Anatomical and functional consequences of dyslexia-gene DCDC2 knockout in a rat model

Information

  • Research Project
  • 10193256
  • ApplicationId
    10193256
  • Core Project Number
    R15HD103479
  • Full Project Number
    1R15HD103479-01A1
  • Serial Number
    103479
  • FOA Number
    PAR-18-714
  • Sub Project Id
  • Project Start Date
    4/1/2021 - 3 years ago
  • Project End Date
    3/31/2024 - 2 months ago
  • Program Officer Name
    MILLER, BRETT
  • Budget Start Date
    4/1/2021 - 3 years ago
  • Budget End Date
    3/31/2024 - 2 months ago
  • Fiscal Year
    2021
  • Support Year
    01
  • Suffix
    A1
  • Award Notice Date
    3/25/2021 - 3 years ago

Anatomical and functional consequences of dyslexia-gene DCDC2 knockout in a rat model

Project Summary/Abstract Dyslexia (DYS) is a common developmental disorder with a strong genetic component which can have a significant impact on academic and vocational success as well as emotional well-being. Children with this disorder have reading scores that are at least 1 standard deviation below their age- and grade- matched peers. In spite of these diagnostic criterion, there is a great deal of heterogeneity within this label, both with regard to the severity of the core deficit(s) as well as in the genetic basis of the disorder. This heterogeneity, combined with a lack of a strong understanding of these mechanisms, leads to a one-size-fits all approach to intervention and a significant portion of individuals do not respond to the intervention option offered. Association studies in humans suggest that the dyslexia- susceptibility gene DCDC2 is associated with anatomical deficits in the brain as well as deficits on tasks that require speed. The current studies will evaluate whether this gene is causally related to these deficits by utilizing a novel knockout rat model recently developed by the PI. If it is confirmed that this gene does impact anatomy and rapid auditory processing, it would suggest that individuals with dyslexia that carry a variant in this gene may respond more effectively to interventions targeting these specific skills.

IC Name
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
  • Activity
    R15
  • Administering IC
    HD
  • Application Type
    1
  • Direct Cost Amount
    225000
  • Indirect Cost Amount
    85956
  • Total Cost
    310956
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    865
  • Ed Inst. Type
    SCHOOLS OF ARTS AND SCIENCES
  • Funding ICs
    NICHD:310956\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    TEXAS CHRISTIAN UNIVERSITY
  • Organization Department
    PSYCHOLOGY
  • Organization DUNS
    043807882
  • Organization City
    FORT WORTH
  • Organization State
    TX
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    761290001
  • Organization District
    UNITED STATES