance with the optical method by using a small amount of sample (for example, blood or urine) such as about 0.1 μL to 3 μL. In other words, the analytical tool 20 is structured as a color comparison sensor provided with a reagent portion indicating a color corresponding to a concentration of a detected component in the sample. The analytical tool 20 is structured, for example, such as to feed the sample fed to a suction port to the reagent portion based on a capillary force, and is formed such that at least a part thereof has a light transmitting performance in such a manner as to be capable of measuring in a photometrical manner the reagent portion and a reaction fluid of the sample. As shown in
As shown in
A support plate 26 coupled to a coil spring 25 is arranged in the accommodation space 23. In other words, the plurality of analytical tools 20 are energized upward by the coil spring 25 in a state in which the analytical tools 20 are laminated on the support plate 26.
The pickup port 24 is utilized at a time of picking up the analytical tool 20 from the accommodation space 23. The pickup port 24 has a pair of wide portions 24A for allowing an insertion of the arm portion 65 of the movable body 60 in the analyzing apparatus 3 mentioned below, and a narrow portion 24B having a thickness corresponding to a thickness of one analytical tool 20.
The rotary member 22 is provided for selecting a state in which the pickup port 24 in the main body portion 21 is exposed and a state (a covered state) in which the pickup port 24 is not exposed, and is rotatably coupled to the main body portion 21. More specifically, the rotary member 22 is coupled to the main body portion 21 by inserting a shaft 28 provided in the main body portion 21 in a through hole 27. In the through hole 27, a spiral convex portion 27A is formed only in one circle although it does not clearly appear on the drawing. On the other hand, the shaft 28 is provided with a spiral groove portion 28A for engaging with the spiral convex portion 27A. Accordingly, the rotary member 22 is relatively rotatable with respect to the main body portion 21 in a state in which the convex portion 28A is engaged with the groove portion 28A, and an angle of rotation is regulated to 180 degree.
The rotary member 22 is further provided with a closely contact member 29. The closely contact member 29 is provided for shielding the pickup port 24 in a state in which the pickup port 24 is covered by the rotary member 22. The closely contact member 29 is constructed by an elastic material such as rubber or the like. In the case that the closely contact member 29 is arranged as mentioned above, it is possible to completely close the pickup port 24 in a state in which the analytical tool 20 is not picked up from the cartridge 2, and it is possible to suppress water content and light from going thereinto via the pickup port 24 so as to suppress a deterioration of the analytic tool 20.
As shown in
The casing 4 is provided for accommodating various elements in addition to the operation body 5 and the loading mechanism 6 as well as defining an outer appearance shape of the analyzing apparatus 3. The casing 4 is formed hollow by combining the first and second members 40 and 41, and has an opening 42 and an insertion port 43.
The opening 42 is provided for making the operation body 5 be exposed to an outer portion of the casing 4, and allowing a movement of the operation body 5, and is provided in the second member 41. The insertion port 43 is utilized at a time of installing the analytical tool 20 (see
As shown in
Each of the hook portions 50 is a portion with which one end portion of the coil spring 30 is engaged. The other end portion of the coil spring 30 is fixed near the opening 42 of the second member 41 in the casing 4, although it is not clearly expressed in the drawing. The operation body 5 is energized in the direction D1 by the coil spring 30 in a standby state. Accordingly, the operation body 5 is structured such as to move in the direction D2 at a time when a load directed to the direction D2 is applied, and return to the standby position at a time when the load in the direction D2 is cancelled.
A plurality of tooth portions 51 are a portion which is utilized for transmitting a power to the movable body 60, and are coupled to a rack portion 66 of the movable body 60 mentioned below via a gear 64 in the loading mechanism 6.
As shown in
As shown in
A pair of arm portions 65 are provided for picking up the analytical tool 20 from the cartridge 2. These arm portions 65 are reciprocated between a position at which the arm portions 65 protrude from the casing 4 and a position at which the arm portions 65 are accommodated in an inner portion of the casing 4, and can be inserted to the accommodation space 23 in the cartridge 2 by being protruded from the casing 4 (see
Each of the arm portions 65 has a hook portion 67 for engaging with the notch 20A (see
The rack portion 66 is utilized for inputting a load for moving the movable body 60, and has a plurality of tooth portions 66A and locking pieces 66B. A plurality of tooth portions 66A are coupled to a plurality of tooth portions 51 of the operation body 5 via the gear 64. The locking piece 66B is provided for locking the coil spring 31.
As shown in
A pair of hook portions 61A are provided for engaging with the second support member 62, and are protruded upward. In a state in which each of the hooks 61A is engaged with the second support member 62, the first and second members 61 and 62 are integrated with each other. A pair of pins 61B are provided for locking one end portion of the coil spring 31. The holder portion 61C is provided for rotatably retaining the gear 64. The holder portion 61C is structured such as to retain the gear 64 in such a manner that a part of the gear 64 protrudes to an upper side and a lower side of the first support member 61. In other words, the gear 64 is retained in the first support member 62 in a state in which the gear 64 can be engaged with the plurality of tooth portions 51 and 66A of the operation body 5 and the movable body 60.
As shown in
A pair of retaining grooves 62A are provided for accommodating a leaf spring portion 63B of the pressing member 63 mentioned below, and extend in the directions D1 and D2. A through hole 62Aa is provided at a position close to an end portion in the direction D2 side, in each of the retaining grooves 62A. The through hole 62Aa is provided for inserting a hook portion 63Ba of the pressing member 63 mentioned below.
The guide concave portion 62B accommodates the arm portion 65 in the movable body 60, and is provided for defining a moving path of the arm portion 65 (the movable body 60).
A pair of first and second hook portions 62C and 62D are provided for fixing the second support member 62 and therefore the loading mechanism 6 to the casing 4. Each of the first hook portions 62C is provided for engaging with the first member 40 in the casing 4, and protrudes upward. On the other hand, the second hook portion 62D is provided for engaging with the engagement portion 45 of the second member 41 in the casing 4, and protrudes toward a lower side.
The holder portion 62E is provided for retaining the light source apparatus 32. The light source apparatus 32 constructs a light measuring mechanism for measuring in a photometrical manner the analytical tool 20, and is provided at a position facing to a reagent portion (not shown) of the analytical tool 20 in a state in which the analytical tool 20 is installed to the analyzing apparatus 3. The light source apparatus 32 includes a light emitting device and a light receiving device although they are omitted on the drawing, and is structured such as to directly receive a part of the light emitted from the light emitting device on the light receiving device, and be capable of monitoring an output of the light emitting device. The holder 62E is provided with a through hole 62Ea. The through hole 62Ea is provided just below a light emitting surface (not shown) in the light emitting element, and plays a role for guiding the light emitted from the light source apparatus 32 (the light emitting device) to a lower side of the second support member 62. In other words, it is structured such that only the light transmitting the through hole 62Ea is irradiated to the reagent portion (not shown) of the analytical tool 20.
As shown in
The light shielding portion 63A comes into contact with the movable body 60 at a time of moving the movable body 60 in the directions D1 and D2. In other words, the light shielding portion 63A is structured such as to be displaced in a vertical direction based on the movement of the arm portion 65 as well as closing the insertion port 43 in a standby state. A notch 63Aa is provided in the light shielding portion 63A. The notch 63Aa is provided for allowing the movement of the arm portion 65 in the movable body 60, and a portion coming into contact with the upper face side taper surface 67A in the hook portion 67 of the arm portion 65 is formed as an inclined taper surface. The light shielding portion 63A can easily run on the upper surface of the arm portion 65 at a time when the arm portion 65 protrudes from the casing 4, based on the taper surface.
A pair of leaf spring portions 63B are provided for applying a downward pressing force to the light shielding portion 63A as well as slidably supporting the light shielding portion 63A. Each of the leaf spring portions 63B has a hook portion 63Ba, and is fixed to the second support member 62 in the hook portion 63Ba. Each of the leaf spring portions 63B has a spring characteristic, and is arranged in such a manner as to deflect at a time when an upward force is applied thereto via the light shielding portion 63A. Accordingly, the pressing member 63 is structured such as to apply a downward snapping force to the light shielding portion 63 at a time when the light shielding portion 63A is displaced upward.
As shown in
As shown in
The light receiving portion 33 is structured such as to construct a light measuring mechanism together with the light source apparatus 32, and receive the light transmitting through the analytical tool 20 in the light emitted from the light source apparatus 32 and irradiated to the analytical tool 20. In other words, the amount of light received in the light receiving portion 33 correlates with a light absorbing characteristic (a level of color) in the reagent portion (not shown) of the analytical tool 20, and it is possible to compute a concentration of a detected component in the sample based on the previous amount of light received.
Next, a description will be given of an analyzing method of the sample by using the analytical kit 1, and operation of the cartridge 2 and the analyzing apparatus 3.
In the case of analyzing the sample by using the analytical kit 1, first of all, the analytical tool 20 accommodated in the cartridge 2 is fed to the analyzing apparatus 3. The analytical tool 20 is fed to the analyzing apparatus 3 by detaching the cartridge 2 from the analyzing apparatus 3 after installing the cartridge 2 to the analyzing apparatus 3.
The cartridge 2 is installed to the analyzing apparatus 3 in a state in which the pickup port 24 is open by turning the rotating member 22 in the cartridge 2 at 180 degree in accordance with a manual operation of a user as shown in
As shown in
On the other hand, in the case that the movable body 60 is moved in the direction D1, the arm portion 65 protrudes from the casing 4 via the insertion port 43, and the arm portion 65 is inserted to the inner portion of the cartridge 2 from the pickup port 24 of the cartridge 2, as shown in
On the contrary, in the case that the cartridge 2 is detached from the analyzing apparatus 3 (in the case that the cartridge 2 is moved relatively in the direction D1 with respect to the analyzing apparatus 3), the load directed to the direction D2 applied to the operation body 5 is canceled, and the operation body 5 is moved in the direction D1 so as to be returned to the original position by the snapping force of the coil spring 31 (see
The movable body 60 moves in the direction D2 so as to be returned to the original position while working with the movement in the direction D1 of the operation body 5. At this time, since the hook portion 63 in the movable body 60 is engaged with the notch 20A of the analytical tool 20, the analytical tool 20 is moved in the direction D2 together with the movable body 60 and is detached from the cartridge 2, as shown in
In the process of moving the analytical tool 20 in the direction D2 together with the movable body 60, a state in which the arm portion 65 comes into contact with the light shielding portion 63A is maintained, at first, as is known from
Further, in the case that the installation of the analytical tool 20 to the analyzing apparatus 3 is finished, the light is irradiated to the reagent portion (not shown) of the analytical tool 20 from the light source apparatus 32 in the light measuring mechanism, and the light transmitting the analytical tool 20 (the reagent portion) is received by the light receiving portion 33 at that time. In the analyzing apparatus 3, the level of the color of the reagent portion is comprehended based on the result of light receiving in the light receiving portion 33, and the concentration of the detected component in the sample is computed.
In the case that the analysis of the sample is finished, it is necessary to dispose the analytical tool 20, however, the analytical tool 20 can be disposed by moving the operation body 5 in the direction D2 by the user. In other words, in the case of moving the operation body 5 in the direction D2, the movable body 60 is moved in the direction D1, and the analytical tool 20 is also moved in the direction D1. Further, in the case that the movable body 60 is moved to the pickup position, a whole of the analytical tool 20 comes to a state of jumping out of the casing 4, and comes down due to its own weight, and the analytical tool 20 can be disposed from the analyzing apparatus 3.
In the analytical kit 1, the analytical tool 20 is installed to the analyzing apparatus 3 by detaching the cartridge 2 from the analyzing apparatus 3 after installing the cartridge 2 to the analyzing apparatus 3. Further, in the installing process of the analytical tool 20, the light shielding portion 63A of the pressing member 63 is closely attached to the arm portion 65, and is then closely attached to the analytical tool 20. Accordingly, since the insertion port 43 of the analyzing apparatus 3 is maintained in the state of being suitably closed by the arm portion 65 or the analytical tool 20 and the light shielding portion 63A, it is possible to suitably suppress the external light from incoming from the insertion port 43 in the process of inserting the analytical tool 20 via the insertion port 43 of the analyzing apparatus 3. As a result, even in the case that the light measuring mechanisms 32 and 33 are calibrated during the term when the sample is fed to the analytical tool, it is possible to inhibit the external light from being received in the light receiving portion 33 at a time of this calibration. Accordingly, it is possible to suitably calibrate the light measuring mechanisms 22 and 23, and it is possible to suppress a disadvantage caused by the incoming radiation of the external light at a time of calibrating, that is, a deterioration of a measuring precision.
Further, in the case of measuring the analytical tool 20 in the photometrical manner, since the light shielding portion 63A is closely attached to the analytical tool 20, it is possible to suitably limit the incoming radiation of the external light from the insertion port 43 at a time of measuring the light. Accordingly, it is possible to suppress the influence of the external light at a time of measuring the light, and it is possible to carry out a more suitable sample analysis.
Further, the light shielding portion 63A of the pressing member 63 closes the insertion port 43 in the standby state, and even in the process of installing the analytical tool 20 to the analyzing apparatus 3 and in the case of measuring the analytical tool 20 in the photometrical manner, the insertion port 43 is suitably closed. Accordingly, even in the case of monitoring the output of the light emitting device of the light source apparatus 32 in the light measuring mechanisms 32 and 33, it is possible to monitor the output of the light emitting device in the light source apparatus 32 while suppressing the influence of the external light, whichever case the timing of the output monitor is the standby state, the inserting process of the analytical tool 20 and under measurement of the analytical tool 20 in the photometrical manner. As a result, since it is possible to suitably comprehend the output of the light emitting device of the light source apparatus 32, it is possible to suppress the deterioration of the measuring precision based on an erroneous recognition of the output of the light emitting device.
Accordingly, in the analyzing apparatus 3, it is possible to inhibit the measuring precision from being deteriorated by the external light, and inhibit a dispersion from being generated in the result of measurement.
Next, a description will be given of an analyzing apparatus in accordance with a second embodiment of the present invention with reference to
An analyzing apparatus 8 shown in
The analyzing apparatus 8 is provided with a pressing member 80 in the same manner as the analyzing apparatus 3 (see
On the other hand, the light shielding portion 81 is formed as a rectangular plate shape in which a lower end edge is formed as a linear shape, and closes the insertion port 43 in its standby state. In other words, since the analyzing apparatus 8 is not structured such as to move the arm portion 65 such as the previous analyzing apparatus 3, the notch 63Aa (see
As shown in
As mentioned above, in the analyzing apparatus 8, the analytical tool 20 is pressed by the light shielding portion 81 continuously in the inserting process of the analytical tool 20 and at a time of measuring the light. Accordingly, in the state in which the insertion port 43 is suitably closed by the light shielding portion 81, the analytical tool 20 is inserted, and the measurement in the photometrical manner of the analytical tool 20 is carried out. As a result, in the same manner as the analyzing apparatus 3 (see
Next, a description will be given of a third embodiment in accordance with the present invention with reference to
An analyzing apparatus 8′ shown in
On the other hand, an analyzing apparatus 8″ shown in
In this case, in the analyzing apparatuses 8′ and 8″, it is not necessary that the rotary members 80′ and 80″ are supported to the casing 4, but the rotary members 80′ and 80″ may be supported to the other element than the casing 4. Further, in the analyzing apparatus 8″, the downward force may be applied to the rotary member 80″ by the other member than the coil spring 85′.
Next, a description will be given of an analyzing apparatus in accordance with a fourth embodiment of the present invention with reference to
The analyzing apparatus 9 shown in
As shown in
The through hole 91 passes through in the directions D1 and D2, and is structured such that a cross sectional area becomes smaller toward an inner portion of the casing 4. A minimum cross sectional area of the through hole 91 is made smaller than the cross sectional area of the analytical tool 20. Accordingly, in the case of inserting the analytical tool 20 via the through hole 91, the through hole 91 is expanded, and a snapping force of the pressing member 90 is applied to a whole of the periphery of the analytical tool 20. Therefore, since the insertion port 43 is set to the state of being suitably closed, at a time of the calibration, at a time of the measurement in the photometrical manner, and at a time of monitoring the output of the light emitting device (not shown) in the light emitting apparatus 22, it is possible to suppress the influence of the external light. Accordingly, in the analyzing apparatus 9, it is possible to inhibit the measuring precision from being deteriorated by the external light, and inhibit the dispersion from being generated in the result of measurement.
Of course, the present invention is not limited to the analyzing apparatuses described in the first to third embodiments, but can be variously designed and modified. For example, the light measuring mechanism in each of the embodiments is structured as the transmitting type, however, the light measuring mechanism may be structured as a reflecting type.
Further, in the first embodiment in accordance with the present invention, the mechanism for picking up the analytical tool 20 from the cartridge 2 can be variously changed. For example, the hook portion 67 in the arm portion 65 may be formed as a curved surface in place of the inclined surface in the lower face side taper surface 67B.
The present invention can be further applied to an analyzing apparatus used by accommodating a plurality of analytical tools in an inner portion and setting the analytical tools in the inner portion of the apparatus.
In the analyzing apparatus 9 in accordance with the fourth embodiment of the present invention, the elastic body 90 is formed as the rectangular ring shape, however, the pressing member 90 may be structured such as to press at least a part of the analytical tools 20. Accordingly, the through hole 91 may be structured such as to have a uniform cross section, and may be arranged at a position which is adjacent to the insertion port 43 in place of the inner portion of the insertion port 43. Further, it is not necessary that the elastic body presses the whole of the periphery of the analytical tool 20, for example, an elastic body 90′ may be formed as a shape having a partly segmented notch 91′, or may be formed as a rod-like shape, or may be constituted by a plurality of parts, as shown in
Number | Date | Country | Kind |
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2006-006829 | Jan 2006 | JP | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/JP2007/050411 | 1/15/2007 | WO | 00 | 1/19/2010 |